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المؤلفون: Stine A. Mikkelsen, Bente Vilsen, Jens Peter Andersen, Rasmus Gantzel, Anna L. Vestergaard, Louise S Mogensen, Robert S. Molday
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Gantzel, R H, Mogensen, L S, Mikkelsen, S A, Vilsen, B, Molday, R S, Vestergaard, A L & Andersen, J P 2017, ' Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates ', Scientific Reports, vol. 7, no. 1, doi: 10.1038/s41598-017-10741-z., pp. 10418 . https://doi.org/10.1038/s41598-017-10741-z
Gantzel, R H, Mogensen, L S, Mikkelsen, S A, Vilsen, B, Molday, R S, Vestergaard, A L & Andersen, J P 2017, ' Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates ', Scientific Reports, vol. 7, 10418 . https://doi.org/10.1038/s41598-017-10741-zمصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Arginine, Protein Conformation, Phospholipid, Gene Expression, lcsh:Medicine, Plasma protein binding, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Protein structure, Phosphatidylcholine, Journal Article, Animals, Genetic Predisposition to Disease, Phospholipid Transfer Proteins, lcsh:Science, Phospholipids, Adenosine Triphosphatases, Multidisciplinary, Binding Sites, lcsh:R, Flippase, Phosphatidylserine, Lipid Metabolism, Enzyme Activation, Transmembrane domain, 030104 developmental biology, chemistry, Mutation, Biophysics, Cattle, lcsh:Q, Protein Binding
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المؤلفون: Louise S Mogensen, Robert S. Molday, Stine A. Mikkelsen, Jens Peter Andersen, Bente Vilsen, Anna L. Vestergaard
المصدر: Mikkelsen, S A, Mogensen, L S, Vilsen, B, Molday, R S, Vestergaard, A L & Andersen, J P 2019, ' Asparagine-905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation ', Journal of Biological Chemistry, vol. 294, no. 15, pp. 5970-5979 . https://doi.org/10.1074/jbc.RA118.007240
مصطلحات موضوعية: 0301 basic medicine, MECHANISM, ATPase, P4-ATPase, CA2+-ATPASE, Biochemistry, chemistry.chemical_compound, CA2+, lipid-protein interaction, CRYSTAL-STRUCTURE, Phospholipid Transfer Proteins, Phosphorylation, Adenosine Triphosphatases, lipid transport, biology, Transmembrane protein, CAMRQ syndrome, Transmembrane domain, membrane lipid, phosphatidylserine transport, transporter, Asparagine, mutagenesis, lipid binding protein, membrane transport, Mutation, Missense, Phospholipid, Dephosphorylation, 03 medical and health sciences, Membrane Biology, Animals, Humans, enzyme mechanism, mutant, Molecular Biology, Lipid Transport, 030102 biochemistry & molecular biology, molecular modeling, Cell Biology, Flippase, Membrane transport, ACIDS, GENE, TRANSPORT, HEK293 Cells, 030104 developmental biology, Amino Acid Substitution, chemistry, Mutagenesis, Site-Directed, biology.protein, Biophysics, RESIDUES, Cattle, membrane enzyme
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c435946ec05d3e30aa5c69e80cb34
https://pure.au.dk/portal/da/publications/asparagine905-of-the-mammalian-phospholipid-flippase-atp8a2-is-essential-for-lipid-substrateinduced-activation-of-atp8a2-dephosphorylation(40a2f586-c05f-4f31-ae96-2f6c19a43f41).html -
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المؤلفون: Simranjeet Kaur, Thomas Mandrup-Poulsen, Peter de Hemmer Horskjær, Christine Bruun, Joachim Størling, Flemming Pociot, Tina Fløyel, Anna L. Vestergaard, Romano Regazzi, Claus Heiner Bang-Berthelsen, Lukas Adrian Berchtold, Jonathan Lucien Stahl, Lisa Christen, Farzaneh Taheri Sotudeh, Klaus Stensgaard Frederiksen, Frida Greek Kofod
المصدر: Vestergaard, A L, Bang-Berthelsen, C H, Floyel, T, Stahl, J L, Christen, L, Sotudeh, F T, Horskjaer, P D H, Frederiksen, K S, Kofod, F G, Bruun, C, Berchtold, L A, Storling, J, Regazzi, R, Kaur, S, Pociot, F & Mandrup-Poulsen, T 2018, ' MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage ', PLOS ONE, vol. 13, no. 9, e0203713, pp. 1-22 . https://doi.org/10.1371/journal.pone.0203713
PloS one, vol. 13, no. 9, pp. e0203713
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0203713 (2018)مصطلحات موضوعية: 0301 basic medicine, Male, Physiology, Microarrays, medicine.medical_treatment, lcsh:Medicine, Gene Expression, Apoptosis, Pathology and Laboratory Medicine, Biochemistry, Diabetes mellitus genetics, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Immune Physiology, Insulin-Secreting Cells, Medicine and Health Sciences, lcsh:Science, Immune Response, Regulation of gene expression, Adult, Animals, Cell Line, Cytokines/metabolism, Diabetes Mellitus/genetics, Diabetes Mellitus/metabolism, Female, Gene Expression Regulation, Histone Deacetylase Inhibitors/pharmacology, Humans, Insulin-Secreting Cells/cytology, Insulin-Secreting Cells/physiology, Islets of Langerhans/metabolism, MicroRNAs/physiology, Middle Aged, NF-kappa B/genetics, NF-kappa B/metabolism, Rats, Rats, Wistar, Innate Immune System, Multidisciplinary, Cell Death, Chemistry, NF-kappa B, Transfection, Enzymes, TNF receptor associated factor, Cytokine, Bioassays and Physiological Analysis, Cell Processes, 030220 oncology & carcinogenesis, Cytokines, medicine.symptom, Oxidoreductases, Luciferase, Research Article, Endocrine Disorders, Immunology, Inflammation, Research and Analysis Methods, 03 medical and health sciences, Islets of Langerhans, Signs and Symptoms, Diagnostic Medicine, medicine, Diabetes Mellitus, Genetics, Givinostat, Molecular Biology Techniques, Molecular Biology, lcsh:R, Biology and Life Sciences, Proteins, Cell Biology, Molecular Development, Histone Deacetylase Inhibitors, MicroRNAs, 030104 developmental biology, Immune System, Metabolic Disorders, Cancer research, Enzymology, lcsh:Q, Histone deacetylase, Developmental Biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb30b397012919ce28ea03bcc811726
https://curis.ku.dk/ws/files/210015667/journal.pone.0203713.pdf -
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المؤلفون: Wendy L. van der Woerd, Stan F.J. van de Graaf, Catharina G.K. Wichers, Coen C. Paulusma, Anna L. Vestergaard, Roderick H.J. Houwen, Jens Peter Andersen
المساهمون: Other departments, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Tytgat Institute for Liver and Intestinal Research, Gastroenterology and Hepatology
المصدر: Journal of hepatology, 64(6), 1339-1347. Elsevier
van der Woerd, W L, Wichers, C G K, Vestergaard, A L, Andersen, J P, Paulusma, C C, Houwen, R H J & van de Graaf, S F J 2016, ' Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis ', Journal of Hepatology, vol. 64, no. 6, pp. 1339-47 . https://doi.org/10.1016/j.jhep.2016.02.001
Journal of Hepatology, 64(6), 1339. Elsevierمصطلحات موضوعية: 0301 basic medicine, Protein Folding, medicine.drug_class, Cell, Cystic Fibrosis Transmembrane Conductance Regulator, Cholestasis, Intrahepatic, Biology, Hydroxamic Acids, Cystic fibrosis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Journal Article, medicine, Humans, Missense mutation, Adenosine Triphosphatases, Vorinostat, Misfolding, Hepatology, Histone deacetylase inhibitor, Progressive familial intrahepatic cholestasis, Intrahepatic cholestasis, Cell Polarity, medicine.disease, Phenylbutyrates, Cystic fibrosis transmembrane conductance regulator, Cell biology, Protein Transport, 030104 developmental biology, Proteostasis, medicine.anatomical_structure, Biochemistry, biology.protein, 030211 gastroenterology & hepatology
وصف الملف: image/pdf
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المؤلفون: Mirwais Osmai, Claus Heiner Bang-Berthelsen, Thomas Mandrup-Poulsen, Emil M.H. Pallesen, Flemming Pociot, Yama Osmai, Anna L. Vestergaard, Guy Wayne Novotny
المصدر: Diabetes/Metabolism Research and Reviews. 32:334-349
مصطلحات موضوعية: 0301 basic medicine, Regulation of gene expression, geography, geography.geographical_feature_category, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Biology, Bioinformatics, Islet, Microvesicles, Proinflammatory cytokine, Cell biology, Transcriptome, 03 medical and health sciences, 030104 developmental biology, Endocrinology, microRNA, Internal Medicine, medicine, Function (biology)
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المؤلفون: Jens Peter Andersen, Robert S. Molday, Anna L. Vestergaard, Louise S Mogensen, Stine A. Mikkelsen, Madhavan Chalat
المصدر: Frontiers in Physiology
