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المؤلفون: Andrew Simon Bell, Marcell Borbely, Yang Li
المصدر: Journal of the American Ceramic Society. 104:2678-2688
مصطلحات موضوعية: 010302 applied physics, Permittivity, Materials science, Condensed matter physics, Doping, Rayleigh law, 02 engineering and technology, Conductivity, 021001 nanoscience & nanotechnology, 01 natural sciences, Ferroelectricity, Piezoelectricity, symbols.namesake, Domain wall (magnetism), 0103 physical sciences, Materials Chemistry, Ceramics and Composites, symbols, 0210 nano-technology, Polarization (electrochemistry)
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المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)مصطلحات موضوعية: Male, Schistosoma Mansoni, Physiology, RC955-962, Pharmacology, Biochemistry, Praziquantel, Mice, 0302 clinical medicine, Animal Cells, Arctic medicine. Tropical medicine, Drug Discovery, Medicine and Health Sciences, Parasite hosting, media_common, 0303 health sciences, biology, Pharmaceutics, Eukaryota, Chemical Synthesis, Animal Models, Lipids, Body Fluids, Infectious Diseases, Blood, Treatment Outcome, Experimental Organism Systems, Liver, Schistosoma, Female, Schistosoma mansoni, Public aspects of medicine, RA1-1270, Anatomy, Cellular Types, medicine.drug, Research Article, Drug, media_common.quotation_subject, 030231 tropical medicine, Schistosomiasis, Mouse Models, Research and Analysis Methods, Blood Plasma, Drug Administration Schedule, 03 medical and health sciences, Schistosomicides, Dose Prediction Methods, Model Organisms, Helminths, medicine, Potency, Juvenile, Animals, Humans, 030304 developmental biology, Plasma Proteins, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Proteins, Cell Biology, biology.organism_classification, medicine.disease, Invertebrates, Schistosomiasis mansoni, Animal Studies, Hepatocytes, Zoology, Oils, Schistosoma species
وصف الملف: application/pdf
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المؤلفون: Gregor A. Lueg, Bartlett E, Martin Janz, Probir Chakravarty, Dinis Pedro Calado, Miriam Llorian-Sopena, Mathew J. Garnett, Carr R, Monica Faronato, Andrew Simon Bell, Roberto Solari, Andrii Gorelik, Edward W. Tate, J.A. Hutton, Francesco Falciani, Eva Caamaño-Gutiérrez, Brzezicha B, Goya Grocin A
مصطلحات موضوعية: Programmed cell death, Chemistry, medicine.medical_treatment, Cancer cell, medicine, Cancer research, Protein biosynthesis, Cancer, Protein myristoylation, Synthetic lethality, medicine.disease, Targeted therapy, Myristoylation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b8cb3010b24b75d18b70086cbba79e19
https://doi.org/10.1101/2021.03.20.436222 -
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المؤلفون: Z. Yu, Shirley M. Roberts, J.A. Hutton, James A. Brannigan, Andrew Simon Bell, Robin J. Leatherbarrow, Daniel Paape, Anthony J. Wilkinson, Megan H. Wright, Charlotte L. Sutherell, Edward W. Tate, Markus Ritzefeld, Deborah F. Smith
المساهمون: Wellcome Trust
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Medicinal & Biomolecular Chemistry, Antiprotozoal Agents, Protozoan Proteins, Leishmania donovani, Thiophenes, 01 natural sciences, 0305 Organic Chemistry, Article, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Drug Discovery, parasitic diseases, Structure–activity relationship, Leishmania major, Enzyme Inhibitors, Amastigote, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Molecular Structure, biology, 0304 Medicinal and Biomolecular Chemistry, Leishmania, biology.organism_classification, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Biomarker, Pyrimidines, Enzyme, chemistry, Biochemistry, Molecular Medicine, 1115 Pharmacology and Pharmaceutical Sciences, Acyltransferases, Intracellular, Protein Binding
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5Abstract 1731: EXS21546, a non-CNS penetrant A2AR-selective antagonist for anti-cancer immunotherapy
المؤلفون: Emilie Mirey, Florie Bertrand, Andrew Simon Bell, Gregory I. Vladimer, Emilie Pelissier, Isabella Alt, Mark Whittaker, Pierre Fons, Joost van Ham, Stephanie Versluys, Andrew Payne, Michael R. Paillasse, Christina Taubert, Virgile Visentin, Sabrina Pagliarusco
المصدر: Cancer Research. 81:1731-1731
مصطلحات موضوعية: Cancer Research, Tumor microenvironment, business.industry, medicine.medical_treatment, Cancer, Immunotherapy, medicine.disease, Adenosine receptor, Adenosine, Oncology, Cancer immunotherapy, Cancer cell, medicine, Cancer research, business, Ex vivo, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::501fd2b7b9a495ec65303724e2b1da20
https://doi.org/10.1158/1538-7445.am2021-1731 -
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المؤلفون: Amin S. Asfor, Robin J. Leatherbarrow, Iva Hopkins-Navratilova, Aurelie Mousnier, Sean Robinson, Anabel Guedán, Inmaculada Pérez-Dorado, Andrew Simon Bell, Joseph Newman, Anthony J. Wilkinson, Markus Ritzefeld, Roberto Solari, Edward W. Tate, J.A. Hutton, Dawid Swieboda, Sebastian L. Johnston, Tobias J. Tuthill, James A. Brannigan, Julia Morales-Sanfrutos
المساهمون: Medical Research Council (MRC), Wellcome Trust, Asthma UK, GlaxoSmithKline Services Unlimited, Cancer Research UK
المصدر: Nature chemistry
Mousnier, A, Bell, A S, Swieboda, D P, Morales-Sanfrutos, J, Pérez-Dorado, I, Brannigan, J A, Newman, J, Ritzefeld, M, Hutton, J A, Guedán, A, Asfor, A S, Robinson, S W, Hopkins-Navratilova, I, Wilkinson, A J, Johnston, S L, Leatherbarrow, R J, Tuthill, T J, Solari, R & Tate, E W 2018, ' Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus ', Nature chemistry, vol. 10, no. 6, pp. 599-606 . https://doi.org/10.1038/s41557-018-0039-2مصطلحات موضوعية: 0301 basic medicine, Viral capsid assembly, Rhinovirus, Chemistry, Multidisciplinary, General Chemical Engineering, viruses, PREVENTS, medicine.disease_cause, Virus Replication, 01 natural sciences, INFECTION, Enzyme Inhibitors, Cytotoxicity, Molecular Structure, Chemistry, Poliovirus, NMT2, MYRISTOYLATION, 3. Good health, Capsid, Physical Sciences, PROTEOMICS, 03 Chemical Sciences, Antiviral Agents, Virus, Article, 03 medical and health sciences, Inhibitory Concentration 50, SDG 3 - Good Health and Well-being, medicine, Humans, Myristoylation, Science & Technology, CYSTIC-FIBROSIS, 010405 organic chemistry, Virus Assembly, Organic Chemistry, General Chemistry, Virology, 0104 chemical sciences, 030104 developmental biology, CELLS, ASTHMA, Linker, Acyltransferases, HeLa Cells
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المؤلفون: Stephanie Versluys, Pierre Fons, Michael R. Paillasse, Celia bergeaud, Federica Ferigo, Andrew Simon Bell, Richard Cox, Jérémy Besnard, Eric Cogo, Simone Culurgioni, Sean Robinson, Frederic Machet, Sabrina Pagliarusco, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Jerome Menegotto, Emilie Mirey, Michael Esquerre, Joanna Lisztwan, Florie Bertrand, Virgile Visentin, Celine Poussereau-Pomie, Andrew Payne, Adrian Schreyer, Andrew L. Hopkins, Mark Whittaker
المصدر: Cancer Research. 79:519-519
مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, Oncology, Drug development, Cancer immunotherapy, chemistry, Drug discovery, medicine.medical_treatment, Philosophy, medicine, Cancer research, Penetrant (biochemical)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01d93767d9b8f4fca64cf05cb71ac2ed
https://doi.org/10.1158/1538-7445.am2019-519 -
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المؤلفون: Michael Esquerre, Florie Bertrand, Celia bergeaud, Andrew Simon Bell, Ghislaine Marchand, Simone Culurgioni, Michael R. Paillasse, Peter N. Ray, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Leonardo-Silvestre Hernani, Jérémy Besnard, Sean Robinson, Mark Whittaker, Joanna Lisztwan, Stephanie Versluys, Andrew L. Hopkins, Andrew Payne, Pierre Fons, Adrian Schreyer, Celine Poussereau-Pomie, Richard S. Cox
المصدر: Cancer Research. 79:507-507
مصطلحات موضوعية: Cancer Research, business.industry, Drug discovery, medicine.medical_treatment, Cancer, Biological activity, medicine.disease, Adenosine, Adenosine receptor, Small molecule, Immune checkpoint, Oncology, Cancer immunotherapy, Cancer research, Medicine, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::85b4f3ba878b339271551e8b3f442d29
https://doi.org/10.1158/1538-7445.am2019-507 -
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المؤلفون: Jeremy N. Burrows, Sally Lyons-Abbott, Anthony A. Holder, Ellen Knuepfer, Chun-Wa Chung, Anja C. Schlott, Roger Bonnert, Edward W. Tate, David Charter, Andrew Simon Bell, Olivia Coburn-Flynn, Alexandra R. Reers, Peter J. Myler, Judith L. Green, Brice Campo, David A. Fidock, Stephen J. Mayclin, Bart Staker
المصدر: Cell Chemical Biology
مصطلحات موضوعية: Plasmodium, Gliding motility, Clinical Biochemistry, Drug resistance, Protein lipidation, 01 natural sciences, Biochemistry, DESIGN, Drug Discovery, BINDING, Transferase, Enzyme Inhibitors, Malaria, Falciparum, chemistry.chemical_classification, biology, PLASMODIUM-FALCIPARUM, myristoylation, DRUG TARGET, genetic manipulation, 3. Good health, GENOME, Drug development, Molecular Medicine, antimalarial target, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, crystal structure, Plasmodium falciparum, malaria, Polymorphism, Single Nucleotide, Article, Antimalarials, Humans, Amino Acid Sequence, PARASITE, Molecular Biology, N-myristoyltransferase, Myristoylation, Pharmacology, Science & Technology, 010405 organic chemistry, biology.organism_classification, drug resistance development, 0104 chemical sciences, Enzyme, chemistry, post-translational modification, DISCOVERY, protein lipidation, Protein Processing, Post-Translational, HUMAN MALARIA, Acyltransferases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfcafa9db9451aea40d2e226d491674
http://europepmc.org/articles/PMC6658617 -
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المؤلفون: Peter G. Dodd, Thomas Ryckmans, Samantha Hughes, David G. Brown, Martin P. Green, Andrew Simon Bell, Willem P. van Hoorn, Christopher A. Hewson, Christopher Phillips, Philip Cohen, Lyn H. Jones, Iain Kilty, Robert T. Smith
المصدر: Chemical Biology & Drug Design. 82:500-505
مصطلحات موضوعية: Lipopolysaccharides, Pharmacology, Tumor Necrosis Factor-alpha, Kinase, Stereochemistry, Chemistry, Organic Chemistry, Phosphatase, Anti-Inflammatory Agents, Chemical biology, MAP Kinase Kinase Kinases, p38 Mitogen-Activated Protein Kinases, Biochemistry, Recombinant Proteins, Drug Discovery, Leukocytes, Mononuclear, Humans, Molecular Medicine, Molecule, Protein Kinase Inhibitors, Protein Binding
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