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1
المؤلفون: Bin Li, Lindsay J. Howett, Shaohui Wang, Rupal Patel, Richard E. Showalter, Mei-Mei Wang, April Averill, Peggy A. Thompson, James R. Appleman
المصدر: ASSAY and Drug Development Technologies. 6:69-81
مصطلحات موضوعية: Protein Denaturation, Hot Temperature, Light, Protein Conformation, Biophysics, Drug Evaluation, Preclinical, Calorimetry, Ligands, Biophysical Phenomena, Adenosine Triphosphate, Genes, Reporter, Drug Discovery, Scattering, Radiation, Histidine, Luciferase, Enzyme Inhibitors, Luciferases, chemistry.chemical_classification, Dose-Response Relationship, Drug, Atlas (topology), Circular Dichroism, Ligand binding assay, Proteins, Ligand (biochemistry), Kinetics, Enzyme, chemistry, Biochemistry, Homogeneous, Calibration, Molecular Medicine, Indicators and Reagents, Target protein, Protein stabilization, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c585bb5acb0d990ed60e17ee0dab5dc
https://doi.org/10.1089/adt.2007.100 -
2
المؤلفون: Yuefen Zhou, Frank Ruebsam, Richard E. Showalter, Thomas Hermann, Lian-Sheng Li, Rupal Patel, Mei Tsan, April Averill, Qiang Zhao, Douglas E. Murphy, Qing Han, Peter S. Dragovich, Charles R. Kissinger, Laurie A. LeBrun, Maria V. Sergeeva, Amit M. Shah, Stephen E. Webber, Tran Chinh Viet
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1419-1424
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Ns5b polymerase, Inhibitory Concentration 50, Drug Stability, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Thiadiazines, biology, Organic Chemistry, Metabolic stability, RNA-Dependent RNA Polymerase, Nucleotidyltransferase, Small molecule, Pyridazines, Enzyme, RNA-Directed RNA Polymerase, chemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine
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3
المؤلفون: Carin L. Perretta, April Averill, Shaosong Chu, Robert Almassy, Stephen Margosiak, Jia Lu, Zhe Nie, Erickson Philip Eugene
المصدر: Bioorganicmedicinal chemistry letters. 18(2)
مصطلحات موضوعية: Male, Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Carboxamide, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, 1,3,5-Triazine, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Casein Kinase II, Molecular Biology, Protein Kinase Inhibitors, Triazine, biology, Triazines, Organic Chemistry, Prostatic Neoplasms, chemistry, Enzyme inhibitor, Drug Design, Colonic Neoplasms, biology.protein, Lactam, Molecular Medicine
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4
المؤلفون: Robert Almassy, Stephen Margosiak, Kraig M. Yager, Shaosong Chu, Carin L. Perretta, April Averill, Erickson Philip Eugene, Zhe Nie, Jia Lu
المصدر: Bioorganicmedicinal chemistry letters. 17(15)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, 1,3,5-Triazine, Cell Line, Tumor, Drug Discovery, Transferase, Humans, Cytotoxicity, Casein Kinase II, Molecular Biology, Protein Kinase Inhibitors, Triazine, chemistry.chemical_classification, Binding Sites, biology, Molecular Structure, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Signal transduction
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5دورية أكاديمية
المؤلفون: Peggy A. Thompson, Shaohui Wang, Lindsay J. Howett, Mei-Mei Wang, Rupal Patel, April Averill, Richard E. Showalter, Bin Li, James R. Appleman
المصدر: Assay & Drug Development Technologies; Feb2008, Vol. 6 Issue 1, p69-81, 13p
مصطلحات موضوعية: LIGANDS (Biochemistry), HIGH throughput screening (Drug development), PROTEINS, LUCIFERASES, PROTEIN binding