المؤلفون: Högnäsbacka, Antonia, Poot, Alex J., Kooijman, Esther, Schuit, Robert C., Schreurs, Maxime, Verlaan, Mariska, van den Hoek, Johan, Heideman, Daniëlle A. M., Beaino, Wissam, van Dongen, Guus A. M. S., Vugts, Danielle J., Windhorst, Albert D.

المساهمون: Radiology and nuclear medicine, Pathology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Amsterdam Neuroscience - Brain Imaging, CCA - Cancer Treatment and quality of life, AII - Cancer immunology, AII - Inflammatory diseases

المصدر: Nuclear Medicine and Biology, 120-121. ELSEVIER SCIENCE INC
Nuclear Medicine and Biology, 120-121:108349. Elsevier Inc.
Högnäsbacka, A, Poot, A J, Kooijman, E, Schuit, R C, Schreurs, M, Verlaan, M, van den Hoek, J, Heideman, D A M, Beaino, W, van Dongen, G A M S, Vugts, D J & Windhorst, A D 2023, ' Synthesis and preclinical evaluation of two osimertinib isotopologues labeled with carbon-11 as PET tracers targeting the tyrosine kinase domain of the epidermal growth factor receptor ', Nuclear Medicine and Biology, vol. 120-121, 108349 . https://doi.org/10.1016/j.nucmedbio.2023.108349

مصطلحات موضوعية: Cancer Research, Carcinoma, Non-Small-Cell Lung/drug therapy, ErbB Receptors/genetics, Carcinoma, Drug Resistance, Non-Small-Cell Lung/drug therapy, Aniline Compounds/pharmacology, Lung Neoplasms/diagnostic imaging, Mice, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Mutation, Neoplasm, Humans, Animals, Molecular Medicine, Female, Tissue Distribution, Radiology, Nuclear Medicine and imaging

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec76b24f89bab52cdcf62473e53dfe0
https://doi.org/10.1016/j.nucmedbio.2023.108349

المؤلفون: Walsh, Louise, Haley, Kathryn E, Moran, Bruce, Mooney, Brian, Tarrant, Finbarr, Madden, Stephen F, Di Grande, Alessandra, Fan, Yue, Das, Sudipto, Rueda, Oscar M, Dowling, Catríona M, Varešlija, Damir, Chin, Suet-Feung, Linn, Sabine, Young, Leonie S, Jirström, Karin, Crown, John P, Bernards, Rene, Caldas, Carlos, Gallagher, William M, O'Connor, Darran P, Ní Chonghaile, Tríona

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 25(23):7139-7150

مصطلحات موضوعية: Aniline Compounds/pharmacology, Antineoplastic Agents/pharmacology, Apoptosis, Azepines/pharmacology, Breast Neoplasms/drug therapy, Carcinoma, Lobular/drug therapy, Cell Cycle, Cell Proliferation, Cohort Studies, Female, Gene Expression Regulation, Neoplastic/drug effects, Humans, Neoplasm Invasiveness, Prognosis, Receptor, ErbB-2/metabolism, Receptors, Estrogen/metabolism, Progesterone/metabolism, Sulfonamides/pharmacology, Survival Rate, Transcription Factors/antagonists & inhibitors, Triazoles/pharmacology, Tumor Cells, Cultured, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology

URL الوصول: https://lup.lub.lu.se/record/b0e5bdc3-31cb-470a-a292-b94d7bcd9fc8
http://dx.doi.org/10.1158/1078-0432.CCR-19-0713

المؤلفون: J. M. Vicencio, R. Evans, R. Green, Z. An, J. Deng, C. Treacy, R. Mustapha, J. Monypenny, C. Costoya, K. Lawler, K. Ng, K. De-Souza, O. Coban, V. Gomez, J. Clancy, S. H. Chen, A. Chalk, F. Wong, P. Gordon, C. Savage, C. Gomes, T. Pan, G. Alfano, L. Dolcetti, J. N. E. Chan, F. Flores-Borja, P. R. Barber, G. Weitsman, D. Sosnowska, E. Capone, S. Iacobelli, D. Hochhauser, J. A. Hartley, M. Parsons, J. N. Arnold, S. Ameer-Beg, S. A. Quezada, Y. Yarden, G. Sala, T. Ng

المصدر: Vicencio Bustamante, J, Evans, R, Green, R, An, Z, Deng, J, Treacy, C, Mustapha, R, Monypenny of Pitmilly, J, Costoya, C, Lawler, K, Ng, K, Desouza, K, Coban, O, Gomez, V, Clancy, J, Chen, SH, Chalk, A, Wong, F, Gordon, P, Savage, C, Gomes, C, Pan, T, Alfano, G, Dolcetti, L, Chan, J N E, Florez-Borja, F, Barber, P, Weitsman, G, Sosnowska, D, Capone, E, Iacobelli, S, Hochhauser, D, Hartley, J, Parsons, M, Arnold, J, Ameer-Beg, S, Quezada, S A, Yarden, Y, Sala, G & Ng, T 2022, ' Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans ', Cell Death & Disease, vol. 13, no. 3, 274 . https://doi.org/10.1038/s41419-022-04701-3

مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung/drug therapy, ErbB Receptors/genetics, Immunology, Aniline Compounds/pharmacology, Protein Serine-Threonine Kinases, Cellular and Molecular Neuroscience, Mice, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Endoribonucleases, Animals, Humans, Lung Neoplasms/drug therapy, Protein Kinase Inhibitors, Acrylamides, Aniline Compounds, Antibodies, Monoclonal, Cell Biology, Nucleotidyltransferases, Antibodies, Monoclonal/pharmacology, ErbB Receptors, Neoplasm Recurrence, Local/drug therapy, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Mutation, Neoplasm Recurrence, Local

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38cc7d5dda59f56e6153cd5799bf0cb
https://kclpure.kcl.ac.uk/ws/files/171263143/s41419_022_04701_3.pdf

المؤلفون: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

المصدر: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373

مصطلحات موضوعية: Cancer Research, Breast Neoplasms, Aniline Compounds/pharmacology, Kaplan-Meier Estimate, bosutinib, Protein Serine-Threonine Kinases, Breast Neoplasms/enzymology, Cell Proliferation/drug effects, Gene Knockout Techniques, Breast cancer, Cell Line, Tumor, Signal Transduction/drug effects, Nitriles, Animals, Humans, Integrin-linked kinase, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Quinolines/pharmacology, Aniline Compounds, Gene Expression Profiling, Xenograft Model Antitumor Assays, synthetic lethality, Gene Expression Regulation, Neoplastic, src-Family Kinases, src-Family Kinases/antagonists & inhibitors, Xenograft Model Antitumor Assays/methods, Oncology, Protein Kinase Inhibitors/pharmacology, Nitriles/pharmacology, Quinolines, MCF-7 Cells, Female, Protein Serine-Threonine Kinases/genetics, Gene Expression Profiling/methods, Signal Transduction, SRC

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf

المؤلفون: Patrícia M. A. Silva, Ana C. Henriques, Bruno Sarmento, Hassan Bousbaa

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Molecular biology, Antineoplastic Agents / pharmacology, Apoptosis, Cell Cycle Proteins, chemistry.chemical_compound, Cancer, Mad2 Proteins / metabolism, Sulfonamides, Multidisciplinary, Navitoclax, Aniline Compounds, Cell Death, Nuclear Proteins / metabolism, Paclitaxel / pharmacology, Nuclear Proteins, siRNAs, Spindle checkpoint, Oncology, Cell Death / drug effects, Mad2 Proteins, Medicine, Spindle Apparatus / drug effects, Programmed cell death, Cell biology, Paclitaxel, Science, Mitosis, Cell Cycle Proteins / metabolism, Antineoplastic Agents, Spindle Apparatus, Apoptosis / drug effects, Article, Target validation, Aniline Compounds / pharmacology, Cell Line, Tumor, Mitosis / drug effects, Gene silencing, Humans, Sulfonamides / pharmacology, Adaptor Proteins, Signal Transducing, Cell Cycle Checkpoints, chemistry, Mitotic exit, A549 Cells, Spindle Apparatus / metabolism, Cancer cell, Cancer research, Adaptor Proteins, Signal Transducing / drug effects, Cell Cycle Checkpoints / drug effects

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65669c7d34d09c189b5e66595f1fe50
https://pubmed.ncbi.nlm.nih.gov/33603057

المؤلفون: Jun-Ichi Abe, Delvac Oceandy, Sukhpal Prehar, Arthur H. Weston, Min Zi, Xin Wang, Wei Liu, Elizabeth J. Cartwright, Tomomi E E Kimura, Jiawei Jin, Ludwig Neyses

المصدر: Circulation Research, 106(5), 961-70. United States (2010).

مصطلحات موضوعية: Male, MAPK/ERK pathway, Indoles, Time Factors, Transcription, Genetic, Physiology, Cardiomegaly/enzymology/genetics/pathology/physiopathology/prevention & control, Ventricular Remodeling/drug effects, Aniline Compounds/pharmacology, Apoptosis, Blood Pressure, Mice, Myocytes, Cardiac, Cells, Cultured, Mice, Knockout, Aniline Compounds, Indoles/pharmacology, Ventricular Remodeling, Systèmes cardiovasculaire & respiratoire [D03] [Sciences de la santé humaine], Cell biology, Myogenic Regulatory Factors, Hypertension, RNA Interference, Signal transduction, Cardiology and Cardiovascular Medicine, Hypertension/enzymology/genetics/pathology/physiopathology, Mef2, medicine.medical_specialty, Mitogen-Activated Protein Kinase 7/antagonists & inhibitors/deficiency/genetics, Cardiomegaly, Biology, Transfection, Article, Myogenic Regulatory Factors/genetics/metabolism, Downregulation and upregulation, Internal medicine, medicine, Animals, Gene silencing, Myocytes, Cardiac/drug effects/enzymology/pathology, Kinase activity, Protein kinase A, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 7, Pressure overload, Apoptosis/drug effects, Fibrosis, Rats, Endocrinology, Animals, Newborn, Protein Kinase Inhibitors/pharmacology, Mutation, Cardiovascular & respiratory systems [D03] [Human health sciences]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5476c4ce0d2bf7f78d0759469703b8d3
https://doi.org/10.1161/circresaha.109.209320

