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المؤلفون: Petro Halkowycz, Zacharia Cheruvallath, Mark Sabat, Bumsup Lee, David J. Hosfield, Andrew John Jennings, Haixia Wang, Mingnam Tang, Stephen L. Gwaltney, Yiqin Wu, Charles E. Grimshaw
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2678-2682
مصطلحات موضوعية: Models, Molecular, Indazoles, Clinical Biochemistry, Allosteric regulation, Administration, Oral, Enzyme Activators, Mice, Obese, Pharmaceutical Science, 01 natural sciences, Biochemistry, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Glucokinase, Drug Discovery, Potassium Channel Blockers, Glucokinase activator, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Indazole, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Glucose Tolerance Test, Ether-A-Go-Go Potassium Channels, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Orally active, Enzyme, Diabetes Mellitus, Type 2, chemistry, Molecular Medicine
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المؤلفون: J. Fraser Glickman, Dinshaw J. Patel, Andrew John Jennings, Vitaly Kuryavyi, Aida Jumpei, Pu Gao, Mayako Michino, Wei Xie, Carolina Adura, Takanobu Kuroita, Lavoisier Ramos-Espiritu, Peter T. Meinke, Michael Miller, Toshihiro Imaeda, L. Lama, Kamei Taku, Thomas Tuschl, Tasos Gogakos, Hashizume Shogo, Rei Okamoto, Andrew Stamford, Asano Yasutomi, Joshua Steinberg, Daisuke Tomita
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)مصطلحات موضوعية: Models, Molecular, Pattern recognition receptors, 0301 basic medicine, Science, medicine.medical_treatment, Primary Cell Culture, Cell, General Physics and Astronomy, 02 engineering and technology, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, 03 medical and health sciences, Interferon, Drug Discovery, medicine, Humans, Enzyme Inhibitors, lcsh:Science, Cells, Cultured, Multidisciplinary, Innate immune system, Chemistry, Macrophages, High-throughput screening, Pattern recognition receptor, DNA, General Chemistry, 021001 nanoscience & nanotechnology, Nucleotidyltransferases, Immunity, Innate, Recombinant Proteins, High-Throughput Screening Assays, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Cell culture, Second messenger system, lcsh:Q, Interferons, Nucleotides, Cyclic, 0210 nano-technology, Intracellular, medicine.drug
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المؤلفون: Stacia Kargman, Andrew John Jennings, Michael Miller, Andrew Stamford, Damodharan Lakshminarasimhan, Lewis C. Cantley, Anita D. Robin, Mayako Michino, David J. Huggins, Jiayi Xu, Edouard Mullarky, Andrea Olland, Daisuke Tomita, Naoyoshi Noguchi, Guoan Zhang, Peter T. Meinke, Taojunfeng Su
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, Serine, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Phosphoglycerate dehydrogenase, Enzyme Inhibitors, Molecular Biology, Phosphoglycerate Dehydrogenase, Cell Proliferation, chemistry.chemical_classification, Indole test, Binding Sites, 010405 organic chemistry, Organic Chemistry, Oxidoreductase inhibitor, Amides, 0104 chemical sciences, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, Metabolic pathway, Enzyme, chemistry, Molecular Medicine, NAD+ kinase
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المؤلفون: Andrew John Jennings, Yelena Istratiy, Mark S. Hixon, Derek C. Cole, Phillip A. Schwartz, Richard Tjhen, Marion Lanier, Michael G. Klein
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: 0301 basic medicine, inorganic chemicals, Serine Proteinase Inhibitors, Brief Article, Drug Evaluation, Preclinical, Crystallography, X-Ray, 01 natural sciences, Serine, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Suzuki reaction, Drug Discovery, Nitriles, Structure–activity relationship, Humans, chemistry.chemical_classification, 010405 organic chemistry, Phosphoric Diester Hydrolases, Serine Endopeptidases, Surface Plasmon Resonance, Boronic Acids, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Molecular Medicine, Autotaxin, Boronic acid
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المؤلفون: Weston Lane, Franz Gruswitz, Yoshihiko Hirozane, Ankita Srivastava, Kathleen Aertgeerts, Kengo Okada, Andrew John Jennings, Jason Yano, Gyorgy Snell, Georgia Kefala, Jasmine T. Nguyen, Anthony Ivetac
المصدر: Nature. 513:124-127
مصطلحات موضوعية: Models, Molecular, Agonist, Surface Properties, medicine.drug_class, Lipid Bilayers, Allosteric regulation, Biology, Crystallography, X-Ray, Ligands, Receptors, G-Protein-Coupled, Allosteric Regulation, Free fatty acid receptor 1, Radioligand, medicine, Humans, Sulfones, Receptor, Protease-activated receptor 2, Benzofurans, G protein-coupled receptor, Binding Sites, Multidisciplinary, Interleukin-13 receptor, Drug Partial Agonism, Diabetes Mellitus, Type 2, Biochemistry, Structural Homology, Protein, Biophysics
