المؤلفون: Bakkers MJG; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; ForgeBio B.V., Amsterdam, The Netherlands., Ritschel T; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; J&J Innovative Medicine Technology, R&D, New Brunswick, NJ, USA., Tiemessen M; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Dijkman J; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Machine Learning Lab, Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands., Zuffianò AA; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; Promaton BV, Amsterdam, The Netherlands., Yu X; Structural & Protein Science, Janssen Research and Development, Spring House, PA, 19044, USA., van Overveld D; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Le L; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Voorzaat R; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., van Haaren MM; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., de Man M; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Tamara S; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., van der Fits L; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Zahn R; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Juraszek J; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines & Prevention BV, Leiden, The Netherlands. hlangedijk@forge-bio.com.; ForgeBio B.V., Amsterdam, The Netherlands. hlangedijk@forge-bio.com.

المصدر: Nature communications [Nat Commun] 2024 Jul 25; Vol. 15 (1), pp. 6270. Date of Electronic Publication: 2024 Jul 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Metapneumovirus*/immunology , Metapneumovirus*/genetics , Antibodies, Neutralizing*/immunology , Antibodies, Viral*/immunology , Viral Fusion Proteins*/immunology , Viral Fusion Proteins*/chemistry , Viral Fusion Proteins*/genetics , Viral Vaccines*/immunology, Animals ; Humans ; Paramyxoviridae Infections/prevention & control ; Paramyxoviridae Infections/immunology ; Cryoelectron Microscopy ; Protein Engineering/methods ; Sigmodontinae ; Female ; Protein Multimerization ; Models, Molecular

المؤلفون: Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA., van Scherpenzeel RC; Janssen Infectious Diseases and Vaccines, 2340, Beerse, Belgium., Bakkers MJG; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; ForgeBio B.V., Amsterdam, The Netherlands., Ramamohan AR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA., van Overveld D; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Le L; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; ForgeBio B.V., Amsterdam, The Netherlands., Kolkman JA; Janssen Infectious Diseases and Vaccines, 2340, Beerse, Belgium., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA. jmclellan@austin.utexas.edu.

المصدر: Nature communications [Nat Commun] 2024 Jun 27; Vol. 15 (1), pp. 5458. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Neutralizing*/immunology , Antibodies, Viral*/immunology , Epitopes*/immunology , Cryoelectron Microscopy*, Animals ; Humans ; Sigmodontinae ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/chemistry ; Viral Fusion Proteins/immunology ; Viral Fusion Proteins/chemistry ; Female ; Camelus/immunology ; Camelus/virology

المؤلفون: Langedijk JPM; Janssen Vaccines & Prevention BV, Leiden, The Netherlands.; ForgeBio, Amsterdam, The Netherlands., Cox F; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., van Overveld D; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Le L; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., van den Hoogen W; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Voorzaat R; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Zahn R; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., van der Fits L; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., Juraszek J; Janssen Vaccines & Prevention BV, Leiden, The Netherlands., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Bakkers MJG; Janssen Vaccines & Prevention BV, Leiden, The Netherlands. mbakkers@forge-bio.com.; ForgeBio, Amsterdam, The Netherlands. mbakkers@forge-bio.com.

المصدر: Nature communications [Nat Commun] 2024 May 31; Vol. 15 (1), pp. 4629. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Viral Fusion Proteins*/immunology , Viral Fusion Proteins*/genetics , Viral Fusion Proteins*/chemistry , Sigmodontinae* , Viral Vaccines*/immunology , Antibodies, Neutralizing*/immunology , Antibodies, Viral*/immunology, Animals ; Female ; Mice ; Humans ; Mice, Inbred BALB C ; Paramyxoviridae Infections/prevention & control ; Paramyxoviridae Infections/immunology ; Paramyxoviridae Infections/virology ; Parainfluenza Virus 3, Human/immunology ; Parainfluenza Virus 3, Human/genetics

المؤلفون: Voorzaat R; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Cox F; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., van Overveld D; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Le L; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Tettero L; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Vaneman J; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Bakkers MJG; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands.

المصدر: Vaccines [Vaccines (Basel)] 2024 Mar 12; Vol. 12 (3). Date of Electronic Publication: 2024 Mar 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Yu X; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Juraszek J; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Rutten L; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Bakkers MJG; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Blokland S; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Melchers JM; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., van den Broek NJF; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Verwilligen AYW; Janssen Vaccines & Prevention BV, Leiden, the Netherlands., Abeywickrema P; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Vingerhoets J; Janssen Pharmaceutica N.V., Clinical Microbiology and Immunology, Beerse, Belgium., Neefs JM; Janssen Pharmaceutica N.V., Discovery Sciences, Beerse, Belgium., Bakhash SAM; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Roychoudhury P; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Greninger A; Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America., Sharma S; Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America., Langedijk JPM; Janssen Vaccines & Prevention BV, Leiden, the Netherlands.

المصدر: PLoS pathogens [PLoS Pathog] 2023 May 01; Vol. 19 (5), pp. e1011308. Date of Electronic Publication: 2023 May 01 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*, Humans ; SARS-CoV-2/genetics ; Antibodies, Neutralizing ; Disulfides ; Immunotherapy ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Viral

المؤلفون: Bakkers MJG; Department of Microbiology, Harvard Medical School, Boston, MA 02115., Moon-Walker A; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Program in Virology, Harvard Medical School, Boston, MA 02115.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037.; Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO 63110., Herlo R; Department of Cell Biology, Harvard Medical School, Boston, MA 02115., Brusic V; Department of Microbiology, Harvard Medical School, Boston, MA 02115., Stubbs SH; Department of Microbiology, Harvard Medical School, Boston, MA 02115., Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037., Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037., Kirchhausen TL; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115., Whelan SPJ; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO 63110.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 08; Vol. 119 (10), pp. e2119676119. Date of Electronic Publication: 2022 Mar 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Virus Internalization*, Lymphocytic choriomeningitis virus/*physiology, A549 Cells ; CRISPR-Cas Systems ; Endolyn/physiology ; Gene Editing ; HEK293 Cells ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Hydrogen-Ion Concentration ; Lymphocytic choriomeningitis virus/pathogenicity ; Membrane Fusion ; Virulence Factors

المؤلفون: Milder FJ; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Jongeneelen M; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Ritschel T; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Bouchier P; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Bisschop IJM; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., de Man M; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Veldman D; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Le L; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Kaufmann B; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Bakkers MJG; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Juraszek J; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Brandenburg B; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands hlangedi@its.jnj.com.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 08; Vol. 119 (6).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Hemagglutinin Glycoproteins, Influenza Virus/*genetics , Hemagglutinins/*genetics, Amino Acids/genetics ; Cell Line ; Humans ; Hydrogen-Ion Concentration ; Influenza Vaccines/genetics ; Influenza, Human/virology ; Mutation/genetics ; Protein Conformation, beta-Strand/genetics

المؤلفون: Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Zahn R; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Wegmann F; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Loos C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, MA, USA., Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Martinez DR; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rutten L; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Bos R; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., van Manen D; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Vellinga J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Custers J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Langedijk JP; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Kwaks T; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Bakkers MJG; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Zuijdgeest D; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Huber SKR; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Burke JS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Feldman J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Hauser BM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Caradonna TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Dagotto G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Hoffman E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Jacob-Dolan C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kirilova M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Li Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Lin Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Mahrokhian SH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Maxfield LF; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nampanya F; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nityanandam R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Patel S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Verrington K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wan H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Pessaint L; Bioqual, Rockville, MD, USA., Van Ry A; Bioqual, Rockville, MD, USA., Blade K; Bioqual, Rockville, MD, USA., Strasbaugh A; Bioqual, Rockville, MD, USA., Cabus M; Bioqual, Rockville, MD, USA., Brown R; Bioqual, Rockville, MD, USA., Cook A; Bioqual, Rockville, MD, USA., Zouantchangadou S; Bioqual, Rockville, MD, USA., Teow E; Bioqual, Rockville, MD, USA., Andersen H; Bioqual, Rockville, MD, USA., Lewis MG; Bioqual, Rockville, MD, USA., Cai Y; Children's Hospital, Boston, MA, USA., Chen B; Children's Hospital, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Schmidt AG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Reeves RK; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Baric RS; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lauffenburger DA; Massachusetts Institute of Technology, Cambridge, MA, USA., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Stoffels P; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Mammen M; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Van Hoof J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Schuitemaker H; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. dbarouch@bidmc.harvard.edu.; Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. dbarouch@bidmc.harvard.edu.

المصدر: Nature [Nature] 2021 Feb; Vol. 590 (7844), pp. E25.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Juraszek J; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Rutten L; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Blokland S; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Bouchier P; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Voorzaat R; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Ritschel T; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Bakkers MJG; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands., Renault LLR; NeCEN, Leiden University, Einsteinweg 55, Leiden, The Netherlands., Langedijk JPM; Janssen Vaccines & Prevention B.V., Archimedesweg 4-6, Leiden, The Netherlands. hlangedi@its.jnj.com.

المصدر: Nature communications [Nat Commun] 2021 Jan 11; Vol. 12 (1), pp. 244. Date of Electronic Publication: 2021 Jan 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*/chemistry , SARS-CoV-2*/genetics , SARS-CoV-2*/metabolism, Spike Glycoprotein, Coronavirus/*chemistry , Spike Glycoprotein, Coronavirus/*metabolism, Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/virology ; Cryoelectron Microscopy ; Humans ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Domains ; Protein Stability ; Spike Glycoprotein, Coronavirus/genetics

المؤلفون: Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Zahn R; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Wegmann F; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Loos C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, MA, USA., Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Martinez DR; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rutten L; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Bos R; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., van Manen D; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Vellinga J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Custers J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Langedijk JP; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Kwaks T; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Bakkers MJG; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Zuijdgeest D; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Rosendahl Huber SK; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Burke JS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Feldman J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Hauser BM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Caradonna TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Dagotto G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Hoffman E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Jacob-Dolan C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kirilova M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Li Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Lin Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Mahrokhian SH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Maxfield LF; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nampanya F; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nityanandam R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Patel S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Verrington K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wan H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Pessaint L; Bioqual, Rockville, MD, USA., Van Ry A; Bioqual, Rockville, MD, USA., Blade K; Bioqual, Rockville, MD, USA., Strasbaugh A; Bioqual, Rockville, MD, USA., Cabus M; Bioqual, Rockville, MD, USA., Brown R; Bioqual, Rockville, MD, USA., Cook A; Bioqual, Rockville, MD, USA., Zouantchangadou S; Bioqual, Rockville, MD, USA., Teow E; Bioqual, Rockville, MD, USA., Andersen H; Bioqual, Rockville, MD, USA., Lewis MG; Bioqual, Rockville, MD, USA., Cai Y; Children's Hospital, Boston, MA, USA., Chen B; Children's Hospital, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Schmidt AG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Reeves RK; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Baric RS; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lauffenburger DA; Massachusetts Institute of Technology, Cambridge, MA, USA., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Stoffels P; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Mammen M; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Van Hoof J; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Schuitemaker H; Janssen Vaccines and Prevention BV, Leiden, The Netherlands., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. dbarouch@bidmc.harvard.edu.; Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. dbarouch@bidmc.harvard.edu.

المصدر: Nature [Nature] 2020 Oct; Vol. 586 (7830), pp. 583-588. Date of Electronic Publication: 2020 Jul 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Macaca mulatta*/immunology , Macaca mulatta*/virology, Betacoronavirus/*immunology , Coronavirus Infections/*immunology , Coronavirus Infections/*prevention & control , Pandemics/*prevention & control , Pneumonia, Viral/*immunology , Pneumonia, Viral/*prevention & control , Viral Vaccines/*administration & dosage , Viral Vaccines/*immunology, Animals ; COVID-19 ; COVID-19 Vaccines ; Disease Models, Animal ; Female ; Immunity, Cellular ; Immunity, Humoral ; Male ; SARS-CoV-2 ; Vaccination ; Viral Load