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1دورية أكاديمية
المؤلفون: Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Mckittrick Brian A, Mihirbaran Mandal, Jared N. Cumming, Andrew Brunskill, Andrew Stamford, Hongwu Wang, Xiaoxiang Liu, Alexei V. Buevich, Robert Mazzola, Peter Orth, Zhaoning Zhu, John P. Caldwell
المصدر: European Journal of Organic Chemistry. 2021:5073-5079
مصطلحات موضوعية: Chemistry, Organic Chemistry, Regioselectivity, Organic chemistry, Amine gas treating, Physical and Theoretical Chemistry, Interception, Curtius rearrangement
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المؤلفون: Mark Duggan, Kazuyoshi Aso, Sasaki Y, Nigel J. Liverton, Liang R, Phillips Re, Stacia Kargman, Mayako Michino, Daisuke Tomita, Shahid M, Peter T. Meinke, Leigh Baxt, DeStanchina E, David J. Huggins, Michael Foley, Andrew Stamford, John Ginn
مصطلحات موضوعية: Methyltransferase, biology, business.industry, Mechanism (biology), Fda approval, EZH2, Cancer, macromolecular substances, medicine.disease, chemistry.chemical_compound, chemistry, biology.protein, Cancer research, Medicine, Protein activity, business, Penetrant (biochemical), PRC2
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d1041e7fd09af897b5fbd7996cd485
https://doi.org/10.1101/2021.06.10.447852 -
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المؤلفون: Hongwu Wang, Leonard Favreau, Jairam Palamanda, Xinjie Lin, Diane Rindgen, John P. Caldwell, Zhaoning Zhu, Pramila Kumari, Alexei V. Buevich, Reshma Kuvelkar, Edward C. Sherer, Andrew Stamford, Kathleen Cox, Jared N. Cumming, Diane Grotz, Matthew E. Kennedy, Xiaoxang Liu, Mihir Mandal, Lynn A. Hyde, Kaushik Mitra, Eric M. Parker, Xia Chen, Robert Mazzola
المصدر: Journal of Medicinal Chemistry. 61:10700-10708
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Metabolite, Oxidative phosphorylation, 030226 pharmacology & pharmacy, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Cytochrome P-450 CYP3A, Animals, Humans, Moiety, Structure–activity relationship, Tissue Distribution, Cytochrome P-450 CYP3A Inhibitors, CYP3A4, Rats, Kinetics, Pyrimidines, 030104 developmental biology, chemistry, Reactive metabolite, Molecular Medicine
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المؤلفون: Kyu Y. Rhee, Peter T. Meinke, Shan Sun, Robert S. Jansen, Takanobu Kuroita, Carl Nathan, Kazuyoshi Aso, Mayako Michino, Xiuju Jiang, Andrew Stamford, Rei Okamoto, Nancy Arango, Nigel J. Liverton, Ruslana Bryk, Christopher D. Lima, Michael Foley, John Ginn, Toshihiro Imaeda, David J. Huggins, Zodwa Mbambo
المصدر: ACS Infect Dis
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, 030106 microbiology, Treatment options, Slow binding, Mycobacterium tuberculosis, Residence time (fluid dynamics), Anti-Bacterial Agents, 03 medical and health sciences, Kinetics, Mice, 030104 developmental biology, Infectious Diseases, Enzyme, chemistry, Biochemistry, Lipoamide Dehydrogenase, Animals, Humans, Tuberculosis, Selectivity, Whole cell, Dihydrolipoamide Dehydrogenase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1123eb45dd02e228ae975e21240cd2
https://europepmc.org/articles/PMC7888283/ -
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المؤلفون: Charles Lee Jayne, Hong Liu, Yan Xia, Santhosh Neelamkavil, William J. Greenlee, Hana Baker, Brian Hawes, Kim O’Neill, Andrew Stamford, Timothy J. Kowalski, Xing Dai, Jinsong Hao, Samuel Chackalamannil, Huadong Tang, Dipshikha Biswas, Bernard R. Neustadt, Craig D. Boyle
المصدر: ACS Medicinal Chemistry Letters. 9:457-461
مصطلحات موضوعية: 0301 basic medicine, Agonist, 010405 organic chemistry, medicine.drug_class, Chemistry, Organic Chemistry, Type 2 diabetes, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, GPR119, Sitagliptin, Drug Discovery, medicine, Potency, Glucose homeostasis, Receptor, medicine.drug, G protein-coupled receptor
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المؤلفون: Carolyn Bahnck-Teets, Xu Min, Lehua Chang, Tracy L. Diamond, M. Katharine Holloway, John F. Fay, David Jonathan Bennett, John A. Mccauley, Jurgen Schulz, Marie Loughran, Peter D. Williams, Alejandro Crespo, Andrew Stamford, Hua-Poo Su, Michael D. Miller, Kartik M. Keertikar, Christopher J. Bungard, Catherine M. Wiscount, Bin Zhong, Jeanine E. Ballard, Sherman T. Waddell, Steven S. Carroll, Tao Ji, Jesse J. Manikowski, Bin Hu, Xin-jie Chu, Gregori J. Morriello, William J. Morris, Michael P. Dwyer
المصدر: ACS Medicinal Chemistry Letters. 8:1292-1297
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, biology, 010405 organic chemistry, Stereochemistry, Protease binding, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Sulfonamide, Enzyme binding, Aspartate binding, Piperazine, chemistry.chemical_compound, chemistry, HIV-1 protease, Drug Discovery, biology.protein, Protease inhibitor (pharmacology)
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المؤلفون: Mark S. Forman, Peter Orth, Ulrich Iserloh, Yusheng Wu, Hongwu Wang, William J. Greenlee, Reshma Kuvelkar, Xia Chen, Jack D. Scott, John Meredith, Lana M. Rossiter, Lynn A. Hyde, Robert A. Hodgson, Andrew Stamford, Julie A. Stone, Irina Kazakevich, Ganfeng Wang, Eric M. Parker, Eric J. Gilbert, Kathleen Cox, Corey O. Strickland, Sarah W. Li, Meagan Slater, Qin Jiang, Johannes H. Voigt, Hong Mei, Andrew Brunskill, Matthew E. Kennedy, Misiaszek Jeffrey A, Jared N. Cumming
المصدر: Journal of Medicinal Chemistry. 59:10435-10450
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, High selectivity, Cathepsin D, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Aspartate protease, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Thiadiazines, biology, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, Biochemistry, chemistry, biology.protein, Molecular Medicine, Verubecestat, Clinical evaluation, Derivative (chemistry)
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المؤلفون: J. Fraser Glickman, Dinshaw J. Patel, Andrew John Jennings, Vitaly Kuryavyi, Aida Jumpei, Pu Gao, Mayako Michino, Wei Xie, Carolina Adura, Takanobu Kuroita, Lavoisier Ramos-Espiritu, Peter T. Meinke, Michael Miller, Toshihiro Imaeda, L. Lama, Kamei Taku, Thomas Tuschl, Tasos Gogakos, Hashizume Shogo, Rei Okamoto, Andrew Stamford, Asano Yasutomi, Joshua Steinberg, Daisuke Tomita
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)مصطلحات موضوعية: Models, Molecular, Pattern recognition receptors, 0301 basic medicine, Science, medicine.medical_treatment, Primary Cell Culture, Cell, General Physics and Astronomy, 02 engineering and technology, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, 03 medical and health sciences, Interferon, Drug Discovery, medicine, Humans, Enzyme Inhibitors, lcsh:Science, Cells, Cultured, Multidisciplinary, Innate immune system, Chemistry, Macrophages, High-throughput screening, Pattern recognition receptor, DNA, General Chemistry, 021001 nanoscience & nanotechnology, Nucleotidyltransferases, Immunity, Innate, Recombinant Proteins, High-Throughput Screening Assays, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Cell culture, Second messenger system, lcsh:Q, Interferons, Nucleotides, Cyclic, 0210 nano-technology, Intracellular, medicine.drug
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المؤلفون: Stacia Kargman, Andrew John Jennings, Michael Miller, Andrew Stamford, Damodharan Lakshminarasimhan, Lewis C. Cantley, Anita D. Robin, Mayako Michino, David J. Huggins, Jiayi Xu, Edouard Mullarky, Andrea Olland, Daisuke Tomita, Naoyoshi Noguchi, Guoan Zhang, Peter T. Meinke, Taojunfeng Su
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, Serine, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Phosphoglycerate dehydrogenase, Enzyme Inhibitors, Molecular Biology, Phosphoglycerate Dehydrogenase, Cell Proliferation, chemistry.chemical_classification, Indole test, Binding Sites, 010405 organic chemistry, Organic Chemistry, Oxidoreductase inhibitor, Amides, 0104 chemical sciences, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, Metabolic pathway, Enzyme, chemistry, Molecular Medicine, NAD+ kinase