المؤلفون: Patidar K; Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA., Pillai N; Global DMPK Modeling & Simulation, Sanofi, 350 Water St, Cambridge, MA, 02141, USA., Dhakal S; Global DMPK Modeling & Simulation, Sanofi, 350 Water St, Cambridge, MA, 02141, USA., Avery LB; Global DMPK Innovation, Sanofi, Cambridge, MA, USA., Mavroudis PD; Global DMPK Modeling & Simulation, Sanofi, 350 Water St, Cambridge, MA, 02141, USA. panteleimon.mavroudis@sanofi.com.

المصدر: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2024 Feb 24. Date of Electronic Publication: 2024 Feb 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101096520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8744 (Electronic) Linking ISSN: 1567567X NLM ISO Abbreviation: J Pharmacokinet Pharmacodyn Subsets: MEDLINE

المؤلفون: de Witte WEA; Sanofi R&D, Ghent, Belgium. wilbert.dewitte@esqlabs.com.; esqLABS GmbH, Saterland, Germany. wilbert.dewitte@esqlabs.com., Avery LB; Sanofi R&D, Cambridge, USA., Mackness BC; Sanofi R&D, Cambridge, USA., Van Bogaert T; Sanofi R&D, Ghent, Belgium., Park A; Sanofi R&D, Cambridge, USA., Sargentini-Maier ML; Sanofi R&D, Ghent, Belgium.

المصدر: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2023 Jun; Vol. 50 (3), pp. 229-241. Date of Electronic Publication: 2023 Mar 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101096520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8744 (Electronic) Linking ISSN: 1567567X NLM ISO Abbreviation: J Pharmacokinet Pharmacodyn Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Fc*/metabolism , Antibodies, Monoclonal*/metabolism, Mice ; Animals ; Endosomes/metabolism ; Immunoglobulin G/metabolism

المؤلفون: Jones HM; BioMedicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA., Zhang Z; RES Group Inc, Needham, Massachusetts, USA., Jasper P; RES Group Inc, Needham, Massachusetts, USA., Luo H; RES Group Inc, Needham, Massachusetts, USA., Avery LB; DMPK, Sanofi, Waltham, Massachusetts, USA., King LE; BioMedicine Design, Pfizer Worldwide R&D, Andover, Massachusetts, USA., Neubert H; BioMedicine Design, Pfizer Worldwide R&D, Andover, Massachusetts, USA., Barton HA; BioMedicine Design, Pfizer Worldwide R&D, Groton, Connecticut, USA., Betts AM; BioMedicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA., Webster R; BioMedicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Oct; Vol. 8 (10), pp. 738-747. Date of Electronic Publication: 2019 Sep 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacokinetics , Histocompatibility Antigens Class I/*genetics , Histocompatibility Antigens Class I/*metabolism , Receptors, Fc/*genetics , Receptors, Fc/*metabolism, Animals ; Antibodies, Monoclonal/pharmacology ; Homozygote ; Humans ; In Vitro Techniques ; Linear Models ; Mice ; Mice, Transgenic ; Models, Biological ; Organ Specificity ; Species Specificity

المؤلفون: Betts A; a Department of Biomedicine Design , Pfizer Inc. , Cambridge , MA , USA., Keunecke A; b LAP&P , The Netherlands., van Steeg TJ; b LAP&P , The Netherlands., van der Graaf PH; c Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research , RA Leiden , The Netherlands., Avery LB; d Department of Biomedicine Design , Pfizer Inc. , Andover , MA , USA., Jones H; a Department of Biomedicine Design , Pfizer Inc. , Cambridge , MA , USA., Berkhout J; b LAP&P , The Netherlands.

المصدر: MAbs [MAbs] 2018 Jul; Vol. 10 (5), pp. 751-764. Date of Electronic Publication: 2018 May 14.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Algorithms* , Models, Biological*, Antibodies, Monoclonal/*immunology , Antibodies, Monoclonal/*pharmacokinetics, Animals ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immunoglobulin G/immunology ; Macaca fascicularis ; Metabolic Clearance Rate ; Mice, Transgenic ; Receptors, Fc/genetics ; Receptors, Fc/metabolism ; Species Specificity ; Tissue Distribution

المؤلفون: Avery LB; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Wade J; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Wang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Tam A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., King A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Piche-Nicholas N; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Kavosi MS; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Penn S; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.; c Medicine Design, Pfizer Inc. , Cambridge , MA , USA., Cirelli D; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA., Kurz JC; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Zhang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Cunningham O; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., Jones R; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.; f Currently Medicine Design, Pfizer Inc. , La Jolla , CA , USA., Fennell BJ; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., McDonnell B; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., Sakorafas P; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA., Apgar J; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Finlay WJ; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.; g Currently CodeBase , Edinburgh , UK., Lin L; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Bloom L; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., O'Hara DM; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.

المصدر: MAbs [MAbs] 2018 Feb/Mar; Vol. 10 (2), pp. 244-255. Date of Electronic Publication: 2018 Jan 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: In Vitro Techniques* , Models, Animal*, Antibodies, Monoclonal/*pharmacokinetics , Drug Discovery/*methods, Animals ; Humans ; Mice ; Mice, Transgenic

المؤلفون: Piche-Nicholas NM; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Avery LB; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA., King AC; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Kavosi M; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Wang M; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA., O'Hara DM; b BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Tchistiakova L; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Katragadda M; a BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.

المصدر: MAbs [MAbs] 2018 Jan; Vol. 10 (1), pp. 81-94. Date of Electronic Publication: 2017 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacokinetics , Complementarity Determining Regions/*metabolism , Histocompatibility Antigens Class I/*metabolism , Immunoglobulin G/*metabolism , Receptors, Fc/*metabolism, Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Binding Sites, Antibody ; CHO Cells ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Cricetulus ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Male ; Mice, Transgenic ; Mutation ; Pharmacogenomic Variants ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, Fc/genetics ; Receptors, Fc/immunology

المؤلفون: Avery LB; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Wang M; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Kavosi MS; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Joyce A; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Kurz JC; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Fan YY; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Dowty ME; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Zhang M; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Zhang Y; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Cheng A; b Pharmaceutical Sciences Analytical R&D, Pfizer Inc. , Andover , MA , USA., Hua F; c PharmaTherapeutics Clinical R&D, Pfizer Inc. , Technology Square, Cambridge , MA , USA., Jones HM; d Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Cambridge , MA , USA., Neubert H; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA., Polzer RJ; d Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Cambridge , MA , USA., O'Hara DM; a Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc. , Andover , MA , USA.

المصدر: MAbs [MAbs] 2016 Aug-Sep; Vol. 8 (6), pp. 1064-78. Date of Electronic Publication: 2016 May 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacokinetics , Drug Discovery/*methods , Histocompatibility Antigens Class I/*genetics , Receptors, Fc/*genetics, Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/analysis ; Chromatography, Liquid ; Hemizygote ; Homozygote ; Humans ; Macaca fascicularis ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Animal ; Predictive Value of Tests ; Tandem Mass Spectrometry

المؤلفون: Fan YY; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA., Avery LB; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA., Wang M; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA., O'Hara DM; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA., Leung S; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA., Neubert H; a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA.

المصدر: MAbs [MAbs] 2016 Jul; Vol. 8 (5), pp. 848-53. Date of Electronic Publication: 2016 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Histocompatibility Antigens Class I/*analysis , Histocompatibility Antigens Class I/*biosynthesis , Receptors, Fc/*analysis , Receptors, Fc/*biosynthesis, Animals ; Chromatography, Affinity/methods ; Humans ; Mass Spectrometry/methods ; Mice ; Mice, Transgenic

المؤلفون: Surcel A; Departments of Cell Biology, asurcel1@jhmi.edu dnr@jhmi.edu., Ng WP; Departments of Cell Biology., West-Foyle H; Departments of Cell Biology., Zhu Q; Pathology, and., Ren Y; Departments of Cell Biology., Avery LB; Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;, Krenc AK; Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637., Meyers DJ; Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;, Rock RS; Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637., Anders RA; Pathology, and., Freel Meyers CL; Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;, Robinson DN; Departments of Cell Biology, Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218; and asurcel1@jhmi.edu dnr@jhmi.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Feb 03; Vol. 112 (5), pp. 1428-33. Date of Electronic Publication: 2015 Jan 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Myosin Type II/*drug effects, Acetophenones/pharmacology ; Carbamates/pharmacology ; HEK293 Cells ; HL-60 Cells ; Humans ; Myosin Type II/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Cells, Cultured

المؤلفون: Prusevich P; Department of Pharmacology, ∥Center for Epigenetics and Department of Medicine, ⊥Department of Ophthalmology, and ¶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States., Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA

المصدر: ACS chemical biology [ACS Chem Biol] 2014 Jun 20; Vol. 9 (6), pp. 1284-93. Date of Electronic Publication: 2014 Apr 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Histone Demethylases/*antagonists & inhibitors , Neurons/*drug effects , Phenelzine/*analogs & derivatives, Animals ; Blotting, Western ; Cell Survival ; Cells, Cultured ; DNA Methylation/drug effects ; Embryo, Mammalian/cytology ; Embryo, Mammalian/drug effects ; Embryo, Mammalian/enzymology ; Fetus/cytology ; Fetus/drug effects ; Fetus/enzymology ; Histones/metabolism ; Humans ; Monoamine Oxidase/chemistry ; Neurons/cytology ; Neurons/enzymology ; Phenelzine/pharmacology ; Rats ; Rats, Sprague-Dawley