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1دورية أكاديميةPI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation
المؤلفون: Sorif Uddin, Augustin Amour, David J. Lewis, Chris D. Edwards, Matthew G. Williamson, Simon Hall, Lisa A. Lione, Edith M. Hessel
المصدر: BMC Immunology, Vol 22, Iss 1, Pp 1-13 (2021)
مصطلحات موضوعية: PI3Kδ, IL33, ILC2, Goblet cell metaplasia, Siglec-Fhi inflammatory eosinophils, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1471-2172
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2دورية أكاديمية
المؤلفون: Melina Michael, Barry McCormick, Karen E. Anderson, Utsa Karmakar, Matthieu Vermeren, Stéphane Schurmans, Augustin Amour, Sonja Vermeren
المصدر: Frontiers in Immunology, Vol 12 (2021)
مصطلحات موضوعية: neutrophil, chemotaxis, recruitment, PI3K, SHIP2, SHIP1, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
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المؤلفون: Wendy C. Rowan, Naomi Clapp, Pelin L Candarlioglu, Augustin Amour
المصدر: Biochemical Society Transactions
مصطلحات موضوعية: organ-on-a-chip, Scope (project management), End user, Computer science, Drug discovery, Pharmacology & Toxicology, Perspective (graphical), Biochemistry, Organ-on-a-chip, drug development, drug discovery, Human disease, Drug development, Biochemical Techniques & Resources, Agricultural & Industrial Bioscience, Models, Chemical, Human–computer interaction, microfluidic models, Biomimetics, Lab-On-A-Chip Devices, Humans, Review Articles, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e12098a500ea82372ef27d248f06e4
http://europepmc.org/articles/PMC8421049 -
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المؤلفون: Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell
المصدر: Journal of Medicinal Chemistry. 63:638-655
مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Cell membrane permeability, Class I Phosphatidylinositol 3-Kinases, Biological Availability, Class iii, Crystallography, X-Ray, Binding, Competitive, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Drug discovery, Chemistry, Class III Phosphatidylinositol 3-Kinases, Combinatorial chemistry, Rats, Bioavailability, Isoenzymes, Molecular Docking Simulation, Toxicity, Molecular Medicine, Selectivity
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المؤلفون: Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
المصدر: Journal of medicinal chemistry. 64(18)
مصطلحات موضوعية: Male, Class I Phosphatidylinositol 3-Kinases, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Potency, Animals, Rats, Wistar, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Mice, Inbred BALB C, Sulfonamides, Molecular Structure, Glutathione, Highly selective, Combinatorial chemistry, Sulfonamide, Bioavailability, chemistry, Molecular Medicine, Amine gas treating, Female, Selectivity, Protein Binding
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المؤلفون: Chris D. Edwards, Edward Taylor, Rebecca H Graves, Olivia J. Robb, Brett O'Brien, Andrew W Harrell, Edith M. Hessel, Augustin Amour, Aarti Patel, Neil A Miller
المصدر: Clinical pharmacokinetics. 61(2)
مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Indazoles, Indoles, media_common.quotation_subject, Administration, Oral, Pharmacology, Models, Biological, Piperazines, Pulmonary Absorption, Route of administration, Pharmacokinetics, Administration, Inhalation, medicine, Distribution (pharmacology), Animals, Humans, Pharmacology (medical), Computer Simulation, Oxazoles, media_common, medicine.diagnostic_test, Inhalation, business.industry, Absorption, Physiological, Rats, Bronchoalveolar lavage, business
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المؤلفون: Ken A. Saunders, Robert Wilson, Wim Vos, Cedric Van Holsbeke, Jan De Backer, Claude Poirier, Glyn Bradley, Ingrid Louise Titlestad, Emily Jarvis, Kieran J. Killian, J. Nicole Hamblin, Stephen Mark, Mark Lennon, Anthony Cahn, Augustin Amour, Rikako Tanaka, Teresa Tang, Edith M. Hessel, David Michalovich, Hannah E Wajdner, J. Mark FitzGerald, Malcolm Begg, Jean Bourbeau, Saki Arai, François Maltais
المصدر: International Journal of COPD, Vol Volume 16, Pp 1621-1636 (2021)
Begg, M, Hamblin, J N, Jarvis, E, Bradley, G, Mark, S, Michalovich, D, Lennon, M, Wajdner, H E, Amour, A, Wilson, R, Saunders, K, Tanaka, R, Arai, S, Tang, T, Van Holsbeke, C, De Backer, J, Vos, W, Titlestad, I L, FitzGerald, J M, Killian, K, Bourbeau, J, Poirier, C, Maltais, F, Cahn, A & Hessel, E M 2021, ' Exploring PI3Kδ molecular pathways in stable COPD and following an acute exacerbation, two randomized controlled trials ', International Journal of COPD, vol. 16, pp. 1621-1636 . https://doi.org/10.2147/COPD.S309303
International Journal of Chronic Obstructive Pulmonary Diseaseمصطلحات موضوعية: Spirometry, medicine.medical_specialty, Exacerbation, International Journal of Chronic Obstructive Pulmonary Disease, Gastroenterology, law.invention, Phosphatidylinositol 3-Kinases, Pulmonary Disease, Chronic Obstructive, transcriptomics, Diseases of the respiratory system, 03 medical and health sciences, 0302 clinical medicine, copd exacerbations, Randomized controlled trial, law, Forced Expiratory Volume, Internal medicine, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Transcriptomics, Original Research, Randomized Controlled Trials as Topic, COPD, Lung, RC705-779, medicine.diagnostic_test, business.industry, Sputum, nemiralisib, Nemiralisib, sputum, General Medicine, PI3Kdelta, medicine.disease, respiratory tract diseases, Clinical trial, medicine.anatomical_structure, 030228 respiratory system, COPD exacerbations, Disease Progression, pi3kdelta, Phosphatidylinositol 3-Kinase, medicine.symptom, business
وصف الملف: text/html; application/pdf
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المؤلفون: Stéphane Schurmans, Karen E. Anderson, Utsa Karmakar, Augustin Amour, Barry McCormick, Melina Michael, Sonja Vermeren, Matthieu Vermeren
المصدر: Michael, M, Mccormick, B, Anderson, K E, Karmakar, U, Vermeren, M, Schurmans, S, Amour, A & Vermeren, S 2021, ' The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment ', Frontiers in Immunology, vol. 12 . https://doi.org/10.3389/fimmu.2021.671756
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)مصطلحات موضوعية: Male, Phagocytosis, Immunology, Phosphatase, Biology, PI3K, Dephosphorylation, Mice, chemistry.chemical_compound, Animals, Immunology and Allergy, Phosphatidylinositol, chemotaxis, PI3K/AKT/mTOR pathway, Original Research, Kinase, neutrophil, Chemotaxis, RC581-607, SHIP2, SHIP1, Cell biology, Mice, Inbred C57BL, Chemotaxis, Leukocyte, recruitment, lipid second messenger, Neutrophil Infiltration, chemistry, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Second messenger system, Female, Immunologic diseases. Allergy
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3245c88952a0b524d39c09248f76aadd
https://doi.org/10.3389/fimmu.2021.671756 -
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المؤلفون: Lucas Kraemer, Lindisley Ferreira Gomides, Mauro M. Teixeira, Celso Martins Queiroz-Junior, Gustavo B. Menezes, Mark Lennon, Braulio H.F. Lima, Edith M. Hessel, Augustin Amour, Remo Castro Russo, Pedro Marques, Matheus Silvério Mattos, Emilio Hirsch
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reportsمصطلحات موضوعية: Adoptive cell transfer, Pulmonary Fibrosis, medicine.medical_treatment, lcsh:Medicine, P110-DELTA ISOFORM, PI3K, NEGATIVE REGULATION, immune system diseases, Class Ib Phosphatidylinositol 3-Kinase, lcsh:Science, Receptor, Lung, Liver injury, TYROSINE PHOSPHORYLATION, Multidisciplinary, INDUCED LIVER-INJURY, PHOSPHOINOSITIDE 3-KINASE GAMMA, hemic and immune systems, Silicon Dioxide, EMBRYONIC LETHALITY, Multidisciplinary Sciences, Crosstalk (biology), Cytokine, Liver, Oligodeoxyribonucleotides, Organ Specificity, Cytokines, Pleura, Science & Technology - Other Topics, PHOSPHATIDYLINOSITOL 3-KINASE, Female, medicine.symptom, Signal Transduction, Cell Survival, chemical and pharmacologic phenomena, Inflammation, Article, Immune system, Phosphoinositol signalling, Quinoxalines, medicine, Animals, PI3K-GAMMA INHIBITION, TOLL-LIKE RECEPTORS, Science & Technology, business.industry, lcsh:R, TLR9, medicine.disease, Toll-like receptors, Mice, Inbred C57BL, Toll-Like Receptor 9, Cancer research, Thiazolidinediones, lcsh:Q, business, Gene Deletion
وصف الملف: Electronic
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المؤلفون: Sorif Uddin, Graham G. A. Inglis, Paul Rowland, Christopher J. Tame, Christopher N. Luscombe, Nick Barton, Natalie Wellaway, Anthony William James Cooper, Josie Morrell, Giovanni Vitulli, David Perez, Augustin Amour, Simon Peace, Craig Jamieson
المصدر: Journal of Medicinal Chemistry. 59:7239-7251
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Respiratory Tract Diseases, Biological Availability, Pharmacology, Rats sprague dawley, RS, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Administration, Inhalation, Drug Discovery, medicine, Animals, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Respiratory disease, medicine.disease, Rats, Bioavailability, Class Ia Phosphatidylinositol 3-Kinase, 030104 developmental biology, Molecular Medicine, Biological availability
وصف الملف: application/pdf
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