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1High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells
المؤلفون: Jon-Paul Jaworski, Lisa A. Payne, Anna Waszkiewicz, Biju Mangatt, Anthony J. Jurewicz, Lorena A. Kallal, Jesus R. Medina, Pat Brady, Xin Zeng, Thomas J. Berrodin, Carolyn Doepner-Buser, Anthony Della Pietra
المصدر: SLAS discovery : advancing life sciences RD. 26(2)
مصطلحات موضوعية: 0301 basic medicine, High-throughput screening, Genes, myc, Biochemistry, Analytical Chemistry, Flow cytometry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Fluorescence Resonance Energy Transfer, Humans, Transcription factor, Reporter gene, medicine.diagnostic_test, Cell growth, Chemistry, Reverse Transcriptase Polymerase Chain Reaction, Cell cycle, Gene signature, Flow Cytometry, Molecular biology, High-Throughput Screening Assays, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Molecular Medicine, Drug Screening Assays, Antitumor, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbee602aec0943dd6af57df9d435d52
https://pubmed.ncbi.nlm.nih.gov/33482073 -
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المؤلفون: Joseph P. Marino, Jonathan B. Basilla, David G. Washburn, Elizabeth A. Davenport, Jeff J. McAtee, Xiaoping Xu, Dan J. Gillie, Lamont Roscoe Terrell, Irina M. Lozinskaya, Christine G. Schnackenberg, Dennis A. Holt, Anna Waszkiewicz, Michael Klein, Timothy C. Jensen, Lorena Kallal Negron, Sharada Manns, Dwight M. Morrow, Linda S. Barton, Christina Pritchard, Jeffrey Guss, Jason W. Dodson, Robert N. Willette, Rusty E. Fries
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4979-4984
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Diglycerides, chemistry.chemical_compound, Transient receptor potential channel, Amide, Drug Discovery, TRPC6 Cation Channel, Humans, Isoquinoline, Thiazole, Molecular Biology, TRPC Cation Channels, Aniline Compounds, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Thiazoles, HEK293 Cells, biology.protein, Molecular Medicine, Piperidine, Pharmacophore
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3Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen
المؤلفون: Stuart Paul Romeril, Gopinath Ganji, Dirk A. Heerding, George P. Livi, Anna Rutkowska-Klute, William Hoi Hong Li, James F. Mack, Elisabeth A. Minthorn, Derrick W. Meinhold, Carolyn A. Buser, Jesus R. Medina, Lorena A. Kallal, Shanker K. Sundaram, Biju Mangatt, Anthony Della Pietra, Sonja Ghidelli-Disse, Anna Waszkiewicz, Jon-Paul Jaworski, Thomas J. Berrodin, Rakesh Kumar, Wendy S. Halsey, Christian S. Sherk, Gerard Drewes
المصدر: Cancer Research. 78:2919-2919
مصطلحات موضوعية: Cancer Research, Oncogene, Cell, Biology, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, chemistry, Transcription (biology), Gene duplication, medicine, Cancer research, Protein stabilization, Signal transduction, Transcription factor, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::64bc4d93904423361b095d651579562d
https://doi.org/10.1158/1538-7445.am2018-2919 -
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المؤلفون: Stefan Angielski, Anna Waszkiewicz, Magdalena Gołos, Jacek M. Witkowski, Barbara Lewko, Jan Stepinski, Elżbieta Latawiec, Anna Maryn, Agnieszka Daca
المصدر: Molecular and Cellular Biochemistry
مصطلحات موضوعية: medicine.medical_specialty, Mechanical stress, Vasodilator Agents, Clinical Biochemistry, Anti-Inflammatory Agents, Motility, S-Nitroso-N-Acetylpenicillamine, Nitric Oxide, Real-Time Polymerase Chain Reaction, Dexamethasone, Article, Podocyte, Nitric oxide, chemistry.chemical_compound, Mice, Atrial natriuretic peptide, Cell Movement, Stress, Physiological, Internal medicine, medicine, Animals, Vasoconstrictor Agents, Rats, Wistar, Molecular Biology, Cyclic guanosine monophosphate, Cyclic GMP, Cells, Cultured, business.industry, Podocytes, Angiotensin II, Cell Biology, General Medicine, Flow Cytometry, Rats, cGMP, Endocrinology, medicine.anatomical_structure, chemistry, S-Nitroso-N-acetylpenicillamine, business, Receptors, Atrial Natriuretic Factor, Glucocorticoid, hormones, hormone substitutes, and hormone antagonists, Atrial Natriuretic Factor, medicine.drug
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المؤلفون: James Tunstead, Robert N. Willette, Linda N. Casillas, Mui Cheung, Guosen Ye, Ming-Yuan Jian, Hasan Alsaid, John J. Lepore, Earl Gordon, John R. Toomey, Daniel S Matasic, Kristeen Maniscalco-Hauk, Chris James, J. Larkin, Kevin S. Thorneloe, Eidam Hilary Schenck, Stephen C. Lenhard, Krista B. Goodman, Lorena A. Kallal, Brian Donovan, Alan R. Olzinski, Pu Qin, Mary I. Townsley, Christine G. Schnackenberg, Lou Elefante, Weike Bao, John A. Krawiec, Theresa J. Roethke, Irina M. Lozinskaya, Kalindi Vaidya, Elizabeth A. Davenport, Melissa H. Costell, Robert W. Marquis, Beat M. Jucker, Mark E. Burgert, Anna Waszkiewicz
المصدر: Science Translational Medicine. 4
مصطلحات موضوعية: medicine.medical_specialty, Endothelium, Administration, Oral, TRPV Cation Channels, Blood Pressure, Pulmonary Edema, Vascular permeability, In Vitro Techniques, Permeability, Mice, Heart Rate, Membrane Transport Modulators, Internal medicine, Edema, Animals, Humans, Medicine, Myocardial infarction, Diuretics, Lung, Heart Failure, Mice, Knockout, business.industry, General Medicine, Water-Electrolyte Balance, Pulmonary edema, medicine.disease, Rats, Disease Models, Animal, Protein Transport, medicine.anatomical_structure, Blood pressure, Anesthesia, Heart failure, Cardiology, Calcium, medicine.symptom, business, Ion Channel Gating
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402bae20d12dbfd611a3be3e27f27d15
https://doi.org/10.1126/scitranslmed.3004276