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المؤلفون: Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Meuser MB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Demarque KC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Fulco TO; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Patrick DA; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunova SM; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunov SA; University of North Carolina, Chapel Hill, North Carolina, USA., Tidwell RR; University of North Carolina, Chapel Hill, North Carolina, USA., Oliveira GM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Britto C; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Moreira OC; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Mar 25; Vol. 60 (4), pp. 2425-34. Date of Electronic Publication: 2016 Mar 25 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Chagas Disease/*drug therapy , Parasitemia/*drug therapy , Terphenyl Compounds/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Amides/chemical synthesis ; Amidines/pharmacology ; Animals ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Disease Models, Animal ; Drug Administration Schedule ; Drug Dosage Calculations ; Drug Synergism ; Drug Therapy, Combination ; Female ; Mice ; Nitroimidazoles/pharmacology ; Parasite Load ; Parasitemia/mortality ; Parasitemia/parasitology ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Survival Analysis ; Terphenyl Compounds/chemical synthesis ; Trypanocidal Agents/chemical synthesis ; Trypanosoma cruzi/growth & development

المؤلفون: Timm BL; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Tidwell RR; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Patrick DA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Jones SK; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Bakunov SA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Bakunova SM; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Soeiro Mde N; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Jul; Vol. 58 (7), pp. 3720-6. Date of Electronic Publication: 2014 Apr 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Amidines/therapeutic use ; Amidines/toxicity ; Animals ; Cell Survival ; Chagas Disease/drug therapy ; Chagas Disease/parasitology ; Galactosidases/metabolism ; Male ; Mice ; Nitroimidazoles/pharmacology ; No-Observed-Adverse-Effect Level ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Primary Cell Culture ; Trypanocidal Agents/therapeutic use ; Trypanocidal Agents/toxicity

المؤلفون: Patrick DA; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Bakunov SA; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Bakunova SM; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Wenzler T; Swiss Tropical and Public Health Institute, Medical Parasitology & Infection Biology, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Brun R; Swiss Tropical and Public Health Institute, Medical Parasitology & Infection Biology, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Tidwell RR; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA. Electronic address: Tidwell@med.unc.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Jan 01; Vol. 22 (1), pp. 559-76. Date of Electronic Publication: 2013 Nov 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*therapeutic use , Isoxazoles/*chemical synthesis , Plasmodium falciparum/*drug effects , Prodrugs/*therapeutic use , Trypanosomiasis, African/*drug therapy, Animals ; Antiprotozoal Agents/pharmacology ; Isoxazoles/chemistry ; Isoxazoles/pharmacology ; Mice ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Patrick DA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA., Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2013 Sep; Vol. 67, pp. 310-24. Date of Electronic Publication: 2013 Jun 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*pharmacology , Leishmania donovani/*drug effects , Pentamidine/*analogs & derivatives , Pentamidine/*pharmacology , Phenyl Ethers/*chemical synthesis , Phenyl Ethers/*pharmacology , Plasmodium falciparum/*drug effects , Trypanosoma brucei rhodesiense/*drug effects , Trypanosomiasis/*drug therapy, Animals ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Dose-Response Relationship, Drug ; Mice ; Molecular Structure ; Myoblasts/drug effects ; Parasitic Sensitivity Tests ; Pentamidine/chemical synthesis ; Pentamidine/chemistry ; Phenyl Ethers/chemistry ; Rats ; Structure-Activity Relationship ; Trypanosomiasis/veterinary

المؤلفون: Bakunov SA; Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA., Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR

المصدر: Journal of medicinal chemistry [J Med Chem] 2010 Jan 14; Vol. 53 (1), pp. 254-72.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*chemical synthesis , Amidines/*pharmacology , Antiprotozoal Agents/*chemical synthesis , Antiprotozoal Agents/*pharmacology , Leishmania donovani/*drug effects , Plasmodium falciparum/*drug effects , Triazoles/*chemical synthesis , Triazoles/*pharmacology , Trypanosoma brucei rhodesiense/*drug effects, Amidines/chemistry ; Animals ; Antiprotozoal Agents/chemistry ; Cell Line ; Cell Survival/drug effects ; Disease Models, Animal ; Female ; Leishmania donovani/growth & development ; Mice ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/growth & development ; Rats ; Stereoisomerism ; Structure-Activity Relationship ; Triazoles/chemistry ; Trypanosoma brucei rhodesiense/growth & development

المؤلفون: Bakunov SA; Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA., Bakunova SM, Bridges AS, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Sep 24; Vol. 52 (18), pp. 5763-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*chemistry , Antiprotozoal Agents/*pharmacology , Benzofurans/*chemistry , Pentamidine/*chemistry , Pentamidine/*pharmacology, Animals ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/toxicity ; Cell Line ; Leishmania donovani/drug effects ; Pentamidine/chemical synthesis ; Pentamidine/toxicity ; Plasmodium falciparum/drug effects ; Rats ; Structure-Activity Relationship ; Trypanosoma brucei rhodesiense/drug effects

المؤلفون: Patrick DA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA., Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2009 Sep; Vol. 44 (9), pp. 3543-51. Date of Electronic Publication: 2009 Mar 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*chemistry , Antiprotozoal Agents/*pharmacology , Benzene/*chemistry , Benzene/*pharmacology , Naphthalenes/*chemistry , Naphthalenes/*pharmacology, Animals ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/therapeutic use ; Benzene/chemical synthesis ; Benzene/therapeutic use ; Cell Survival/drug effects ; Leishmania donovani/drug effects ; Mice ; Myoblasts/drug effects ; Naphthalenes/chemical synthesis ; Naphthalenes/therapeutic use ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Rats ; Structure-Activity Relationship ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosomiasis, African/drug therapy

المؤلفون: Bakunova SM; Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA., Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Aug 13; Vol. 52 (15), pp. 4657-67.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*chemical synthesis , Pentamidine/*analogs & derivatives , Pyridines/*chemical synthesis, Animals ; Antiprotozoal Agents/pharmacology ; Female ; Leishmania donovani/drug effects ; Mice ; Pentamidine/chemical synthesis ; Plasmodium falciparum/drug effects ; Pyridines/pharmacology ; Rats ; Structure-Activity Relationship

المؤلفون: Bakunova SM; Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599, USA., Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Apr 09; Vol. 52 (7), pp. 2016-35.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*chemical synthesis , Cadaverine/*analogs & derivatives , Imidazoles/*chemical synthesis , Pentamidine/*analogs & derivatives , Pentamidine/*chemical synthesis , Trypanocidal Agents/*chemical synthesis, Animals ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Cadaverine/chemical synthesis ; Cadaverine/chemistry ; Cadaverine/pharmacology ; Drug Resistance ; Female ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Leishmania donovani/drug effects ; Mice ; Myoblasts/cytology ; Myoblasts/drug effects ; Parasitic Sensitivity Tests ; Pentamidine/chemistry ; Pentamidine/pharmacology ; Plasmodium falciparum/drug effects ; Rats ; Structure-Activity Relationship ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosomiasis/drug therapy