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1
المؤلفون: Guosen Ye, Arthur Shu, Dennis A. Holt, Patrick Stoy, Carla A. Donatelli, Larry J. Jolivette, Ralph A. Rivero, Mark Youngman, Lamont Roscoe Terrell, Jaclyn R. Patterson, Brian G. Lawhorn, Theresa J. Roethke
المصدر: Journal of medicinal chemistry. 63(23)
مصطلحات موضوعية: Steric effects, Nitrile, TRPV Cation Channels, Ether, Diamines, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Electronic effect, Moiety, Animals, Cytochrome P-450 CYP3A, Humans, 030304 developmental biology, 0303 health sciences, Sulfonamides, Molecular Structure, Aryl, Hydrogen Bonding, Stereoisomerism, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, chemistry, Intramolecular force, Drug Design, Microsomes, Liver, Molecular Medicine, Amine gas treating, Protein Binding
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2
المؤلفون: Arthur Shu, Yiqian Lian, Huijie Li, Curt Dale Haffner, Terry Vincent Hughes, Ami S. Lakdawala, Julie A. Cox, Pamela A. Haile, Constantine Kreatsoulas, Beth Anne Knapp-Reed, Lisa M. Shewchuk, David B. Lipshutz, John F. Mehlmann, Michael T. Ouellette, Christopher J Aquino, Mark Elban, Nicole Cathleen Goodwin, Huiqiang Zhou, Adam Kenneth Charnley, Bartholomew J. Votta, Robert W. Marquis, Joseph J. Romano, Linda N. Casillas, Peter J. Gough, Máire A. Convery, John Bertin
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Kinase, Chemistry, Organic Chemistry, Pyrazole, 01 natural sciences, Biochemistry, 0104 chemical sciences, RIPK2, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, NOD2, Drug Discovery, NOD1, Transferase, RECEPTOR-INTERACTING PROTEIN
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3
المؤلفون: Brian G. Lawhorn, Brian Budzik, Karl F. Erhard, Huijie Li, Carla A. Donatelli, Kalindi Vaidya, Melissa H. Costell, Joseph E. Pero, John J. McAtee, Carl Brooks, Lorraine M. Posobiec, Larry J. Jolivette, Dennis A. Holt, Theresa J. Roethke, Stephen H. Eisennagel, Michael C. Fischer, Matthews Jay M, Arthur Shu, Brent W. Mccleland, Lamont Roscoe Terrell, Sender Matthew Robert, Katrina Rivera, David J. Behm, Israil Pendrak, Ralph A. Rivero, Xiaoping Xu, Edward J. Brnardic, Peng Li
المصدر: Journal of medicinal chemistry. 61(24)
مصطلحات موضوعية: 0301 basic medicine, TRPV4, Male, Pyrrolidines, Drug Evaluation, Preclinical, TRPV Cation Channels, Pulmonary Edema, Pharmacology, 01 natural sciences, Pyrrolidine, Sulfone, Rats, Sprague-Dawley, 03 medical and health sciences, Transient receptor potential channel, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Sulfones, Receptor, Sulfonamides, 010405 organic chemistry, Sulfonamide (medicine), Pulmonary edema, medicine.disease, 0104 chemical sciences, 030104 developmental biology, chemistry, Molecular Medicine, medicine.drug
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المؤلفون: Arthur Shu, Carla A. Donatelli, Sanchez Robert, Melissa H. Costell, Carl Brooks, Yanan He, Jeff J. McAtee, David J. Behm, Guosen Ye, Dennis A. Holt, Theresa J. Roethke, Brian G. Lawhorn, Grazyna Graczyk-Millbrandt, Lamont Roscoe Terrell, Edward J. Brnardic, Patrick Stoy, Linda S. Barton, Karl F. Erhard
المصدر: Journal of medicinal chemistry. 61(21)
مصطلحات موضوعية: 0301 basic medicine, TRPV4, Pyrrolidines, Substituent, Administration, Oral, Biological Availability, TRPV Cation Channels, 010402 general chemistry, 01 natural sciences, Pyrrolidine, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Animals, chemistry.chemical_classification, Sulfonamides, Combinatorial chemistry, 0104 chemical sciences, Sulfonamide, Rats, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, Target protein, Lead compound
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المؤلفون: Scott D Sigethy, Elisabeth A. Minthorn, Jesus R. Medina, Thomas Mencken, Charity Atkins, Kirsten M. Kahler, William Hoi Hong Li, Annie M. Hassell, Xuan Hong, Stuart Paul Romeril, Aaron S. Goetz, Ginger H. Tomberlin, Qi Liu, Dirk A. Heerding, Lisa M. Shewchuk, Robert T. Gampe, Sridhar K. Rabindran, Arthur Shu, Rakesh Kumar, Jeffrey M. Axten, Thomas B. Stanley, Yanhong Feng, Seth W. Grant, J. David Taylor
