نتائج البحث - "Antimalarials chemical synthesis"

1

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

المؤلفون: Jiri Gut, Nuno Vale, Fátima Nogueira, Luísa Aguiar, Philip J. Rosenthal, Paula Gomes, Xavier Fernàndez-Busquets, David Andreu, Elena Lantero, Arnau Biosca

المساهمون: Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Vector borne diseases and pathogens (VBD), Instituto de Investigação e Inovação em Saúde

المصدر: Molecules
Volume 24
Issue 24
Recercat. Dipósit de la Recerca de Catalunya
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مصطلحات موضوعية: Plasmodium, Primaquine, Erythrocytes, Pharmaceutical Science, Peptide, Antimalarial, Cell-Penetrating Peptides, red blood cell, 01 natural sciences, Erythrocytes / parasitology, Analytical Chemistry, Chloroquine, Drug Discovery, Recombinant Fusion Proteins / chemistry, Flow cytometry, Antimalarials / chemistry, chemistry.chemical_classification, 0303 health sciences, Microscopy, antimalarial, Recombinant Fusion Proteins / pharmacology, Chemistry, Chloroquine / pharmacology, Primaquine / chemistry, Haemolysis, Hemolysis, Red blood cell, Infectious Diseases, Biochemistry, Chemistry (miscellaneous), microscopy, Molecular Medicine, Erythrocytes / metabolism, Intracellular, medicine.drug, Primaquine / pharmacology, primaquine, Recombinant Fusion Proteins, Plasmodium falciparum, Article, Chloroquine / chemistry, 03 medical and health sciences, Antimalarials, SDG 3 - Good Health and Well-being, erythrocyte fluorescence, medicine, Humans, Physical and Theoretical Chemistry, Aminoquinolines, Antimalarials / pharmacology, 030304 developmental biology, Cell penetrating peptide, 010405 organic chemistry, Cell-Penetrating Peptides/ pharmacology, flow cytometry, Organic Chemistry, Erythrocyte fluorescence, medicine.disease, 0104 chemical sciences, cell penetrating peptide, Cell-penetrating peptide, Cell-Penetrating Peptides / chemistry, Plasmodium falciparum / growth & development, hemolysis, Antimalarials / chemical synthesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9e043ec8e6faa1d496331b652f11c
https://pubmed.ncbi.nlm.nih.gov/31842498

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2

Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.

المؤلفون: Ersmark, Karolina, Nervall, Martin, Hamelink, Elizabeth, Janka, Linda K, Clemente, Jose C, Dunn, Ben M, Blackman, Michael J, Samuelsson, Bertil, Aqvist, Johan, Hallberg, Anders

المصدر: J Med Chem. 48(19):6090-6106

مصطلحات موضوعية: Animals, Antimalarials/*chemical synthesis/chemistry, Aspartic Endopeptidases/*antagonists & inhibitors/chemistry, Cathepsin D/antagonists & inhibitors, Humans, Hydrazines/*chemical synthesis/chemistry, Mannitol/*analogs & derivatives/*chemical synthesis/chemistry, Models, Molecular, Molecular Conformation, Oxadiazoles/*chemical synthesis/chemistry, Plasmodium falciparum/enzymology, Protein Binding, Quantitative Structure-Activity Relationship, Research Support, Non-U.S. Gov't, Stereoisomerism, Thermodynamics

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-75614
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16162010&dopt=Citation

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3

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.

المؤلفون: Muthas, Daniel, Nötteberg, Daniel, Sabnis, Yogesh A, Hamelink, Elizabeth, Vrang, Lotta, Samuelsson, Bertil, Karlen, Anders, Hallberg, Anders

المصدر: Bioorg Med Chem. 13(18):5371-90

مصطلحات موضوعية: Animals, Antimalarials/*chemical synthesis/chemistry/*pharmacology, Aspartic Endopeptidases/*antagonists & inhibitors, Computer Simulation, Models, Biological, Molecular, Plasmodium falciparum/enzymology, Protease Inhibitors/chemical synthesis/chemistry/*pharmacology, Quantitative Structure-Activity Relationship, Research Support, Non-U.S. Gov't

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-75615
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16054370&dopt=Citation

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4

Synthesis and antimalarial activity of new amino analogues of amodiaquine

المؤلفون: Emilia Păunescu, Elisabeth Mouray, Patricia Melnyk, R. A. Varga, Philippe Grellier, E. Boll, S. Susplugas

المساهمون: Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Medicinal Chemistry
Medicinal Chemistry, Bentham Science Publishers, 2008, 4 (5), pp.405-427. ⟨10.2174/157340608785700153⟩

مصطلحات موضوعية: MESH: Amines/chemistry, Pyrrolidines, Stereochemistry, MESH: Antimalarials/pharmacology, [SDV]Life Sciences [q-bio], Plasmodium falciparum, Amodiaquine, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Amopyroquine, Antimalarials, Structure-Activity Relationship, MESH: Structure-Activity Relationship, Chloroquine, MESH: Plasmodium falciparum/growth & development, Drug Discovery, medicine, MESH: Amodiaquine/chemical synthesis, [CHIM]Chemical Sciences, Animals, MESH: Animals, MESH: Hydrogen Bonding, MESH: Amodiaquine/pharmacology, Amines, Cytotoxicity, biology, 010405 organic chemistry, Chemistry, Hydrogen bond, MESH: Models, Chemical, MESH: Amodiaquine/analogs & derivatives, Hydrogen Bonding, biology.organism_classification, MESH: Crystallography, X-Ray, 3. Good health, 0104 chemical sciences, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Mechanism of action, Models, Chemical, MESH: Pyrrolidines/chemistry, MESH: Plasmodium falciparum/drug effects, medicine.symptom, Selectivity, MESH: Antimalarials/chemical synthesis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eae846d114100c5db132d3cb4c4abf
https://pubmed.ncbi.nlm.nih.gov/18782038

5

Probing the role of the covalent linkage of ferrocene into a chloroquine template

المؤلفون: Natascha Chavain, Christophe Biot, Cheikh M. N'Diaye, Patricia Melnyk, Jamal Khalife, Alain Pellet, Christian Jarry, Jacques Brocard, Lydie Pelinski, Isabelle Forfar-Bares, Daniel Dive, Wassim Daher, Bruno Pradines, Laurent Fraisse

المساهمون: Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Schistosomiase, paludisme et inflammation, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Université Lille 2 - Faculté de Médecine, Université de Lille, Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), Service de Santé des Armées, SANOFI Recherche, Pharmacochimie (EA2962), Université Bordeaux Segalen - Bordeaux 2, This work was supported by Sanofi Aventis (fellowship attributed to W.D.), by the 'Fondation des Treilles' (fellowship attributed to W.D.) by the CNRS, by the Universités de Lille I and Lille II, and by the Inserm. A BDI fellowship from CNRS and Region Nord-Pas-de-Calais to N.C. is also gratefully acknowledged., C.B. thanks Timothy J. Egan for stimulating discussions and careful reading of the manuscript. L. Maciejewski is acknowledged for helpful discussions. I. Ricard, L. Cattiaux, H. Kalamou, and D. Lamberton are acknowledged for their expert technical intervention., Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Henri Warembourg - Université de Lille

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2006, 49, pp.4707-4714. ⟨10.1021/jm060259d⟩
Journal of Medicinal Chemistry, 2006, 49, pp.4707-4714. ⟨10.1021/jm060259d⟩

مصطلحات موضوعية: MESH: Ferrous Compounds/chemistry, Metallocenes, MESH: Ferrous Compounds/chemical synthesis, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, MESH: Parasitic Sensitivity Tests, MESH: Quinolines/pharmacology, 01 natural sciences, Chemical synthesis, chemistry.chemical_compound, MESH: Structure-Activity Relationship, Parasitic Sensitivity Tests, MESH: Antimalarials/pharmacology, Drug Discovery, MESH: Aminoquinolines, Moiety, MESH: Animals, MESH: Quinolines/chemistry, MESH: Quinolines/chemical synthesis, biology, Chloroquine, MESH: Chloroquine/chemistry, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Covalent bond, Lipophilicity, Aminoquinolines, Quinolines, Molecular Medicine, MESH: Antimalarials/chemical synthesis, Metallocene, Hemeproteins, MESH: Plasmodium falciparum/drug effects, Stereochemistry, MESH: Hemeproteins/antagonists & inhibitors, Plasmodium falciparum, 010402 general chemistry, Antimalarials, Structure-Activity Relationship, MESH: Antimalarials/chemistry, Animals, Structure–activity relationship, Ferrous Compounds, MESH: Hemeproteins/chemical synthesis, 010405 organic chemistry, biology.organism_classification, MESH: Ferrous Compounds/pharmacology, 0104 chemical sciences, Ferrocene, chemistry