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المؤلفون: Escobar PA; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Sobol Z; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Miller RR; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Ferry-Martin S; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Stermer A; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Jacob B; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Muniappa N; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Sanchez R; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Blanchard KT; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Galijatovic-Idrizbegovic A; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Amin RP; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA., Troth SP; Nonclinical Drug Safety and Pharmacokinetics Dynamics Metabolism and Bioanalysis, Preclinical Development, Merck & Co. Inc, Rahway, New Jersey, USA.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

المؤلفون: Dong S; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhao Z; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li G; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Pan J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Gu X; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Jiang J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xiao L; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scapin G; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hunter DN; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang D; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Huang Y; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bennett F; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang SW; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mandal M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Su J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tudge C; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., deJesus RK; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ding FX; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lombardo M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hicks JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Fischmann T; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mirza A; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dayananth P; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Painter RE; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Villafania A; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Garlisi CG; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zhang R; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Si Q; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Li N; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Amin RP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bhatt B; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chen F; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan CP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan H; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lin X; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu J; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pollack SR; Discovery Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scott JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nargund RP; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Therien AG; Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02139, United States., Black T; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Young K; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pasternak A; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3400-3418. Date of Electronic Publication: 2024 Feb 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: beta-Lactamase Inhibitors*/pharmacology , beta-Lactamase Inhibitors*/therapeutic use , beta-Lactamase Inhibitors*/chemistry , Anti-Bacterial Agents*/chemistry, Humans ; Imipenem/pharmacology ; beta-Lactamases ; Gram-Negative Bacteria ; Microbial Sensitivity Tests

المؤلفون: Himmel H; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.) herbert.himmel@bayer.com., Lagrutta A; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Vömel M; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Amin RP; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Imredy JP; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Johnson T; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Vinzing M; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Prescott J; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.)., Blaustein RO; Research and Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany (H.H., Mat.V., May.V.) and Merck & Co., Inc., Rahway, New Jersey (A.L., R.P.A., J.P.I., T.J., J.P., R.O.B.).

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Jul; Vol. 386 (1), pp. 26-34. Date of Electronic Publication: 2023 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Heart Failure* , Heterocyclic Compounds, 2-Ring*, Humans ; Animals ; Dogs ; Soluble Guanylyl Cyclase/metabolism ; Pyrimidines ; Vasodilator Agents ; Ether-A-Go-Go Potassium Channels