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المؤلفون: Daniel Otero-Albiol, Sandra Muñoz-Galván, Eva M. Verdugo-Sivianes, Amancio Carnero, Ana M. Rojas
المساهمون: [Verdugo-Sivianes,EM, Muñoz-Galván,S, Otero-Albiol,D, Carnero,AS] Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Spain. [Verdugo-Sivianes,EM, Carnero,AS] CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. [Rojas,AM] Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Sevilla, Spain., This work was supported by grants from the Ministerio de Ciencia, Innovación y Universidades (MCIU) Plan Estatal de I+D+I 2018, a la Agencia Estatal de Investigación (AEI) y al Fondo Europeo de Desarrollo Regional (MCIU/AEI/FEDER, UE): RTI2018-097455-B-I00 and RTI2018-096735-B-I00grant from AEI-MICIU/FEDER (RED2018-102723-T), from CIBER de Cáncer (CB16/12/00275), co-funded by FEDER from Regional Development European Funds (European Union), from Consejeria de Salud (PI-0397-2017) and Consejeria of Economía, Conocimiento, Empresas y Universidad of the Junta de Andalucia (P18-RT-2501). Special thanks are also due to the Fundacion AECC and Fundacion Eugenio Rodriguez Pascual for supporting this work., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Junta de Andalucía, Fundación Científica Asociación Española Contra el Cáncer, Fundación Eugenio Rodríguez Pascual
المصدر: Theranostics
Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: 0301 basic medicine, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor [Medical Subject Headings], Proteína de retinoblastoma, Carcinogenesis, Mutant, Medicine (miscellaneous), Anatomy::Cells::Stem Cells::Neoplastic Stem Cells [Medical Subject Headings], medicine.disease_cause, environment and public health, Retinoblastoma Protein, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, 0302 clinical medicine, Breast cancer, pRB, Anatomy::Cells::Cells, Cultured::Cell Line [Medical Subject Headings], stem cell phenotype, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins [Medical Subject Headings], Protein Phosphatase 1, Organisms::Eukaryota::Animals [Medical Subject Headings], Proteína fosfatasa 1, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Drug Evaluation, Preclinical::Drug Screening Assays, Antitumor::Xenograft Model Antitumor Assays [Medical Subject Headings], Phosphorylation, Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation [Medical Subject Headings], Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle [Medical Subject Headings], Cell Line, Transformed, Mutation, Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins [Medical Subject Headings], Retinoblastoma, Línea celular, Microfilament Proteins, Proteína 1 de unión a retinoblastoma, Cell cycle, Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis [Medical Subject Headings], PP1, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Cycle Checkpoints::G1 Phase Cell Cycle Checkpoints [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Tumor Suppressor Proteins::Tumor Suppressor Protein p53 [Medical Subject Headings], Gene Expression Regulation, Neoplastic, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Eye Neoplasms::Retinal Neoplasms [Medical Subject Headings], SPINOPHILIN, 030220 oncology & carcinogenesis, Neoplasias de la mama, Neoplastic Stem Cells, Cell lines, Female, biological phenomena, cell phenomena, and immunity, Research Paper, Signal Transduction, Carcinogénesis, cancer stem cell, animal structures, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Stem cell phenotype, Mice, Nude, Breast Neoplasms, Nerve Tissue Proteins, macromolecular substances, Biology, Resting Phase, Cell Cycle, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Tumor Suppressor Proteins::Retinoblastoma Protein [Medical Subject Headings], Dephosphorylation, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Phosphoprotein Phosphatases::Protein Phosphatase 1 [Medical Subject Headings], 03 medical and health sciences, Cancer stem cell, Cell Line, Tumor, medicine, Animals, Humans, Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings], Células madre neoplásicas, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Nude [Medical Subject Headings], pocket proteins, medicine.disease, G1 Phase Cell Cycle Checkpoints, Xenograft Model Antitumor Assays, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic [Medical Subject Headings], enzymes and coenzymes (carbohydrates), tumorigenesis, 030104 developmental biology, Check Tags::Female [Medical Subject Headings], Tumor progression, Cell culture, Retinoblastoma protein, Tumorigenesis, Cancer research, Tumor Suppressor Protein p53, Pocket proteins, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Holoenzymes [Medical Subject Headings]
وصف الملف: application/pdf
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2
المؤلفون: José Terrón-Bautista, Felipe Cortés-Ledesma, Gonzalo Millán-Zambrano, Andrés Herrero-Ruiz, Silvia Jimeno-González, Pedro Manuel Martínez-García, Jenna Ariel Lieberman
المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Junta de Andalucía, European Research Council, Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Asociación Española Contra el Cáncer, [Herrero-Ruiz,A, Martínez-García,PM, Terrón-Bautista,J, Millán-Zambrano,G, Jimeno-González,S, Cortés-Ledesma,F] Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain. [Lieberman,JA] Lymphocyte Nuclear Biology, NIAMS, NIH, Bethesda, MD, USA. [Jimeno-González,S] Departamento de Genética, Universidad de Sevilla, Sevilla, Spain. [Herrero-Ruiz,A, Cortés-Ledesma,F] Topology and DNA Breaks Group, Spanish National Cancer Centre (CNIO), Madrid, Spain., This work was funded with grants from the Spanish and Andalusian governments (SAF2017-89619-R, CVI-7948, and European Regional Development Fund) and the European Research Council (ERC-CoG-2014-647359), and with individual fellowships for A.H.-R. (Contratos para la Formación de Doctores, BES-2015-071672, and Ministerio de Economía y Competitividad), S.J.-G. (Ramó n y Cajal, RYC-2015-17246, and Ministerio de Economía y Competitividad), J.T.-B. (Formación Profesorado Universitario, FPU15/03656, and Ministerio de Educación, Cultura y Deporte), and G.M.-Z. (AECC Postdoctoral Fellowships). CABIMER is supported by the Andalusian Government., Universidad de Sevilla. Departamento de Genética, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
المصدر: Cell Reports, Vol 35, Iss 2, Pp 108977-(2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Fundacion Sancho el Sabio Fundazioa (FSS)
Cell Reportsمصطلحات موضوعية: 0301 basic medicine, Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Protein Binding [Medical Subject Headings], Transcription, Genetic, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation [Medical Subject Headings], RNA polymerase II, Retinal Pigment Epithelium, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, 0302 clinical medicine, Transcription (biology), Gene expression, Topoisomerase II Inhibitors, DNA topoisomerases, Biology (General), Poly-ADP-Ribose Binding Proteins, Promoter Regions, Genetic, Cell Line, Transformed, Regulation of gene expression, Elongación de la transcripción genética, biology, Chemistry, DNA, Superhelical, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Barbiturates::Thiobarbiturates [Medical Subject Headings], Thiobarbiturates, DNA supercoiling, Cell biology, DNA topology, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed [Medical Subject Headings], Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Circular::DNA, Superhelical [Medical Subject Headings], DNA supercoil, RNA Polymerase II, Proto-Oncogene Proteins c-fos, Anatomy::Sense Organs::Eye::Retina::Retinal Pigment Epithelium [Medical Subject Headings], Protein Binding, QH301-705.5, Article, General Biochemistry, Genetics and Molecular Biology, promoter-proximal pausing, 03 medical and health sciences, Humans, transcription elongation, Genes, Immediate-Early, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Immediate-Early [Medical Subject Headings], Topoisomerase, Promoter, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Nucleotidyltransferases::RNA Nucleotidyltransferases::DNA-Directed RNA Polymerases::RNA Polymerase II [Medical Subject Headings], Epithelial Cells, Anatomy::Cells::Epithelial Cells [Medical Subject Headings], 030104 developmental biology, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Topoisomerase Inhibitors::Topoisomerase II Inhibitors [Medical Subject Headings], DNA Topoisomerases, Type II, ADN-topoisomerasas, Gene Expression Regulation, biology.protein, gene expression, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::DNA Topoisomerases::DNA Topoisomerases, Type II [Medical Subject Headings], 030217 neurology & neurosurgery, DNA, Expresión génica, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Proto-Oncogene Proteins c-fos [Medical Subject Headings]
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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المؤلفون: Lourdes Lopez-Onieva, Pedro Carmona-Sáez, Irene Tejada, Amador Gallardo, Helena G Asenjo, David Landeira, Jordi Martorell-Marugán
المساهمون: [Asenjo,HG, Gallardo,A, López-Onieva,L, Tejada,I, Martorell-Marugán,J, Carmona-Sáez,P, Landeira,D] Centre for Genomics and Oncological Research (GENYO), Granada, Spain. [Asenjo,HG, Landeira,D] Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain. [Asenjo,HG, Landeira,D] Instituto de Investigación Biosanitaria ibs.GRANADA, Hospital Virgen de las Nieves, Granada, Spain. [López-Onieva,L] Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Granada, Spain. [Martorell-Marugán,J] Atrys Health S.A., Barcelona, Spain., This study was supported by the Spanish Ministry of Economy and Competitiveness (SAF2013-40891-R and BFU2016-75233-P) and the Andalusian Regional Government (PC-0246-2017). D.L. is a Ramón y Cajal researcher of the Spanish Ministry of Economy and Competitiveness (RYC-2012-10019)
المصدر: Science Advances
Digibug. Repositorio Institucional de la Universidad de Granada
