المؤلفون: Di Wu, Hui Li, Hongqin Yang, Qingle Zeng, Ze He

المصدر: Journal of Pharmaceutical and Biomedical Analysis. 178:112962

مصطلحات موضوعية: Circular dichroism, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Serum Albumin, Human, Molecular Dynamics Simulation, 01 natural sciences, Piperazines, Fluorescence spectroscopy, Analytical Chemistry, Molecular dynamics, Drug Discovery, medicine, Humans, Protein Kinase Inhibitors, Spectroscopy, Binding Sites, 010405 organic chemistry, Kinase, Chemistry, Circular Dichroism, 010401 analytical chemistry, Human serum albumin, Fluorescence, 0104 chemical sciences, Molecular Docking Simulation, body regions, Spectrometry, Fluorescence, Aurora kinase inhibitor MK-0457, Docking (molecular), embryonic structures, Biophysics, Thermodynamics, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ae432468fb66b92dde7ff741c79f04
https://doi.org/10.1016/j.jpba.2019.112962

المؤلفون: Yan Zhao, Xian Ren Wang, Xiang Bo Wan, Xue Fei Huang, Zi Jie Long, Liu Li, Ming Huang Hong, Min Yan, Xiao Feng Zhu, Jie Xu, Liang Ping Xia, Quentin Liu

المصدر: Carcinogenesis. 29:1930-1937

مصطلحات موضوعية: Cancer Research, MAP Kinase Signaling System, Nasopharyngeal neoplasm, Down-Regulation, Apoptosis, Protein Serine-Threonine Kinases, Biology, Epithelium, Piperazines, Mesoderm, Aurora Kinases, Cell Line, Tumor, Nitriles, Butadienes, medicine, Humans, Neoplasm Invasiveness, Centrosome duplication, Epithelial–mesenchymal transition, Phosphorylation, RNA, Small Interfering, Protein kinase A, Mitosis, beta Catenin, Neoplasm Staging, Nasopharyngeal Neoplasms, General Medicine, Middle Aged, Cadherins, medicine.disease, Nasopharyngeal carcinoma, Aurora kinase inhibitor MK-0457, Cancer cell, Cancer research, Mitogen-Activated Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944bbe1893ac6cc7b5f9daccd77d17c2
https://doi.org/10.1093/carcin/bgn176

المؤلفون: Maria Alessandra Santucci, Chiara Marcozzi, Manuela Mancini, Elisa Leo, Enza Barbieri, Michela Aluigi, Enrica Borsi

المساهمون: Manuela Mancini, Elisa Leo, Michela Aluigi, Chiara Marcozzi, Enrica Borsi, Enza Barbieri, Maria Alessandra Santucci

مصطلحات موضوعية: Transcriptional Activation, Cancer Research, Fusion Proteins, bcr-abl, Antineoplastic Agents, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Biology, Piperazines, Epigenesis, Genetic, Histones, Mice, Histone H3, Aurora kinase, Aurora Kinases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Transcriptional regulation, Animals, Humans, Promoter Regions, Genetic, Protein Kinase Inhibitors, Transcription factor, Cells, Cultured, Gene Expression Regulation, Leukemic, Nuclear Proteins, Promoter, Hematology, Up-Regulation, Chromatin, Oncology, Aurora kinase inhibitor MK-0457, Drug Resistance, Neoplasm, Cancer research, K562 Cells, Tyrosine kinase, CHRONIC MYELOID LEUKEMIA (CML), Octamer Transcription Factor-1

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0667c9ed3886f5851b23bb253c430ca
http://hdl.handle.net/11585/384294

المؤلفون: Chiara Marcozzi, Maria Alessandra Santucci, Michela Aluigi, Manuela Mancini, Enza Barbieri, Elisa Leo, Fausto Castagnetti

المساهمون: Mancini M., Aluigi M., Leo E., Marcozzi C., Castagnetti F., Barbieri E., Santucci MA.

