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المؤلفون: Craig A. Beam, Lorraine Yeo, Mark Peakman, Martin Eichmann, Alyssa Woodwyk, Garry Dolton, Alka Saxena, Rossella Melchiotti, Sanjana Sood, Irma Pujol-Autonell, Andrew K. Sewell, Ania Skowera, Efthymios Fidanis, Katie Tungatt, Anna Lorenc, Susanne Heck
المصدر: Journal of Clinical Investigation
Yeo, L, Woodwyk, A, Sood, S, Lorenc, A, Eichmann, M, Pujol-Autonell, I, Melchiotti, R, Skowera, A, Fidanis, E, Dolton, G M, Tungatt, K, Sewell, A K, Heck, S, Saxena, A, Beam, C A & Peakman, M 2018, ' Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes ', Journal of Clinical Investigation, vol. 128, no. 8, pp. 3460-3474 . https://doi.org/10.1172/JCI120555مصطلحات موضوعية: 0301 basic medicine, Adult, Male, T cell, Islets of Langerhans Transplantation, CD8-Positive T-Lymphocytes, medicine.disease_cause, Autoimmunity, Islets of Langerhans, 03 medical and health sciences, 0302 clinical medicine, Memory, Insulin-Secreting Cells, medicine, Cytotoxic T cell, Humans, Child, Effector, Chemistry, Pancreatic islets, CD28, Cell Differentiation, General Medicine, Cell biology, Granzyme B, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Female, Immunologic Memory, CD8, Research Article, 030215 immunology
وصف الملف: application/pdf
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المؤلفون: James E. McLaren, Kristin Ladell, Emma Gostick, Robin R. Knight, Ania Skowera, David Price, Katherine K. Matthews, Martin Eichmann, Andrew K. Sewell, Deborah Kronenberg-Versteeg, Garry Dolton, Colin M. Dayan, Polly J. Bingley, Mark Peakman, Susanne Heck, Jake Powrie, John J. Miles
المصدر: Diabetes. 64:916-925
مصطلحات موضوعية: Adult, Male, Endocrinology, Diabetes and Metabolism, Cellular differentiation, Human leukocyte antigen, CD8-Positive T-Lymphocytes, Biology, Autoantigens, Article, Flow cytometry, Insulin-Secreting Cells, Diabetes mellitus, Internal Medicine, medicine, Humans, Cytotoxic T cell, Receptor-Like Protein Tyrosine Phosphatases, Class 8, Type 1 diabetes, medicine.diagnostic_test, Glutamate Decarboxylase, T-cell receptor, Cell Differentiation, Flow Cytometry, medicine.disease, Phenotype, Diabetes Mellitus, Type 1, QR180, Immunology, Female, RC
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dea629812a2376ea48ed423fab9e41
https://doi.org/10.2337/db14-0332 -
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المؤلفون: Eddie A, James, Joana R F, Abreu, John W, McGinty, Jared M, Odegard, Yvonne E, Fillié, Claire N, Hocter, Slobodan, Culina, Kristin, Ladell, David A, Price, Aimon, Alkanani, Marynette, Rihanek, Lisa, Fitzgerald-Miller, Ania, Skowera, Cate, Speake, Peter, Gottlieb, Howard W, Davidson, F Susan, Wong, Bart, Roep, Roberto, Mallone
المصدر: Diabetologia. 61(3)
مصطلحات موضوعية: Adult, Male, Young Adult, Diabetes Mellitus, Type 1, Insulin-Secreting Cells, HLA-A2 Antigen, Humans, Insulin, Female, CD8-Positive T-Lymphocytes, Biomarkers
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المؤلفون: Helen E. Thomas, Andrew M. Lew, Ania Skowera, Kate L. Graham, Hyun Ja Ko, Robyn M. Sutherland, Jonathan Chee, Tara Catterall, Thomas W.H. Kay, Balasubramanian Krishnamurthy, Mark Peakman, Gaurang Jhala
المصدر: The Journal of Immunology. 192:572-580
مصطلحات موضوعية: Pathology, medicine.medical_specialty, ZAP70, Immunology, Biology, medicine.disease, Natural killer T cell, Interleukin 21, medicine, Immunology and Allergy, Cytotoxic T cell, IL-2 receptor, Insulitis, Interleukin 3, NOD mice
