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1دورية أكاديمية
المؤلفون: David J. Huggins, Bryn S. Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J. Narvaez, Meredith Roberts-Thomson, Alex T. Crooks, Robert G. Boyle, Richard Boyce, David W. Walker, Natalia Mateu, Grahame J. McKenzie, David R. Spring, Ashok R. Venkitaraman
المصدر: ACS Omega, Vol 5, Iss 1, Pp 822-831 (2019)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2470-1343
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المؤلفون: Chris Abell, Kalina T. Haas, Matthias T. Ehebauer, Luca Pellegrini, Amy Emery, May Marsh, David J. Huggins, Chiara R. Valenzano, Tom L. Blundell, Ashok R. Venkitaraman, Bryn Hardwick, Miyoung Lee, Lorraine Barber, Timothy Sharpe, Rajavel Srinivasan, John Skidmore, Nicola J. Francis-Newton, Alessandro Esposito, Duncan Scott, Claudio Dagostin, Marko Hyvönen, Gerhard Fischer, Andrew R. Bayly, Grahame J. McKenzie, Trevor Perrior, Tommaso Moschetti, Anthony G. Coyne
المساهمون: Scott, Duncan [0000-0003-1917-9576], Coyne, Anthony [0000-0003-0205-5630], Esposito, Alessandro [0000-0002-5051-091X], Pellegrini, Luca [0000-0002-9300-497X], Blundell, Tom [0000-0002-2708-8992], Skidmore, John [0000-0001-9108-7858], Abell, Chris [0000-0001-9174-1987], Apollo - University of Cambridge Repository
المصدر: Cell Chemical Biology
'Cell Chemical Biology ', vol: 28, pages: 835-847 (2021)مصطلحات موضوعية: Models, Molecular, DNA repair, DNA damage, Poly ADP ribose polymerase, Clinical Biochemistry, genetic processes, RAD51, Molecular Conformation, homologous recombination, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, law.invention, Small Molecule Libraries, chemistry.chemical_compound, law, Drug Discovery, Tumor Cells, Cultured, Humans, structure-guided drug discovery, Molecular Biology, Polymerase, Pharmacology, BRCA2 Protein, radiosensitizer, biology, Cell Death, 010405 organic chemistry, BRCA2, protein-protein interaction inhibition, 0104 chemical sciences, Cell biology, enzymes and coenzymes (carbohydrates), chemistry, biology.protein, Recombinant DNA, health occupations, Molecular Medicine, cancer therapy, Rad51 Recombinase, biological phenomena, cell phenomena, and immunity, Homologous recombination, RAD51 inhibitor, DNA, DNA Damage, Protein Binding
وصف الملف: 835 - 847 (+ e1 - e5); Print-Electronic; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e8b51ead91fb6e0441f1e51a013c4f
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المؤلفون: Vikrant Kumar, Bryn Hardwick, Saranya Giridharan, Sneha Sudhakar, Markus Muellner, Manjunath A. Hurakadli, Ashok R. Venkitaraman, Gayathri Sadasivam, T.K. Prasad, Neelagandan Kamariah, Grahame J. McKenzie, Alex T. Crooks, Subashini Mathivanan, Paul M. Watt, Miguel Coelho, Sneha Bairy, Nadia Milech, Chandan Mithra, Christopher J. Torrance, Amy Emery, Kavitha Bharatham
المصدر: Cell Chemical Biology
مصطلحات موضوعية: Phenotypic screening, Systems biology, Clinical Biochemistry, Peptide, Computational biology, Biology, medicine.disease_cause, 01 natural sciences, Biochemistry, Article, Protein–protein interaction, law.invention, Small Molecule Libraries, protein-protein interaction, Peptide Library, target identification, law, Drug Discovery, medicine, Humans, Genes, Tumor Suppressor, Phosphorylation, FOXO3a, lead discovery, Peptide library, Molecular Biology, Cells, Cultured, 14-3-3, Pharmacology, chemistry.chemical_classification, Mutation, 010405 organic chemistry, Forkhead Box Protein O3, phenotypic screening, Small molecule, 0104 chemical sciences, prokaryal genomes, target validation, chemistry, bioactive peptide, Molecular Medicine, Suppressor, Female, protein interference
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009 -
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المؤلفون: Pooja Sharma, Marko Hyvönen, Robert Mahen, Bryn Hardwick, David J. Huggins, David R. Spring, Ashok R. Venkitaraman, M. Rossmann, Jamie E. Stokes, Amy Emery, D.L. Kunciw, Grahame J. McKenzie
المساهمون: Apollo - University of Cambridge Repository, Rossmann, Maxim [0000-0001-8811-3277], Huggins, David [0000-0003-1579-2496], Spring, David [0000-0001-7355-2824]
المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)مصطلحات موضوعية: 0301 basic medicine, 82/29, NEDD1, lcsh:Medicine, Cell Cycle Proteins, Polo-like kinase, 01 natural sciences, Substrate Specificity, Chromosome segregation, Histones, Chromosome Segregation, RNA, Small Interfering, 14/19, lcsh:Science, Kinetochores, 3' Untranslated Regions, 13/89, 45/70, Multidisciplinary, Kinetochore, Chemistry, Small molecules, article, 45/77, Cell biology, Chromatin, 3. Good health, 631/92/275, RNA Interference, 631/92/612/1246, Protein Binding, Cell Survival, 631/80/103/1966, 145, Mitosis, Kinases, 13/106, 13/109, Protein Serine-Threonine Kinases, PLK1, 631/92/613, 03 medical and health sciences, Protein Domains, Proto-Oncogene Proteins, Humans, Protein Kinase Inhibitors, 14/35, 010405 organic chemistry, 631/80/641/1655, lcsh:R, Phosphoproteins, 0104 chemical sciences, Protein Structure, Tertiary, 030104 developmental biology, Mutagenesis, Phosphoprotein, 14/63, lcsh:Q, 82/51, HeLa Cells
وصف الملف: application/pdf; text/xml; application/zip
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae35f160ed3a220ca50570e2ae438818
https://www.repository.cam.ac.uk/handle/1810/312387 -
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المؤلفون: Ana J. Narvaez, Meredith Roberts-Thomson, Richard J. Boyce, Suzan Ber, Christopher J. Torrance, Alex T. Crooks, Robert George Boyle, Grahame J. McKenzie, David Perera, Samuel P. Barker, Estrella Guarino Almeida, Ian A. Prior, Bryn Hardwick, David J. Huggins, Ashok R. Venkitaraman, David W. Walker, Fiona E. Hood, Roberta Azzarelli, Amy Emery
المساهمون: Huggins, David [0000-0003-1579-2496], Apollo - University of Cambridge Repository
المصدر: Cell Chemical Biology
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Mutant, protein-protein interactions, Cell Cycle Proteins, Polo-like kinase, medicine.disease_cause, Biochemistry, Substrate Specificity, 0302 clinical medicine, Drug Discovery, Mutation, Molecular Structure, Kinase, Protein-Serine-Threonine Kinases, 3. Good health, 030220 oncology & carcinogenesis, Molecular Medicine, cancer therapy, PLK4, KRAS, Drug, PLK1, Protein Binding, Cell Survival, Mitosis, Protein Serine-Threonine Kinases, Biology, Article, Dose-Response Relationship, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Structure-Activity Relationship, c-MET, mutant KRAS, Polo-box domain, PPI inhibitor, Dose-Response Relationship, Drug, Humans, Protein Interaction Domains and Motifs, Proto-Oncogene Proteins, medicine, Molecular Biology, Pharmacology, 030104 developmental biology, Cancer research
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f2f37f22ae1cd96be9703289bb40c
http://hdl.handle.net/11568/1013971 -
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المؤلفون: Matej, Janeček, Maxim, Rossmann, Pooja, Sharma, Amy, Emery, David J, Huggins, Simon R, Stockwell, Jamie E, Stokes, Yaw S, Tan, Estrella Guarino, Almeida, Bryn, Hardwick, Ana J, Narvaez, Marko, Hyvönen, David R, Spring, Grahame J, McKenzie, Ashok R, Venkitaraman
المصدر: Scientific Reports
مصطلحات موضوعية: Mitosis, Nuclear Proteins, Cell Cycle Proteins, Spindle Apparatus, Phosphoproteins, Article, Neoplasm Proteins, Small Molecule Libraries, Cell Line, Tumor, Humans, Protein Interaction Maps, Microtubule-Associated Proteins, Protein Kinases, Aurora Kinase A, HeLa Cells, Protein Binding
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المؤلفون: David M. Glover, Frederic Scaerou, Emma Easthope, David O. Jones, David A. Sorrell, Amy Emery, Daniella Zheleva, Stacy Lawrence, Mark W. Stockdale
المصدر: SLAS Discovery. 16:925-931
مصطلحات موضوعية: Mitotic index, Cell, Aurora inhibitor, Regulator, Aurora A kinase, Mitosis, Uterine Cervical Neoplasms, Antineoplastic Agents, macromolecular substances, Protein Serine-Threonine Kinases, Biology, Biochemistry, Piperazines, Analytical Chemistry, Small Molecule Libraries, Aurora Kinases, medicine, Humans, Phosphorylation, Protein Kinase Inhibitors, Automation, Laboratory, Centrosome, Tumor Suppressor Proteins, Organophosphates, High-Throughput Screening Assays, Molecular Imaging, Cell biology, enzymes and coenzymes (carbohydrates), medicine.anatomical_structure, embryonic structures, Quinazolines, Molecular Medicine, Female, biological phenomena, cell phenomena, and immunity, Antibodies, Phospho-Specific, Microtubule-Associated Proteins, HeLa Cells, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1544d1b347478bdde0bac8b9e63930fd
https://doi.org/10.1177/1087057111413923 -
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المؤلفون: Grahame J. McKenzie, Ashok R. Venkitaraman, Luca Laraia, David R. Spring, Jamie E. Stokes, Amy Emery
المصدر: ACS medicinal chemistry letters. 5(5)
مصطلحات موضوعية: Tubulin Modulators, Phenotypic screening, Organic Chemistry, Allosteric regulation, Pharmacology, Biology, Biochemistry, Vinblastine, chemistry.chemical_compound, Tubulin, chemistry, High-content screening, Drug Discovery, medicine, biology.protein, Colchicine, Antimitotic Agent, medicine.drug
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المؤلفون: Amy Emery, Nicola L. Rogers, Michael G. Thomas, David Blake, Graeme Thomson, Stuart Jones, Simon Green, Abhijeet Choudhary, David M. Glover, Frederic Scaerou, Claire June Flynn, Jonathan Hollick, Janice Mclachlan
المصدر: Cancer Research. 70:4435-4435
مصطلحات موضوعية: Cancer Research, Kinase, Cell, Polo-like kinase, Biology, medicine.disease_cause, PLK1, medicine.anatomical_structure, Oncology, Immunology, Cancer research, medicine, Protein kinase A, Carcinogenesis, Mitosis, Cytokinesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf88c64f7cfba9166c2c19d15758b182
https://doi.org/10.1158/1538-7445.am10-4435