المؤلفون: Axell E; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Hu J; Division of Physical Chemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Lindberg M; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Dear AJ; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, Cambridge University, CB2 1EW Cambridge, United Kingdom., Ortigosa-Pascual L; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Andrzejewska EA; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, Cambridge University, CB2 1EW Cambridge, United Kingdom., Šneiderienė G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, Cambridge University, CB2 1EW Cambridge, United Kingdom., Thacker D; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, Cambridge University, CB2 1EW Cambridge, United Kingdom., Sparr E; Division of Physical Chemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden., Linse S; Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 18; Vol. 121 (25), pp. e2322572121. Date of Electronic Publication: 2024 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid*/metabolism , Amyloid*/chemistry, Kinetics ; Humans ; Shear Strength ; Protein Aggregates ; Peptides/chemistry ; Peptides/metabolism ; Alzheimer Disease/metabolism

المؤلفون: Dear AJ; Biochemistry and Structural Biology, Lund University, Lund 221 00, Sweden.; Centre for Misfolding Diseases Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Thacker D; Biochemistry and Structural Biology, Lund University, Lund 221 00, Sweden., Wennmalm S; Department of Applied Physics, Biophysics Group, SciLifeLab, Royal Institute of Technology-KTH, Solna 171 65, Sweden., Ortigosa-Pascual L; Biochemistry and Structural Biology, Lund University, Lund 221 00, Sweden., Andrzejewska EA; Centre for Misfolding Diseases Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Meisl G; Centre for Misfolding Diseases Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Linse S; Biochemistry and Structural Biology, Lund University, Lund 221 00, Sweden., Knowles TPJ; Centre for Misfolding Diseases Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.; Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, U.K.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 05; Vol. 15 (11), pp. 2296-2307. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/chemistry , Peptide Fragments*/chemistry , Peptide Fragments*/metabolism, Humans ; Amyloid/metabolism ; Amyloid/chemistry ; Alzheimer Disease/metabolism ; Kinetics

المؤلفون: Horne RI; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Andrzejewska EA; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Alam P; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Brotzakis ZF; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Srivastava A; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Aubert A; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Nowinska M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Gregory RC; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Staats R; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Possenti A; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Chia S; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Sormanni P; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Caughey B; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. mv245@cam.ac.uk.

المصدر: Nature chemical biology [Nat Chem Biol] 2024 May; Vol. 20 (5), pp. 634-645. Date of Electronic Publication: 2024 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: alpha-Synuclein*/antagonists & inhibitors , alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , Machine Learning* , Drug Discovery*/methods , Protein Aggregates*/drug effects, Humans ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Structure-Activity Relationship

المؤلفون: Sahtoe DD; Department of Biochemistry, University of Washington, Seattle, WA, USA. d.sahtoe@hubrecht.eu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. d.sahtoe@hubrecht.eu.; HHMI, University of Washington, Seattle, WA, USA. d.sahtoe@hubrecht.eu.; Hubrecht Institute, Utrecht, the Netherlands. d.sahtoe@hubrecht.eu., Andrzejewska EA; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Han HL; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Rennella E; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Schneider MM; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Meisl G; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Ahlrichs M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Decarreau J; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Nguyen H; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kang A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Levine P; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Lamb M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Li X; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bera AK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kay LE; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Knowles TPJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Cavendish Laboratory, University of Cambridge, Cambridge, UK., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; HHMI, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2024 Mar 19. Date of Electronic Publication: 2024 Mar 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE