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المؤلفون: Douglas LEJ; School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK., Reihill JA; School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK., Ho MWY; GlaxoSmithKline Research and Development, Collegeville, PA 19426, USA., Axten JM; GlaxoSmithKline Research and Development, Collegeville, PA 19426, USA., Campobasso N; GlaxoSmithKline Research and Development, Collegeville, PA 19426, USA., Schneck JL; GlaxoSmithKline Research and Development, Collegeville, PA 19426, USA., Rendina AR; GlaxoSmithKline Research and Development, Collegeville, PA 19426, USA., Wilcoxen KM; Boston Pharmaceuticals, Cambridge, MA 02142, USA., Martin SL; School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. Electronic address: l.martin@qub.ac.uk.

المصدر: Cell chemical biology [Cell Chem Biol] 2022 Jun 16; Vol. 29 (6), pp. 947-957.e8. Date of Electronic Publication: 2022 Feb 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/metabolism , Furin*/antagonists & inhibitors, Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Humans ; Mucociliary Clearance

المؤلفون: Koren SA; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA., Hamm MJ; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA., Cloyd R; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Fontaine SN; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Chishti E; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Lanzillotta C; Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy., Rodriguez-Rivera J; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Ingram A; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Bell M; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Galvis-Escobar SM; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA., Zulia N; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA., Di Domenico F; Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy., Duong D; Department of Biochemistry and Emory Integrated Proteomics Core, Emory University School of Medicine, Atlanta, GA 30322, USA., Seyfried NT; Department of Biochemistry and Emory Integrated Proteomics Core, Emory University School of Medicine, Atlanta, GA 30322, USA., Powell D; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY 40504, USA., Vandsburger M; Department of Bioengineering, University of California, Berkeley, CA 94720, USA., Frolinger T; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hartz AMS; Sanders Brown Center on Aging & Department of Physiology, University of Kentucky, Lexington, KY 40504, USA., Koren J 3rd; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA., Axten JM; GlaxoSmithKline, Research and Development, King of Prussia, PA 19406, USA., Laping NJ; GlaxoSmithKline, Research and Development, King of Prussia, PA 19406, USA., Abisambra JF; Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32669, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 26; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Neurons/*drug effects , Neurons/*metabolism , Protein Kinase Inhibitors/*pharmacology , Tauopathies/*etiology , Tauopathies/*metabolism, Animals ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Mice ; Mice, Transgenic ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Phosphorylation ; Protein Kinase Inhibitors/therapeutic use ; Proteome ; Proteomics/methods ; Severity of Illness Index ; Tauopathies/diagnosis ; Tauopathies/drug therapy ; Unfolded Protein Response ; eIF-2 Kinase/metabolism ; tau Proteins/metabolism

المؤلفون: Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. chetz@med.uchile.cl.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. chetz@med.uchile.cl.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. chetz@med.uchile.cl.; Buck Institute for Research on Aging, Novato, CA, USA. chetz@med.uchile.cl.; Department of Immunology and Infectious diseases, Harvard School of Public Health, Boston, MA, USA. chetz@med.uchile.cl., Axten JM; Medicinal Chemistry, Medicine Design, GlaxoSmithKline, Collegeville, PA, USA. Jeffrey.M.Axten@gsk.com., Patterson JB; Orinove Inc., Newbury Park, CA, USA. jpatterson@orinove.com.

المصدر: Nature chemical biology [Nat Chem Biol] 2019 Nov; Vol. 15 (11), pp. 1129.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. chetz@med.uchile.cl.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. chetz@med.uchile.cl.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. chetz@med.uchile.cl.; Buck Institute for Research on Aging, Novato, CA, USA. chetz@med.uchile.cl.; Department of Immunology and Infectious diseases, Harvard School of Public Health, Boston, MA, USA. chetz@med.uchile.cl., Axten JM; Medicinal Chemistry, Medicine Design, GlaxoSmithKline, Collegeville, PA, USA. Jeffrey.M.Axten@gsk.com., Patterson JB; Orinove Inc., Newbury Park, CA, USA. jpatterson@orinove.com.

المصدر: Nature chemical biology [Nat Chem Biol] 2019 Aug; Vol. 15 (8), pp. 764-775. Date of Electronic Publication: 2019 Jul 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Delivery Systems* , Signal Transduction* , Unfolded Protein Response*, Animals ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/physiology ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism