المؤلفون: Jun S; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Angueira AR; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Fein EC; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tan JME; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Weller AH; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Cheng L; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Batmanov K; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ishibashi J; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sakers AP; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Stine RR; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Seale P; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sealep@pennmedicine.upenn.edu.

المصدر: Developmental cell [Dev Cell] 2023 Nov 06; Vol. 58 (21), pp. 2195-2205.e5. Date of Electronic Publication: 2023 Aug 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes, Brown*/metabolism , Dipeptidyl Peptidase 4*/metabolism, Animals ; Mice ; Adipogenesis ; Adipose Tissue, Brown/metabolism ; Obesity/metabolism ; Thermogenesis/genetics

المؤلفون: Klarin D; Veterans Affairs (VA) Palo Alto Healthcare System, Palo Alto, CA, USA. dklarin@stanford.edu.; Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA. dklarin@stanford.edu., Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Sendamarai AK; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Angueira AR; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Shen YH; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Pirruccello JP; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Karnam PR; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Li Y; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA., Wang M; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Aragam KG; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Paruchuri K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zuber V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK., Shakt GE; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tsao NL; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Judy RL; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Vy HMT; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Verma SS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rader DJ; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Do R; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bavaria JE; Division of Cardiovascular Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nadkarni GN; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Burgess S; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Guo DC; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA., LeMaire SA; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, USA.; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA., Milewicz DM; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsao PS; Veterans Affairs (VA) Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford, CA, USA., Pyarajan S; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. scott.damrauer@pennmedicine.upenn.edu.

مؤلفون مشاركون: VA Million Veteran Program

المصدر: Nature genetics [Nat Genet] 2023 Jul; Vol. 55 (7), pp. 1106-1115. Date of Electronic Publication: 2023 Jun 12.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Veterans* , Aortic Aneurysm, Thoracic*/genetics , Aortic Dissection*/genetics, Humans ; Genome-Wide Association Study ; Pedigree

المؤلفون: Rahbani JF; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Scholtes C; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Lagarde DM; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Hussain MF; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Roesler A; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Dykstra CB; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Bunk J; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Samborska B; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., O'Brien SL; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK., Tripp E; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK., Pacis A; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Angueira AR; Institute for Diabetes, Obesity & Metabolism and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Johansen OS; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Cinkornpumin J; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Hossain I; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Lynes MD; Maine Medical Center Research Institute, Scarborough, ME, USA., Zhang Y; Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., White AP; Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Pastor WA; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Chondronikola M; Department of Nutrition and Radiology, University of California, Davis, Davis, CA, USA.; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Sidossis L; Department of Kinesiology and Health, School of Arts and Sciences, Rutgers University, New Brunswick, NJ, USA., Klein S; Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO, USA., Kralli A; Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cypess AM; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Pedersen SB; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Aarhus N, Denmark., Jessen N; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Tseng YH; Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Seale P; Institute for Diabetes, Obesity & Metabolism and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Calebiro D; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK., Giguère V; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Kazak L; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. lawrence.kazak@mcgill.ca.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada. lawrence.kazak@mcgill.ca.

المصدر: Nature metabolism [Nat Metab] 2022 Nov; Vol. 4 (11), pp. 1459-1473. Date of Electronic Publication: 2022 Nov 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

مواضيع طبية MeSH: Creatine*/metabolism , Thermogenesis*/genetics, Adipocytes/metabolism ; Energy Metabolism/genetics ; Creatine Kinase/metabolism

المؤلفون: Angueira AR; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Sakers AP; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Holman CD; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Cheng L; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Arbocco MN; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Shamsi F; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Lynes MD; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Shrestha R; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Renal Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Okada C; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Batmanov K; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Susztak K; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Renal Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Tseng YH; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Liaw L; Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA., Seale P; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. sealep@pennmedicine.upenn.edu.; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. sealep@pennmedicine.upenn.edu.

المصدر: Nature metabolism [Nat Metab] 2021 Apr; Vol. 3 (4), pp. 469-484. Date of Electronic Publication: 2021 Apr 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes, Brown/*physiology , Adipose Tissue, Brown/*physiology , Cell Lineage/*physiology , Thermogenesis/*physiology, Adipocytes, White/physiology ; Adipogenesis/physiology ; Adipose Tissue, Brown/growth & development ; Animals ; Animals, Newborn ; Aorta/cytology ; Aorta/physiology ; Blood Vessels/physiology ; Cell Lineage/genetics ; Fibroblasts/physiology ; Gene Expression Regulation/physiology ; Humans ; Infant, Newborn ; Mice ; Mice, Inbred C57BL ; Myocytes, Smooth Muscle/physiology ; Stem Cells/physiology ; Thermogenesis/genetics

المؤلفون: Angueira AR; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Shapira SN; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Ishibashi J; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Sampat S; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Sostre-Colón J; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Emmett MJ; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Titchenell PM; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lazar MA; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lim HW; Department of Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, USA., Seale P; Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: sealep@pennmedicine.upenn.edu.

المصدر: Cell reports [Cell Rep] 2020 Mar 03; Vol. 30 (9), pp. 2869-2878.e4.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes, Brown/*metabolism , Basic Helix-Loop-Helix Transcription Factors/*metabolism , Thermogenesis/*genetics, Adipose Tissue, Brown/metabolism ; Animals ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cold Temperature ; Diet, High-Fat ; Gene Expression Regulation ; Mice ; NIH 3T3 Cells ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Receptors, Estrogen ; Transcription, Genetic ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism ; ERRalpha Estrogen-Related Receptor

المؤلفون: Ludvik AE; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Pusec CM; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Priyadarshini M; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Angueira AR; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Guo C; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Lo A; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Hershenhouse KS; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Yang GY; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Ding X; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Reddy TE; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Lowe WL Jr; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612., Layden BT; Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612.

المصدر: Endocrinology [Endocrinology] 2016 Sep; Vol. 157 (9), pp. 3452-61. Date of Electronic Publication: 2016 Jul 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Glucose/*metabolism , Hexokinase/*metabolism , Pregnancy, Animal/*metabolism, Animals ; Energy Metabolism ; Female ; Glucose Tolerance Test ; Homeostasis ; Humans ; Male ; Mice, Transgenic ; Pregnancy

المؤلفون: Villa SR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Priyadarshini M; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Fuller MH; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bhardwaj T; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brodsky MR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Angueira AR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mosser RE; Vanderbilt University, Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Nashville, TN, USA., Carboneau BA; Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN, USA., Tersey SA; Department of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Mancebo H; Multispan Inc., Hayward, CA, USA., Gilchrist A; Midwestern University Department of Pharmaceutical Sciences, Downers Grove, IL, USA., Mirmira RG; Department of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, IN, USA., Gannon M; Vanderbilt University, Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Nashville, TN, USA.; Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN, USA.; Tennessee Valley Health Authority, Department of Veterans Affairs, Nashville, TN, USA., Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.

المصدر: Scientific reports [Sci Rep] 2016 Jun 21; Vol. 6, pp. 28159. Date of Electronic Publication: 2016 Jun 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*metabolism , Insulin-Secreting Cells/*metabolism , Pancreas/*pathology , Receptors, Cell Surface/*metabolism, Animals ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Fatty Acids, Nonesterified/metabolism ; Fatty Acids, Volatile/metabolism ; Humans ; Insulin Resistance ; Insulin-Secreting Cells/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Cell Surface/genetics ; Signal Transduction

المؤلفون: Fuller M; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Priyadarshini M; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Gibbons SM; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, Illinois; Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, Illinois;, Angueira AR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Brodsky M; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Hayes MG; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Kovatcheva-Datchary P; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden;, Bäckhed F; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden;, Gilbert JA; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, Illinois; Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, Illinois; Department of Ecology and Evolution, University of Chicago, Chicago, Illinois; Marine Biological Laboratory, Woods Hole, Massachusetts; College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China; Department of Surgery, University of Chicago, Chicago, Illinois; and., Lowe WL Jr; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;, Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois b-layden@northwestern.edu.

المصدر: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2015 Nov 15; Vol. 309 (10), pp. E840-51. Date of Electronic Publication: 2015 Sep 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Microbiome*, Diabetes, Gestational/*metabolism , Fatty Acids, Volatile/*metabolism , Insulin/*metabolism , Insulin-Secreting Cells/*metabolism , Receptors, Cell Surface/*metabolism, Actinobacteria/classification ; Actinobacteria/growth & development ; Actinobacteria/isolation & purification ; Actinobacteria/metabolism ; Animals ; Bacteroidetes/classification ; Bacteroidetes/growth & development ; Bacteroidetes/isolation & purification ; Bacteroidetes/metabolism ; Cecum/metabolism ; Cecum/microbiology ; Diabetes, Gestational/blood ; Diabetes, Gestational/microbiology ; Fatty Acids, Volatile/blood ; Female ; Fermentation ; Gastrointestinal Contents/chemistry ; Gastrointestinal Contents/microbiology ; Insulin/blood ; Insulin Secretion ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Typing ; Pregnancy ; Pregnancy Maintenance ; Principal Component Analysis ; Receptors, Cell Surface/agonists ; Receptors, Cell Surface/genetics ; Tenericutes/classification ; Tenericutes/growth & development ; Tenericutes/isolation & purification ; Tenericutes/metabolism ; Tissue Culture Techniques

المؤلفون: Angueira AR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL., Ludvik AE; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL., Reddy TE; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC Institute of Genome Science and Policy, Duke University, Durham, NC., Wicksteed B; Kovler Diabetes Center, The University of Chicago, Chicago, IL., Lowe WL Jr; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL., Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Jesse Brown Veterans Affairs Medical Center, Chicago, IL b-layden@northwestern.edu.

المصدر: Diabetes [Diabetes] 2015 Feb; Vol. 64 (2), pp. 327-34.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes, Gestational/*metabolism , Glucose/*metabolism, Blood Glucose ; Female ; Gene Expression Regulation ; Genetic Markers ; Genome-Wide Association Study ; Genomics ; Gluconeogenesis ; Humans ; Insulin Resistance ; Insulin-Secreting Cells/physiology ; Polymorphism, Genetic ; Pregnancy

المؤلفون: Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3008, USA. b-layden@northwestern.edu, Angueira AR, Brodsky M, Durai V, Lowe WL Jr

المصدر: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2013 Mar; Vol. 161 (3), pp. 131-40. Date of Electronic Publication: 2012 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE

مواضيع طبية MeSH: Fatty Acids, Volatile/*metabolism , Receptors, Cell Surface/*metabolism , Receptors, G-Protein-Coupled/*metabolism, Animals ; Cholesterol/metabolism ; Digestive System/metabolism ; Digestive System/microbiology ; Fatty Acids, Volatile/chemistry ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Lipid Metabolism ; Obesity/metabolism ; Signal Transduction ; Translational Research, Biomedical