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1
المؤلفون: Kalyan Das, Joseph D. Bauman, Eddy Arnold, Steven F. Baker, Edmond J. LaVoie, D. Patel, Ajit K. Parhi, R. S. K. Vijayan, Luis Martinez-Sobrido, Amy Xiang
المصدر: ACS Chemical Biology. 8:2501-2508
مصطلحات موضوعية: Orthomyxoviridae, Drug Evaluation, Preclinical, RNA-binding protein, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Article, Inhibitory Concentration 50, Endonuclease, Catalytic Domain, Pandemic, Humans, Enzyme Inhibitors, Cells, Cultured, Polymerase, Chelating Agents, biology, Pandemic influenza, Active site, General Medicine, Endonucleases, biology.organism_classification, Virology, biology.protein, Molecular Medicine, Structure based, Biological Assay
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2
المؤلفون: Lawrence C. Kuo, Gee-Hong Kuo, Weimei Sun, Fengbing Song, Zhihua Sui, Amy Xiang, Alan C. Gibbs, Marta C. Abad, Xuqing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4762-4767
مصطلحات موضوعية: Models, Molecular, Indazole, Indazoles, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Pyrazole, Crystallography, X-Ray, Biochemistry, Combinatorial chemistry, Fructokinases, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Drug Discovery, Pyrazoles, Molecular Medicine, Molecular Biology
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3
المؤلفون: Kalyan Das, R. S. K. Vijayan, Joseph D. Bauman, Eddy Arnold, Amy Xiang, Ajit K. Parhi, D. Patel, Edmond J. LaVoie
المصدر: Bioorganicmedicinal chemistry. 21(21)
مصطلحات موضوعية: Stereochemistry, Cell Survival, Pyridones, Metal ions in aqueous solution, Clinical Biochemistry, Pharmaceutical Science, Crystal structure, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Endonuclease, Structure-Activity Relationship, Influenza A Virus, H1N1 Subtype, RNA polymerase, Catalytic Domain, Drug Discovery, Humans, Chelation, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Endonucleases, Small molecule, Recombinant Proteins, Enzyme, HEK293 Cells, chemistry, biology.protein, Molecular Medicine, Protein Binding
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4
المؤلفون: Keith T. Demarest, Mona Patel, Richard Look, Min Amy Xiang, Donald W. Combs, Robert Chen, William Hageman, Joseph W. Gunnet, William V. Murray
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2987-2989
مصطلحات موضوعية: Stereochemistry, Vasopressin Receptor Antagonists, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Ligands, Biochemistry, Chemical synthesis, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, Arginine vasopressin receptor 2, Drug Discovery, Cyclic AMP, Humans, Spiro Compounds, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Biological activity, General Medicine, Benzazepines, V1a vasopressin receptor, In vitro, Competitive antagonist, Molecular Medicine, Antidiuretic Hormone Receptor Antagonists, Receptor antagonist activity, Protein Binding
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5
المؤلفون: H. Marlon Zhong, Frank J. Villani, Philip J. Rybczynski, Lisa Minor, Bruce P. Damiano, Yuanping Wang, Mona Patel, Bruce E. Maryanoff, Han-Cheng Zhang, David F. McComsey, Chen Robert H, Richard Look, Min Amy Xiang, Joseph W. Gunnet, Keith T. Demarest
المصدر: Bioorganicmedicinal chemistry letters. 17(23)
مصطلحات موضوعية: Male, medicine.medical_specialty, Vasopressin, Receptors, Vasopressin, medicine.drug_class, Vasopressins, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Biochemistry, In vivo, Internal medicine, Arginine vasopressin receptor 2, Drug Discovery, medicine, Animals, Humans, Rats, Long-Evans, Spiro Compounds, Molecular Biology, Antihypertensive Agents, Vasopressin receptor, Chemistry, Organic Chemistry, Antagonist, Biological activity, Benzazepines, Receptor antagonist, Rats, Clinical trial, Endocrinology, Molecular Medicine, Female, Antidiuretic Hormone Receptor Antagonists
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6
المؤلفون: Min Amy Xiang, Joseph W. Gunnet, Philip J. Rybczynski, Donald W. Combs, Richard Look, Mona Patel, Keith T. Demarest, Chen Robert H, William V. Murray, William Hageman
المصدر: ChemInform. 35
مصطلحات موضوعية: Receptors, Vasopressin, Vasopressin, Stereochemistry, medicine.drug_class, Vasopressin Receptor Antagonists, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, Cell Line, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Vasopressin receptor, Chemistry, Organic Chemistry, Antagonist, General Medicine, Benzazepines, Rats, Molecular Medicine, Antidiuretic Hormone Receptor Antagonists, hormones, hormone substitutes, and hormone antagonists, Vasopressin Antagonists