المؤلفون: Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/2db89135c8f8435582d1f2cd71ae72c8

المؤلفون: Andrew J. Hayes, Jiulia Satiaputra, Louise M. Sternicki, Ashleigh S. Paparella, Zikai Feng, Kwang J. Lee, Beatriz Blanco-Rodriguez, William Tieu, Bart A. Eijkelkamp, Keith E. Shearwin, Tara L. Pukala, Andrew D. Abell, Grant W. Booker, Steven W. Polyak

المصدر: Antibiotics, Vol 9, Iss 4, p 165 (2020)

مصطلحات موضوعية: antimicrobial resistance, Gram-positive bacteria, Staphylococcus aureus, advanced resistance studies, biotin, biotin protein ligase, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/9/4/165; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/03c962d4a73c448cad98240fb2c62993

المؤلفون: Jiage Feng, Ashleigh S. Paparella, Grant W. Booker, Steven W. Polyak, Andrew D. Abell

المصدر: Antibiotics, Vol 5, Iss 3, p 26 (2016)

مصطلحات موضوعية: antibiotic, biotin, biotin protein ligase, Staphylococcus aureus, inhibitor design, X-ray crystallography, in situ click chemistry, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2079-6382/5/3/26; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/f00fa77ec74a45e9923c4d0563782b60

المؤلفون: Ashleigh S. Paparella, Sean M. Cahill, Briana L. Aboulache, Vern L. Schramm

المصدر: ACS Chemical Biology. 17:2507-2518

مصطلحات موضوعية: Molecular Medicine, General Medicine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ef83f3971f24193bfb9fdf227e269bb4
https://doi.org/10.1021/acschembio.2c00408

المؤلفون: Rajesh K. Harijan, Briana L. Aboulache, Ashleigh S. Paparella, Kathryn S. Potts, Vern L. Schramm, Peter C. Tyler

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

مصطلحات موضوعية: Science, Bacterial Toxins, Cell, Iminosugar, General Physics and Astronomy, Article, General Biochemistry, Genetics and Molecular Biology, Microbiology, Enterotoxins, Bacterial Proteins, Transferases, Transition state analog, medicine, Humans, Cytoskeleton, Cytotoxicity, X-ray crystallography, Microbial toxins, Multidisciplinary, Transition (genetics), Clostridioides difficile, Chemistry, General Chemistry, Clostridium difficile, Anti-Bacterial Agents, Enzymes, Kinetics, medicine.anatomical_structure, Clostridium Infections

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a13febf8d8e34a0a7d2013b797bc5ff
https://doaj.org/article/2db89135c8f8435582d1f2cd71ae72c8

المؤلفون: Ashleigh S. Paparella, Rajesh K. Harijan, Vern L. Schramm, Briana L. Aboulache, Peter Charles Tyler

المصدر: The FASEB Journal. 35

مصطلحات موضوعية: Genetics, Clostridium difficile, Biology, Molecular Biology, Biochemistry, Biotechnology, Microbiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3b946e6167e4bffa24e7643f3e2056b1
https://doi.org/10.1096/fasebj.2021.35.s1.01786

المؤلفون: Kwangjun Lee, Andrew D. Abell, Steven W. Polyak, Beatriz Blanco-Rodriguez, John B. Bruning, Danielle Cini, Grant W. Booker, Robert W. Milne, Benjamin Noll, Andrew J. Hayes, Andrew C Marshall, Ashleigh S. Paparella, Jiage Feng, Matthew C.J. Wilce, Jingxian Yu, William Tieu

المساهمون: Lee, Kwang Jun, Tieu, William, Blanco-Rodriguez, Beatriz, Paparella, Ashleigh S, Yu, Jingxian, Hayes, Andrew, Feng, Jiage, Marshall, Andrew C, Noll, Benjamin, Milne, Robert, Cini, Danielle, Wilce, Matthew CJ, Booker, Grant W, Bruning, John B, Polyak, Steven W, Abell, Andrew D

