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1
المؤلفون: Aurelie C. Champigny, Daniel Thomas, Ian Robert Baldwin, Simon Gaines, Paul Faulder, Benjamin D. Bax, Laura M. Inglesby, Z.A. Henley, Yoshiaki Washio, Joelle Le
المصدر: ACS Medicinal Chemistry Letters. 8:1093-1098
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Indazole, Kinase, Organic Chemistry, PIM1, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, Drug Discovery, Kinome, Selectivity, Lead compound, PI3K/AKT/mTOR pathway
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2
المؤلفون: Rebecca H. Graves, Panayiotis A. Procopiou, Simon Teanby Hodgson, Afjal Hussain Miah, Jonathan M. Percy, Aurelie C. Champigny
المصدر: Bioorganicmedicinal chemistry. 25(20)
مصطلحات موضوعية: 0301 basic medicine, Male, Receptors, CCR4, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Pyrazolopyrimidine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Solubility, Rats, Wistar, Molecular Biology, chemistry.chemical_classification, Indazole, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Sulfonamide, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Lipophilicity, Molecular Medicine
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3
المؤلفون: Geoffrey J. Cutler, Paul Bamborough, James V. Morey, Geoffrey W. Mellor, Timothy Longstaff, William L. Rumsey, Ian Robert Baldwin, Mary A. Morse, Aurelie C. Champigny, Hong Nie, Taggart John J, Jeffrey K. Kerns, David D. Miller, John A. Christopher
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2255-2258
مصطلحات موضوعية: Indoles, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, Indole test, Virtual screening, Binding Sites, biology, Chemistry, Kinase, Organic Chemistry, I-Kappa-B Kinase, Amides, I-kappa B Kinase, Rats, Enzyme inhibitor, biology.protein, Molecular Medicine
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4
المؤلفون: Aurelie C. Champigny, Benjamin D. Bax, James R. Musgrave, Emma J. Jones, Murray J. B. Brown, J. Mosley, John A. Christopher, Francis Louis Atkinson, Tsu Tshen Chuang
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2230-2234
مصطلحات موضوعية: Molecular model, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Fluorescence Polarization, Biochemistry, Chemical synthesis, Mitogen-Activated Protein Kinase 14, chemistry.chemical_compound, Mitogen-Activated Protein Kinase 10, Drug Discovery, Humans, Mitogen-Activated Protein Kinase 8, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Bicyclic molecule, Aryl, Ligand binding assay, Organic Chemistry, Isoquinolines, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
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5
المؤلفون: Gareth Wayne, Aoife C. Maxwell, Catherine M. Alder, Amanda J. Campbell, Aurelie C. Champigny, Donald O. Somers, Sean M. Lynn, Martin Ambler, Christopher J. Tame, Angela M. Deakin, Chris J. Mooney, Tim Longstaff, Callum Scullion, Ian Edward David Smith, James Michael Woolven, Onkar M. P. Singh, John D. Harling, Carol A. Harris, Caroline Wilson
المصدر: ACS medicinal chemistry letters. 4(10)
مصطلحات موضوعية: chemistry.chemical_compound, Nonsteroidal, Chemistry, Kinase, Organic Chemistry, Drug Discovery, Computational biology, Bioinformatics, Biochemistry
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6
المؤلفون: Barbara G. Avitabile, Paul Bamborough, John A. Christopher, Michael J. Wilson, Aurelie C. Champigny, Geoffrey W. Mellor, Ken Grace, Jeremy D. A. Kitson, Nicholas Probst, Clive A. Smith, Champa Patel, Susan L. Dyos, William L. Rumsey, Jeffrey K. Kerns, James V. Morey, Mary A. Morse, Carolyn F. O’Malley, Geoffrey J. Cutler
المصدر: Bioorganicmedicinal chemistry letters. 17(14)
مصطلحات موضوعية: Models, Molecular, Molecular model, cells, Clinical Biochemistry, Pharmaceutical Science, IκB kinase, environment and public health, Biochemistry, Drug Discovery, Enzyme Inhibitors, skin and connective tissue diseases, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Hydrogen Bonding, In vitro, Enzyme assay, I-kappa B Kinase, enzymes and coenzymes (carbohydrates), Enzyme, chemistry, Enzyme inhibitor, Benzamides, biology.protein, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Signal transduction