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1دورية أكاديمية
المؤلفون: Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne Buck, Lauren Besenhofer, Erwin Boghaert, Dong Cheng, Dan Cojocari, Kelly Doyle, T. Matthew Hansen, Kevin Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, John C. Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes E. Wolff, Katherine M. Bell-McGuinn, Andrew J. Souers
المصدر: Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
مصطلحات موضوعية: Medicine
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2730-664X
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المؤلفون: Andrew J. Souers, Wei Qiu, Thomas D. Penning, Darren C. Phillips, Xiaoqin Liu, Rick F. Clark, Joel D. Leverson, Amanda M. Olson, Chunqiu Lai, Daniel H. Albert, Gui-Dong Zhu, Yunsong Tong, Peter Kovar, Kenton L. Longenecker, Anthony Mastracchio, Morey L. Smith, Bailin Shaw, Alan S. Florjancic, Stephen K. Tahir, Donald J. Osterling
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Serine, In vivo, Oral administration, Chemistry, Kinase, Organic Chemistry, Drug Discovery, Toxicity, Cyclin-dependent kinase 9, Dosing, Pharmacology, Pharmacophore, Biochemistry
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3
المؤلفون: Velitchka Bontcheva, Maricel Torrent, David Maag, Anthony Mastracchio, Fritz G. Buchanan, Loren M. Lasko, Debra Ferguson, Thomas D. Penning, Alexander R. Shoemaker, Kenneth D. Bromberg, Chunqiu Lai, Eric F. Johnson
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1481-1486
مصطلحات موضوعية: biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Cell Cycle Proteins, Protein-Tyrosine Kinases, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Structure-Activity Relationship, 010404 medicinal & biomolecular chemistry, Wee1, G2/M checkpoint, Heterocyclic Compounds, In vivo, Drug Discovery, biology.protein, Humans, Molecular Medicine, Molecular Biology, Human breast
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المؤلفون: Chunqiu Lai, Alexander R. Shoemaker, Fritz G. Buchanan, Eric F. Johnson, David Maag, Anthony Mastracchio, Velitchka Bontcheva, Kenneth D. Bromberg, Thomas D. Penning, Debra Ferguson, Maricel Torrent, Loren M. Lasko
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:126895
مصطلحات موضوعية: Wee1, biology, Stereochemistry, Kinase, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, biology.protein, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
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5دورية أكاديمية
المصدر: Nature, Nature. 475(7355):183-188
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6
المؤلفون: Sangita B. Patel, Scott D. Edmondson, Ann E. Weber, Reshma A. Patel, Aleksandr Petrov, Kathryn A. Lyons, Bing Zhu, Joseph K. Wu, Anthony Mastracchio, Shiyao Xu, George J. Eiermann, Ranabir Sinha Roy, Giovanna Scapin, Nancy A. Thornberry, Jason M. Cox, Huaibing He
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4097-4101
مصطلحات موضوعية: Benzimidazole, Imidazopyridine, animal structures, Pyridines, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Dogs, Piperidines, Glucagon-Like Peptide 1, In vivo, Drug Discovery, Animals, Humans, Potency, education, Molecular Biology, Dipeptidyl peptidase-4, Dipeptidyl-Peptidase IV Inhibitors, education.field_of_study, biology, Hydrolysis, Sitagliptin Phosphate, Organic Chemistry, Imidazoles, Triazoles, Macaca mulatta, Dipeptidyl peptidase 8, Rats, chemistry, Enzyme inhibitor, Drug Design, Pyrazines, biology.protein, Molecular Medicine, Benzimidazoles
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المؤلفون: Joseph K. Wu, Reshma A. Patel, Nancy A. Thornberry, Ann E. Weber, Jason M. Cox, Shiyao Xu, Bing Zhu, Barbara Leiting, Kathryn A. Lyons, Scott D. Edmondson, Ranabir Sinha Roy, Bart Harper, Huaibing He, Anthony Mastracchio
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4579-4583
مصطلحات موضوعية: CYP2D6, animal structures, Clinical Biochemistry, hERG, Biological Availability, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Piperidines, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Potency, Molecular Biology, Dipeptidyl peptidase-4, Dipeptidyl-Peptidase IV Inhibitors, Molecular Structure, biology, Chemistry, Calcium channel, Organic Chemistry, Biological activity, Potassium channel, Rats, Enzyme inhibitor, Area Under Curve, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Joseph K. Wu, KellyAnn D. Pryor, Ann E. Weber, George J. Eiermann, Reshma A. Patel, Dooseop Kim, Jinyou Xu, Nancy A. Thornberry, Anthony Mastracchio, Scott D. Edmondson, Jennifer E. Kowalchick, Huaibing He, Barbara Leiting, Kathryn A. Lyons
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3373-3377
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Piperazines, Dipeptidyl peptidase, Sitagliptin Phosphate, Structure-Activity Relationship, Oral administration, Drug Discovery, medicine, Animals, Structure–activity relationship, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, biology, Chemistry, Organic Chemistry, Triazoles, Amides, Rats, Enzyme, Enzyme inhibitor, Pyrazines, Sitagliptin, biology.protein, Molecular Medicine, medicine.drug
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المصدر: Science. 316:582-585
مصطلحات موضوعية: Aldehydes, Multidisciplinary, Molecular Structure, Chemistry, Aryl, Enantioselective synthesis, Halogenation, Stereoisomerism, General Medicine, Combinatorial chemistry, Catalysis, Enamine, chemistry.chemical_compound, Tsuji–Trost reaction, Halogens, Cyclization, Organocatalysis, Electrophile, Organic chemistry, Organic synthesis, Amines, Organic Chemicals, Oxidation-Reduction
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3debbabd124bef2334b368ade7e4b4c
https://doi.org/10.1126/science.1142696 -
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المؤلفون: Reshma A. Patel, Aleksandr Petrov, Frank Marsilio, Barbara Leiting, Kathryn A. Lyons, Anthony Mastracchio, Lan Wei, Jinyou Xu, Ann E. Weber, Nancy A. Thornberry, George J. Eiermann, Joseph F. Leone, Joseph K. Wu, Scott D. Edmondson, Huaibing He, Robert J. Mathvink
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1346-1349
مصطلحات موضوعية: Adenosine Deaminase, Nitrogen, Pyridones, Dipeptidyl Peptidase 4, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Sensitivity and Specificity, Biochemistry, Chemical synthesis, Substrate Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, Drug Discovery, Adenosine Deaminase Inhibitors, Animals, Humans, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Dipeptidyl peptidase-4, Glycoproteins, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Amides, Macaca mulatta, Rats, Bioavailability, Enzyme, chemistry, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine