المؤلفون: Roy S; Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. ssinha@rockefeller.edu., Axup JY, Forsyth JS, Goswami RK, Hutchins BM, Bajuri KM, Kazane SA, Smider VV, Felding BH, Sinha SC

المصدر: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Apr 11; Vol. 53 (30), pp. 4234-4237.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: PubMed not MEDLINE

المؤلفون: Wold ED; Department of Chemistry and the Skaggs Institute for Chemical Biology, ‡Department of Chemical Physiology, and §Department of Cell and Molecular Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Axup JY; Department of Chemistry and the Skaggs Institute for Chemical Biology, ‡Department of Chemical Physiology, and §Department of Cell and Molecular Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Felding BH; Department of Chemistry and the Skaggs Institute for Chemical Biology, ‡Department of Chemical Physiology, and §Department of Cell and Molecular Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Smider VV; Department of Chemistry and the Skaggs Institute for Chemical Biology, ‡Department of Chemical Physiology, and §Department of Cell and Molecular Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2015 Dec 16; Vol. 26 (12), pp. 2311-4. Date of Electronic Publication: 2015 Nov 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Folate Receptor 1/*metabolism , Folic Acid/*chemistry , Folic Acid/*pharmacology , Immunoglobulin Fc Fragments/*chemistry , Immunoglobulin Fc Fragments/*pharmacology , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology, Breast/drug effects ; Breast/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Female ; Humans

المؤلفون: Cao Y; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Axup JY; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Ma JS; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Wang RE; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Choi S; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Tardif V; Department of Immunology and Microbial Science, The Scripps Research Institute (USA)., Lim RK; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Pugh HM; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Lawson BR; Department of Immunology and Microbial Science, The Scripps Research Institute (USA)., Welzel G; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Kazane SA; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Sun Y; EuCode Technology, Ambrx, Inc. 10975 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Tian F; EuCode Technology, Ambrx, Inc. 10975 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Srinagesh S; EuCode Technology, Ambrx, Inc. 10975 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Javahishvili T; EuCode Technology, Ambrx, Inc. 10975 N Torrey Pines Rd, La Jolla, CA 92037 (USA)., Schultz PG; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037 (USA). Schultz@scripps.edu.; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA). Schultz@scripps.edu., Kim CH; California Institute for Biomedical Research, 11119 N Torrey Pines Rd, La Jolla, CA 92037 (USA). chkim@calibr.org.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Jun 08; Vol. 54 (24), pp. 7022-7. Date of Electronic Publication: 2015 Apr 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Bispecific/*chemistry , T-Lymphocytes/*metabolism, Animals ; Antibodies, Bispecific/immunology ; Antibodies, Bispecific/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CD3 Complex/immunology ; Cell Line, Tumor ; Female ; Humans ; Jurkat Cells ; Leukocytes, Mononuclear/immunology ; Mice ; Receptor, ErbB-2/immunology ; Receptors, Fc/chemistry ; Receptors, Fc/metabolism ; T-Lymphocytes/immunology ; Trastuzumab/chemistry ; Trastuzumab/immunology ; Xenograft Model Antitumor Assays

المؤلفون: Wold ED, McBride R, Axup JY, Kazane SA; ‡California Institute for Biomedical Research (Calibr), 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Smider VV

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2015 May 20; Vol. 26 (5), pp. 807-11. Date of Electronic Publication: 2015 Apr 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin Fab Fragments/*metabolism , Oligonucleotides/*metabolism , Protein Array Analysis/*methods, Binding Sites ; Cell Line, Tumor ; Cells, Immobilized/metabolism ; DNA/chemistry ; DNA/metabolism ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/immunology ; Models, Molecular ; Nucleic Acid Conformation ; Oligonucleotides/chemistry ; Phenylalanine/chemistry ; Receptor, ErbB-2/immunology ; Substrate Specificity

المؤلفون: Kim CH; Departments of Chemistry, Immunology and Microbial Science, and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Axup JY, Lawson BR, Yun H, Tardif V, Choi SH, Zhou Q, Dubrovska A, Biroc SL, Marsden R, Pinstaff J, Smider VV, Schultz PG

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Oct 29; Vol. 110 (44), pp. 17796-801. Date of Electronic Publication: 2013 Oct 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , Immunoglobulin Fab Fragments/*therapeutic use , Prostatic Neoplasms/*drug therapy, Animals ; CD3 Complex/immunology ; Heterografts/immunology ; Humans ; Immunoglobulin Fab Fragments/immunology ; Immunotherapy/methods ; Leukocytes, Mononuclear ; Male ; Mice ; Prostatic Neoplasms/immunology ; Protein Engineering

المؤلفون: Kim CH; California Institute for Biomedical Research, 11119 N. Torrey Pines Road, La Jolla, CA 92037, United States., Axup JY, Schultz PG

المصدر: Current opinion in chemical biology [Curr Opin Chem Biol] 2013 Jun; Vol. 17 (3), pp. 412-9. Date of Electronic Publication: 2013 May 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9811312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0402 (Electronic) Linking ISSN: 13675931 NLM ISO Abbreviation: Curr Opin Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids/*genetics , Genetic Engineering/*methods , Proteins/*chemistry, Amino Acids/chemistry ; Animals ; Humans

المؤلفون: Kazane SA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Axup JY, Kim CH, Ciobanu M, Wold ED, Barluenga S, Hutchins BA, Schultz PG, Winssinger N, Smider VV

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2013 Jan 09; Vol. 135 (1), pp. 340-6. Date of Electronic Publication: 2012 Dec 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin Fab Fragments/*chemistry , Peptide Nucleic Acids/*chemistry, Animals ; Cell Line, Tumor ; Dimerization ; Dose-Response Relationship, Drug ; Humans ; Immunoglobulin Fab Fragments/pharmacology ; Leukocytes, Mononuclear/drug effects ; Mice ; Models, Molecular ; Molecular Structure ; Peptide Nucleic Acids/pharmacology ; Structure-Activity Relationship ; T-Lymphocytes/drug effects

المؤلفون: Axup JY; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, Halder R, Forsyth JS, Santidrian AF, Stafin K, Lu Y, Tran H, Seller AJ, Biroc SL, Szydlik A, Pinkstaff JK, Tian F, Sinha SC, Felding-Habermann B, Smider VV, Schultz PG

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Oct 02; Vol. 109 (40), pp. 16101-6. Date of Electronic Publication: 2012 Sep 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids/*chemistry , Antibodies, Monoclonal, Humanized/*chemistry , Breast Neoplasms/*drug therapy , Immunoconjugates/*chemistry , Protein Engineering/*methods, Aminobenzoates/chemistry ; Animals ; Cell Line, Tumor ; Drug Discovery/methods ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli ; Female ; Humans ; Immunoconjugates/pharmacokinetics ; Immunoconjugates/therapeutic use ; Immunoglobulin G/chemistry ; Mice ; Mice, SCID ; Oligopeptides/chemistry ; Receptor, ErbB-2/chemistry ; Receptor, ErbB-2/immunology ; Trastuzumab

المؤلفون: Kim CH; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA., Axup JY, Dubrovska A, Kazane SA, Hutchins BA, Wold ED, Smider VV, Schultz PG

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2012 Jun 20; Vol. 134 (24), pp. 9918-21. Date of Electronic Publication: 2012 Jun 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids/*chemistry , Antibodies, Bispecific/*chemistry , Antibodies, Bispecific/*immunology , CD3 Complex/*immunology , Receptor, ErbB-2/*immunology, Cell Line ; Cell Line, Tumor ; Cytotoxicity, Immunologic ; Humans ; Models, Molecular

المؤلفون: Thielges MC; Department of Chemistry, Stanford University, Stanford, California 94305, USA., Axup JY, Wong D, Lee HS, Chung JK, Schultz PG, Fayer MD

المصدر: The journal of physical chemistry. B [J Phys Chem B] 2011 Sep 29; Vol. 115 (38), pp. 11294-304. Date of Electronic Publication: 2011 Aug 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation*, Amino Acids/*chemistry , Myoglobin/*chemistry , Spectrophotometry, Infrared/*methods, Amino Acid Substitution ; Amino Acids/genetics ; Azides/chemistry ; Carbon Monoxide/chemistry ; Heme/chemistry ; Ligands ; Mutation ; Myoglobin/genetics ; Protein Binding ; Protein Conformation ; Spectroscopy, Fourier Transform Infrared ; Vibration