المؤلفون: Finkbeiner, Steven, Barmada, SJ, Serio, A, Arjun, A, Bilican, B, Daub, A, Ando, DM, Tsvetkov, A, Pleiss, M, Li, X, Peisach, D

URL الوصول: https://escholarship.org/uc/item/0q3836sf

المؤلفون: Barmada, SJ, Serio, A, Arjun, A, Bilican, B, Daub, A, Ando, DM, Tsvetkov, A, Pleiss, M, Li, X, Peisach, D, Shaw, C, Chandran, S, Finkbeiner, S

المصدر: Nature Chemical Biology. 10(8)

مصطلحات موضوعية: Biochemistry & Molecular Biology, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6z83h67w

المؤلفون: Coram MA; Google Research Applied Science, Mountain View, California 94043, United States., Wang L; Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608, United States., Godinez WJ; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608, United States., Barkan DT; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608, United States., Armstrong Z; Google Research Applied Science, Mountain View, California 94043, United States., Ando DM; Google Research Applied Science, Mountain View, California 94043, United States., Feng BY; Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608, United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2022 Jan 14; Vol. 8 (1), pp. 66-77. Date of Electronic Publication: 2021 Dec 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents*/pharmacology , Drug Resistance, Multiple, Bacterial*, Drug Synergism ; Microbial Sensitivity Tests

المؤلفون: Davidson MS; Department of Life Sciences, Imperial College London, London, United Kingdom., Andradi-Brown C; Department of Life Sciences, Imperial College London, London, United Kingdom.; Department of Infectious Disease, Imperial College London, London, United Kingdom., Yahiya S; Department of Life Sciences, Imperial College London, London, United Kingdom., Chmielewski J; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia., O'Donnell AJ; Institute of Evolutionary Biology, and Institute of Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Gurung P; Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA., Jeninga MD; Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany., Prommana P; Medical Molecular Biotechnology Research Group National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani, Thailand., Andrew DW; Thailand Center of Excellence for Life Sciences, Bangkok, Thailand., Petter M; Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany., Uthaipibull C; Medical Molecular Biotechnology Research Group National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani, Thailand.; Thailand Center of Excellence for Life Sciences, Bangkok, Thailand., Boyle MJ; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Ashdown GW; Department of Life Sciences, Imperial College London, London, United Kingdom., Dvorin JD; Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA., Reece SE; Institute of Evolutionary Biology, and Institute of Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.; Burnet Institute, Melbourne, Victoria, Australia., Cunningham KA; Google Cloud AI, Sunnyvale, California, USA., Ando DM; Applied Science Team, Google Research, Mountain View, California, USA., Dimon M; Applied Science Team, Google Research, Mountain View, California, USA., Baum J; Department of Life Sciences, Imperial College London, London, United Kingdom.

المصدر: Biological imaging [Biol Imaging] 2021 Aug 02; Vol. 1, pp. e2. Date of Electronic Publication: 2021 Aug 02 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 9918284179906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-903X (Electronic) Linking ISSN: 2633903X NLM ISO Abbreviation: Biol Imaging Subsets: PubMed not MEDLINE

المؤلفون: Qian WW; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana 61801, IL, USA., Xia C; Google Research, 1600 Amphitheatre Parkway Mountain View, CA 94043., Venugopalan S; Google Research, 1600 Amphitheatre Parkway Mountain View, CA 94043., Narayanaswamy A; Google Research, 1600 Amphitheatre Parkway Mountain View, CA 94043., Dimon M; Google Research, 1600 Amphitheatre Parkway Mountain View, CA 94043., Ashdown GW; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., Baum J; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., Peng J; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana 61801, IL, USA., Ando DM; Google Research, 1600 Amphitheatre Parkway Mountain View, CA 94043.

