المؤلفون: Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang

المصدر: Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)

مصطلحات موضوعية: lipolysis and fatty acid metabolism, insulin resistance, diabetes, fatty acid, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520337834; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/1d5d6bb81f4b48f7aa3c095bb5ab4e88

المؤلفون: Barbara Pio, Ravi P. Nargund, Yan Guo, Daniel Kosinski, Josien Hubert B, Michael Wright, Michele Pachanski, Harry R. Chobanian, Xiaoping Zhang, Richard Tschirret-Guth, Melissa Kirkland, Andrew D. Howard, Sarah Souza, Eric R. Ashley, Robert K. Orr, Steven L. Colletti, Joel Mane, Jerry Di Salvo, Michael W. Miller, Boonlert Cheewatrakoolpong, Koppara Samuel, William K. Hagmann, James Lamca, Juliann Ehrhart, Maria E. Trujillo, Jackie Shang, Qing Chen, Adam B. Weinglass, Randal M. Bugianesi

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1842-1848

مصطلحات موضوعية: Agonist, endocrine system, medicine.drug_class, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Enteroendocrine cell, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Receptor, Mode of action, Molecular Biology, geography, geography.geographical_feature_category, 010405 organic chemistry, Chemistry, Organic Chemistry, Islet, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Drug Design, Indans, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67130fd906c302e54806df711af08d1b
https://doi.org/10.1016/j.bmcl.2019.04.050

المؤلفون: Weiguo Liu, Ramzi F. Sweis, Feroze Ujjainwalla, Remond Moningka, F. Anthony Romero, Yi Zang, Paul E. Finke, Zahid Hussain, Karen H. Dingley, Michael A. Plotkin, Andrew D. Howard, Jin Shang, Beth Ann Murphy, Jianming Bao, Gino Salituro, Harold B. Wood, Joseph L. Duffy

المصدر: ACS Medicinal Chemistry Letters. 9:1088-1093

مصطلحات موضوعية: 0301 basic medicine, Somatostatin receptor, Chemistry, Organic Chemistry, 030209 endocrinology & metabolism, Metabolism, Pharmacology, Biochemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3022cb6ad0fbfbeb2a2945fb1685174d
https://doi.org/10.1021/acsmedchemlett.8b00306

المؤلفون: Amber B, Paulus, Andrew D, Howard, Brandy A, Vinson

المصدر: Nephrology nursing journal : journal of the American Nephrology Nurses' Association. 48(1)

مصطلحات موضوعية: Prospective Payment System, Renal Dialysis, Humans, Kidney Failure, Chronic, Medicare, United States, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::911065292d28db322d5d794d13bf9f2e
https://pubmed.ncbi.nlm.nih.gov/33683840

المؤلفون: Ying Li, Renato Felipe Pereira, J. Alan Maschek, Joseph L. Wilkerson, Annelise M Poss, Scott A. Summers, Vincent A. Kaddai, David E. Kelley, Xiaolan Shen, William L. Holland, Doris Hissako Sumida, Jared Rutter, Margaret Wu, Ying Qian, Jun Yao, Aleksandr Petrov, Graeme I. Lancaster, David G. McLaren, Trevor S. Tippetts, Liangsu Wang, Santhosh Satapati, Mackenzie J. Pearson, Christian N. Nunes, Rafael Mayoral Monibas, Heather Zhou, Liping Wang, Monowarul Mobin Siddique, Mark D. Erion, Stephen F. Previs, Bhagirath Chaurasia, C. Rufus Sweeney, Jinqi Liu, Ying Chen, James E. Cox, Andrew D. Howard

المساهمون: University of Utah, Merck, Universidade Estadual Paulista (Unesp), Baker IDI Heart and Diabetes Institute, University of Brunei Darussalam, Sciex, Howard Hughes Medical Institute, Bristol Myers Squibb, Morphic Therapeutic, Johnson and Johnson

المصدر: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Science

مصطلحات موضوعية: 0301 basic medicine, Leptin, medicine.medical_specialty, Ceramide, Double bond, Adipose tissue, 030209 endocrinology & metabolism, Ceramides, Diet, High-Fat, Article, 03 medical and health sciences, Mice, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Internal medicine, Diabetes Mellitus, medicine, Humans, Animals, chemistry.chemical_classification, Sphingolipids, Multidisciplinary, Leptin Deficiency, Membrane Proteins, Dihydroceramide desaturase, medicine.disease, Sphingolipid, Mice, Mutant Strains, Fatty Liver, 030104 developmental biology, Endocrinology, Lipotoxicity, chemistry, Insulin Resistance, Steatosis, Oxidoreductases, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece126f2119f2026d40f42c46830040b
https://doi.org/10.1530/ey.17.15.11

المؤلفون: Daniel Metzger, Joseph L. Duffy, Weiguo Liu, Jiafang He, Garry Chicchi, Gino Salituro, Ann E. Weber, Margaret Wu, Cai Li, John Wang, Taro E. Akiyama, Andrew D. Howard, Shao Pengcheng Patrick, John Bawiec, Beth Ann Murphy, Gui-Bai Liang, Yun-Ping Zhou, Susan D. Aster, Kwei-Lan Tsao, Jin Shang

المصدر: ACS Medicinal Chemistry Letters. 9:1082-1087

مصطلحات موضوعية: 0301 basic medicine, Chemistry, Insulin, medicine.medical_treatment, Organic Chemistry, Glucose challenge, Antagonist, 030209 endocrinology & metabolism, Glucose excursion, Pharmacology, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Incretin Hormone, Drug Discovery, medicine, Potency, Dipeptidyl peptidase-4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f799c113adab203716f4e156f34e4f72
https://doi.org/10.1021/acsmedchemlett.8b00305

المؤلفون: Jerry Di Salvo, Santhosh Satapati, Mark D. Erion, Jin Shang, Stephen F. Previs, Adam B. Weinglass, John S. Debenham, Margaret Wu, Sheng-Ping Wang, Andrew D. Howard, Ying Chen, Aleksandr Petrov, Ge Dai, Yonghua Zhu, Liangsu Wang, David E. Kelley, Ying Qian, Xiaolan Shen, Eric S. Muise, Jason M. Cox, Ping Lan, Vinit Shah, Emanuel Zycband

المصدر: Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, Lipolysis, medicine.medical_treatment, Adipose tissue, 030209 endocrinology & metabolism, QD415-436, CHO Cells, Biochemistry, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, Islets of Langerhans, Mice, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Endocrinology, Insulin resistance, Cricetinae, Internal medicine, Free fatty acid receptor 1, medicine, Animals, Research Articles, diabetes, Chemistry, Insulin, GPR120, Cell Biology, medicine.disease, lipolysis and fatty acid metabolism, Rats, 030104 developmental biology, Adipose Tissue, Gene Expression Regulation, Mechanism of action, fatty acid, Insulin Resistance, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add95890b365e73d2c2d83d70eee2142
https://doi.org/10.1194/jlr.m075044

المؤلفون: Judith N. Gorski, Maria E. Trujillo, Brande Thomas-Fowlkes, Adam B. Weinglass, Jerry Di Salvo, Aimie M. Ogawa, Sarah Souza, Christopher W. Plummer, Joel Mane, Michele Pachanski, Boonlert Cheewatrakoolpong, Andrew D. Howard, Steven L. Colletti

المصدر: American Journal of Physiology-Endocrinology and Metabolism. 313:E37-E47

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, Physiology, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Gastric motility, Biology, Partial agonist, Receptors, G-Protein-Coupled, Eating, Mice, 03 medical and health sciences, Glucagon-Like Peptide 1, Weight loss, Physiology (medical), Internal medicine, Free fatty acid receptor 1, Weight Loss, medicine, Animals, Mice, Knockout, Appetite Regulation, Insulin, Body Weight, Glucagon-like peptide-1, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, medicine.symptom, Weight gain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc4daac847ef7e96602196782cbdb63
https://doi.org/10.1152/ajpendo.00435.2016

المؤلفون: Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne

المصدر: Nature Structural & Molecular Biology. 24:570-577

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Binding Sites, biology, Protein Conformation, Allosteric regulation, Cooperativity, Crystallography, X-Ray, Partial agonist, Receptors, G-Protein-Coupled, 03 medical and health sciences, Transmembrane domain, 030104 developmental biology, Allosteric Regulation, Allosteric enzyme, Biochemistry, Structural Biology, Free fatty acid receptor 1, biology.protein, Free fatty acid receptor, Biophysics, Humans, Binding site, Molecular Biology, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4bc0224021f59b552cc8f44381dfe9
https://doi.org/10.1038/nsmb.3417

المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan

المصدر: ACS Medicinal Chemistry Letters. 8:221-226

مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942c1dd589ae2364bd7ea069018de04
https://doi.org/10.1021/acsmedchemlett.6b00443