المؤلفون: Awasthi BP; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Chaudhary P; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Lim D; Innovo Therapeutics Inc., Daeduck Biz Center C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Republic of Korea., Yadav K; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Lee IH; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Banskota S; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Chaudhary CL; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Karmacharya U; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Lee J; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Im SM; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do 15588, Republic of Korea., Nam Y; Bio Industry Department, Gyeonggido Business & Science Accelerator, Suwon 16229, Republic of Korea., Eun JW; Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu 41944, Republic of Korea., Lee S; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do 15588, Republic of Korea., Lee JM; Cell & Matrix Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea., Kim ES; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea., Ryou C; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do 15588, Republic of Korea., Kim TH; Innovo Therapeutics Inc., Daeduck Biz Center C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Republic of Korea., Park HD; Innovo Therapeutics Inc., Daeduck Biz Center C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Republic of Korea., Kim JA; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Nam TG; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do 15588, Republic of Korea., Jeong BS; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10601-10621. Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, G-Protein-Coupled*/antagonists & inhibitors , Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/agonists , Inflammatory Bowel Diseases*/drug therapy , Inflammatory Bowel Diseases*/metabolism , Receptors, Estrogen*/metabolism , Receptors, Estrogen*/antagonists & inhibitors, Humans ; Animals ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Interleukin-6/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Mice ; Molecular Docking Simulation ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/chemical synthesis ; Pyridines/pharmacology ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/therapeutic use ; Mice, Inbred C57BL ; Structure-Activity Relationship

المؤلفون: Majhi S; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201 002, India., Awasthi BP; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201 002, India., Sharma RK; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201 002, India., Mitra K; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201 002, India.

المصدر: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada [Microsc Microanal] 2024 Jul 04; Vol. 30 (3), pp. 521-538.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9712707 Publication Model: Print Cited Medium: Internet ISSN: 1435-8115 (Electronic) Linking ISSN: 14319276 NLM ISO Abbreviation: Microsc Microanal Subsets: MEDLINE

مواضيع طبية MeSH: Leishmania donovani*/drug effects , Leishmania donovani*/physiology , Mitochondria*/drug effects , Mitochondria*/ultrastructure , Apoptosis*/drug effects , Antiprotozoal Agents*/pharmacology , Naphthoquinones*/pharmacology, Caspases/metabolism ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission

المؤلفون: Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Jee JG; College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea., Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: jakim@yu.ac.kr., Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: jeongb@ynu.ac.kr.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2023 Jan 05; Vol. 369, pp. 110255. Date of Electronic Publication: 2022 Nov 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/drug therapy, Humans ; Macrophage Colony-Stimulating Factor/genetics ; Macrophage Colony-Stimulating Factor/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/metabolism

المؤلفون: Chaudhary CL; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Lim D; Innovo Therapeutics Inc, Daejeon, Republic of Korea., Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Park HD; Innovo Therapeutics Inc, Daejeon, Republic of Korea., Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 844-856.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Carcinoma, Hepatocellular/*drug therapy , Liver Neoplasms/*drug therapy , Pyridines/*pharmacology , Pyrimidines/*pharmacology, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Chickens ; Dose-Response Relationship, Drug ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Models, Molecular ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea., Lee H; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea.; Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA., Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Mar 23; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Pyridoxine* , Pyrroles*, Oxazoles

المؤلفون: Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Jee JG; College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea., Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea., Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1884-1897.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Carcinoma, Hepatocellular/*pathology , Liver Neoplasms/*pathology , Pyrimidines/*chemistry , Sorafenib/*chemistry, Animals ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chick Embryo ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays

المؤلفون: Karmacharya U; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Regmi SC; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Awasthi BP; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Chaudhary P; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Kim YE; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea., Lee IH; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea., Nam TG; Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea. Electronic address: tnam@hanyang.ac.kr., Kim JA; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: jakim@yu.ac.kr., Jeong BS; College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: jeongb@ynu.ac.kr.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jul 01; Vol. 43, pp. 128059. Date of Electronic Publication: 2021 Apr 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Acetamides/*pharmacology , Colitis/*drug therapy , Interleukin-6/*antagonists & inhibitors , Tumor Necrosis Factor-alpha/*antagonists & inhibitors, Acetamides/chemical synthesis ; Acetamides/chemistry ; Animals ; Cell Adhesion/drug effects ; Colitis/chemically induced ; Colitis/metabolism ; Dose-Response Relationship, Drug ; Interleukin-6/metabolism ; Molecular Structure ; Rats ; Structure-Activity Relationship ; Trinitrobenzenesulfonic Acid ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Karmacharya U; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea., Chaudhary P; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea., Lim D; Innovo Therapeutics Inc., Daeduck Biz Center C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Republic of Korea., Dahal S; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea., Awasthi BP; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea., Park HD; Innovo Therapeutics Inc., Daeduck Biz Center C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Republic of Korea., Kim JA; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea. Electronic address: jakim@yu.ac.kr., Jeong BS; College of Pharmacy, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea. Electronic address: jeongb@ynu.ac.kr.

المصدر: Bioorganic chemistry [Bioorg Chem] 2021 May; Vol. 110, pp. 104805. Date of Electronic Publication: 2021 Mar 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antineoplastic Agents/*pharmacology , Piperidines/*pharmacology , Prostatic Neoplasms/*drug therapy , Pyridines/*pharmacology , Receptor, Muscarinic M3/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Receptor, Muscarinic M3/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: Awasthi BP; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226 031, India., Mitra K; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226 031, India. k_mitra@cdri.res.in.; Academy of Scientific and Innovative Research, Chennai, 600113, India. k_mitra@cdri.res.in.

المصدر: Apoptosis : an international journal on programmed cell death [Apoptosis] 2018 Aug; Vol. 23 (7-8), pp. 420-435.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Homeostasis/*drug effects , Mitochondria/*drug effects , Natamycin/*pharmacology, Animals ; Calcium/metabolism ; Cytosol/metabolism ; Leishmania donovani/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism

المؤلفون: Awasthi BP; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research, Chennai, 600113, India., Kathuria M; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India., Pant G; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India., Kumari N; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India., Mitra K; Electron Microscopy Unit, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, 226031, India. k_mitra@cdri.res.in.; Academy of Scientific and Innovative Research, Chennai, 600113, India. k_mitra@cdri.res.in.

المصدر: Apoptosis : an international journal on programmed cell death [Apoptosis] 2016 Aug; Vol. 21 (8), pp. 941-53.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Cell Death/*drug effects , Leishmania donovani/*drug effects , Mitochondria/*drug effects , Naphthoquinones/*pharmacology, Adenosine Triphosphate/metabolism ; Annexin A5/metabolism ; Calcium/metabolism ; Caspases/metabolism ; Cells, Cultured ; Cytosol/drug effects ; Cytosol/metabolism ; Fluorescein-5-isothiocyanate/analogs & derivatives ; Fluorescein-5-isothiocyanate/metabolism ; In Situ Nick-End Labeling/methods ; Leishmania donovani/metabolism ; Lipid Peroxidation/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; NADH, NADPH Oxidoreductases/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism