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المؤلفون: Mark J. O'Connor, Alan Lau, Keith W. Caldecott, Niall M.B. Martin, David Rudge, Jos Jonkers, Sven Rottenberg, Marina Pajic, Robert H. Bradbury, Attilla Ting, Bastiaan Evers, Charlotte Knights, Louise Jones, Janneke E. Jaspers, Henry Brown, Rajesh Odedra, Aaron N. Cranston, Stuart L. Rulten, Lenka Oplustil O'Connor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2109b65c80b64c5dc8e0c07cc7793822
https://doi.org/10.1158/0008-5472.c.6508109 -
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المؤلفون: Mark J. O'Connor, Alan Lau, Keith W. Caldecott, Niall M.B. Martin, David Rudge, Jos Jonkers, Sven Rottenberg, Marina Pajic, Robert H. Bradbury, Attilla Ting, Bastiaan Evers, Charlotte Knights, Louise Jones, Janneke E. Jaspers, Henry Brown, Rajesh Odedra, Aaron N. Cranston, Stuart L. Rulten, Lenka Oplustil O'Connor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730097b7c140c8178ff65dd44a170b76
https://doi.org/10.1158/0008-5472.22410926.v1 -
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المؤلفون: Niall M. B. Martin, Bastiaan Evers, Charlotte Knights, Janneke E. Jaspers, Jos Jonkers, Attilla Ting, Henry Brown, Keith W. Caldecott, Sven Rottenberg, Rajesh Odedra, Lenka Oplustil O'Connor, Robert Hugh Bradbury, Aaron Cranston, David Alan Rudge, Mark J. O'Connor, Marina Pajic, Louise J. Jones, Alan Lau, Stuart L. Rulten
المصدر: Cancer Research. 76:6084-6094
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, medicine.medical_treatment, Genes, BRCA1, Synthetic lethality, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Biology, Q1, Piperazines, Olaparib, Mice, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Bone Marrow, Cell Line, Tumor, Drug Discovery, Temozolomide, medicine, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, PARP Inhibitor AZD2461, Chemotherapy, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Rats, 3. Good health, Dacarbazine, 030104 developmental biology, medicine.anatomical_structure, Oncology, Tolerability, chemistry, PARP inhibitor, Phthalazines, Bone marrow, Poly(ADP-ribose) Polymerases, DNA Damage
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318c6f6c6cc972443af48c50dbf1283f
https://doi.org/10.1158/0008-5472.can-15-3240 -
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المؤلفون: Charlene Fallan, Derek Barratt, Gillian M. Lamont, Elaine Cadogan, Frederick W. Goldberg, Mercedes Vazquez-Chantada, Antonio Ramos Montoya, Anna Cronin, Simon J. Hollingsworth, Andrew D. Campbell, D. Beattie, Raymond AstraZeneca R D Alderley Finlay, Jacqueline H. L. Fok, Emma Dean, Joanna Harding, Jane Norris, Attilla Ting, Barry R. Davies
المصدر: Cancer Research. 79:DDT01-02
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Kinase, DNA damage, DNA repair, Poly ADP ribose polymerase, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, In vivo, 030220 oncology & carcinogenesis, Cancer research, Growth inhibition, IC50
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::55596045c1b3fd811eba667906d5e018
https://doi.org/10.1158/1538-7445.am2019-ddt01-02 -
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المؤلفون: Andrew David Morley, Galith Karoutchi, Stefan Gerhardt, Attilla Ting, Chris De Savi, Nash Ian Alun, Ken Page
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:271-277
مصطلحات موضوعية: Models, Molecular, Zinc binding, Matrix metalloproteinase inhibitor, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Matrix Metalloproteinase 13, Osteoarthritis, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Lead (electronics), Molecular Biology, Chemistry, Organic Chemistry, Dosing regimen, Combinatorial chemistry, Rats, Bioavailability, Zinc, Models, Chemical, Solubility, Drug Design, Molecular Medicine, Selectivity
