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1
المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679
مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured
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2
المؤلفون: Jay S. Tung, Nanhua Yao, Shawn Gauby, Kevin P. Quinn, May Lin, Lany Ruslim, Jennifer Sealy, Michael A. Pleiss, Luke Tso, John A. Tucker, Hu Pan, Gergely Toth, Sukanto Sinha, Andrei W. Konradi, Varghese John, Ying-Zi Xu, Anh P. Truong, Darren B. Dressen, Wes Zmolek, Gary Probst, Hing L. Sham, Eric Brecht, Jagodzinska Barbara, Jacek Jagodzinski, Michael P. Bova, Simeon Bowers, Roy K. Hom, John-Michael Sauer, Dean R. Artis, Brian P. Stupi, Ted Yednock, Andrea Gailunas, Jose Aquino
المصدر: Bioorganicmedicinal chemistry letters. 20(20)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, Hydrolase, medicine, Ethylamines, Structure–activity relationship, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, biology, Chemistry, Aryl, Organic Chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amine gas treating, Amyloid Precursor Protein Secretases, Linker, Protein Binding
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3
المؤلفون: Nancy Jewett, Jay S Tung, Larry Fang, David L. Davis, Joseph B. Moon, Roy K. Hom, Donald E Walker, Shumeye Mamo, Varghese John, Thorsett Eugene D, Andrea Gailunas
المصدر: Journal of medicinal chemistry. 47(1)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Isostere, Peptidomimetic, Phthalic Acids, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Statine, Endopeptidases, Amyloid precursor protein, Structure–activity relationship, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, biology, Molecular Mimicry, Dipeptides, Ethylenes, Small molecule, Amides, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
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المؤلفون: John P. Anderson, Shumeye Mamo, David L. Davis, Roy K. Hom, Ashley C. Guinn, Thorsett Eugene D, Donald Walker, Jay S. Tung, Sukanto Sinha, Varghese John, J. Knops, Larry Fang, Nancy Jewett, Andrea Gailunas
المصدر: Journal of medicinal chemistry. 46(10)
مصطلحات موضوعية: medicine.drug_class, Peptidomimetic, Stereochemistry, Carboxamide, Chemical synthesis, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Statine, Endopeptidases, medicine, Aspartic Acid Endopeptidases, Humans, Secretion, Amino Acids, Enzyme Inhibitors, chemistry.chemical_classification, Amyloid beta-Peptides, biology, Molecular Mimicry, In vitro, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Oligopeptides
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