المؤلفون: Tom M. Quinn, Erin E. Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin G. Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Gwyer Findlay, Sunny Jabbal, Andrew Duncan, Sinéad Plant, Adam D.L. Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair F. Nimmo, Islom B. Nazarov, Grant C. Churchill, James S.O. McCullagh, Kourosh H. Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard A. Parker, Ahsan R. Akram, Daniel C. Anthony, James W. Dear, Nik Hirani, Kevin Dhaliwal

المصدر: EBioMedicine, Vol 76, Iss , Pp 103856- (2022)

مصطلحات موضوعية: Respiratory medicine, Infectious diseases, SARS-CoV-2/COVID-19, Nafamostat mesylate, Total manuscript word count, Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422000408; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/30aabc317f5544bcb011f0340db28762

المؤلفون: Erin E. Gaughan, Tom M. Quinn, Andrew Mills, Annya M. Bruce, Jean Antonelli, Alison C. MacKinnon, Vassilios Aslanis, Feng Li, Richard O’Connor, Cecilia Boz, Ross Mills, Philip Emanuel, Matthew Burgess, Giulia Rinaldi, Asta Valanciute, Bethany Mills, Emma Scholefield, Gareth Hardisty, Emily Gwyer Findlay, Richard A. Parker, John Norrie, James W. Dear, Ahsan R. Akram, Oliver Koch, Kate Templeton, David H. Dockrell, Timothy S. Walsh, Stephen Partridge, Duncan Humphries, Jie Wang-Jairaj, Robert J. Slack, Hans Schambye, De Phung, Lise Gravelle, Bertil Lindmark, Manu Shankar-Hari, Nikhil Hirani, Tariq Sethi, Kevin Dhaliwal

المصدر: American Journal of Respiratory and Critical Care Medicine. 207:138-149

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::43fb8472c9f7aba3f7abdc6b479f8ec2
https://doi.org/10.1164/rccm.202203-0477oc

المؤلفون: Erin E, Gaughan, Tom M, Quinn, Andrew, Mills, Annya M, Bruce, Jean, Antonelli, Alison, MacKinnon, Vassilios, Aslanis, Feng, Li, Richard, O'Connor, Cecilia, Boz, Ross, Mills, Philip, Emanuel, Matthew, Burgess, Giulia, Rinaldi, Asta, Valanciute, Bethany, Mills, Emma, Scholefield, Gareth, Hardisty, Emily, Gwyer Findlay, Richard A, Parker, John, Norrie, James W, Dear, Ahsan R, Akram, Oliver, Koch, Kate, Templeton, David H, Dockrell, Timothy S, Walsh, Stephen, Partridge, Duncan, Humphries, Jie, Wang-Jairaj, Robert J, Slack, Hans, Schambye, De, Phung, Lise, Gravelle, Bertil, Lindmark, Manu, Shankar-Hari, Nikhil, Hirani, Tariq, Sethi, Kevin, Dhaliwal

المصدر: Gaughan, E E, Quinn, T M, Mills, A, Bruce, A M, Antonelli, J, Mackinnon, A, Aslanis, V, Li, F, O'connor, R, Boz, C, Mills, R, Emanuel, P, Burgess, M, Rinaldi, G, Valanciute, A, Mills, B, Scholefield, E, Hardisty, G, Gwyer Findlay, E, Parker, R A, Norrie, J, Dear, J W, Akram, A R, Koch, O, Templeton, K, Dockrell, D H, Walsh, T S, Partridge, S, Humphries, D, Wang-jairaj, J, Slack, R J, Schambye, H, Phung, D, Gravelle, L, Lindmark, B, Shankar-Hari, M, Hirani, N, Sethi, T & Dhaliwal, K 2022, ' An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE) : A Phase Ib/IIa Randomised Controlled Trial ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0477OC

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cbdceb9f003b857818278fa3a4d79ec
https://www.pure.ed.ac.uk/ws/files/298426001/rccm.202203_0477oc_1_.pdf

المؤلفون: Clark D Russell, Sara Clohisey, Wael Al Qsous, Stuart D. Armstrong, Naomi N. Gachanja, Asta Valanciute, Jo Stevens, Bo Wang, Rebekah Penrice-Randal, Gabriel C Oniscu, David J. Harrison, Kevin Dhaliwal, Ahsan R. Akram, Christopher D. Lucas, Julian A. Hiscox, David A. Dorward, J Kenneth Baillie, Jillian Stephen, William A Wallace

المساهمون: University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, University of St Andrews. School of Medicine

المصدر: Russell, C D, Valanciute, A, Gachanja, N, Stephen, J, Penrice-Randal, R, Armstrong, S D, Clohisey, S, Wang, B, Al Qsous, W, Wallace, W, Oniscu, G, Stevens, J, Harrison, D J, Dhaliwal, K, Hiscox, J A, Baillie, J K, Akram, A R, David, D & Lucas, C D 2021, ' Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19 ', American Journal of Respiratory Cell and Molecular Biology . https://doi.org/10.1165/rcmb.2021-0358OC

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Macrophage colony-stimulating factor, Male, Proteomics, Clinical Biochemistry, Spleen, Inflammation, E-NDAS, SDG 3 - Good Health and Well-being, RA0421, Immunopathology, RA0421 Public health. Hygiene. Preventive Medicine, Parenchyma, medicine, Macrophage, Humans, Molecular Biology, Lung, health care economics and organizations, Aged, QR355, Aged, 80 and over, business.industry, SARS-CoV-2, Macrophages, COVID-19, Cell Biology, medicine.anatomical_structure, Gene Expression Regulation, RB Pathology, Splenic Tissue, Immunology, Female, Autopsy, medicine.symptom, business, RB, QR355 Virology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c5dcea01d80e432188291189379617
https://pubmed.ncbi.nlm.nih.gov/34758278

المؤلفون: Oliver Koch, Andrew Duncan, Jean Antonelli, Timothy S. Walsh, Annya Bruce, Kay Russell, Colin Ferrett, Colin Church, James S. O. McCullagh, Jürgen Schwarze, Cecilia Boz, Giulia Rinaldi, Sinéad Plant, Gareth Hardisty, Anne Moore, Ahsan R. Akram, Kourosh Honarmand Ebrahimi, Sarah McNamara, Feng Li, Kevin G. Blyth, K. Dhaliwal, David H. Dockrell, Asta Valanciute, Ross Mills, Bethany Mills, Claire L. Mackintosh, Daniel C. Anthony, Tom Quinn, Steve P. Rannard, John Norrie, Irene Young, Keith Finlayson, Kate Templeton, Alastair F. Nimmo, Richard A. O’Connor, Erin Gaughan, Emma Scholefield, James W. Dear, Richard Parker, Andrew Owen, Philip Emanuel, Manu Shankar-Hari, Grant C. Churchill, Adam Marshall, Nik Hirani, Islom B. Nazarov, Matthew Burgess, Emily Gwyer Findlay, Sunny Jabball

المصدر: Quinn, T, Gaughan, E E, Bruce, A, Antonelli, J, O'Connor, R A, Li, F, McNamara, S, Koch, O, Mackintosh, C, Dockrell, D, Walsh, T, Blyth, K G, Church, C, Schwarze, J, Boz, C, Valanciute, A, Burgess, M, Emanuel, P, Mills, B, Rinaldi, G, Hardisty, G, Mills, R, Gwyer Findlay, E L, Jabbal, S, Duncan, A, Plant, S, Marshall, A D L, Young, I, Russell, K, Scholefield, E, Nimmo, A F, Nazarov, I B, Churchill, G C, McCullagh, J S O, Ebrahimi, K H, Ferrett, C, Templeton, K E, Rannard, S, Owen, A, Moore, A, Finlayson, K, Shankar-Hari, M, Akram, A R, Parker, R A, Dear, J W, Hirani, N & Dhaliwal, K 2022, ' Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2022.103856
EBioMedicine, Vol 76, Iss, Pp 103856-(2022)

مصطلحات موضوعية: Male, Medicine (General), History, Polymers and Plastics, Kaplan-Meier Estimate, Guanidines, Industrial and Manufacturing Engineering, law.invention, Randomized controlled trial, Informed consent, law, SARS-CoV-2/COVID-19, Nafamostat mesylate, Medicine, Aged, 80 and over, education.field_of_study, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Middle Aged, Viral Load, Nafamostat, Thromboelastometry, Total manuscript word count, Treatment Outcome, Anesthesia, Infectious diseases, Administration, Intravenous, Female, Half-Life, Adult, medicine.medical_specialty, Population, Drug Administration Schedule, General Biochemistry, Genetics and Molecular Biology, Immunophenotyping, Respiratory medicine, R5-920, Pharmacokinetics, Internal medicine, Humans, Business and International Management, education, Aged, Pneumonitis, SARS-CoV-2, business.industry, COVID-19, medicine.disease, Benzamidines, COVID-19 Drug Treatment, Clinical trial, Pharmacodynamics, business, Biomarkers

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08984770a1c6b75fcf7ed0f83784327
https://doi.org/10.2139/ssrn.3958859

المؤلفون: J K Baillie, Julian A. Hiscox, Wael Al Qsous, Naomi N. Gachanja, David J. Harrison, Ahsan R. Akram, Rebekah Penrice-Randal, Jillian Stephen, Bo Wang, Christopher D. Lucas, William Wallace, Oniscu Gc, David A. Dorward, Asta Valanciute, Chris Russell, K. Dhaliwal, Sara Clohisey, Jo Stevens, Stuart D. Armstrong

