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المؤلفون: Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
المصدر: ChemMedChem.
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
المصدر: ChemMedChem. 17
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
المصدر: ChemMedChem. 17(19)
مصطلحات موضوعية: Pharmacology, Neoplasms, Organic Chemistry, Drug Discovery, Molecular Medicine, Humans, YAP-Signaling Proteins, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Adaptor Proteins, Signal Transducing, Transcription Factors
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المؤلفون: Pascal Furet, Bahaa Salem, Yannick Mesrouze, Tobias Schmelzle, Ian Lewis, Joerg Kallen, Patrick Chène
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2316-2319
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, YAP-Signaling Proteins, Biochemistry, Small Molecule Libraries, Structure-Activity Relationship, Drug Design, Drug Discovery, Humans, Molecular Medicine, Peptides, Molecular Biology, Adaptor Proteins, Signal Transducing, Protein Binding, Transcription Factors
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5Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
المؤلفون: Sandra W. Cowan-Jacob, A.A. Wylie, Bahaa Salem, J.M. Groell, Franco Lombardo, Peter Drueckes, Gabriele Rummel, Paul W. Manley, G. Berellini, Robert Martin Grotzfeld, Alice Loo, Markus Warmuth, Chrystelle Henry, Andreas Marzinzik, A.Q. Hassan, Xavier Pelle, V. Iyer, Stephanie Kay Dodd, Joseph Schoepfer, Simona Cotesta, Pascal Furet, Darryl Brynley Jones, Doriano Fabbro, Tobias Gabriel, Wolfgang Jahnke, S. Buonamici, Thomas Zoller
المصدر: Journal of Medicinal Chemistry. 61:8120-8135
مصطلحات موضوعية: Male, Models, Molecular, Niacinamide, 0301 basic medicine, Protein Conformation, Allosteric regulation, Fusion Proteins, bcr-abl, Drug resistance, medicine.disease_cause, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Allosteric Regulation, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Mutation, ABL, Molecular Structure, Drug discovery, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Pyrazoles, Molecular Medicine, Tyrosine kinase, Chronic myelogenous leukemia
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6
المؤلفون: Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem
المصدر: Journal of Medicinal Chemistry. 60:1946-1958
مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, In silico, medicine.medical_treatment, 010402 general chemistry, 01 natural sciences, 03 medical and health sciences, Catalytic Domain, Complement Factor D, Drug Discovery, Hydrolase, medicine, Humans, Protease Inhibitors, Serine protease, Protease, Molecular Structure, biology, Chemistry, 0104 chemical sciences, Complement system, 030104 developmental biology, Biochemistry, Drug Design, biology.protein, Alternative complement pathway, Molecular Medicine, Factor D
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7
المؤلفون: François Gessier, Robert Mah, Philipp Holzer, Therese-Marie Stachyra, Andrea Vaupel, Vito Guagnano, Emmanuelle Wirth, Patrick Chène, Pascal Furet, Joseph Schoepfer, Aude Izaac, Bahaa Salem, Stefan Stutz, Joerg Kallen, Keiichi Masuya, Achim Schlapbach, Suzanne Chau
المصدر: ChemMedChem. 14(14)
مصطلحات موضوعية: MDMX, Chemical compound, Cell Cycle Proteins, Computational biology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Protein–protein interaction, chemistry.chemical_compound, Heterocyclic Compounds, Proto-Oncogene Proteins, Drug Discovery, Humans, General Pharmacology, Toxicology and Pharmaceutics, Therapeutic strategy, Pharmacology, chemistry.chemical_classification, DNA ligase, Binding Sites, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Proto-Oncogene Proteins c-mdm2, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Flip, biology.protein, Molecular Medicine, Mdm2, Function (biology), Protein Binding
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8
المؤلفون: Aude Izaac, Stefan Stutz, Patrick Chène, Emmanuelle Wirth, Achim Schlapbach, Keiichi Masuya, François Gessier, Robert Mah, Bahaa Salem, Andrea Vaupel, Therese-Marie Stachyra, Philipp Holzer, Vito Guagnano, Joseph Schoepfer, Pascal Furet, Joerg Kallen, Suzanne Chau
المصدر: ChemMedChem. 14:1304-1304
مصطلحات موضوعية: Pharmacology, Chemical compound, Chemistry, Organic Chemistry, X-ray, Biochemistry, Protein–protein interaction, chemistry.chemical_compound, Crystallography, Front cover, Drug Discovery, X-ray crystallography, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics
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المؤلفون: Bahaa Salem, Jean Suffert, Christophe Bour, Gaëlle Blond
المصدر: Organic Letters. 10:1075-1078
مصطلحات موضوعية: inorganic chemicals, Magnetic Resonance Spectroscopy, Organic Chemistry, chemistry.chemical_element, Single step, Biochemistry, Combinatorial chemistry, Catalysis, chemistry, Cascade reaction, Cascade, Polycyclic Compounds, Physical and Theoretical Chemistry, Palladium
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المؤلفون: Ken Yamada, Hyi-Man Park, Dean F Rigel, Keith DiPetrillo, Erin J Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A Burdick, Shari L Caplan, Michael P Capparelli, Guanjing Chen, Wei Chen, Bethany Dale, Lin Deng, Fumin Fu, Norio Hamamatsu, Kouki Harasaki, Tracey Herr, Peter Hoffmann, Qi-Ying Hu, Waan-Jeng Huang, Neeraja Idamakanti, Hidetomo Imase, Yuki Iwaki, Monish Jain, Jey Jeyaseelan, Mitsunori Kato, Virendar K Kaushik, Darcy Kohls, Vidya Kunjathoor, Daniel LaSala, Jongchan Lee, Jing Liu, Yang Luo, Fupeng Ma, Ruowei Mo, Sarah Mowbray, Muneto Mogi, Flavio Ossola, Pramod Pandey, Sejal J Patel, Swetha Raghavan, Bahaa Salem, Yuka H Shanado, Gary M Trakshel, Gordon Turner, Hiromichi Wakai, Chunhua Wang, Stephen Weldon, Jennifer B Wielicki, Xiaoling Xie, Lingfei Xu, Yukiko I Yagi, Kayo Yasoshima, Jianning Yin, David Yowe, Ji-Hu Zhang, Gang Zheng, Lauren Monovich
المصدر: Nature chemical biology. 12(11)
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Pyrrolidines, Renal function, Mice, Transgenic, Biology, Protein Serine-Threonine Kinases, Kidney, Kidney Function Tests, complex mixtures, Cardiovascular System, Rats, Sprague-Dawley, Small Molecule Libraries, 03 medical and health sciences, Mice, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, urogenital system, Kinase Family, Kinase, Imidazoles, Cell Biology, Electrolyte excretion, Small molecule, Rats, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Blood pressure, Biochemistry, 030220 oncology & carcinogenesis, bacteria
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