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1
المؤلفون: Theresa J. Roethke, Ning Wang, Clark A. Sehon, Catherine C.K. Yuan, Christopher A. Evans, Jason W. Dodson, Deyou Sha, Luz H. Carballo, Rakesh Nagilla, Mark A. Hilfiker, Harvey E. Fries, Gren Z. Wang, David J. Behm, Michael J. Neeb, Sarah E. Dowdell, Krista B. Goodman, Stephen A. Douglas, Xiaoping Xu, Nambi Aiyar, Andrew Q. Viet, John J. McAtee, Daohua Zhang, Gerald R. Girard
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3500-3503
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Urotensin-II receptor, Biochemistry, κ-opioid receptor, Cell Line, Receptors, G-Protein-Coupled, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Receptor, Molecular Biology, Piperidones, Aniline Compounds, Molecular Structure, biology, Bicyclic molecule, Organic Chemistry, Cytochrome P450, Stereoisomerism, Small molecule, Rats, Molecular Weight, chemistry, biology.protein, Molecular Medicine, Urotensin-II, Lead compound
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2
المؤلفون: Larry J. Jolivette, Erding Hu, Andrew Q. Viet, Lois L Wright, Edward Dul, Robert B. Kirkpatrick, Robert A. Stavenger, Haifeng Cui, Weiwei Xu, Gren Z. Wang, David Kendallc Jung, Ross Bentley, David J. Behm, Robert L. Ivy, Dimitri E. Gaitanopoulos, Christopher P. Doe, Tracey Yi, Dennis Lee, Krista B. Goodman, Sarah E. Dowdell, Sanjay S. Khandekar, Gary K Smith, Christopher P. Evans, Guosen Ye, Harvey E. Fries, Simon Semus, Clark A. Sehon
المصدر: Journal of Medicinal Chemistry. 50:6-9
مصطلحات موضوعية: Models, Molecular, Indazoles, Pyridones, Blood Pressure, In Vitro Techniques, Protein Serine-Threonine Kinases, Muscle, Smooth, Vascular, Structure-Activity Relationship, chemistry.chemical_compound, Rats, Inbred SHR, Drug Discovery, Animals, ROCK1, Protein kinase A, Rho-associated protein kinase, Antihypertensive Agents, Aorta, rho-Associated Kinases, Indazole, biology, Intracellular Signaling Peptides and Proteins, Amides, Rats, Bioavailability, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Vascular smooth muscle contraction, Muscle Contraction
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3
المؤلفون: Deyou Sha, Chun-wa Chung, Krista B. Goodman, Christine L. Webb, Subhas J. Chakravorty, Tom Daniel, Sarah E. Dowdell, Dennis Lee, Benjamin Belot, Andrew Q. Viet, Ruben Quek, Pamela A. Haile, Gren Z. Wang, Jacques Briand, Christopher P. Evans, Alan R. Olzinski, Norbert Varga, Clark A. Sehon, Amanda Emmons, Carla A. Cornejo, Roberta E. Bernard, Xuan Hong, Peter J. Gough
المصدر: Bioorganicmedicinal chemistry letters. 21(24)
مصطلحات موضوعية: medicine.drug_class, Receptors, CCR2, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Plasma protein binding, Biochemistry, chemistry.chemical_compound, Mice, Amide, Drug Discovery, medicine, Animals, Humans, Gene Knock-In Techniques, Receptor, Molecular Biology, Serum Albumin, Whole blood, Sulfonamides, Aryl, Organic Chemistry, Receptor antagonist, Human serum albumin, Rats, Mice, Inbred C57BL, chemistry, Guanosine 5'-O-(3-Thiotriphosphate), Molecular Medicine, Linker, medicine.drug, Protein Binding
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4
المؤلفون: Gren Z. Wang, Larry J. Jolivette, Christopher Evans, Tracey Yi, David J. Behm, Krista B. Goodman, Erding Hu, Gary K. Smith, Robert B. Kirkpatrick, Semus Simon, Sarah E. Dowdell, Lois L. Wright, Patricia A. Elkins, Andrew Q. Viet, Ross Bentley, Edward Dul, Sanjay S. Khandekar, Dennis Lee, Clark A. Sehon, Christopher P. Doe
المصدر: Journal of medicinal chemistry. 51(21)
مصطلحات موضوعية: Models, Molecular, Indazoles, Administration, Oral, Pharmacology, Crystallography, X-Ray, Structure-Activity Relationship, Adenosine Triphosphate, Drug Discovery, Animals, ROCK1, Rho-associated protein kinase, Protein Kinase Inhibitors, chemistry.chemical_classification, Aldehydes, rho-Associated Kinases, biology, Molecular Structure, Kinase, Cytochrome P450, In vitro, Rats, Enzyme, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, Cardiovascular Diseases, biology.protein, Molecular Medicine, Signal transduction
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5
المؤلفون: John J. McAtee, Andrew Q. Viet, Jason W. Dodson, Sarah E. Dowdell, Daohua Zhang, Krista B. Goodman, Luz H. Carballo, Clark A. Sehon, Zining Wu, David J. Behm, Michael J. Neeb, Stephen A. Douglas, Mark A. Hilfiker, Gren Z. Wang
