المؤلفون: Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384

المؤلفون: Mckittrick Brian A, Mihirbaran Mandal, Jared N. Cumming, Andrew Brunskill, Andrew Stamford, Hongwu Wang, Xiaoxiang Liu, Alexei V. Buevich, Robert Mazzola, Peter Orth, Zhaoning Zhu, John P. Caldwell

المصدر: European Journal of Organic Chemistry. 2021:5073-5079

مصطلحات موضوعية: Chemistry, Organic Chemistry, Regioselectivity, Organic chemistry, Amine gas treating, Physical and Theoretical Chemistry, Interception, Curtius rearrangement

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::df583a27443bdf99ebdd82d44726c381
https://doi.org/10.1002/ejoc.202101056

المؤلفون: Mark Duggan, Kazuyoshi Aso, Sasaki Y, Nigel J. Liverton, Liang R, Phillips Re, Stacia Kargman, Mayako Michino, Daisuke Tomita, Shahid M, Peter T. Meinke, Leigh Baxt, DeStanchina E, David J. Huggins, Michael Foley, Andrew Stamford, John Ginn

مصطلحات موضوعية: Methyltransferase, biology, business.industry, Mechanism (biology), Fda approval, EZH2, Cancer, macromolecular substances, medicine.disease, chemistry.chemical_compound, chemistry, biology.protein, Cancer research, Medicine, Protein activity, business, Penetrant (biochemical), PRC2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d1041e7fd09af897b5fbd7996cd485
https://doi.org/10.1101/2021.06.10.447852

المؤلفون: Hongwu Wang, Leonard Favreau, Jairam Palamanda, Xinjie Lin, Diane Rindgen, John P. Caldwell, Zhaoning Zhu, Pramila Kumari, Alexei V. Buevich, Reshma Kuvelkar, Edward C. Sherer, Andrew Stamford, Kathleen Cox, Jared N. Cumming, Diane Grotz, Matthew E. Kennedy, Xiaoxang Liu, Mihir Mandal, Lynn A. Hyde, Kaushik Mitra, Eric M. Parker, Xia Chen, Robert Mazzola

المصدر: Journal of Medicinal Chemistry. 61:10700-10708

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Metabolite, Oxidative phosphorylation, 030226 pharmacology & pharmacy, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Cytochrome P-450 CYP3A, Animals, Humans, Moiety, Structure–activity relationship, Tissue Distribution, Cytochrome P-450 CYP3A Inhibitors, CYP3A4, Rats, Kinetics, Pyrimidines, 030104 developmental biology, chemistry, Reactive metabolite, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff6cf8405739a6779b4176b25e3536
https://doi.org/10.1021/acs.jmedchem.8b01326

المؤلفون: Kyu Y. Rhee, Peter T. Meinke, Shan Sun, Robert S. Jansen, Takanobu Kuroita, Carl Nathan, Kazuyoshi Aso, Mayako Michino, Xiuju Jiang, Andrew Stamford, Rei Okamoto, Nancy Arango, Nigel J. Liverton, Ruslana Bryk, Christopher D. Lima, Michael Foley, John Ginn, Toshihiro Imaeda, David J. Huggins, Zodwa Mbambo

المصدر: ACS Infect Dis

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, 030106 microbiology, Treatment options, Slow binding, Mycobacterium tuberculosis, Residence time (fluid dynamics), Anti-Bacterial Agents, 03 medical and health sciences, Kinetics, Mice, 030104 developmental biology, Infectious Diseases, Enzyme, chemistry, Biochemistry, Lipoamide Dehydrogenase, Animals, Humans, Tuberculosis, Selectivity, Whole cell, Dihydrolipoamide Dehydrogenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1123eb45dd02e228ae975e21240cd2
https://europepmc.org/articles/PMC7888283/

المؤلفون: Charles Lee Jayne, Hong Liu, Yan Xia, Santhosh Neelamkavil, William J. Greenlee, Hana Baker, Brian Hawes, Kim O’Neill, Andrew Stamford, Timothy J. Kowalski, Xing Dai, Jinsong Hao, Samuel Chackalamannil, Huadong Tang, Dipshikha Biswas, Bernard R. Neustadt, Craig D. Boyle

المصدر: ACS Medicinal Chemistry Letters. 9:457-461

مصطلحات موضوعية: 0301 basic medicine, Agonist, 010405 organic chemistry, medicine.drug_class, Chemistry, Organic Chemistry, Type 2 diabetes, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, GPR119, Sitagliptin, Drug Discovery, medicine, Potency, Glucose homeostasis, Receptor, medicine.drug, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb59bda5cd880fcaccd1cfaabd07b78
https://doi.org/10.1021/acsmedchemlett.8b00073

المؤلفون: Carolyn Bahnck-Teets, Xu Min, Lehua Chang, Tracy L. Diamond, M. Katharine Holloway, John F. Fay, David Jonathan Bennett, John A. Mccauley, Jurgen Schulz, Marie Loughran, Peter D. Williams, Alejandro Crespo, Andrew Stamford, Hua-Poo Su, Michael D. Miller, Kartik M. Keertikar, Christopher J. Bungard, Catherine M. Wiscount, Bin Zhong, Jeanine E. Ballard, Sherman T. Waddell, Steven S. Carroll, Tao Ji, Jesse J. Manikowski, Bin Hu, Xin-jie Chu, Gregori J. Morriello, William J. Morris, Michael P. Dwyer

المصدر: ACS Medicinal Chemistry Letters. 8:1292-1297

مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, biology, 010405 organic chemistry, Stereochemistry, Protease binding, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Sulfonamide, Enzyme binding, Aspartate binding, Piperazine, chemistry.chemical_compound, chemistry, HIV-1 protease, Drug Discovery, biology.protein, Protease inhibitor (pharmacology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6240d0128d9c35a558caa2cfbba15fa5
https://doi.org/10.1021/acsmedchemlett.7b00386

المؤلفون: Mark S. Forman, Peter Orth, Ulrich Iserloh, Yusheng Wu, Hongwu Wang, William J. Greenlee, Reshma Kuvelkar, Xia Chen, Jack D. Scott, John Meredith, Lana M. Rossiter, Lynn A. Hyde, Robert A. Hodgson, Andrew Stamford, Julie A. Stone, Irina Kazakevich, Ganfeng Wang, Eric M. Parker, Eric J. Gilbert, Kathleen Cox, Corey O. Strickland, Sarah W. Li, Meagan Slater, Qin Jiang, Johannes H. Voigt, Hong Mei, Andrew Brunskill, Matthew E. Kennedy, Misiaszek Jeffrey A, Jared N. Cumming

المصدر: Journal of Medicinal Chemistry. 59:10435-10450

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, High selectivity, Cathepsin D, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Aspartate protease, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Thiadiazines, biology, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, Biochemistry, chemistry, biology.protein, Molecular Medicine, Verubecestat, Clinical evaluation, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88617ac0382047768a81e118b787b6ca
https://doi.org/10.1021/acs.jmedchem.6b00307

المؤلفون: J. Fraser Glickman, Dinshaw J. Patel, Andrew John Jennings, Vitaly Kuryavyi, Aida Jumpei, Pu Gao, Mayako Michino, Wei Xie, Carolina Adura, Takanobu Kuroita, Lavoisier Ramos-Espiritu, Peter T. Meinke, Michael Miller, Toshihiro Imaeda, L. Lama, Kamei Taku, Thomas Tuschl, Tasos Gogakos, Hashizume Shogo, Rei Okamoto, Andrew Stamford, Asano Yasutomi, Joshua Steinberg, Daisuke Tomita

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Models, Molecular, Pattern recognition receptors, 0301 basic medicine, Science, medicine.medical_treatment, Primary Cell Culture, Cell, General Physics and Astronomy, 02 engineering and technology, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, 03 medical and health sciences, Interferon, Drug Discovery, medicine, Humans, Enzyme Inhibitors, lcsh:Science, Cells, Cultured, Multidisciplinary, Innate immune system, Chemistry, Macrophages, High-throughput screening, Pattern recognition receptor, DNA, General Chemistry, 021001 nanoscience & nanotechnology, Nucleotidyltransferases, Immunity, Innate, Recombinant Proteins, High-Throughput Screening Assays, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Cell culture, Second messenger system, lcsh:Q, Interferons, Nucleotides, Cyclic, 0210 nano-technology, Intracellular, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4139db3298e4c59f67101ce311ac0251
https://doi.org/10.1038/s41467-019-08620-4

المؤلفون: Stacia Kargman, Andrew John Jennings, Michael Miller, Andrew Stamford, Damodharan Lakshminarasimhan, Lewis C. Cantley, Anita D. Robin, Mayako Michino, David J. Huggins, Jiayi Xu, Edouard Mullarky, Andrea Olland, Daisuke Tomita, Naoyoshi Noguchi, Guoan Zhang, Peter T. Meinke, Taojunfeng Su

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, Serine, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Phosphoglycerate dehydrogenase, Enzyme Inhibitors, Molecular Biology, Phosphoglycerate Dehydrogenase, Cell Proliferation, chemistry.chemical_classification, Indole test, Binding Sites, 010405 organic chemistry, Organic Chemistry, Oxidoreductase inhibitor, Amides, 0104 chemical sciences, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, Metabolic pathway, Enzyme, chemistry, Molecular Medicine, NAD+ kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f16e67aacdf7a18e54b2d994c08873d
https://pubmed.ncbi.nlm.nih.gov/31327531