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المؤلفون: Michael James, Gordon A. Hamlin, Stefan Gerhardt, David Ryan, Nash Ian Alun, Attilla Ting, Stephen J. Norris, Galith Karoutchi, Chris De Savi, Neil Rankine, David J. Hargreaves, Christine M. Wood, Sarah V. Baker, Philip A. MacFaul, Andrew David Morley, Kostas Karabelas
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4215-4219
مصطلحات موضوعية: Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Carboxamide, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Catalytic Domain, Matrix Metalloproteinase 13, Drug Discovery, Hydrolase, medicine, Structure–activity relationship, Protease Inhibitors, Binding site, Molecular Biology, Binding Sites, biology, Chemistry, Organic Chemistry, Zinc, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
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المؤلفون: Stefan Gerhardt, Andrew Pape, Christopher D. Davies, Attilla Ting, Scott G. Lamont, David Milne, Chris De Savi, Peter R. Moore, Jeremy N. Burrows, Yvonne Sawyer, Mark Mills, John G. Cumming, Calum Cook, Peter D. Smith
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1376-1381
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Clinical Biochemistry, Anti-Inflammatory Agents, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Enzyme activator, In vivo, Osteoarthritis, Drug Discovery, Humans, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, Formamides, biology, Chemistry, Organic Chemistry, ADAM Proteins, Enzyme Activation, carbohydrates (lipids), Enzyme, Enzyme inhibitor, Drug Design, ADAMTS4 Protein, biology.protein, Molecular Medicine, Procollagen N-Endopeptidase
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المؤلفون: Keith Allan Menear, Ian R. Hardcastle, Edward Jolyon Griffen, M. Raymond V. Finlay, Roger J. Griffin, Kate M. Clapham, Bernard T. Golding, Celine Cano, Attilla Ting, Turner Paul, Julia Bardos, Gail L. Young
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:966-970
مصطلحات موضوعية: DNA repair, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, DNA-Activated Protein Kinase, Plasma protein binding, Biochemistry, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Protein structure, Drug Discovery, Humans, Structure–activity relationship, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Organic Chemistry, Protein Structure, Tertiary, chemistry, Chromones, Molecular Medicine, Pharmacophore, DNA, Protein Binding, Binding domain
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المؤلفون: Peter Newham, Eleanor Henshaw, Philip A. MacFaul, Keith Oldham, Andrew David Morley, Neil Rankine, Christine M. Wood, David Elliot, Ken Page, Attilla Ting, Paul T. Sharpe
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4832-4835
مصطلحات موضوعية: biology, Cell adhesion molecule, medicine.drug_class, Chemistry, Organic Chemistry, Clinical Biochemistry, Integrin, Pharmaceutical Science, Carboxamide, Biochemistry, In vitro, embryonic structures, Drug Discovery, cardiovascular system, medicine, biology.protein, Molecular Medicine, Structure–activity relationship, Potency, Binding site, Arginine binding, Molecular Biology
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المؤلفون: Roger J. Griffin, Celine Cano, Bernard T. Golding, Attilla Ting, Mark Frigerio, Keith Allan Menear, Julia Bardos, Christopher M. Bailey, Marc Geoffrey Hummersone, Kappusamy Saravanan, Kerry Shea, Ian R. Hardcastle, Caroline Richardson, Nicola J. Curtin, Pia Thommes, Graeme C. M. Smith, David R. Newell
المصدر: Journal of medicinal chemistry. 56(16)
مصطلحات موضوعية: Chemistry, Stereochemistry, Morpholines, DNA-Activated Protein Kinase, In vitro, chemistry.chemical_compound, In vivo, Morpholine, Drug Discovery, Molecular Medicine, Moiety, Humans, Phosphatidylinositol, Protein kinase A, Cytotoxicity, Protein Kinase Inhibitors, Acetamide, HeLa Cells, Phosphoinositide-3 Kinase Inhibitors