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المؤلفون: Deepak Dalvie, Yong Wang, Theodore O. Johnson, Michael Siu, Cripps Stephan James, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Taylor Wendy Dianne, Stanley William Kupchinsky, Ping Kang, Sue Zhou, Jacques Ermolieff, Andrea Fanjul, Sajiv Krishnan Nair, Arturo Castro, Jennifer E. Vogel, Jean Joo Matthews, Amy LaPaglia, Cheng Hengmiao, Paul A. Rejto, Christopher Ronald Smith, Martin Paul Edwards, Natilie Hosea
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2344-2348
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Dehydrogenase, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Sulfonamides, biology, Chemistry, Organic Chemistry, HEK 293 cells, Glutathione, HEK293 Cells, Reactive metabolite, Risk-benefit analysis, biology.protein, Molecular Medicine
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المؤلفون: Cripps Stephan James, Thomas A. Pauly, Natilie Hosea, Martin Paul Edwards, Sajiv Krishnan Nair, Arturo Castro, Jacques Ermolieff, Theodore O. Johnson, Andrea Fanjul, Jean Joo Matthews, Yong Wang, Michael Siu, Amy LaPaglia, Jennifer E. Vogel, Taylor Wendy Dianne
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:3493-3497
مصطلحات موضوعية: Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Dehydrogenase, Crystallography, X-Ray, Biochemistry, Isozyme, Cell Line, Structure-Activity Relationship, Cricetinae, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Computer Simulation, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Organic Chemistry, Biological activity, Ligand (biochemistry), Rats, Enzyme, chemistry, Lipophilic efficiency, Drug Design, Molecular Medicine, Cortisone, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, medicine.drug