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1دورية أكاديمية
المؤلفون: Bérénice Hatat, Romain Boularand, Claire Bringuier, Nicolas Chanut, Stéphane Besnard, Andrea M. Mueller, Kathrin Weyer, Bernd Seilheimer, Brahim Tighilet, Christian Chabbert
المصدر: Frontiers in Neurology, Vol 13 (2022)
مصطلحات موضوعية: vestibular disorders, unilateral vestibular lesion, sequential bilateral lesion, central vestibular compensation, spatial cognitive deficits, natural drug, Neurology. Diseases of the nervous system, RC346-429
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Bérénice Hatat, Romain Boularand, Claire Bringuier, Nicolas Chanut, Christian Chabbert, Brahim Tighilet
المصدر: Biomedicines, Vol 10, Iss 9, p 2097 (2022)
مصطلحات موضوعية: vestibular disorders, vestibular compensation, vertigo, vestibular function recovery, fluoxetine, acacetin, Biology (General), QH301-705.5
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Bérénice Hatat, Samir Yahiaoui, Cédric Lecoutey, Audrey Davis, Thomas Freret, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne
المصدر: Frontiers in Aging Neuroscience, Vol 11 (2019)
مصطلحات موضوعية: Alzheimer’s disease, acetylcholinesterase, 5-HT4 receptors, 5-HT6 receptors, MTDL, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: François-Xavier Toublet, Cédric Lecoutey, Julien Lalut, Bérénice Hatat, Audrey Davis, Marc Since, Sophie Corvaisier, Thomas Freret, Jana Sopkova de Oliveira Santos, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagne, Christophe Rochais
المصدر: Molecules, Vol 24, Iss 15, p 2786 (2019)
مصطلحات موضوعية: Alzheimer’s disease, prodrug, acetylcholinesterase, 5-HT4 receptors, MTDL, Organic chemistry, QD241-441
وصف الملف: electronic resource
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المؤلفون: Thomas Freret, Michel Boulouard, Audrey Davis, Marc Since, Bérénice Hatat, Sylvie Claeysen, François-Xavier Toublet, Patrick Dallemagne, Julien Lalut, Jana Sopkova-de Oliveira Santos, Sophie Corvaisier, Christophe Rochais, Cédric Lecoutey
المساهمون: Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by funding from the Fondation Vaincre Alzheimer (#FR-15072) and the Fondation Plan Alzheimer (AAP2015 Project TRIAD 016). The authors gratefully acknowledge the Conseil Régional de Normandie, as well as the European Community (FEDER) for theircontribution to the CERMN’s analytical platform. European COST action CA15135 (Multi-Target Paradigm for Innovative Ligand Identification in the Drug Discovery Process, MuTaLig) supports this article. Part of this work was performed using computing resources of CRIANN (Normandy, France) as well as the European Community (FEDER) for the molecular modeling software. We thank Oksana Lockridge at Eppley Institute University of Nebraska Medical Center Omaha, for providing us human BuChE., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Guerineau, Nathalie C., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩مصطلحات موضوعية: [CHIM.THER] Chemical Sciences/Medicinal Chemistry, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Context (language use), Idalopirdine, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, 01 natural sciences, MTDL, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Prodrugs, Receptor, Butyrylcholinesterase, 030304 developmental biology, Cholinesterase, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Antagonist, General Medicine, 5-HT(6) receptors, Acetylcholinesterase, 3. Good health, 0104 chemical sciences, 5-HT6 receptor, biology.protein, Alzheimer’s disease
وصف الملف: application/pdf
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المؤلفون: François-Xavier, Toublet, Julien, Lalut, Bérénice, Hatat, Cédric, Lecoutey, Audrey, Davis, Marc, Since, Sophie, Corvaisier, Thomas, Freret, Jana, Sopková-de Oliveira Santos, Sylvie, Claeysen, Michel, Boulouard, Patrick, Dallemagne, Christophe, Rochais
المصدر: European journal of medicinal chemistry. 210
مصطلحات موضوعية: Male, Models, Molecular, Dose-Response Relationship, Drug, Molecular Structure, Mice, Structure-Activity Relationship, Alzheimer Disease, Butyrylcholinesterase, Drug Design, Receptors, Serotonin, Electrophorus, Animals, Humans, Prodrugs, Cholinesterase Inhibitors, Locomotion
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المؤلفون: Caroline, Lanthier, Hugo, Payan, Irene, Liparulo, Bérénice, Hatat, Cédric, Lecoutey, Marc, Since, Audrey, Davis, Christian, Bergamini, Sylvie, Claeysen, Patrick, Dallemagne, Maria-Laura, Bolognesi, Christophe, Rochais
المصدر: European journal of medicinal chemistry. 182
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Biphenyl Compounds, Ligands, Antioxidants, Serotonin 5-HT4 Receptor Agonists, Structure-Activity Relationship, Picrates, Alzheimer Disease, Cell Line, Tumor, COS Cells, Chlorocebus aethiops, Animals, Humans, Receptors, Serotonin, 5-HT4, Drug Screening Assays, Antitumor, Reactive Oxygen Species, Cell Proliferation
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المؤلفون: Bérénice, Hatat, Samir, Yahiaoui, Cédric, Lecoutey, Audrey, Davis, Thomas, Freret, Michel, Boulouard, Sylvie, Claeysen, Christophe, Rochais, Patrick, Dallemagne
المصدر: Frontiers in Aging Neuroscience
مصطلحات موضوعية: acetylcholinesterase, 5-HT6 receptors, Alzheimer’s disease, 5-HT4 receptors, MTDL, Neuroscience, Original Research
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المؤلفون: Irene Liparulo, Maria-Laura Bolognesi, Christophe Rochais, Christian Bergamini, Audrey Davis, Patrick Dallemagne, Hugo Payan, Bérénice Hatat, Caroline Lanthier, Cédric Lecoutey, Sylvie Claeysen, Marc Since
المساهمون: Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), University of Bologna, This work was supported by funding from the Fondation Plan Alzheimer (AAP2015 Project TRIAD 016). The authors gratefully acknowledge the Conseil Régional de Normandie, as well as the European Community (FEDER) for their contribution to the CERMN's analytical platform. European COST action CA15135 (Multi-Target Paradigm for Innovative Ligand Identification in the Drug Discovery Process, MuTaLig) supports this article with the funding of a Short-Term Scientific Mission attributed to CL, Lanthier, Caroline, Payan, Hugo, Liparulo, Irene, Hatat, Bérénice, Lecoutey, Cédric, Since, Marc, Davis, Audrey, Bergamini, Christian, Claeysen, Sylvie, Dallemagne, Patrick, Bolognesi, Maria-Laura, Rochais, Christophe
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩مصطلحات موضوعية: Antioxidant, antioxidant, medicine.medical_treatment, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Disease, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, medicine.disease_cause, Alzheimer's Disease, MTDL, 03 medical and health sciences, 0302 clinical medicine, Multi target, Aβ protein, Drug Discovery, medicine, phenol, 5-HT4 receptor, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Chemistry, Alzheimer's disease, 5-HT4 receptor, Antioxidant, Phenol, MTDL, Organic Chemistry, General Medicine, 3. Good health, Active compound, 030217 neurology & neurosurgery, Oxidative stress
وصف الملف: ELETTRONICO
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المؤلفون: Patrick Dallemagne, François-Xavier Toublet, Julien Lalut, Marc Since, Bérénice Hatat, Cédric Lecoutey, Thomas Freret, Jana Sopkova-de Oliveira Santos, Christophe Rochais, Audrey Davis, Sophie Corvaisier, Sylvie Claeysen, Michel Boulouard
المساهمون: Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by funding from the Fondation Vaincre Alzheimer (#FR-15072) and the Fondation Plan Alzheimer (AAP2015 Project TRIAD 016). The authors gratefully acknowledge the Conseil Régional de Normandie, as well as the European Community (FEDER) for their contribution to the CERMN’s analytical platform. European COST action CA15135 (Multi-Target Paradigm for Innovative Ligand Identification in the Drug Discovery Process, MuTaLig) supports this article., Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Molecules
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Molecules, MDPI, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Molecules, Vol 24, Iss 15, p 2786 (2019)
Volume 24
Issue 15مصطلحات موضوعية: 5-HT4 receptors, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Pharmaceutical Science, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, Ligands, Neuroprotection, Article, MTDL, Analytical Chemistry, lcsh:QD241-441, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Alzheimer Disease, In vivo, Drug Discovery, Humans, Medicine, Prodrugs, Physical and Theoretical Chemistry, Receptor, Active metabolite, 030304 developmental biology, 0303 health sciences, biology, business.industry, Organic Chemistry, Brain, acetylcholinesterase, Prodrug, Acetylcholinesterase, 3. Good health, chemistry, Chemistry (miscellaneous), Chaperone (protein), biology.protein, Molecular Medicine, Carbamates, Cholinesterase Inhibitors, Receptors, Serotonin, 5-HT4, prodrug, business, Alzheimer’s disease, 030217 neurology & neurosurgery
وصف الملف: application/pdf