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1دورية أكاديمية
المؤلفون: Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blair
المصدر: PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Anthony Hazel, Chad A. Dickey, Mackenzie D. Martin, Shannon E. Hill, Raquel L. Lieberman, James C. Gumbart, Michelle S. Kwon, Amirthaa Suntharalingam
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Nonsynonymous substitution, Mutant, Context (language use), Molecular Dynamics Simulation, Gene mutation, Protein aggregation, Biochemistry, 03 medical and health sciences, Protein structure, Humans, Eye Proteins, Molecular Biology, Myocilin, Glycoproteins, Genetics, Extracellular Matrix Proteins, 030102 biochemistry & molecular biology, Chemistry, Genetic Variation, Glaucoma, Cell Biology, Cytoskeletal Proteins, HEK293 Cells, 030104 developmental biology, Mutation, Protein Structure and Folding, Protein folding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e922b7332b16dc2b6886daa6548341
https://doi.org/10.1074/jbc.ra119.009419 -
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المؤلفون: Dustin J. E. Huard, John Koren, Laura J. Blair, Jack M. Webster, Bryce A. Nordhues, Christopher L. Passaglia, Brian S. J. Blagg, Vincent M. Crowley, Raquel L. Lieberman, Andrew R. Stothert, Xiaolan Tang, Amirthaa Suntharalingam, Sanket J. Mishra, Chad A. Dickey
المصدر: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Gene isoform, genetic structures, Mutant, lcsh:Medicine, Mice, Transgenic, Article, 03 medical and health sciences, 0302 clinical medicine, Heat shock protein, Animals, HSP90 Heat-Shock Proteins, lcsh:Science, Myocilin, Membrane Glycoproteins, Multidisciplinary, biology, Chemistry, lcsh:R, Phenotype, Hsp90, eye diseases, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Protein folding, sense organs, Glaucoma, Open-Angle
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المؤلفون: Chad A. Dickey, Laura J. Blair, Markus Zweckstetter, Jeremy D. Baker, Dali Zheng, Stefan Becker, Leia E. Sullivan, Parth K. Solanki, Zheying Sun, Filippo Favretto, April L. Darling, Vladimir N. Uversky, Jonathan J. Sabbagh, Eckhard Mandelkow, Mackenzie D. Martin, Lindsey B. Shelton, John Koren, Amirthaa Suntharalingam, Bryce A. Nordhues
المصدر: PLoS Biology
PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)
PLoS biology 15(6), e2001336 (2017). doi:10.1371/journal.pbio.2001336مصطلحات موضوعية: Male, genetics [Amyloid], genetics [Cognition Disorders], metabolism [Neurodegenerative Diseases], Biochemistry, Cyclophilins, Animal Cells, Electron Microscopy, metabolism [alpha-Synuclein], Amino Acids, Biology (General), Isomerases, Cyclophilin, Neurons, Organic Compounds, Physics, metabolism [Cyclophilins], Magnetism, Brain, 3. Good health, Tauopathies, Physical Sciences, genetics [alpha-Synuclein], Cyclosporine, Cellular Types, General Agricultural and Biological Sciences, Cyclophilin D, Amyloid, Proline, QH301-705.5, Nuclear Magnetic Resonance, Blotting, Western, tau Proteins, Intrinsically disordered proteins, Protein Aggregation, Pathological, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Microscopy, Electron, Transmission, Alzheimer Disease, Humans, Alpha-synuclein, PPIF protein, mouse, HEK 293 cells, Chemical Compounds, genetics [Tauopathies], Biology and Life Sciences, Proteins, drug effects [Protein Aggregates], Cyclic Amino Acids, Protein Aggregation, Chaperone Proteins, genetics [tau Proteins], 030104 developmental biology, chemistry, Amyloid Proteins, metabolism [Tauopathies], Cognition Disorders, Neuroscience, 0301 basic medicine, genetics [Alzheimer Disease], Protein aggregation, physiopathology [Brain], chemistry.chemical_compound, pathology [Brain], Protein secondary structure, Microscopy, General Neuroscience, Neurodegenerative Diseases, Animal Models, Condensed Matter Physics, Enzymes, Chemistry, Experimental Organism Systems, physiopathology [Cognition Disorders], genetics [Cyclophilins], alpha-Synuclein, Female, metabolism [Alzheimer Disease], Research Article, Tau protein, Mouse Models, Mice, Transgenic, Biology, Research and Analysis Methods, Protein Aggregates, Model Organisms, metabolism [Cognition Disorders], mental disorders, Animals, ddc:610, metabolism [Amyloid], pharmacology [Cyclosporine], General Immunology and Microbiology, Organic Chemistry, Cell Biology, metabolism [tau Proteins], Disease Models, Animal, HEK293 Cells, metabolism [Brain], Cellular Neuroscience, genetics [Neurodegenerative Diseases], Enzymology, biology.protein, ultrastructure [Amyloid], Transmission Electron Microscopy