المؤلفون: Vandevoorde, S, Jonsson, K-O, Labar, G, Persson, Emma, Lambert, D M, Fowler, C J

المصدر: Br J Pharmacol. 150(2):186-91

مصطلحات موضوعية: Amidohydrolases/*antagonists & inhibitors, Aniline Compounds/*pharmacology, Animals, Arachidonic Acids/*metabolism, Benzoxazines/*pharmacology, Biphenyl Compounds/*pharmacology, Cell Line, Tumor, Cells, Cultured, Cerebellum/metabolism, Cytosol/metabolism, Glycerides/*metabolism, Humans, Hydrolysis, Male, Membranes/metabolism, Mice, Monoacylglycerol Lipases/*antagonists & inhibitors, Polyunsaturated Alkamides/*metabolism, Rats, Wistar, Recombinant Proteins/antagonists & inhibitors

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-5989
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17143303&dopt=Citation

المؤلفون: Elisabeth Christiansen, Robert Wagner, Felicia Gerst, Maria E Due-Hansen, Hans-Ulrich Häring, Fausto Machicao, Gabriele Kaiser, Susanne Ullrich, Manuel Grundmann, Andreas Fritsche, Evi Kostenis, Trond Ulven, Andreas Peter

المصدر: Diabetes
Wagner, R, Kaiser, G, Gerst, F, Christiansen, E, Due-Hansen, M E, Grundmann, M, Machicao, F, Peter, A, Kostenis, E, Ulven, T, Fritsche, A, Häring, H-U & Ullrich, S 2013, ' Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans ', Diabetes, vol. 62, no. 6, pp. 2106-2111 . https://doi.org/10.2337/db12-1249
Diabetes 62, 2106-2111 (2013)

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Diabetes risk, Insulin/metabolism, Genotype, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Palmitates, Aniline Compounds/pharmacology, Phenylpropionates/pharmacology, Fatty Acids, Nonesterified, In Vitro Techniques, Pathophysiology, Cell Line, Receptors, G-Protein-Coupled, Islets of Langerhans, Mice, NEFA, Insulin-Secreting Cells/cytology, Receptors, G-Protein-Coupled/agonists, Free fatty acid receptor 1, Internal medicine, Insulin receptor substrate, Insulin-Secreting Cells, Insulin Secretion, Internal Medicine, medicine, Glucose homeostasis, Animals, Humans, Insulin, Cells, Cultured, Original Research, Aniline Compounds, biology, Phenylpropionates, Islets of Langerhans/drug effects, Fatty Acids, Nonesterified/blood, Insulin receptor, Endocrinology, biology.protein, Palmitates/pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbf6a919c1337a60dddec2f74dd010b
https://pubmed.ncbi.nlm.nih.gov/23378609

المؤلفون: Vandevoorde, Séverine, Jonsson, Kent-Olov, Labar, Geoffray, Persson, Emma, Lambert, Didier, Fowler, Christopher J.

المساهمون: UCL - MD/FARM - Ecole de pharmacie

المصدر: British Journal of Pharmacology, Vol. 150, no. 2, p. 186-91 (2007)

مصطلحات موضوعية: Male, Amidohydrolases - antagonists & inhibitors, Membranes - metabolism, Polyunsaturated Alkamides, Arachidonic Acids, In Vitro Techniques, Glycerides - metabolism, Amidohydrolases, Glycerides, Mice, Cytosol, Polyunsaturated Alkamides - metabolism, Cell Line, Tumor, Cerebellum, Aniline Compounds - pharmacology, Arachidonic Acids - metabolism, Animals, Humans, Rats, Wistar, Cells, Cultured, Aniline Compounds, Membranes, Biphenyl Compounds - pharmacology, Hydrolysis, Cytosol - metabolism, Biphenyl Compounds, Research Papers, Monoacylglycerol Lipases, Recombinant Proteins, Benzoxazines, Rats, Monoacylglycerol Lipases - antagonists & inhibitors, Cerebellum - metabolism, Recombinant Proteins - antagonists & inhibitors, Benzoxazines - pharmacology, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::930c27b0ae82690f4a572d8d8ef0c072
https://europepmc.org/articles/PMC2042901/

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