مصطلحات موضوعية: 0301 basic medicine, flippases, phospholipid transport, Physiology, ATPase, Phospholipid, Review, CDC50, Biology, 03 medical and health sciences, chemistry.chemical_compound, Ion binding, Physiology (medical), P-type ATPases, Lipid bilayer, Phosphatidylethanolamine, Phospholipid transport, Phosphatidylserine, membrane asymmetry, Cell biology, 030104 developmental biology, ATP8A2, chemistry, P4-ATPases, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632010a83b0148a4e13e599c15f8c6cd
https://pubmed.ncbi.nlm.nih.gov/27458383 -
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المؤلفون: Morten Lundh, Claus Heiner Bang-Berthelsen, Jonathan Lucien Stahl, Flemming Pociot, Anna L. Vestergaard, Guy Wayne Novotny, Thomas Mandrup-Poulsen, Emil M.H. Pallesen, Maaike Blankestijn
المصدر: Vestergaard, A L, Blankestijn, M, Stahl, J L, Pallesen, E M H, Bang-Berthelsen, C H, Pociot, F, Novotny, G W, Lundh, M & Mandrup-Poulsen, T 2016, ' A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells ', International Journal of Molecular Sciences (Online), vol. 17, no. 6, 896 . https://doi.org/10.3390/ijms17060896
International Journal of Molecular Sciences, Vol 17, Iss 6, p 896 (2016)
International Journal of Molecular Sciencesمصطلحات موضوعية: 0301 basic medicine, Normalization (statistics), RNA Stability, purification, Microarray, Computational biology, Biology, Real-Time Polymerase Chain Reaction, Catalysis, lcsh:Chemistry, Inorganic Chemistry, Transcriptome, 03 medical and health sciences, Insulin-Secreting Cells, microRNA, Animals, pancreas, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Regulation of gene expression, Genetics, Gene Expression Profiling, Communication, Organic Chemistry, Reproducibility of Results, General Medicine, quantification, Rats, Computer Science Applications, Gene expression profiling, MicroRNAs, qPCR, normalization, 030104 developmental biology, Real-time polymerase chain reaction, Gene Expression Regulation, lcsh:Biology (General), lcsh:QD1-999, method
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f10e1f98eb36e42f90a08b7342bc5ce
https://curis.ku.dk/ws/files/177414481/ijms_17_00896.pdf -
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المؤلفون: Kasper R. Andersen, Just Justesen, Karina Hansen Kjær, Jesper Buchhave Poulsen, Pia M. Martensen, Anna L. Vestergaard
المصدر: Biochimie. 94:1098-1107
مصطلحات موضوعية: chemistry.chemical_classification, Pyrophosphatase, Nuclease, Oligoribonucleotides, Adenine Nucleotides, Phosphoric Diester Hydrolases, RNase P, 2'-5'-Oligoadenylate, Immunoblotting, Endoribonuclease, Computational Biology, RNA, Phosphodiesterase, General Medicine, Biology, Biochemistry, chemistry.chemical_compound, Ribonucleases, Enzyme, chemistry, biology.protein, Humans, Pyrophosphatases
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المؤلفون: Bente Vilsen, Anna L. Vestergaard, Jens Peter Andersen, Robert S. Molday, Jonathan A. Coleman, Stine A. Mikkelsen
المصدر: Vestergaard, A L, Mikkelsen, S A, Coleman, J A, Molday, R S, Vilsen, B & Andersen, J P 2015, ' Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit ', FEBS Letters, vol. 589, pp. 3908-3914 . https://doi.org/10.1016/j.febslet.2015.11.031
مصطلحات موضوعية: Glycosylation, Protein subunit, Biophysics, Biology, Molecular Dynamics Simulation, medicine.disease_cause, Biochemistry, Cell membrane, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Catalytic Domain, Genetics, medicine, Animals, Phospholipid Transfer Proteins, Molecular Biology, 030304 developmental biology, 0303 health sciences, Mutation, Binding Sites, 030302 biochemistry & molecular biology, Cell Membrane, Membrane Proteins, Cell Biology, Flippase, Membrane transport, Cell biology, Protein Subunits, medicine.anatomical_structure, chemistry, Membrane protein, P-type ATPase, lipids (amino acids, peptides, and proteins), Cattle
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المؤلفون: Mirwais, Osmai, Yama, Osmai, Claus H, Bang-Berthelsen, Emil M H, Pallesen, Anna L, Vestergaard, Guy W, Novotny, Flemming, Pociot, Thomas, Mandrup-Poulsen
المصدر: Diabetes/metabolism research and reviews. 32(4)
مصطلحات موضوعية: MicroRNAs, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Gene Expression Regulation, Insulin-Secreting Cells, Animals, Humans, Biomarkers
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