المؤلفون: Watanabe Y; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Haneda T; Laboratory of Microbiology, School of Pharmacy, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Kimishima A; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Kuwae A; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Suga T; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Suzuki T; Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Iwabuchi Y; Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Honsho M; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Honma S; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Iwatsuki M; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Matsui H; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Hanaki H; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Kanoh N; Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; School of Pharmacy and Pharmaceutical Sciences, and Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan., Abe A; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Asami Y; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Ōmura S; Ōmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 23; Vol. 121 (17), pp. e2322363121. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Type III Secretion Systems*/metabolism , Aurodox*/pharmacology, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Gram-Negative Bacteria/metabolism ; Bacterial Proteins/metabolism

المؤلفون: McHugh RE; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK.; Institute of Infection, Immunity and Inflammation, University of Glasgowgrid.8756.c, Glasgow, UK., Munnoch JT; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK., Braes RE; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK., McKean IJW; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK.; Department of Pure and Applied Chemistry, University of Strathclydegrid.11984.35, Glasgow, UK., Giard J; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK., Taladriz-Sender A; Department of Pure and Applied Chemistry, University of Strathclydegrid.11984.35, Glasgow, UK., Peschke F; Department of Pure and Applied Chemistry, University of Strathclydegrid.11984.35, Glasgow, UK., Burley GA; Department of Pure and Applied Chemistry, University of Strathclydegrid.11984.35, Glasgow, UK., Roe AJ; Institute of Infection, Immunity and Inflammation, University of Glasgowgrid.8756.c, Glasgow, UK., Hoskisson PA; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, UK.

المصدر: Applied and environmental microbiology [Appl Environ Microbiol] 2022 Aug 09; Vol. 88 (15), pp. e0069222. Date of Electronic Publication: 2022 Jul 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Aurodox*/pharmacology , Streptomyces*/genetics, Anti-Bacterial Agents/pharmacology ; Multigene Family ; Polyketide Synthases/genetics ; Type III Secretion Systems

المؤلفون: Kimishima A; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Hagimoto D; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan., Honsho M; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Watanabe Y; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Iwatsuki M; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Tsutsumi H; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Inahashi Y; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Naher K; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Sakai K; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Kuwae A; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Abe A; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan., Asami Y; Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan; Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan. Electronic address: yasami@lisci.kitasato-u.ac.jp.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Aug 01; Vol. 69, pp. 128779. Date of Electronic Publication: 2022 May 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Aurodox*/pharmacology , Enteropathogenic Escherichia coli* , Escherichia coli Proteins*, Anti-Bacterial Agents/pharmacology ; Structure-Activity Relationship ; Type III Secretion Systems

المؤلفون: Kimura K; Department of Drug Discovery Sciences, Infection Control and Immunology, Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan., Iwatsuki M, Nagai T, Matsumoto A, Takahashi Y, Shiomi K, Omura S, Abe A

المصدر: The Journal of antibiotics [J Antibiot (Tokyo)] 2011 Feb; Vol. 64 (2), pp. 197-203. Date of Electronic Publication: 2010 Dec 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*therapeutic use , Aurodox/*therapeutic use , Bacterial Proteins/*antagonists & inhibitors , Citrobacter rodentium/*drug effects , Enterobacteriaceae Infections/*drug therapy , Membrane Transport Proteins/*metabolism, Animals ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Aurodox/isolation & purification ; Aurodox/pharmacology ; Drug Evaluation, Preclinical ; Escherichia coli/drug effects ; Female ; Hemolysis/drug effects ; Inhibitory Concentration 50 ; Mice ; Streptomyces/metabolism ; Survival Analysis ; Treatment Outcome

المؤلفون: McHugh RE; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom., O'Boyle N; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Connolly JPR; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Hoskisson PA; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom., Roe AJ; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom Andrew.Roe@glasgow.ac.uk.

