نتائج البحث - "Anne-Marinette Cao"

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دورية أكاديمية

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

المؤلفون: Anne-Marinette Cao, Robert B. Quast, Fataneh Fatemi, Philippe Rondard, Jean-Philippe Pin, Emmanuel Margeat

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/a14531ed08b24689ae4bc18c982d5788

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Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

المؤلفون: Emmanuel Margeat, Robert B. Quast, Anne-Marinette Cao, Philippe Rondard, Fataneh Fatemi, Jean-Philippe Pin

المساهمون: Centre de Biochimie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Shahid Beheshti University, Institut de Génomique Fonctionnelle (IGF), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Guerineau, Nathalie C., Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Margeat, Emmanuel

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5426. ⟨10.1038/s41467-021-25620-5⟩
Nature Communications, 2021, 12 (1), pp.5426. ⟨10.1038/s41467-021-25620-5⟩

مصطلحات موضوعية: [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Protein Conformation, cooperativity, [SDV]Life Sciences [q-bio], Gene Expression, General Physics and Astronomy, Molecular neuroscience, insights, Disaccharides, Receptors, Metabotropic Glutamate, taste, 0302 clinical medicine, G protein-coupled receptors, Glucosides, Catalytic Domain, Fluorescence Resonance Energy Transfer, Amino Acids, Receptor, Micelles, 0303 health sciences, Multidisciplinary, Chemistry, Glutamate receptor, Molecular conformation, Recombinant Proteins, Single Molecule Imaging, stabilization, 3. Good health, protein-coupled receptors, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV] Life Sciences [q-bio], Transmembrane domain, Indans, single-molecule fret, Cholesterol Esters, Allosteric Site, Protein Binding, Agonist, Allosteric modulator, Octoxynol, medicine.drug_class, Science, Gi alpha subunit, Allosteric regulation, mechanism, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Glutamic Acid, Diosgenin, Article, General Biochemistry, Genetics and Molecular Biology, Bridged Bicyclo Compounds, 03 medical and health sciences, Single-molecule biophysics, Allosteric Regulation, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030304 developmental biology, G protein-coupled receptor, Biphenyl Compounds, Cell Membrane, General Chemistry, Bridged Bicyclo Compounds, Heterocyclic, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, HEK293 Cells, Xanthenes, Metabotropic glutamate receptor, Biophysics, activation, Glycolipids, Protein Multimerization, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804f3c258609247b2593e7ff463951f3
https://doaj.org/article/a14531ed08b24689ae4bc18c982d5788

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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

المؤلفون: Jean-Philippe Pin, Ann Van Eeckhaut, Pauline Scholler, Ilse Julia Smolders, Emmanuel Margeat, Linnea Olofsson, Alexandre Cabayé, Philippe Rondard, Fanny Malhaire, Amélie S. Tora, Xavier Rovira, Cyril Goudet, Anne-Marinette Cao, Francine Acher, Hayeon Baik

المساهمون: Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Universitat de Vic, Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Vrije Universiteit [Brussels] (VUB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Vrije Universiteit Brussel (VUB), Pharmaceutical and Pharmacological Sciences, Experimental Pharmacology, Alliance for Modulation in Epilepsy

المصدر: Neuropharmacology
Neuropharmacology, Elsevier, 2018, 140, pp.275-286. ⟨10.1016/j.neuropharm.2018.08.011⟩

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Allosteric regulation, Glutamic Acid, Chloride, Radioligand Assay, 03 medical and health sciences, Cellular and Molecular Neuroscience, GPCR, Allosteric Regulation, Chlorides, Constitutive activity, Inosine Monophosphate, medicine, Humans, Receptors, AMPA, Allostery, Receptor, Cells, Cultured, G protein-coupled receptor, Pharmacology, Binding Sites, Chemistry, Glutamate receptor, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, 030104 developmental biology, Metabotropic glutamate receptor, Luminescent Measurements, Mutation, Excitatory postsynaptic potential, Biophysics, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Metabotropic glutamate receptor 3, Glutamate