المصدر: Bioinformatics (Oxford, England) [Bioinformatics] 2020 Dec 30; Vol. 36 (Suppl_2), pp. i875-i883.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

مواضيع طبية MeSH: Image Processing, Computer-Assisted* , Neural Networks, Computer*, Artifacts

المؤلفون: Ashdown GW; Department of Life Sciences, Imperial College London, London, UK., Dimon M; Google Research, Applied Science Team., Fan M; Google Research, Applied Science Team., Sánchez-Román Terán F; Department of Life Sciences, Imperial College London, London, UK., Witmer K; Department of Life Sciences, Imperial College London, London, UK., Gaboriau DCA; Facility for Imaging by Light Microscopy, Imperial College London, London, UK., Armstrong Z; Google Research, Applied Science Team., Ando DM; Google Research, Applied Science Team. mando@google.com jake.baum@imperial.ac.uk., Baum J; Department of Life Sciences, Imperial College London, London, UK. mando@google.com jake.baum@imperial.ac.uk.

المصدر: Science advances [Sci Adv] 2020 Sep 25; Vol. 6 (39). Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Malaria*/drug therapy, Drug Discovery ; Humans ; Machine Learning ; Supervised Machine Learning

المؤلفون: Smith TC 2nd; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.; Center for Integrated Management of Antimicrobial Resistance (CIMAR), Tufts University, Boston, MA 02111., Pullen KM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139., Olson MC; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111., McNellis ME; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111., Richardson I; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.; Roxbury Latin School, West Roxbury, MA 02132., Hu S; Department of Bioinformatics and Computational Biology, University of Maryland, Baltimore County, Baltimore, MD 21250., Larkins-Ford J; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.; Tufts University School of Graduate Biomedical Sciences, Boston, MA 02111.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115., Wang X; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ 07103., Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ 07103.; Division of Infectious Disease, Department of Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103.; Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, NJ 07103., Ando DM; Applied Science Team, Google Research, Mountain View, CA 94043., Aldridge BB; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111; bree.aldridge@tufts.edu.; Center for Integrated Management of Antimicrobial Resistance (CIMAR), Tufts University, Boston, MA 02111.; Tufts University School of Graduate Biomedical Sciences, Boston, MA 02111.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Biomedical Engineering, Tufts University School of Engineering, Medford, MA 02155.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18744-18753. Date of Electronic Publication: 2020 Jul 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Mycobacterium tuberculosis*/cytology , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/metabolism , Software*, Antitubercular Agents/*pharmacology , Drug Discovery/*methods, Cell Wall/drug effects ; Diarylquinolines ; High-Throughput Screening Assays ; Transcriptome/drug effects

المؤلفون: Yang SJ; 1 Google, LLC, Mountain View, CA, USA., Lipnick SL; 2 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; 3 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; 4 Center for Assessment Technology & Continuous Health (CATCH), Massachusetts General Hospital, Boston, MA, USA., Makhortova NR; 2 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; 5 Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Venugopalan S; 1 Google, LLC, Mountain View, CA, USA., Fan M; 1 Google, LLC, Mountain View, CA, USA., Armstrong Z; 1 Google, LLC, Mountain View, CA, USA., Schlaeger TM; 5 Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Deng L; 6 Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY, USA., Chung WK; 6 Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY, USA., O'Callaghan L; 1 Google, LLC, Mountain View, CA, USA., Geraschenko A; 1 Google, LLC, Mountain View, CA, USA., Whye D; 2 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Berndl M; 1 Google, LLC, Mountain View, CA, USA., Hazard J; 1 Google, LLC, Mountain View, CA, USA., Williams B; 1 Google, LLC, Mountain View, CA, USA., Narayanaswamy A; 1 Google, LLC, Mountain View, CA, USA., Ando DM; 1 Google, LLC, Mountain View, CA, USA., Nelson P; 1 Google, LLC, Mountain View, CA, USA., Rubin LL; 2 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; 7 Harvard Stem Cell Institute, Cambridge, MA, USA.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2019 Sep; Vol. 24 (8), pp. 829-841. Date of Electronic Publication: 2019 Jul 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays* , Machine Learning* , Molecular Imaging* , Neural Networks, Computer*, Deep Learning ; Humans ; Image Processing, Computer-Assisted

المؤلفون: Christiansen EM; Google, Inc., Mountain View, CA 94043, USA. Electronic address: ericmc@google.com., Yang SJ; Google, Inc., Mountain View, CA 94043, USA., Ando DM; Google, Inc., Mountain View, CA 94043, USA., Javaherian A; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., Skibinski G; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., Lipnick S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Center for Assessment Technology and Continuous Health, Massachusetts General Hospital, Boston, MA 02114, USA., Mount E; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., O'Neil A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Shah K; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., Lee AK; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., Goyal P; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA., Fedus W; Google, Inc., Mountain View, CA 94043, USA; Montreal Institute of Learning Algorithms, University of Montreal, Montreal, QC, Canada., Poplin R; Google, Inc., Mountain View, CA 94043, USA., Esteva A; Google, Inc., Mountain View, CA 94043, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA., Berndl M; Google, Inc., Mountain View, CA 94043, USA., Rubin LL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Nelson P; Google, Inc., Mountain View, CA 94043, USA. Electronic address: pqnelson@google.com., Finkbeiner S; Taube/Koret Center for Neurodegenerative Disease Research and DaedalusBio, Gladstone Institutes, San Francisco, CA 94158, USA; Departments of Neurology and Physiology, University of California, San Francisco, 94158, USA. Electronic address: sfinkbeiner@gladstone.ucsf.edu.

المصدر: Cell [Cell] 2018 Apr 19; Vol. 173 (3), pp. 792-803.e19. Date of Electronic Publication: 2018 Apr 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Fluorescent Dyes/*chemistry , Image Processing, Computer-Assisted/*methods , Microscopy, Fluorescence/*methods , Motor Neurons/*cytology, Algorithms ; Animals ; Cell Line, Tumor ; Cell Survival ; Cerebral Cortex/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Machine Learning ; Neural Networks, Computer ; Neurosciences ; Rats ; Software ; Stem Cells/cytology

المؤلفون: Skibinski G; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158., Hwang V; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158., Ando DM; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143., Daub A; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158.; Medical Scientist Training Program, University of California, San Francisco, CA 94143.; Program in Bioengineering, University of California, San Francisco, CA 94143., Lee AK; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158., Ravisankar A; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158., Modan S; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158., Finucane MM; Gladstone Institute of Neurological Disease, San Francisco, CA 94158., Shaby BA; Department of Statistics, Penn State University, State College, PA 16802., Finkbeiner S; Gladstone Institute of Neurological Disease, San Francisco, CA 94158; sfinkbeiner@gladstone.ucsf.edu.; The Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, CA 94158.; The Hellman Foundation Program in Alzheimer's Disease Research, San Francisco, CA 94158.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.; Department of Neurology, University of California, San Francisco, CA 94143.; Department of Physiology, University of California, San Francisco, CA 94143.; Graduate Programs in Neuroscience, University of California, San Francisco, CA 94143.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jan 31; Vol. 114 (5), pp. 1165-1170. Date of Electronic Publication: 2016 Dec 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*antagonists & inhibitors , NF-E2-Related Factor 2/*physiology , Nerve Tissue Proteins/*metabolism , Neurons/*drug effects , Parkinson Disease/*metabolism , alpha-Synuclein/*antagonists & inhibitors, Animals ; Cerebral Cortex/cytology ; Genes, Reporter ; HEK293 Cells ; Humans ; Hydroquinones/pharmacology ; Inclusion Bodies ; Induced Pluripotent Stem Cells/cytology ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/toxicity ; NF-E2-Related Factor 2/biosynthesis ; NF-E2-Related Factor 2/genetics ; Neurons/metabolism ; Primary Cell Culture ; Protein Aggregation, Pathological ; Proteostasis ; Rats ; Recombinant Fusion Proteins/metabolism ; Single-Cell Analysis ; Time Factors ; alpha-Synuclein/metabolism ; alpha-Synuclein/toxicity