المصدر: Infection and immunity [Infect Immun] 2019 Jan 24; Vol. 87 (2). Date of Electronic Publication: 2019 Jan 24 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Aurodox/*pharmacology , Escherichia coli/*drug effects , Escherichia coli Proteins/*metabolism , Streptomyces/*metabolism , Type III Secretion Systems/*antagonists & inhibitors, Bacterial Translocation/drug effects ; Escherichia coli/metabolism ; Virulence/drug effects

المؤلفون: Smitka TA; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285., Bonjouklian R, Perun TJ Jr, Hunt AH, Boeck LV, Yao RC

المصدر: The Journal of antibiotics [J Antibiot (Tokyo)] 1992 Apr; Vol. 45 (4), pp. 433-43.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print Cited Medium: Print ISSN: 0021-8820 (Print) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

مواضيع طبية MeSH: Actinomyces/*chemistry , Aurodox/*analogs & derivatives , Aurodox/*isolation & purification, Anti-Bacterial Agents ; Aurodox/chemistry ; Aurodox/pharmacology ; Bacteria/drug effects ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Microbiological Techniques ; Molecular Weight ; Stereoisomerism

المؤلفون: Selva E; Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (Varese), Italy., Beretta G, Pallanza R, Goldstein BP, Berti M, Edwards DM, Denaro M

المصدر: The Journal of antibiotics [J Antibiot (Tokyo)] 1990 Nov; Vol. 43 (11), pp. 1349-58.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print Cited Medium: Print ISSN: 0021-8820 (Print) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

مواضيع طبية MeSH: Aurodox/*analogs & derivatives , Bacteria/*drug effects , Streptomyces/*classification, Animals ; Aurodox/chemistry ; Aurodox/isolation & purification ; Aurodox/pharmacokinetics ; Aurodox/pharmacology ; Aurodox/therapeutic use ; Chromatography, High Pressure Liquid ; Fermentation ; Haemophilus influenzae/drug effects ; Mice ; Molecular Structure ; Neisseria/drug effects ; Sepsis/drug therapy ; Soil Microbiology ; Streptococcus/drug effects ; Streptomyces/metabolism ; Ureaplasma/drug effects

المؤلفون: Hall CC; Roche Research Center, Nutley, New Jersey 07110., Watkins JD, Georgopapadakou NH

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1991 Nov; Vol. 35 (11), pp. 2366-70.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Aminoglycosides* , Peptides*, Anti-Bacterial Agents/*pharmacology , Aurodox/*analogs & derivatives , Escherichia coli/*metabolism , Peptide Elongation Factor Tu/*drug effects , Staphylococcus aureus/*metabolism, Adenosine Triphosphatases/metabolism ; Aurodox/pharmacology ; Chromatography, DEAE-Cellulose ; Drug Resistance, Microbial ; Escherichia coli/drug effects ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/metabolism ; Molecular Weight ; Peptide Biosynthesis ; Peptide Elongation Factor Tu/isolation & purification ; Pyridones/pharmacology ; Staphylococcus aureus/drug effects

المؤلفون: Ferrari P; MDRI--Lepetit Research Center, Gerenzano, Italy., Edwards D, Gallo GG, Selva E

المصدر: The Journal of antibiotics [J Antibiot (Tokyo)] 1990 Nov; Vol. 43 (11), pp. 1359-66.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print Cited Medium: Print ISSN: 0021-8820 (Print) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

مواضيع طبية MeSH: Aurodox/*analogs & derivatives, Acid-Base Equilibrium ; Aurodox/chemistry ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Molecular Structure ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; Stereoisomerism

المؤلفون: Duncan MC; Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA., Wong WR, Dupzyk AJ, Bray WM, Linington RG, Auerbuch V

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014; Vol. 58 (2), pp. 1118-26. Date of Electronic Publication: 2013 Dec 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacterial Secretion Systems/*drug effects , NF-kappa B/*genetics , Pyridines/*pharmacology , Yersinia pseudotuberculosis/*drug effects, Actinomycetales/chemistry ; Animals ; Anti-Bacterial Agents/isolation & purification ; Aurodox/pharmacology ; Bacterial Outer Membrane Proteins/antagonists & inhibitors ; Bacterial Outer Membrane Proteins/metabolism ; CHO Cells ; Cricetulus ; Dose-Response Relationship, Drug ; Gene Expression Regulation ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; NF-kappa B/metabolism ; Protein Transport/drug effects ; Pyridines/isolation & purification ; Yersinia pseudotuberculosis/metabolism