المؤلفون: Susan L. Dyos, Emma Hiley, Angela A. Dunne, Mary A. Morse, Fiona Flett, Martin Rüdiger, Edward Hollingsworth, Namir J. Hassan, Martin Hibbs, Jonathan P. Hutchinson, David G. Tew, Amanda Emmons, David J. Powell, Jeremy D. A. Kitson, Sheraz Gul

المصدر: Biochemical Journal. 419:65-73

مصطلحات موضوعية: Blotting, Western, Cell, Chromosomal translocation, Protein Serine-Threonine Kinases, Spodoptera, Biology, Models, Biological, Biochemistry, Cell Line, law.invention, NF-kappa B p52 Subunit, law, medicine, Animals, Humans, Phosphorylation, Molecular Biology, Gene, Insect cell, Kinase, NF-kappa B, Cell Biology, Kinase inhibition, Molecular biology, I-kappa B Kinase, Cell biology, medicine.anatomical_structure, Recombinant DNA, Biological Assay, Nucleus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4f87f33b575ebe8700adca9d63259f
https://doi.org/10.1042/bj20081646

المؤلفون: Sumitra Ramachandran, Angela A. Dunne, Neil Derek Miller, Laiq Chaudry, Vincent Jaquet, Craig Allan, Aleksandra Filippova, Jean Lim, Ceri H. Davies, Agnes B. Ong, May Thu Ma, Shabina Nasir, Woei Shin Chen, Nicole Y. Ye, Edward R. Browne, Kiew Ching K Lee, Shihua Liao, Douglas G. Johns, Angela Bridges, Yasuji Matsuoka, Chiu Cheong Aw, A. Richard Rutter, Adeline L.W. Chueng, Dizheng Li, Deborah W. Chen, Sri Mulyanidewi, Sarah Duncan, Tamara Seredenina, Gary Pettman, Kazufumi Hirano, Pamela P. Oon

المصدر: Antioxidants & redox signaling, Vol. 23, No 5 (2015) pp. 358-374

مصطلحات موضوعية: Male, Physiology, Clinical Biochemistry, Aminopyridines, ddc:616.07, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, Enzyme Inhibitors / therapeutic use, Membrane Glycoproteins / metabolism, Drug Discovery, Enzyme Inhibitors, Pancreatitis / drug therapy, Cells, Cultured, General Environmental Science, chemistry.chemical_classification, Sulfonamides, Membrane Glycoproteins, NADPH oxidase, biology, Chemistry, Enzyme Inhibitors / pharmacology, respiratory system, Small molecule, 3. Good health, Aminopyridines / chemistry, NADPH Oxidase 2, cardiovascular system, Sulfonamides / chemistry, circulatory and respiratory physiology, inorganic chemicals, In vivo, Forum Original Research Communication, medicine, Animals, NADPH Oxidases / metabolism, Molecular Biology, NOx, Sulfonamides / pharmacology, Reactive oxygen species, Aminopyridines / pharmacology, NADPH Oxidases / antagonists & inhibitors, Reactive Oxygen Species / metabolism, NADPH Oxidases, Cell Biology, In vitro, Mice, Inbred C57BL, Enzyme, Pancreatitis, Membrane Glycoproteins / antagonists & inhibitors, biology.protein, General Earth and Planetary Sciences, Reactive Oxygen Species, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ea3e136424a97ddab898f120e2665
https://europepmc.org/articles/PMC4545375/

المؤلفون: Mike I. Jowett, Angela A. Dunne, Stephen Rees

المصدر: Methods in Molecular Biology ISBN: 9781603272575

مصطلحات موضوعية: End point, Primary (chemistry), Human blood, Recombinant expression, Drug target, Molecular targets, Target protein, Computational biology, Biological materials

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4009035d7c828c15cb0fae35afbbe53d
https://doi.org/10.1007/978-1-60327-258-2_12

المؤلفون: Namir J. Hassan, Sheraz Gul, Fiona Flett, Edward Hollingsworth, Angela A. Dunne, Amanda J. Emmons, Jonathan P. Hutchinson, Martin J. Hibbs, Susan Dyos, Jeremy D. Kitson, Emma Hiley, Martin Rüdiger, David G. Tew, David J. Powell, Mary A. Morse

المصدر: Biochemical Journal; Apr2009, Vol. 419 Issue 1, p65-73, 9p

مصطلحات موضوعية: BIOLOGICAL assay, INSECT cytology, NF-kappa B, ENZYME inhibitors, BACULOVIRUSES, RECOMBINANT proteins, TUMOR necrosis factors

المؤلفون: Behar L; Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, United Kingdom., Chadwick D; The James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, United Kingdom., Dunne A; Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, United Kingdom., Jones CI; Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, BN1 9PS, United Kingdom., Proctor C; The James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, United Kingdom., Rajkumar C; Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, United Kingdom; Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, BN1 9PS, United Kingdom., Sharratt P; Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, United Kingdom., Stanley P; Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, United Kingdom., Whiley A; Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4, Newark Street, London, E1 2AT, United Kingdom., Wilks M; Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4, Newark Street, London, E1 2AT, United Kingdom; Department of Infection, Barts Health NHS Trust, Pathology and Pharmacy, 80, Newark St, London, E1 2ES, United Kingdom., Llewelyn MJ; Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, United Kingdom; Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, BN1 9PS, United Kingdom. Electronic address: m.j.llewelyn@bsms.ac.uk.

المصدر: The Journal of infection [J Infect] 2017 Jul; Vol. 75 (1), pp. 20-25. Date of Electronic Publication: 2017 Apr 21.

نوع المنشور: Journal Article; Observational Study

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE

مواضيع طبية MeSH: Hospitalization*, Bacterial Toxins/*biosynthesis , Clostridioides difficile/*isolation & purification , Clostridium Infections/*epidemiology , Cross Infection/*epidemiology , Enterotoxins/*biosynthesis, Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Clostridioides difficile/classification ; Clostridioides difficile/drug effects ; Clostridioides difficile/genetics ; Clostridium Infections/drug therapy ; Clostridium Infections/microbiology ; Clostridium Infections/mortality ; Cross Infection/microbiology ; Diarrhea/epidemiology ; England/epidemiology ; Feces/microbiology ; Female ; Humans ; Logistic Models ; Male ; Polymerase Chain Reaction ; Prospective Studies ; Ribotyping ; Risk Factors

المؤلفون: Rimland J; Medicines Research Centre, Verona, Italy., Dunne A, Hunjan SS, Sasse R, Uings I, Montanari D, Caivano M, Shah P, Standing D, Gray D, Brown D, Cairns W, Trump R, Smith PW, Bertheleme N, D'Alessandro P, Gul S, Vimal M, Smith DN, Watson SP

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 01; Vol. 20 (7), pp. 2340-3. Date of Electronic Publication: 2010 Feb 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Glucocorticoid/*antagonists & inhibitors , Receptors, Glucocorticoid/*metabolism , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology, Animals ; Rats ; Small Molecule Libraries/metabolism ; Structure-Activity Relationship

المؤلفون: Dunne A; Screening and Compound Profiling Department, GlaxoSmithKline, Harlow, Essex, UK., Jowett M, Rees S

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2009; Vol. 565, pp. 239-57.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Print ISSN: 1064-3745 (Print) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Evaluation, Preclinical/*methods, Cells, Cultured ; Electrophysiology/methods ; Humans ; Leukocytes, Mononuclear/metabolism ; Luminescent Measurements ; Models, Theoretical

المؤلفون: Graczyk PP; Eisai London Research Laboratories, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK. piotr_graczyk@eisai.net, Khan A, Bhatia GS, Palmer V, Medland D, Numata H, Oinuma H, Catchick J, Dunne A, Ellis M, Smales C, Whitfield J, Neame SJ, Shah B, Wilton D, Morgan L, Patel T, Chung R, Desmond H, Staddon JM, Sato N, Inoue A

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Nov 01; Vol. 15 (21), pp. 4666-70.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Mitogen-Activated Protein Kinase 10/*antagonists & inhibitors , Protein Kinase Inhibitors/*chemical synthesis, Animals ; Cell Death/drug effects ; Cerebellum/cytology ; Imidazoles ; Neurons/cytology ; Neurons/drug effects ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/pharmacology ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-jun/metabolism ; Rats ; Stereoisomerism ; Structure-Activity Relationship ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors