يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Azusa Nozu"', وقت الاستعلام: 1.02s تنقيح النتائج
  1. 1
    Dioxotriazine derivatives as a new class of P2X

    المؤلفون: Hiroyuki, Kai, Tohru, Horiguchi, Takayuki, Kameyama, Kentaro, Asahi, Takeshi, Endoh, Sae, Jikihara, Tsuyoshi, Hasegawa, Satoru, Tanaka, Azusa, Nozu, Chie, Takeyama, Maki, Tomari, Fumiyo, Takahashi, Naomi, Tamura, Shigenori, Yagi, Tetsuji, Itoh, Yasuyoshi, Isou

    المصدر: Bioorganicmedicinal chemistry letters. 37

    مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Purinergic P2X Receptor Antagonists, Triazines, Microsomes, Liver, Administration, Oral, Animals, Humans, Neuralgia, Receptors, Purinergic P2X3, Rats

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a4019344e324f19935dc99174206a556
    https://pubmed.ncbi.nlm.nih.gov/33540044

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  2. 2
    Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

    المؤلفون: Maki Tomari, Sae Jikihara, Fumiyo Takahashi, Takeshi Endoh, Tetsuji Itoh, Takayuki Kameyama, Yasuyoshi Isou, Hiroyuki Kai, Azusa Nozu, Tohru Horiguchi, Tsuyoshi Hasegawa, Kentaro Asahi, Satoru Tanaka, Naomi Tamura, Shigenori Yagi, Chie Takeyama

    المصدر: Bioorganic & Medicinal Chemistry Letters. 37:127833

    مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Oral administration, Drug Discovery, medicine, Receptor, Molecular Biology, IC50, 010405 organic chemistry, Organic Chemistry, Purinergic receptor, Chronic pain, medicine.disease, 0104 chemical sciences, body regions, 010404 medicinal & biomolecular chemistry, Allodynia, chemistry, Neuropathic pain, Molecular Medicine, medicine.symptom, Lead compound

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::67f38922c44c9054af972ebfe45a6814
    https://doi.org/10.1016/j.bmcl.2021.127833

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  3. 3
    Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

    المؤلفون: Narumi Horita, Daiki Nagamatsu, Yasuhide Morioka, Miki Tanimura, Gaku Sakaguchi, Azusa Nozu, Yasuyoshi Iso, Toshiyuki Kanemasa, Natsue Yamanada, Mikie Hinata, Toshiyuki Asaki, Masayuki Imai, Hidetoshi Matsuda, Kenji Takaya, Osamu Yoshida, Hiromi Nakai, Akira Yukimasa, Shinji Suzuki, Masahiko Soga, Naoki Tsuno, Tomoyuki Ogawa, Hiroki Yamaguchi, Miyuki Yamamoto, Satoko Funaki, Motohiro Fujiu

    المصدر: Bioorganic & Medicinal Chemistry. 25:2177-2190

    مصطلحات موضوعية: 0301 basic medicine, Analgesic effect, TRPV4, Spectrometry, Mass, Electrospray Ionization, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Guinea Pigs, Clinical Biochemistry, TRPV Cation Channels, Pharmaceutical Science, Biochemistry, Guinea pig, Structure-Activity Relationship, 03 medical and health sciences, Mechanical Hyperalgesia, 0302 clinical medicine, Microsomes, Drug Discovery, Animals, Humans, Pain Management, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Antagonist, Complete adjuvant, Rats, Thiazoles, 030104 developmental biology, Molecular Medicine, Azabicyclo Compounds, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa29140063fa0c3811b33e5cee9b2d9e
    https://doi.org/10.1016/j.bmc.2017.02.047

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  4. 4
    Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2

    المؤلفون: Mikie Hinata, Toshiyuki Asaki, Miyuki Yamamoto, Azusa Nozu, Osamu Yoshida, Masayuki Imai, Gaku Sakaguchi, Satoko Funaki, Kenji Takaya, Yasuyoshi Iso, Narumi Horita, Akira Yukimasa, Shinji Suzuki, Naoki Tsuno, Hidetoshi Matsuda, Masahiko Soga, Toshiyuki Kanemasa, Daiki Nagamatsu, Motohiro Fujiu, Hiromi Nakai, Yasuhide Morioka, Hiroki Yamaguchi, Yoko Nishimura, Tetsuji Ito, Tomoyuki Ogawa

    المصدر: Bioorganicmedicinal chemistry letters. 26(20)

    مصطلحات موضوعية: 0301 basic medicine, TRPV4, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmacology, Biochemistry, Guinea pig, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Cricetinae, Drug Discovery, medicine, Structure–activity relationship, Animals, Thiazole, Molecular Biology, Chemistry, Drug discovery, Organic Chemistry, Bioavailability, Thiazoles, 030104 developmental biology, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07851f926e3ee62eead1648e33994ed6
    https://pubmed.ncbi.nlm.nih.gov/27634196

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