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1
المؤلفون: Takaaki Akasaka, Ryoichi Hamasuna, Hisami Aono, Masahiro Matsumoto, Jørgen Skov Jensen, Ikko Tomisaki, Hiroyuki Hanzawa, Ayako Moritomo, Naohiro Fujimoto
المصدر: Journal of Infection and Chemotherapy. 28:377-383
مصطلحات موضوعية: DNA Topoisomerase IV, Microbiology (medical), Sitafloxacin, Stereochemistry, Topoisomerase IV, Mycoplasma genitalium, Microbial Sensitivity Tests, DNA gyrase, Serine, 23S ribosomal RNA, Moxifloxacin, Drug Resistance, Bacterial, medicine, Humans, Mycoplasma Infections, Pharmacology (medical), Asparagine, biology, Chemistry, bacterial infections and mycoses, biology.organism_classification, Anti-Bacterial Agents, Infectious Diseases, DNA Gyrase, Mutation, biology.protein, Fluoroquinolones, medicine.drug
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2
المؤلفون: Itsuro Shimada, Ayako Moritomo, Yutaka Kondoh, Kazuo Kurosawa, Yoshinori Iwai, Takahiro Matsuya, Kazuhiko Iikubo, Hiroshi Tomiyama, Akio Kamikawa
المصدر: Bioorganic & Medicinal Chemistry. 27:1683-1692
مصطلحات موضوعية: medicine.drug_class, Recombinant Fusion Proteins, Transplantation, Heterologous, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Cell Cycle Proteins, Carboxamide, Echinoderm Microtubule-Associated Protein-Like 4, 01 natural sciences, Biochemistry, 3T3 cells, Mice, Structure-Activity Relationship, Oral administration, Cell Line, Tumor, Neoplasms, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Molecular Biology, Binding Sites, 010405 organic chemistry, Chemistry, Kinase, Serine Endopeptidases, Organic Chemistry, 3T3 Cells, medicine.disease, Amides, Protein Structure, Tertiary, 0104 chemical sciences, Lymphoma, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Solubility, Pyrazines, Cancer research, Molecular Medicine, Microtubule-Associated Proteins
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3
المؤلفون: Hidehiko Fukahori, Kaoru Yamagami, Satoshi Kubo, Yukihito Sugano, Fumie Takahashi, Ayako Moritomo, Koji Kato, Susumu Yamaki, Koji Nakamura, Koji Yokoo, Toshihiro Hamajima, Suzuki Daisuke
المصدر: Bioorganic & Medicinal Chemistry. 27:1056-1064
مصطلحات موضوعية: Gene isoform, Scaffold, Pyrrolidines, Pyrimidine, Class I Phosphatidylinositol 3-Kinases, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potency, Molecular Biology, Cells, Cultured, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, 010405 organic chemistry, Chemistry, Organic Chemistry, Highly selective, 0104 chemical sciences, Molecular Docking Simulation, Antibody production, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female
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4
المؤلفون: Koichiro Mukoyoshi, Kaoru Yamagami, Kousei Yoshihara, Koji Yokoo, Susumu Yamaki, Fumie Takahashi, Toshihiro Hamajima, Yukihito Sugano, Koji Kato, Hidehiko Fukahori, Ayako Moritomo
المصدر: Bioorganic & Medicinal Chemistry. 26:2410-2419
مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Pyridines, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Amide, Drug Discovery, Pyrazolopyridine, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Biological evaluation, Mice, Inbred BALB C, Molecular Structure, Chemistry, Organic Chemistry, Nuclear Proteins, Stereoisomerism, Molecular Docking Simulation, 030104 developmental biology, Pyrazoles, Molecular Medicine, Female, Selectivity, Transcription Factors
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5
المؤلفون: Hiroyuki Usuda, Fumihiro Nakamori, Takayuki Inoue, Hiroaki Tominaga, Yutaka Nakajima, Masamichi Inami, Ayako Moritomo, Misato Ito, Jun Maeda, Takeshi Hondo, Yasuyuki Higashi, Hiroki Morio, Koji Nakamura, Shohei Shirakami, Hiroaki Yamagishi
المصدر: Bioorganic & Medicinal Chemistry. 25:5311-5326
مصطلحات موضوعية: Male, 0301 basic medicine, Cell Membrane Permeability, Membrane permeability, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Polar surface area, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Adjuvants, Immunologic, Drug Discovery, medicine, Animals, Humans, Pyrroles, Protein Kinase Inhibitors, Molecular Biology, Janus Kinases, Janus kinase inhibitor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Graft Survival, Organic Chemistry, In vitro, Rats, Rats, Inbred ACI, Disease Models, Animal, 030104 developmental biology, Cytokine, chemistry, Rats, Inbred Lew, 030220 oncology & carcinogenesis, Heart Transplantation, Molecular Medicine, Female, Signal transduction, Janus kinase, Tricyclic