المصدر: Journal of Medicinal Chemistry. 55:7193-7207
مصطلحات موضوعية: Male, Models, Molecular, endocrine system, Indoles, Protein Conformation, Transplantation, Heterologous, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, eIF-2 Kinase, Dogs, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Pyrroles, PERK inhibitors, ASK1, Phosphorylation, Chemistry, Kinase, Adenine, Endoplasmic reticulum, Protein kinase R, Molecular biology, Rats, Transplantation, Pyrimidines, Biochemistry, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation
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المؤلفون: J. R. Heys, A. J. Villani, Arthur Shu, D. Saunders
المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 45:49-57
مصطلحات موضوعية: chemistry.chemical_classification, Chiral auxiliary, Nitrile, Organic Chemistry, Strecker amino acid synthesis, Enantioselective synthesis, Diastereomer, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Dicarboxylic acid, chemistry, Drug Discovery, Organic chemistry, Radiology, Nuclear Medicine and imaging, Enantiomer, Suberic acid, Spectroscopy
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المؤلفون: Dirk A. Heerding, Yanhong Feng, Arthur Shu, Jeffrey M. Axten, Seth W. Grant, Nathan Gaul, Jeffrey M. Ralph, A.M. Hassell, Rakesh Kumar, Elisabeth A. Minthorn, Jesus R. Medina, Thomas B. Stanley, William Hoi Hong Li, Stuart Paul Romeril, Charity Atkins, Robert T. Gampe, Aaron S. Goetz, Thomas Mencken
المصدر: ACS medicinal chemistry letters. 4(10)
مصطلحات موضوعية: endocrine system, Drug discovery, Kinase, business.industry, Endoplasmic reticulum, Organic Chemistry, Pharmacology, Biochemistry, Protein kinase R, Pharmacokinetics, Drug Discovery, Medicine, Tumor growth inhibition, Structure–activity relationship, PERK inhibitors, business
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المؤلفون: Dennis S. Yamashita, Arthur Shu, J. Richard Heys, Dennis A. Holt
المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 38:227-237
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Cleavage (embryo), Biochemistry, Aldehyde, Chemical synthesis, Analytical Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Tributyltin, Radiology, Nuclear Medicine and imaging, Azide, Spectroscopy, Bond cleavage
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7983c09718531dda0e78b91dafc4933
https://doi.org/10.1002/(sici)1099-1344(199603)38:3<227::aid-jlcr837>3.0.co;2-1 -
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المؤلفون: J. Richard Heys, Arthur Shu
المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 34:587-596
مصطلحات موضوعية: chemistry.chemical_classification, Hydrogen compounds, biology, Chemistry, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Biochemistry, Analytical Chemistry, 5α reductase, Steroid, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, Chemical preparation, medicine, Radiology, Nuclear Medicine and imaging, Tritium, Carbon-14, Spectroscopy
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المؤلفون: William H. Miller, Stuart Paul Romeril, Jesus R. Medina, Valery Sudakin, Sridhar K. Rabindran, Dirk A. Heerding, Mark A. Bobko, Jeffrey M. Axten, Celine Duquenne, Antony Chadderton, Melissa Dumble, Seth A. Gilbert, Charles W. Blackledge, Arthur Shu, Daryl A. Scherzer, Nino Campobasso, Christopher Becker, Hong Xiang, William Hoi Hong Li, Pat Brady, Qi Liu, Paris Ward, Christine M. Gardiner, Seth W. Grant, Yanhong Feng
المصدر: Journal of medicinal chemistry. 54(6)
مصطلحات موضوعية: Models, Molecular, animal structures, Indazoles, Morpholines, Transplantation, Heterologous, Antineoplastic Agents, Mice, SCID, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Piperidines, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Phosphorylation, Protein kinase B, PI3K/AKT/mTOR pathway, Protein-Serine-Threonine Kinases, Molecular Structure, Kinase, Chemistry, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Stereoisomerism, Cell biology, Transplantation, Pyrimidines, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Phosphoinositide-dependent kinase-1, Protein Binding