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f6b2bd08582824ce677c0cf860aa60
https://hdl.handle.net/21.11116/0000-0001-7953-A -
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المؤلفون: Dustin J. E. Huard, Sarah N. Fontaine, Amirthaa Suntharalingam, Andrew R. Stothert, Brian S. J. Blagg, Raquel L. Lieberman, Sanket J. Mishra, Vincent M. Crowley, Chad A. Dickey
المصدر: Human Molecular Genetics. 23:6470-6480
مصطلحات موضوعية: Protein Folding, genetic structures, Mutant, Plasma protein binding, Protein aggregation, Biology, Protein Aggregates, Protein structure, Trabecular Meshwork, Genetics, medicine, Humans, RNA, Small Interfering, Eye Proteins, Protein Structure, Quaternary, Molecular Biology, Genetics (clinical), Myocilin, Glycoproteins, Regulation of gene expression, Membrane Glycoproteins, Dose-Response Relationship, Drug, HEK 293 cells, Imidazoles, Articles, General Medicine, eye diseases, Protein Structure, Tertiary, Cell biology, Molecular Docking Simulation, body regions, carbohydrates (lipids), Cytoskeletal Proteins, HEK293 Cells, medicine.anatomical_structure, Gene Expression Regulation, sense organs, Trabecular meshwork, Glaucoma, Open-Angle, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0820ac904af2b35c2d53984f9ab27846
https://doi.org/10.1093/hmg/ddu367 -
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المؤلفون: Timothy A.J. Haystead, Lindsey B. Shelton, Jeremy D. Baker, Chad A. Dickey, Mackenzie D. Martin, Jonathan J. Sabbagh, Jason E. Gestwicki, Bryce A. Nordhues, Dali Zheng, Amirthaa Suntharalingam
المصدر: ACS chemical biology. 11(7)
مصطلحات موضوعية: 0301 basic medicine, tau Proteins, Pharmacology, In Vitro Techniques, Inhibitory postsynaptic potential, Biochemistry, Article, Small Molecule Libraries, 03 medical and health sciences, mental disorders, medicine, Humans, HSP70 Heat-Shock Proteins, Cytotoxicity, Chemistry, HEK 293 cells, General Medicine, medicine.disease, In vitro, Hsp70, Chronic traumatic encephalopathy, 030104 developmental biology, HEK293 Cells, Mechanism of action, Molecular Medicine, medicine.symptom, Ex vivo
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المؤلفون: Umesh K. Jinwal, Amirthaa Suntharalingam, Karthik Arulselvam, Sarah Brady, Matthew Cockman, Ying Jin, Jose F. Abisambra, Chad A. Dickey, Bo Zhang
المصدر: Journal of Molecular Biology. 421:653-661
مصطلحات موضوعية: Amyloid, Gene knockdown, biology, Protein Stability, Chemistry, tau Proteins, HSP40 Heat-Shock Proteins, Models, Biological, Cellular defense, Article, Cell biology, Hsp70, Pathogenesis, Protein stability, Biochemistry, Structural Biology, In vivo, Chaperone (protein), mental disorders, biology.protein, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, HeLa Cells
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المؤلفون: John Koren, Brian S. J. Blagg, Matthew Cockman, Shannon E. Hill, Umesh K. Jinwal, Laura J. Blair, Jose F. Abisambra, Adam S. Duerfeldt, Myung Kuk Joe, Bo Zhang, Stanislav I. Tomarev, John C. O'Leary, Amirthaa Suntharalingam, Raquel L. Lieberman, Chad A. Dickey
المصدر: The Journal of biological chemistry. 287(48)
مصطلحات موضوعية: genetic structures, Glucose-regulated protein, Plasma protein binding, Endoplasmic-reticulum-associated protein degradation, Endoplasmic Reticulum, Biochemistry, Autophagy, ERAD pathway, Humans, Eye Proteins, Molecular Biology, Myocilin, Glycoproteins, Membrane Glycoproteins, biology, Endoplasmic reticulum, Molecular Bases of Disease, Cell Biology, Endoplasmic Reticulum-Associated Degradation, Hsp90, eye diseases, Cell biology, body regions, carbohydrates (lipids), Cytoskeletal Proteins, Chaperone (protein), Mutation, biology.protein, sense organs, Glaucoma, Open-Angle, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d040ca7d581454c4c1b2be589b44a765
https://pubmed.ncbi.nlm.nih.gov/23035116
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