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, education, Spleen, Inflammation, Disease, Lung injury, medicine.disease_cause, Pathogenesis, medicine.anatomical_structure, Informed consent, Internal medicine, Immunopathology, medicine, medicine.symptom, business, health care economics and organizations, Coronavirus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ce80221eb431389b60272998df223282
https://doi.org/10.2139/ssrn.3854606

المؤلفون: Thomas Jamieson, Owen J. Sansom, Susan M. Farrington, Karen Dunbar, Farhat V N Din, Anna-Maria Ochocka-Fox, Vidya Rajasekaran, Mark J. Arends, James P. Blackmur, Asta Valanciute, Malcolm G. Dunlop, Alice Guazzelli, Paz Freile Vinuela, Patrizia Cammareri, Ana Cristina Silva Lima, Kevin Myant

المصدر: Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, Intravital Microscopy, Colorectal cancer, Stem cell marker, Mice, 0302 clinical medicine, Invasion, LGR5, leucine-rich repeat-containing G-protein coupled receptor 5, TROY, tumor necrosis factor receptor superfamily member 19, Intestinal Mucosa, Wnt Signaling Pathway, Migration, Original Research, Stem Cells, Gastroenterology, Wnt signaling pathway, HRP, horseradish peroxidase, Cell migration, APC, adenomatous polyposis coli, TCF, T-cell factor, 3. Good health, Gene Expression Regulation, Neoplastic, Organoids, Adenomatous Polyposis Coli, CRC, colorectal cancer, Intercellular Signaling Peptides and Proteins, Female, 030211 gastroenterology & hepatology, Stem cell, EMT, epithelial-mesenchymal transition, LRP6, low-density lipoprotein receptor-related protein 6, Epithelial-Mesenchymal Transition, Adenomatous Polyposis Coli Protein, Primary Cell Culture, PBS, phosphate-buffered saline, Mice, Transgenic, Biology, Familial adenomatous polyposis, 03 medical and health sciences, ZO-1, zona occludens 1, Cancer stem cell, DKK-1, Dickkopf-1, medicine, Animals, Humans, FAP, familial adenomatous polyposis, Epithelial–mesenchymal transition, RhoA, ras homolog gene family, member A, ROCK1, rho-associated protein kinase 1, ROCK2, rho-associated protein kinase 2, GSK-3B, glycogen synthase kinase 3B, Aspirin, Hepatology, HCT116 Cells, medicine.disease, CSC, cancer stem cell, Disease Models, Animal, F-actin, filamentous actin, 030104 developmental biology, siRNA, small interfering RNA, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2538cbe3f86187479ab63b0f72308398

المؤلفون: Kevin Myant, T. Jamieson, Dunbar K, Susan M. Farrington, Owen J. Sansom, Rajasekaran, Vinuela Pf, Mark J. Arends, Lima A, Malcolm G. Dunlop, Asta Valanciute, Ochocka-Fox A, Farhat V N Din, James P. Blackmur

مصطلحات موضوعية: Cancer stem cell, Colorectal cancer, Cell culture, Organoid, medicine, Wnt signaling pathway, Cancer research, Cell migration, Biology, Stem cell marker, medicine.disease, Phenotype

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072c9f3e801df3745576843a56a18b65

المؤلفون: Daria Zibrova, Asta Valanciute, Malcolm G. Dunlop, Vanessa P. Houde, Kevin A. Green, Dario R. Alessi, Farhat V N Din, Kei Sakamoto

المصدر: Din, F V N, Valanciute, A, Houde, V P, Zibrova, D, Green, K A, Sakamoto, K, Alessi, D R & Dunlop, M G 2012, ' Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells ', Gastroenterology, vol. 142, no. 7, pp. 1504-1515e3 . https://doi.org/10.1053/j.gastro.2012.02.050

مصطلحات موضوعية: Cell Cycle Proteins, P70-S6 Kinase 1, AMP-Activated Protein Kinases, mTORC2, Article, Mice, Phenformin, Cell Line, Tumor, Autophagy, Animals, Humans, Intestinal Mucosa, Phosphorylation, Protein kinase B, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Mice, Knockout, Ribosomal Protein S6, Phosphoinositide 3-kinase, Hepatology, biology, Aspirin, TOR Serine-Threonine Kinases, RPTOR, Anti-Inflammatory Agents, Non-Steroidal, Gastroenterology, AMPK, Ribosomal Protein S6 Kinases, 70-kDa, Phosphoproteins, biology.protein, Cancer research, Female, Colorectal Neoplasms, Transcription Factors, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df747e7cdae12149fe324e87254202c
https://www.pure.ed.ac.uk/ws/files/8384773/Aspirin_Inhibits_mTOR_Signaling_Activates_AMP_Activated_Protein_Kinase_and_Induces_Autophagy_in_Colorectal_Cancer_Cells.pdf

المؤلفون: Asta Valanciute, Covadonga Huidobro

المصدر: The Biochemist. 37:50

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f7866218d0329531686db176025c06e7
https://doi.org/10.1042/bio03701050