المصدر: ACS Chemical Biology. 14:1990-1997

مصطلحات موضوعية: pharmacokinetic profile, 0301 basic medicine, Staphylococcus aureus, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Biochemistry, metabolic stability, Microbiology, Mice, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Drug Stability, Biotin, medicine, Animals, Carbon-Nitrogen Ligases, Enzyme Inhibitors, chemistry.chemical_classification, Sulfonamides, DNA ligase, 010405 organic chemistry, molecular dynamics simulations, General Medicine, Phosphate, Anti-Bacterial Agents, Rats, 0104 chemical sciences, Sulfonamide, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17972eb42541dd574d7fb900e1b5a4a3
https://doi.org/10.1021/acschembio.9b00463

المؤلفون: Wanida Phetsang, Mark A. T. Blaskovich, Zikai Feng, Ashleigh S. Paparella, Jiage Feng, Mark E. Cooper, Andrew D. Abell, Beatriz Blanco-Rodriguez, Grant W. Booker, Steven W. Polyak

المساهمون: Paparella, Ashleigh S, Feng, Jiage, Blanco-Rodriguez, Beatriz, Feng, Zikai, Phetsang, Wanida, Blaskovich, Mark AT, Cooper, Matthew A, Booker, Grant W, Polyak, Steven W, Abell, Andrew D

المصدر: Tetrahedron. 74:1175-1183

مصطلحات موضوعية: staphylococcus aureus, 0301 basic medicine, enzyme inhibitors, Mutant, medicine.disease_cause, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Biotin, antibiotic, Drug Discovery, medicine, Fluorescence microscope, biotin protein ligase, Escherichia coli, chemistry.chemical_classification, DNA ligase, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, Molecular biology, 0104 chemical sciences, 030104 developmental biology, Staphylococcus aureus, azide-alkyne cycloaddition, Efflux, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ee83d4c85812f14daf2c21ac1dd82
https://doi.org/10.1016/j.tet.2017.10.032

المؤلفون: Sarah Clark, Andrew J. Hayes, Ashleigh S. Paparella, Grant W. Booker, David Heim, Steven W. Polyak, William Tieu, Andrew D. Abell, Jiage Feng

المساهمون: Feng, Jiage, Paparella, Ashleigh S, Tieu, William, Heim, David, Clark, Sarah, Hayes, Andrew, Booker, Grant W, Polyak, Steven W, Abell, Andrew D

المصدر: ACS Medicinal Chemistry Letters. 7:1068-1072

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, Staphylococcus aureus, enzyme inhibitors, Binding pocket, Biology, medicine.disease_cause, Biochemistry, antibiotics, 03 medical and health sciences, chemistry.chemical_compound, Biotin, Drug Discovery, Ribose, medicine, biotin protein ligase, Cytotoxicity, chemistry.chemical_classification, DNA ligase, Organic Chemistry, 030104 developmental biology, chemistry, Hepg2 cells, Benzyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e60b92eb571193cac10eeb87712df75
https://doi.org/10.1021/acsmedchemlett.6b00248

المؤلفون: Steven W. Polyak, Sonali Deshmukh, Grant W. Booker, Andrew D. Abell, Zikai Feng, Andrew J. Hayes, Matthew C.J. Wilce, Ashleigh S. Paparella, Danielle Cini, Kwang J. Lee, Jiage Feng

المساهمون: Paparella, Ashleigh S, Lee, Kwang Jun, Hayes, Andrew J, Feng, Jiage, Feng, Zikai, Cini, Danielle, Deshmukh, Sonali, Booker, Grant W, Wilce, Matthew CJ, Polyak, Steven W, Abell, Andrew D

المصدر: ACS infectious diseases. 4(2)

مصطلحات موضوعية: 0301 basic medicine, inorganic chemicals, Models, Molecular, Staphylococcus aureus, Halogenation, enzyme inhibitor, Molecular Conformation, Biotin, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Ligases, 03 medical and health sciences, chemistry.chemical_compound, Minimum inhibitory concentration, antibiotic, medicine, Humans, biotin protein ligase, Binding site, Enzyme Inhibitors, chemistry.chemical_classification, DNA ligase, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, Molecular biology, Anti-Bacterial Agents, 030104 developmental biology, Infectious Diseases, Biochemistry, chemistry, Enzyme inhibitor, biology.protein, Antibacterial activity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd8141af481d9078bd05a9f48708682
https://pubmed.ncbi.nlm.nih.gov/29131575