المصدر: Bioorganicmedicinal chemistry letters. 18(16)
مصطلحات موضوعية: medicine.drug_class, Taurine, Acamprosate, Chemistry, Pharmaceutical, Urotensins, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Piperazines, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aorta, Bicyclic molecule, Receptors, Opioid, kappa, Organic Chemistry, Antagonist, In vitro, Rats, Piperazine, Opioid, chemistry, Models, Chemical, Drug Design, Hypertension, Molecular Medicine, medicine.symptom, Vasoconstriction, medicine.drug
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6
المؤلفون: Xiaoping Xu, Christopher A. Evans, Theresa J. Roethke, Jason W. Dodson, Clark A. Sehon, Luz H. Carballo, Yonghui Wang, John J. McAtee, Ning Wang, Mark A. Hilfiker, Karl F. Erhard, Gren Z. Wang, Feng Wang, Deyou Sha, Gerald R. Girard, Stephen A. Douglas, Daohua Zhang, Nambi Aiyar, Andrew Q. Viet, Dongchuan Shi, Jian Jin, David J. Behm, Sarah E. Dowdell, Krista B. Goodman, Michael J. Neeb, Harvey E. Fries, Catherine C.K. Yuan, Rakesh Nagilla
المصدر: Bioorganicmedicinal chemistry letters. 18(13)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Chemistry, Pharmaceutical, Urotensins, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Carboxamide, Urotensin-II receptor, Diamines, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Chromatography, High Pressure Liquid, Bicyclic molecule, Chemistry, Receptors, Opioid, kappa, Organic Chemistry, Brain, Stereoisomerism, Small molecule, Bioavailability, Rats, Models, Chemical, Drug Design, Molecular Medicine, Urotensin-II, Lead compound
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7
المؤلفون: Joseph P. Marino, Sanjay S. Khandekar, David J. Behm, Patricia A. Elkins, Dennis Lee, Sarah E. Dowdell, Robert G. Franz, Dimitri Gaitanopoulos, Haifeng Cui, Hye-Ja Oh, Mark A. Hilfiker, Yongdong Zhao, Weiwei Xu, Erding Hu, Zunxuan X. Chen, Christopher P. Doe, Jack D. Leber, David Kendall Jung, Robert B. Kirkpatrick, Robert L. Ivy, Andrew Q. Viet, Ross Bentley, Tracey Yi, Larry J. Jolivette, Krista B. Goodman, Edward Dul, Guosen Ye, Semus Simon, Lois L. Wright, Daohua Zhang, Robert A. Stavenger, Martha S. Head, Gary K. Smith
المصدر: Journal of medicinal chemistry. 50(1)
مصطلحات موضوعية: Models, Molecular, Blood Pressure, In Vitro Techniques, Protein Serine-Threonine Kinases, Muscle, Smooth, Vascular, Structure-Activity Relationship, In vivo, Rats, Inbred SHR, Drug Discovery, Structure–activity relationship, Animals, Protein kinase A, Rho-associated protein kinase, Antihypertensive Agents, Aorta, chemistry.chemical_classification, Oxadiazoles, rho-Associated Kinases, biology, Chemistry, Kinase, Intracellular Signaling Peptides and Proteins, Rats, Enzyme, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Signal transduction, Muscle Contraction
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8دورية أكاديمية
المؤلفون: Clark A. Sehon, Gren Z. Wang, Andrew Q. Viet, Krista B. Goodman, Sarah E. Dowdell, Patricia A. Elkins, Simon F. Semus, Christopher Evans, Larry J. Jolivette, Robert B. Kirkpatrick, Edward Dul, Sanjay S. Khandekar, Tracey Yi, Lois L. Wright, Gary K. Smith, David J. Behm, Ross Bentley, Christopher P. Doe, Erding Hu, Dennis Lee
المصدر: Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 21, p6631-6634, 4p
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9دورية أكاديمية
المؤلفون: Krista B. Goodman, Haifeng Cui, Sarah E. Dowdell, Dimitri E. Gaitanopoulos, Robert L. Ivy, Clark A. Sehon, Robert A. Stavenger, Gren Z. Wang, Andrew Q. Viet, Weiwei Xu, Guosen Ye, Simon F. Semus, Christopher Evans, Harvey E. Fries, Larry J. Jolivette, Robert B. Kirkpatrick, Edward Dul, Sanjay S. Khandekar, Tracey Yi, David K. Jung
المصدر: Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p6-9, 4p
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10دورية أكاديمية
المؤلفون: Robert A. Stavenger, Haifeng Cui, Sarah E. Dowdell, Robert G. Franz, Dimitri E. Gaitanopoulos, Krista B. Goodman, Mark A. Hilfiker, Robert L. Ivy, Jack D. Leber, Joseph P. Marino Jr., Hye-Ja Oh, Andrew Q. Viet, Weiwei Xu, Guosen Ye, Daohua Zhang, Yongdong Zhao, Larry J. Jolivette, Martha S. Head, Simon F. Semus, Patricia A. Elkins
المصدر: Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p2-5, 4p