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a1f63ae240869c6543facb6dc383a33d
https://doi.org/10.4049/jimmunol.1302100 -
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المؤلفون: Mathew Clement, James A. Pearson, Stephanie Gras, Hugo A. van den Berg, Anya Lissina, Sian Llewellyn-Lacey, Mark D. Willis, Tamsin Dockree, James E. McLaren, Julia Ekeruche-Makinde, Emma Gostick, Neil P. Robertson, Jamie Rossjohn, Scott R. Burrows, David A. Price, F. Susan Wong, Mark Peakman, Ania Skowera, Linda Wooldridge
المصدر: Clement, M, Pearson, J A, Gras, S, van den Berg, H A, Lissina, A, Llewellyn-Lacey, S, Willis, M D, Dockree, T, McLaren, J E, Ekeruche-Makinde, J, Gostick, E, Robertson, N P, Rossjohn, J, Burrows, S R, Price, D A, Wong, F S, Peakman, M, Skowera, A & Wooldridge, L 2016, ' Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies ', Scientific Reports, vol. 6, 35332 . https://doi.org/10.1038/srep35332
Clement, M, Pearson, J, Gras, S, van den Berg, H A, Lissina, A, Llewellyn-Lacey, S, Willis, M, Dockree, T, McLaren, J E, Ekeruche-Makinde, J, Gostick, E, Robertson, N P, Rossjohn, J, Burrows, S R, Price, D A, Wong, S, Peakman, M, Skowera, A & Wooldridge, L 2016, ' Targeted suppression of autoreactive CD8 + T-cell activation using blocking anti-CD8 antibodies ', Scientific Reports, vol. 6, 35332 . https://doi.org/10.1038/srep35332مصطلحات موضوعية: STRUCTURAL BASIS, Science & Technology, type 1 diabetes, CORECEPTOR FUNCTION, RECEPTOR RECOGNITION, Autoimmunity, MULTIPLE-SCLEROSIS, KILL BETA-CELLS, CD8 T-cells, Multidisciplinary Sciences, MHC CLASS-I, LONG-TERM REMISSION, novel therapy, CROSS-REACTIVITY, Science & Technology - Other Topics, COMPLEX CLASS-I, CD8+T CELLS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af32db4092e819f68f7f11ca97ae1d32
https://kclpure.kcl.ac.uk/ws/files/58649953/Targeted_suppression_of_CLEMENT_Accepted_9September2016_GOLD_VoR_CCBY.pdf -
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المؤلفون: Timothy Tree, Anthony E. Ting, Amy Raber, Robin R. Knight, Jef Pinxteren, James L. Reading, Robert J. Deans, Jennie H M Yang, Ania Skowera, Bart Vaes, Timothy E Allsopp, Sarah A. Busch, Shereen Sabbah
المصدر: The Journal of Immunology. 190:4542-4552
مصطلحات موضوعية: Adult, Graft Rejection, Male, medicine.medical_treatment, T cell, Immunology, Islets of Langerhans Transplantation, Autoimmunity, Biology, Lymphocyte Activation, medicine.disease_cause, T-Lymphocytes, Regulatory, Immunomodulation, Cell therapy, Young Adult, Immune system, medicine, Humans, Immunology and Allergy, Progenitor cell, Cells, Cultured, Cell Proliferation, Stem Cells, Mesenchymal stem cell, Tryptophan, Immunotherapy, Th1 Cells, Interleukin-10, Transplantation, Adult Stem Cells, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Th17 Cells
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43d5c06c825102bc4d8fdb1462ec21
https://doi.org/10.4049/jimmunol.1202710 -
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المؤلفون: Andrea J. A. Schauenburg, David Price, David K. Cole, John J. Miles, Johanne M. Pentier, Andrew Trimby, Julia Ekeruche-Makinde, Hugo A. van den Berg, Ania Skowera, Mai Ping Tan, Jamie Rossjohn, Garry Dolton, Anna Marta Bulek, Tamsin Williams, Andrew K. Sewell, Kim M. Miles, Sian Llewellyn-Lacey, Mick Bailey, Linda Wooldridge, Mathew Clement, Pierre J. Rizkallah, Scott R. Burrows, Mark Peakman
المصدر: Blood. 121:1112-1123
مصطلحات موضوعية: Models, Molecular, Receptors, Antigen, T-Cell, alpha-beta, T cell, Immunology, Antigen presentation, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, Biology, Biochemistry, Immune system, Peptide Library, MHC class I, medicine, Humans, Amino Acid Sequence, Antigens, Peptide library, Peptide sequence, Immunobiology, Antigen Presentation, Immunity, Cellular, Histocompatibility Antigens Class I, T-cell receptor, food and beverages, Cell Biology, Hematology, Peptide Fragments, Clone Cells, Cell biology, medicine.anatomical_structure, biology.protein, Oligopeptides, CD8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d0f45966e93cb14ef7416cdd998570
https://doi.org/10.1182/blood-2012-06-437202 -
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المؤلفون: Ania Skowera, Linda Wooldridge, Min Zhao, Robin R. Knight, Mark Peakman, Martin Eichmann, David K. Cole, Deborah Kronenberg, Andrew K. Sewell, Anna Marta Bulek, Guo Cai Huang
المصدر: Diabetes
مصطلحات موضوعية: Cytotoxicity, Immunologic, Preproinsulin, Fas Ligand Protein, Endocrinology, Diabetes and Metabolism, T cell, Receptors, Antigen, T-Cell, CD8-Positive T-Lymphocytes, Biology, Cell Degranulation, Epitope, Cell Line, Antigen, Insulin-Secreting Cells, Internal Medicine, medicine, Humans, Insulin, Cytotoxic T cell, fas Receptor, Protein Precursors, Tumor Necrosis Factor-alpha, Degranulation, Molecular biology, Cell biology, Cell killing, medicine.anatomical_structure, Immunology and Transplantation, CD8
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المؤلفون: David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell
المصدر: Cole, D K, Bulek, A M, Dolton, G, Schauenberg, A J, Szomolay, B, Rittase, W, Trimby, A, Jothikumar, P, Fuller, A, Skowera, A, Rossjohn, J, Zhu, C, Miles, J J, Peakman, M, Wooldridge, L, Rizkallah, P J & Sewell, A K 2016, ' Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity ', Journal of Clinical Investigation, vol. 126, no. 6, pp. 2191-2204 . https://doi.org/10.1172/JCI85679
Cole, D K, Bulek, A M, Dolton, G, Schauenberg, A J, Szomolay, B, Rittase, W, Trimby, A, Jothikumar, P, Fuller, A, Skowera, A, Rossjohn, J, Zhu, C, Miles, J J, Peakman, M, Wooldridge, L, Rizkallah, P J & Sewell, A K 2016, ' Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity ', The Journal of clinical investigation, vol. 126, no. 6, pp. 2191-2204 . https://doi.org/10.1172/JCI85679مصطلحات موضوعية: Models, Molecular, HLA-A Antigens, T-Lymphocytes, Receptors, Antigen, T-Cell, Autoimmunity, General Medicine, Cross Reactions, Ligands, Clone Cells, Kinetics, QR180, Humans, Insulin, Amino Acid Sequence, Protein Precursors, Corrigendum, Oligopeptides, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Mathew, Clement, James A, Pearson, Stephanie, Gras, Hugo A, van den Berg, Anya, Lissina, Sian, Llewellyn-Lacey, Mark D, Willis, Tamsin, Dockree, James E, McLaren, Julia, Ekeruche-Makinde, Emma, Gostick, Neil P, Robertson, Jamie, Rossjohn, Scott R, Burrows, David A, Price, F Susan, Wong, Mark, Peakman, Ania, Skowera, Linda, Wooldridge
المصدر: Scientific Reports
مصطلحات موضوعية: Immunosuppression Therapy, CD8 Antigens, Histocompatibility Antigens Class I, Receptors, Antigen, T-Cell, Mice, Transgenic, CD8-Positive T-Lymphocytes, Ligands, Lymphocyte Activation, Antibodies, Article, Autoimmune Diseases, Cell Line, Epitopes, Islets of Langerhans, Mice, Mice, Inbred NOD, Animals, Humans, Peptides
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