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المؤلفون: Yasuyoshi Arikawa, Pamela Farrell, Betty Lam, Lihong Shi, Zhe Nie, Jones Benjamin, Jonathan Zalevsky, Takahashi Masashi, Victoria A. Feher, Isaac Hoffman, Joshua Cramlett, Corey Wyrick, Hiroshi Miyake, Jennifer Matuszkiewicz, Joanne Miura, Ron de Jong, Charles E. Grimshaw, Jason Yano, Qing Dong, Srinivasa Reddy Natala, Ewan Taylor, Andrew John Jennings
المصدر: Bioorganicmedicinal chemistry letters. 26(24)
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Syk, Antineoplastic Agents, Biochemistry, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Mediator, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Syk Kinase, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Cell growth, Organic Chemistry, Neoplasms, Experimental, medicine.disease, Pyrrolidinones, Lymphoma, Mice, Inbred C57BL, Haematopoiesis, Leukemia, 030104 developmental biology, Pyrimidines, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Nivolumab, Drug Screening Assays, Antitumor
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المؤلفون: Phong H. Vu, Anthony R. Gangloff, Ron de Jong, Mark S. Hixon, Ruhi Kamran, Charles E. Grimshaw, Douglas R. Dougan, Ewan Taylor, Shawn M. O’Connell, Andrew John Jennings, Jason W. Brown, Kiryanov Andre A
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4501-4505
مصطلحات موضوعية: Drug, Stereochemistry, media_common.quotation_subject, Clinical Biochemistry, Mice, Nude, Pharmaceutical Science, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Benzoxazines, Enzyme Activation, Enzyme, chemistry, Drug Design, Molecular Medicine, Structure based
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المؤلفون: Stephen L. Gwaltney, Mark Sabat, Yiqin Wu, Zacharia Cheruvallath, Bumsup Lee, Prasuna Guntupalli, David J. Hosfield, Andrew John Jennings, Jun Feng, Mingnam Tang, Joanne Miura, Haixia Wang
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2166-2171
مصطلحات موضوعية: Models, Molecular, Pyridones, Clinical Biochemistry, Cell, Enzyme Activators, Mice, Obese, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, Glucokinase, Drug Discovery, Glucokinase activator, medicine, Animals, Hypoglycemic Agents, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Glucose Tolerance Test, Enzyme Activation, Mice, Inbred C57BL, Disease Models, Animal, Enzyme, medicine.anatomical_structure, chemistry, Design synthesis, Drug Design, Molecular Medicine
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المؤلفون: Yoshinobu Kinugawa, Lihong Shi, Charles E. Grimshaw, Takuo Kosaka, Emiko Koumura, Andrew John Jennings, Koji Takeuchi, Ruhi Kamran, Nobuhiro Nishigaki, Hiroki Sano, Hikaru Ueno, Akiyoshi Tani
المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157509 (2016)مصطلحات موضوعية: 0301 basic medicine, Male, Time Factors, endocrine system diseases, Physiology, lcsh:Medicine, Type 2 diabetes, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Piperidines, Medicine and Health Sciences, Enzyme Inhibitors, lcsh:Science, Trelagliptin, Mammals, Multidisciplinary, Crystallography, Chemistry, Physics, digestive, oral, and skin physiology, Chemical Reactions, Hematology, Proteases, Condensed Matter Physics, Body Fluids, Type 2 Diabetes, Enzymes, Blood, 030220 oncology & carcinogenesis, Sitagliptin, Physical Sciences, Vertebrates, Crystal Structure, Anatomy, Alogliptin, medicine.drug, Research Article, medicine.medical_specialty, endocrine system, Chemical Dissociation, Endocrine Disorders, Dipeptidyl Peptidase 4, digestive system, Dipeptidyl peptidase, Blood Plasma, 03 medical and health sciences, Dogs, Internal medicine, medicine, Diabetes Mellitus, Animals, Humans, Solid State Physics, Uracil, Dipeptidyl peptidase-4, Dipeptidyl-Peptidase IV Inhibitors, lcsh:R, Sitagliptin Phosphate, Organisms, nutritional and metabolic diseases, Biology and Life Sciences, Proteins, medicine.disease, In vitro, 030104 developmental biology, Diabetes Mellitus, Type 2, Metabolic Disorders, Amniotes, Enzymology, lcsh:Q
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المؤلفون: Ron de Jong, Shawn M. O’Connell, Robert Melkus, Andrew John Jennings, Marc Navre, Jerome C. Bressi, Anthony R. Gangloff, Yiqin Wu, Charles E. Grimshaw, Robert J. Skene
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3142-3145
مصطلحات موضوعية: Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Histone Deacetylase 2, Pharmaceutical Science, Carboxamide, Crystal structure, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, medicine, Humans, Structure–activity relationship, Benzamide, Molecular Biology, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Aromatic amine, HCT116 Cells, Receptor–ligand kinetics, Histone Deacetylase Inhibitors, Kinetics, chemistry, Benzamides, Molecular Medicine
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