المؤلفون: Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay

المصدر: iScience, Vol 16, Iss , Pp 206-217 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004219301658; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/4a91a3c282f3471bad0373765ad436f8

المؤلفون: Owen R. Davies, Chia-Yi Lin, Aliaksandra Radzisheuskaya, Xinzhi Zhou, Jessica Taube, Guillaume Blin, Anna Waterhouse, Andrew J.H. Smith, Sally Lowell

المصدر: Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713000247; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/97cbf2c3a810446b9f806e783c39da4a

المؤلفون: Jacqueline A. Sharpe, D.M. Jeziorska, B. Christoffer Lagerholm, Doug Higgs, Andrew J.H. Smith, Veronica J. Buckle, Jill M. Brown, Jacqueline A. Sloane-Stanley, Edward Tunnacliffe, Helena Ayyub, Christian Babbs

مصطلحات موضوعية: Transcriptional bursting, Transcriptional activity, Transcription (biology), Dynamics (mechanics), Gene expression, Erythropoiesis, Biology, Gene, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6e4db11b1abd57f4db562bf24fd3a0d
https://doi.org/10.1101/2021.11.26.470114

المؤلفون: David C. Hay, Baltasar Lucendo-Villarin, Andrew J.H. Smith, Ronald T. Hay, Jan G. Hengstler, Tilo Kunath, Timothy R. Rudd, Michael H. Tatham, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Patricio Godoy, Yu Wang, Carolyn Swann, Wolfgang Schmidt-Heck

المصدر: iScience, Vol 16, Iss, Pp 206-217 (2019)
iScience
iScience, 16:206-17
Wang, Y, Tatham, M H, Schmidt-Heck, W, Swann, C, Singh Dolt, K, Meseguer Ripolles, J, Lucendo-Villarin, B, Kunath, T, Rudd, T R, Smith, A, Hengstler, J G, Godoy, P & Hay, D C 2019, ' Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation ', iScience . https://doi.org/10.1016/j.isci.2019.05.028

مصطلحات موضوعية: 0301 basic medicine, Protein domain, 02 engineering and technology, Biology, biological sciences, developmental biology, cell biology, stem cells research, Article, 03 medical and health sciences, Stem Cells Research, Genome editing, medicine, Induced pluripotent stem cell, lcsh:Science, Transcription factor, Hepatocyte differentiation, Multidisciplinary, Cell Biology, Biological Sciences, 021001 nanoscience & nanotechnology, Cell biology, Hepatocyte nuclear factors, 030104 developmental biology, medicine.anatomical_structure, Hepatocyte, lcsh:Q, 0210 nano-technology, Developmental biology, Developmental Biology

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d4735d7efb7fedb784d64495dec47c
http://www.sciencedirect.com/science/article/pii/S2589004219301658

المؤلفون: Yu Wang, Andrew J.H. Smith, David C. Hay

المصدر: Wang, Y, Smith, A & Hay, D 2020, ' Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing ', Journal of Visualized Experiments (JoVE) . https://doi.org/10.3791/61152

مصطلحات موضوعية: Gene Editing, Pluripotent Stem Cells, Base Sequence, General Immunology and Microbiology, Genome, Human, Point mutation, General Chemical Engineering, General Neuroscience, Genetic Vectors, Locus (genetics), Computational biology, Biology, Genome, General Biochemistry, Genetics and Molecular Biology, Plasmid, Genome editing, Gene knockin, DNA Transposable Elements, CRISPR, Humans, Point Mutation, CRISPR-Cas Systems, Induced pluripotent stem cell

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5b5a95c7f6a2511919d864fda7e382
https://doi.org/10.3791/61152-v

المؤلفون: Cristina Tufarelli, Ricarda Gaentzsch, Robert J S Murray, Danuta M. Jeziorska, Jim R. Hughes, Bryony Graham, Marco De Gobbi, Jonathan N. Lund, Andrew J.H. Smith, Helena Ayyub, En Li, Magnus D. Lynch, Taiping Chen, Jelena Telenius, Douglas R. Higgs, David Garrick

المصدر: Jeziorska, D M, Murray, R J S, De Gobbi, M, Gaentzsch, R, Garrick, D, Ayyub, H, Chen, T, Li, E, Telenius, J, Lynch, M, Graham, B, Smith, A J H, Lund, J N, Hughes, J R, Higgs, D R & Tufarelli, C 2017, ' DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease ', Proceedings of the National Academy of Sciences, vol. 114, no. 36, pp. E7526-E7535 . https://doi.org/10.1073/pnas.1703087114

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, Cell Differentiation/genetics, DNMT3B, Intragenic CGIs, Biology, Cell Line, Epigenesis, Genetic, 03 medical and health sciences, Mice, CGI transcription, Animals, Humans, Epigenetics, Promoter Regions, Genetic, Transcription, Genetic/genetics, CGI methylation, Genetics, DNA methylation, H3K36me3, Multidisciplinary, Genome, Human, Epigenesis, Genetic/genetics, Promoter, Cell Differentiation, Methylation, Sequence Analysis, DNA, DNA Methylation, Promoter Regions, Genetic/genetics, CpG Islands/genetics, Chromatin, 030104 developmental biology, Sequence Analysis, DNA/methods, CpG site, PNAS Plus, Genome, Human/genetics, Human genome, CpG Islands, DNA Methylation/genetics

وصف الملف: PDF; application/pdf; text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b09643ca63009b33e0f3c4a62192df6

المؤلفون: Jacqueline A. Sharpe, William G. Wood, Douglas Vernimmen, Ailbhe Jane Brazel, Jacqueline A. Sloane-Stanley, Marco De Gobbi, Andrew J.H. Smith

المصدر: De Gobbi, M, Brazel, A J, Sharpe, J A, Sloane-stanley, J A, Smith, A, Wood, W G & Vernimmen, D 2017, ' Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression ', Blood Cells, Molecules and Diseases, vol. 64, pp. 10-12 . https://doi.org/10.1016/j.bcmd.2017.02.006

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Mice, Transgenic, Biology, 03 medical and health sciences, Mice, alpha-Globins, Internal medicine, Gene expression, medicine, Animals, Base sequence, Alpha globulin, Enhancer, Molecular Biology, Sequence Deletion, Genetics, Regulation of gene expression, Hematology, Base Sequence, Molecular Medicine, Cell Biology, Phenotype, Molecular medicine, 030104 developmental biology, Enhancer Elements, Genetic, Gene Expression Regulation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14bb7124969f55a45165eacaf449c8b
https://pubmed.ncbi.nlm.nih.gov/28292728

المؤلفون: Anna Waterhouse, Sally Lowell, Rodrigo Osorno, Ian Chambers, Andrew J.H. Smith, Mattias Malaguti, Xinzhi Zhou, Chia-Yi Lin, Guillaume Blin

المصدر: Stem Cells (Dayton, Ohio)

مصطلحات موضوعية: Pluripotent Stem Cells, STAT3 Transcription Factor, Notch, Cellular differentiation, Down-Regulation, Biology, Transfection, Embryonic Stem Cells/Induced Pluripotent Stem Cells, Mice, 03 medical and health sciences, 0302 clinical medicine, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, HES1, Induced pluripotent stem cell, Embryonic Stem Cells, 030304 developmental biology, Homeodomain Proteins, Genetics, 0303 health sciences, Stat3, Receptors, Notch, LIF, Cell Differentiation, Nanog Homeobox Protein, Cell Biology, Embryonic stem cell, Cell biology, Hes1, embryonic structures, Transcription Factor HES-1, Molecular Medicine, Stem cell, Signal transduction, 030217 neurology & neurosurgery, Function (biology), Signal Transduction, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773c8a9d3d569b3b2dc534068c99e346
https://doi.org/10.1002/stem.1426

المؤلفون: Xinzhi Zhou, Aliaksandra Radzisheuskaya, Anna Waterhouse, Andrew J.H. Smith, Chia-Yi Lin, Guillaume Blin, Jessica Taube, Owen R. Davies, Sally Lowell

المصدر: Cell Reports
Davies, O R, Lin, C-Y, Radzisheuskaya, A, Zhou, X, Taube, J, Blin, G, Waterhouse, A, Smith, A & Lowell, S 2013, ' Tcf15 Primes Pluripotent Cells for Differentiation ', Cell Reports, vol. 3, no. 2, pp. 472-484 . https://doi.org/10.1016/j.celrep.2013.01.017
Cell Reports, Vol 3, Iss 2, Pp 472-484 (2013)

مصطلحات موضوعية: Homeobox protein NANOG, Cellular differentiation, Down-Regulation, Embryoid body, Biology, Fibroblast growth factor, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Basic Helix-Loop-Helix Transcription Factors, Animals, Induced pluripotent stem cell, Transcription factor, lcsh:QH301-705.5, Cells, Cultured, Embryonic Stem Cells, 030304 developmental biology, Homeodomain Proteins, 0303 health sciences, Otx Transcription Factors, Biochemistry, Genetics and Molecular Biology(all), Endoderm, Nanog Homeobox Protein, Gene Expression Regulation, Developmental, Cell Differentiation, Embryo, Mammalian, Molecular biology, Embryonic stem cell, Cell biology, Fibroblast Growth Factors, lcsh:Biology (General), 030217 neurology & neurosurgery, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94402b93065527350227d41945bd06ac
http://europepmc.org/articles/PMC3607254

المؤلفون: F. Marques-Kranc, Jim R. Hughes, Doug Higgs, Jacqueline A. Sharpe, M. Richardson, F. Luna de Crespo, Andrew J.H. Smith, Helen Wallace, William G. Wood

مصطلحات موضوعية: Functional analysis, Molecular Medicine, Cell Biology, Hematology, Computational biology, Biology, Bioinformatics, Molecular Biology, Synteny

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec88ab4d2484f0f82f6e62b97b33e78
https://ora.ox.ac.uk/objects/uuid:d56a1ecf-f275-4a49-953e-cd0ecd5aed66