مصطلحات موضوعية: AURORA KINASES, Aurora inhibitor, IMATINIB MESYLATE, Protein Serine-Threonine Kinases, Chronic myeloid leukaemia, Piperazines, Histones, Mice, Histone H3, Bcr abl1, CHROMATIN MODIFICATIONS, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Animals, Humans, Protein Kinase Inhibitors, BCR-ABL, Chemistry, Imatinib, Hematology, Pyrimidines, Imatinib mesylate, Aurora kinase inhibitor MK-0457, Drug Resistance, Neoplasm, Covalent bond, Benzamides, Cancer research, CHRONIC MYELOID LEUKEMIA (CML), medicine.drug

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6890741abe25ba3ab0c00048077045
http://hdl.handle.net/11585/131369

المؤلفون: Diane Giannola, Luke F. Peterson, Nicholas J. Donato, Moshe Talpaz, Hanshi Sun, Dexing Fang

المصدر: Biochemical pharmacology. 79(5)

مصطلحات موضوعية: Cell Survival, DNA Mutational Analysis, Aurora inhibitor, Fusion Proteins, bcr-abl, Antineoplastic Agents, Apoptosis, Biology, Protein Serine-Threonine Kinases, Biochemistry, Piperazines, chemistry.chemical_compound, Aurora kinase, Aurora Kinases, hemic and lymphatic diseases, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Gene Silencing, Kinase activity, Enzyme Inhibitors, VX-680, neoplasms, Pharmacology, Cyclin-dependent kinase 2, Imatinib, Protein-Tyrosine Kinases, Genes, p53, Gene Expression Regulation, Neoplastic, Imatinib mesylate, Pyrimidines, Aurora kinase inhibitor MK-0457, chemistry, Drug Resistance, Neoplasm, Benzamides, Cancer research, biology.protein, Imatinib Mesylate, medicine.drug, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fec6db4f15d2f966cdfeb02778cadb4
https://pubmed.ncbi.nlm.nih.gov/19874801

المؤلفون: Thomas Hielscher, Axel Benner, Jonathon Blake, Thomas Möhler, Vladimir Benes, Thierry Rème, Jürgen Zimmermann, John De Vos, Alwin Krämer, Anja Seckinger, Bart Barlogie, Hartmut Goldschmidt, Jean François Rossi, Tobias Meissner, Michael Hundemer, Kai Neben, Bernard Klein, Anna Jauch, Uta Bertsch, Joe Lewis, Jérôme Moreaux, Jens Hillengass, Dirk Hose, John D. Shaughnessy

المساهمون: Department of Internal Medicine V, Universität Heidelberg [Heidelberg], Nationales Centrum für Tumorerkrankungen, Institut de recherche en biothérapie (IRB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), European Molecular Biology Laboratory [Heidelberg] (EMBL), Abteilung für Biostatistik, Deutsches Krebsforschungszentrum Heidelberg, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences (UAMS), Institut für Humangenetik, This work was supported in part by grants from the Hopp-Foundation, Germany, the University of Heidelberg, Germany, the National Centre for Tumor Diseases, Heidelberg, Germany, the Tumorzentrum Heidelberg/Mannheim, Germany, the European Myeloma Stem Cell Network (MSCNET) funded within the 6th framework program of the European Community, the Deutsche Krebshilfe, Bonn, Germany, the Ligue Nationale Contre Le Cancer (équipe labellisée), Paris, France. It is also part of a national program called 'Carte d'Identité des Tumeurs' (CIT) funded by the Ligue Nationale Contre le Cancer, France., Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Frei, Monique

المصدر: Blood
Blood, American Society of Hematology, 2009, 113 (18), pp.4331-4340. ⟨10.1182/blood-2008-09-178350⟩

مصطلحات موضوعية: Apoptosis, Biochemistry, Piperazines, 0302 clinical medicine, Aurora kinase, Aurora Kinases, Bone Marrow, Risk Factors, Chromosome instability, hemic and lymphatic diseases, Tumor Cells, Cultured, Aurora Kinase C, Multiple myeloma, In Situ Hybridization, Fluorescence, Oligonucleotide Array Sequence Analysis, 0303 health sciences, Hematology, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, Flow Cytometry, Prognosis, Combined Modality Therapy, 3. Good health, 030220 oncology & carcinogenesis, Multiple Myeloma, medicine.medical_specialty, Immunology, Blotting, Western, Aurora inhibitor, Biology, Protein Serine-Threonine Kinases, Transplantation, Autologous, Article, 03 medical and health sciences, Internal medicine, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Interphase, 030304 developmental biology, Cell Proliferation, Chromosome Aberrations, Gene Expression Profiling, Cell Biology, medicine.disease, Molecular biology, Aurora kinase inhibitor MK-0457, Cancer research, Fluorescence in situ hybridization, Stem Cell Transplantation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f70ba291d9d5252d6d852c8d491bd74
https://www.hal.inserm.fr/inserm-00368414/document

المؤلفون: Twee Tsao, Michael Andreeff, Marina Konopleva, Kensuke Kojima, Hideki Nakakuma

مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, Programmed cell death, Cell cycle checkpoint, Immunology, Aurora inhibitor, Mitosis, Apoptosis, Biology, Protein Serine-Threonine Kinases, Biochemistry, Piperazines, Aurora kinase, Aurora Kinases, Cell Line, Tumor, Gene Duplication, Humans, Neoplasia, Kinase, G1 Phase, Imidazoles, Drug Synergism, Proto-Oncogene Proteins c-mdm2, Cell Biology, Hematology, DNA, Neoplasm, Cell cycle, Mitochondria, enzymes and coenzymes (carbohydrates), Leukemia, Myeloid, Acute, Aurora kinase inhibitor MK-0457, Drug Resistance, Neoplasm, Cancer research, Signal transduction, Tumor Suppressor Protein p53

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad51c94da79b992f0481fd1ffbad2cc5
https://europepmc.org/articles/PMC2556624/

المؤلفون: Valentina Agnese, Daniele Santini, Daniele Fanale, Giuseppe Colucci, Vincenzo Adamo, Viviana Bazan, Francesco Fiorentino, Giuseppe Badalamenti, Antonio Russo

المساهمون: AGNESE V, BAZAN V, FIORENTINO FP, FANALE D, BADALAMENTI G, COLUCCI G, ADAMO V, SANTINI D, RUSSO A

مصطلحات موضوعية: Aurora inhibitor, Antineoplastic Agents, macromolecular substances, Protein Serine-Threonine Kinases, Biology, chemistry.chemical_compound, Aurora kinase, Aurora Kinases, Neoplasms, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Mitosis, Hematology, Cell biology, ZM447439, Aurora-A, cancer treatment, kinase inhibitor, mitosis, small molecule, enzymes and coenzymes (carbohydrates), Spindle checkpoint, Nocodazole, Oncology, Aurora kinase inhibitor MK-0457, chemistry, embryonic structures, biological phenomena, cell phenomena, and immunity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f521b212e6c29975cc4c77081ccc29
http://hdl.handle.net/11573/1642361

المؤلفون: A. Haregewoin, M.W. Harding, R.R. Hoover

المصدر: European Journal of Cancer Supplements. 5:66-67

مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, Oncology, Docetaxel, Aurora kinase inhibitor MK-0457, Chemistry, medicine, Cancer research, VX-680, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e375959c2609ce4740a2c712d9f415b6
https://doi.org/10.1016/s1359-6349(07)70354-3

المؤلفون: Kung Chao Chang, Hui Ju Lin, Ya-Ping Chen, Jiann Shiuh Chen, Ming-Ying Tsai, Liang Yi Hung, Tsai Yun Chen

المصدر: Blood. 120:4907-4907

مصطلحات موضوعية: Gene knockdown, Kinase, Immunology, Aurora inhibitor, Cell Biology, Hematology, Biology, Cell cycle, Biochemistry, Molecular biology, Gene expression profiling, Aurora kinase, Aurora kinase inhibitor MK-0457, Cell culture

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9918ecd31a426a6254c415f4005b45f5
https://doi.org/10.1182/blood.v120.21.4907.4907