instnameمصطلحات موضوعية: Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation [Medical Subject Headings], Transcription, Genetic, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred C57BL [Medical Subject Headings], Ratones, Cellular differentiation, Elongin, Cell, RNA polymerase II, Cromatina, Mice, Organisms::Eukaryota::Animals [Medical Subject Headings], Promoter Regions, Genetic, Induced pluripotent stem cell, Complejo Represivo Polycomb 2, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle [Medical Subject Headings], Research Articles, Cell Line, Transformed, Mice, Knockout, 0303 health sciences, Ciclo Celular, Multidisciplinary, biology, Chemistry, 030302 biochemistry & molecular biology, Cell Cycle, Polycomb Repressive Complex 2, Gene Expression Regulation, Developmental, SciAdv r-articles, Cell Differentiation, Mouse Embryonic Stem Cells, Cell cycle, Chromatin, Chemicals and Drugs::Macromolecular Substances::Multiprotein Complexes::Polycomb-Group Proteins::Polycomb Repressive Complex 2 [Medical Subject Headings], Cell biology, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed [Medical Subject Headings], medicine.anatomical_structure, Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockout [Medical Subject Headings], RNA Polymerase II, PRC2, Protein Binding, Signal Transduction, Research Article, Pluripotent Stem Cells, Protein subunit, macromolecular substances, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Developmental [Medical Subject Headings], 03 medical and health sciences, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Protein Subunits [Medical Subject Headings], Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Protein Binding [Medical Subject Headings], medicine, Animals, Enhancer of Zeste Homolog 2 Protein, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic [Medical Subject Headings], Molecular Biology, 030304 developmental biology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Células Madre Embrionarias de Ratones, Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Chromatin [Medical Subject Headings], fungi, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Nucleotidyltransferases::RNA Nucleotidyltransferases::DNA-Directed RNA Polymerases::RNA Polymerase II [Medical Subject Headings], Cell Biology, Embryonic stem cell, Mice, Inbred C57BL, Protein Subunits, Genes, biology.protein, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Regulatory Elements, Transcriptional::Promoter Regions, Genetic [Medical Subject Headings], Células Madre Pluripotentes
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf71563ec0f74f4b56f3ec337095186
https://hdl.handle.net/10668/3496 -
4
المؤلفون: Rosa Macías-Ruiz, Ricardo Caballero, Mercedes Núñez, Miguel Álvarez-López, Marcos Matamoros, Marta Pérez-Hernández, Eva Delpón, Pablo Dolz-Gaitón, Juan Tamargo, Marta González de la Fuente, Lucía Núñez, Luis Tercedor-Sánchez, Adriana Barana, Irene Amorós, Juan Jiménez-Jáimez
المساهمون: [Dolz-Gaitón,P: Núñez,M, Barana,A, Amorós,I, Matamoros,M, Pérez-Hernández,M, González de la Fuente,M, Delpón,E, Caballero,R, Tamargo,J] Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain. [Dolz-Gaitón,P, Núñez,M, Caballero,R] Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain. [Barana,A, Tamargo,J] Instituto de Investigación Sanitaria Hospital Clínico San Carlos, School of Medicine, Universidad Complutense, Madrid, Spain. [Núñez,L] Complejo Hospitalario Universitario de A Coruña and Instituto de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain. [ Álvarez-López,M, Macías-Ruiz,R, Tercedor-Sánchez,L, Jiménez-Jáimez,J] Arrhytmias Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain., Financial support provided by Instituto de Salud Carlos III [PI11/01030, Red HERACLES RD06/0009 and Red Española de Investigación Cardiovascular RD12/0042/0011], Comunidad Autónoma de Madrid (S2012/BMD-2374), Ministerio de Ciencia e Innovación [SAF2011-30088, and SAF2011-30112], Centro Nacional de Investigaciones Cardiovasculares [CNIC-08-2009], and Sociedad Española de Cardiología grants.
المصدر: RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e81493 (2013)مصطلحات موضوعية: Proband, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Ion Channel Gating [Medical Subject Headings], lcsh:Medicine, Nav1.5, NAV1.5 Voltage-Gated Sodium Channel, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Variable Expression, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Voltage-Gated Sodium Channels::NAV1.5 Voltage-Gated Sodium Channel [Medical Subject Headings], Análisis Mutacional de ADN, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis [Medical Subject Headings], Síndrome de Brugada, lcsh:Science, Frameshift Mutation, Brugada syndrome, Brugada Syndrome, Genetics, Multidisciplinary, biology, Middle Aged, Phenylbutyrates, Humanos, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed [Medical Subject Headings], Diseases::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac [Medical Subject Headings], Mutation (genetic algorithm), cardiovascular system, Female, Mutación del Sistema de Lectura, Research Article, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Arritmias Cardíacas, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Sodium Channels [Medical Subject Headings], Mexiletine, macromolecular substances, Phenylbutyrate, Frameshift mutation, Internal medicine, medicine, Humans, cardiovascular diseases, Transporte Biológico, lcsh:R, Biological Transport, medicine.disease, Endocrinology, Canal de Sodio Activado por Voltaje NAV1.5, Activación del Canal Iónico, Ventricular fibrillation, biology.protein, lcsh:Q, Línea Celular Transformada, Diseases::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Brugada Syndrome [Medical Subject Headings]
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c9644b8d4e88228f28abf129f20784
http://hdl.handle.net/20.500.11940/914