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6
المؤلفون: Ayako Moritomo, Kosei Yoshihara, Susumu Yamaki, Mitsuhiro Kondo, Yuji Koga, Yoshiaki Shimada, Keitaro Kadono, Akira Nagashima
المصدر: Bioorganic & Medicinal Chemistry. 25:4110-4122
مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Glycine, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Oral administration, Drug Discovery, medicine, Animals, Humans, Diabetic Nephropathies, Molecular Biology, Benzoic acid, Proteinuria, CYP3A4, 010405 organic chemistry, Organic Chemistry, Adhesion, bacterial infections and mycoses, Streptozotocin, medicine.disease, Rats, respiratory tract diseases, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Amine Oxidase (Copper-Containing), medicine.symptom, Cell Adhesion Molecules, Lead compound, medicine.drug
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7
المؤلفون: Ryosuke Munakata, Tsukasa Ishihara, Ayako Moritomo, Kenichi Mori
المصدر: Chem-Bio Informatics Journal. 17:1-18
مصطلحات موضوعية: 0301 basic medicine, Scaffold, medicine.drug_mechanism_of_action, Computer science, Factor Xa Inhibitor, computer.software_genre, Biochemistry, 03 medical and health sciences, 030104 developmental biology, Workflow, Fragment (logic), medicine, Data mining, computer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6fcd14a53c92219e26b8fa174fe0ea40
https://doi.org/10.1273/cbij.17.1 -
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المؤلفون: Daisuke Sasuga, Hirofumi Ishii, Ayako Moritomo, Kazuo Kurosawa, Ryota Shiraki, Tomoaki Kawano, Mitsuru Hosaka, Seiji Yoshimura, Takanori Koike, Hiroki Fukudome, Shinya Mimasu
المصدر: Chemicalpharmaceutical bulletin. 67(8)
مصطلحات موضوعية: Male, medicine.medical_treatment, Adipose tissue, Administration, Oral, Mice, Obese, Dehydrogenase, Pharmacology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Oral administration, Corticosterone, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Enzyme Inhibitors, Trifluoromethyl, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Insulin, Type 2 Diabetes Mellitus, General Chemistry, General Medicine, Triazoles, 0104 chemical sciences, HEK293 Cells, Diabetes Mellitus, Type 2, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e873e3ce1a9d632552b40556811975b
https://pubmed.ncbi.nlm.nih.gov/31366832 -
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المؤلفون: Toshihiro Hamajima, Fumie Takahashi, Yukihito Sugano, Susumu Yamaki, Satoshi Kubo, Kaoru Yamagami, Koji Kato, Koji Nakamura, Nozomu Hamakawa, Koji Yokoo, Hidehiko Fukahori, Ayako Moritomo
المصدر: Bioorganicmedicinal chemistry. 26(14)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Models, Molecular, Class I Phosphatidylinositol 3-Kinases, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, Pyrazolopyridine, Potency, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Computational Biology, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Microsome, Molecular Medicine, Pyrazoles, Female, Antibody, Selectivity
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المؤلفون: Kazuo Nakai, Hiroyuki Usuda, Keiko Hatanaka, Hiroshi Sasaki, Ayako Moritomo, Shohei Shirakami, Yutaka Nakajima, Takayuki Inoue, Koichiro Mukoyoshi, Hisao Hamaguchi, Yasuyuki Higashi, Akira Tanaka, Masamichi Inami, Shigeki Kunikawa, Fumie Takahashi
المصدر: Bioorganic & Medicinal Chemistry. 23:4871-4883
مصطلحات موضوعية: Graft Rejection, Male, Transplantation, Heterotopic, Pyridines, medicine.drug_class, T-Lymphocytes, T cell, Clinical Biochemistry, hERG, Administration, Oral, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, chemistry.chemical_compound, Dogs, Immune system, In vivo, Drug Discovery, medicine, Animals, Humans, Immunologic Factors, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Binding Sites, biology, Chemistry, Organic Chemistry, Janus Kinase 3, Haplorhini, Janus Kinase 1, Janus Kinase 2, Amides, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, medicine.anatomical_structure, Rats, Inbred Lew, Lipophilicity, Microsomes, Liver, biology.protein, Interleukin-2, Molecular Medicine, Janus kinase, Lead compound, Half-Life
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