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المؤلفون: Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La
المصدر: Journal of Medicinal Chemistry. 64:3843-3869
مصطلحات موضوعية: Male, Ovalbumin, Guinea Pigs, CHO Cells, Ligands, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, Transient receptor potential channel, Cricetulus, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Ankyrin, Binding site, Furans, TRPA1 Cation Channel, Ion channel, 030304 developmental biology, Inflammation, chemistry.chemical_classification, Oxadiazoles, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, Small molecule, Asthma, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Purines, Biophysics, Molecular Medicine, medicine.symptom, Protein Binding
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المؤلفون: Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
المصدر: Journal of Experimental Medicine. 218
مصطلحات موضوعية: 0301 basic medicine, Neurogenic inflammation, Contraction (grammar), business.industry, Immunology, Antagonist, Airway inflammation, food and beverages, medicine.disease, 03 medical and health sciences, Transient receptor potential channel, 030104 developmental biology, 0302 clinical medicine, Edema, medicine, Immunology and Allergy, medicine.symptom, Airway, business, psychological phenomena and processes, 030217 neurology & neurosurgery, Asthma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637 -
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المؤلفون: Peter W. Fan, Sarah G. Hymowitz, Teresa Dong, Xingyu Lin, Zoe Zhong, Connie Chan, Paul A. McEwan, Wyne P. Lee, Swathi Sujatha-Bhaskar, Baihua Hu, Nicole Blaquiere, Jason Burch, Jianwen Feng, Hans Brightbill, Steven T. Staben, Alison J Hole, James J. Crawford, Guosheng Wu, Suzanne Brown, Moulay Hicham Alaoui Ismaili, Georgette Castanedo, Patrick Lee, Hoa Le, Leonid M. Berezhkovskiy, Po-Chang Chiang, Robert Godemann, Brent S. McKenzie, Emily B. Gogol, Hernani L Silvestre, Ning Liu, Eric Suto, Nico Ghilardi, Yamin Zhang, Lawren C. Wu, Alice Grabbe
المصدر: Journal of Medicinal Chemistry. 61:6801-6813
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell Survival, Protein Conformation, Protein Serine-Threonine Kinases, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, B-cell activating factor, Protein Kinase Inhibitors, B cell, Dose-Response Relationship, Drug, Chemistry, Kinase, Drug discovery, Dendritic cell, In vitro, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Molecular Medicine
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5دورية أكاديمية
المؤلفون: Chan, Bryan K., Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F., Le An, Blench, Toby, Cartwright, Matthew W., Chan, Grace Ka Yan, Choo, Edna F., Drummond, Jason, Elliott, Richard L., Gancia, Emanuela, Gazzard, Lewis, Baihua Hu, Jones, Graham E., Xifeng Luo, Madin, Andrew, Malhotra, Sushant, Moffat, John G., Pang, Jodie
المصدر: ACS Medicinal Chemistry Letters; 1/13/2022, Vol. 13 Issue 1, p84-91, 8p
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المؤلفون: Christopher McNally, James J. Mousseau, Jay Wrobel, Carl Morris, Matthew R. Yudt, Susan Chippari, Kevin D. Parris, Chulho Choi, Olugbeminiyi O. Fadeyi, Thomas Kenney, Sunil Nagpal, Baihua Hu, Karthick Vishwanathan, Adam M. Gilbert, Eugene Lvovich Piatnitski Chekler, Dennis Powell, Catherine Thompson, Edward J. Kilbourne, Ray Unwalla
المصدر: Journal of Medicinal Chemistry. 60:6451-6457
مصطلحات موضوعية: Male, 0301 basic medicine, Hypothalamo-Hypophyseal System, Stereochemistry, 030209 endocrinology & metabolism, Crystallography, X-Ray, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Anabolic Agents, 0302 clinical medicine, In vivo, Nitriles, Drug Discovery, Animals, Structure–activity relationship, Pyrroles, Muscle, Skeletal, Receptor, Pyrrole, Prostate, Seminal Vesicles, Organ Size, Ligand (biochemistry), Rats, Molecular Docking Simulation, Androgen receptor, 030104 developmental biology, chemistry, Organ Specificity, Receptors, Androgen, Hormone receptor, Androgens, Molecular Medicine, Structure based
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المؤلفون: Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
المصدر: Journal of medicinal chemistry. 61(8)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Molecular model, Proline, Molecular Conformation, Pharmacology, Ligands, 01 natural sciences, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Transient receptor potential channel, Structure-Activity Relationship, Dogs, Drug Stability, In vivo, Drug Discovery, Structure–activity relationship, Ankyrin, Animals, Humans, Prodrugs, TRPA1 Cation Channel, chemistry.chemical_classification, Sulfonamides, 010405 organic chemistry, Drug discovery, Chemistry, Prodrug, 0104 chemical sciences, Sulfonamide, Rats, 030104 developmental biology, Solubility, Microsomes, Liver, Molecular Medicine
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المؤلفون: Baihua Hu, Elaine Quinet, Irene Feingold, Igor Goljer, Thomas J. Berrodin, Mark J. Evans, James W Jetter, Jay Wrobel, Rayomand J. Unwalla, Michael D Basso, Annika Goos Nilsson, Anna Wilhelmsson
المصدر: Journal of Medicinal Chemistry. 53:3296-3304
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Agonist, Duodenum, medicine.drug_class, Pharmacology, Kidney, Cell Line, Sulfone, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Quinoxaline, Quinoxalines, Drug Discovery, Coactivator, medicine, Animals, Humans, Structure–activity relationship, Sulfones, Liver X receptor, Triglycerides, Liver X Receptors, Mice, Knockout, Chemistry, Kidney metabolism, Atherosclerosis, Orphan Nuclear Receptors, Mice, Inbred C57BL, Cholesterol, Liver, Biochemistry, Organ Specificity, Cell culture, Area Under Curve, Molecular Medicine, ATP-Binding Cassette Transporters, lipids (amino acids, peptides, and proteins), ATP Binding Cassette Transporter 1, Half-Life
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المؤلفون: Baihua Hu, Rayomand J. Unwalla, Mark J. Evans, Jay E. Wrobel, Annika Goos-Nilsson, Anna Wilhelmsson, Michael D. Collini, Irene Feingold, Ron Bernotas, Ponnal Nambi, Elaine Quinet
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:689-693
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Blood–brain barrier, Biochemistry, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Computer Simulation, Sulfones, Liver X receptor, Molecular Biology, Binding selectivity, Liver X Receptors, Binding Sites, Organic Chemistry, Quinoline, Hydrogen Bonding, Quinoline analog, Orphan Nuclear Receptors, Rats, medicine.anatomical_structure, Nuclear receptor, chemistry, Blood-Brain Barrier, Quinolines, Molecular Medicine, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter 1, Protein Binding
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المؤلفون: Erik Wagner, Jonathan A. Bard, Kristine Svenson, Guixan Jin, Rajiv Chopra, Mei-Chu Lo, Minakshi Jani, Eric S. Manas, Pawel Nowak, Derek C. Cole, John W. Ellingboe, Baihua Hu, Robichaud Albert Jean, Kristi Fan, Michael S. Malamas, Rani Narasimhan, Jim Turner, Ann Aulabaugh, Ping Zhou, Rebecca Cowling, Steve Jacobsen, Peter H. Reinhart, Joseph Raymond Stock, Joan Subrath
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:632-635
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Ring (chemistry), Biochemistry, Chemical synthesis, Catalytic Domain, Drug Discovery, Amyloid precursor protein, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Hydantoins, Organic Chemistry, Imidazoles, Hydrogen Bonding, Biological activity, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, β secretase, Molecular Medicine, Amyloid Precursor Protein Secretases
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