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المؤلفون: Santos CC; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Lionel JR; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Peres RB; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Batista MM; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., da Silva PB; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., de Oliveira GM; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., da Silva CF; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Batista DGJ; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Souza SMO; Laboratory of Structural Biology (LBE), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil., Andrade CH; Laboratory for Molecular Modeling and Drug Design (LabMol), Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Brazil., Neves BJ; Laboratory for Molecular Modeling and Drug Design (LabMol), Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Brazil., Braga RC; Laboratory for Molecular Modeling and Drug Design (LabMol), Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Brazil., Patrick DA; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Bakunova SM; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Tidwell RR; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Soeiro MNC; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Jan 25; Vol. 62 (2). Date of Electronic Publication: 2018 Jan 25 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Animals ; Chagas Disease/drug therapy ; Male ; Mice ; Nitroimidazoles/pharmacology ; Parasitemia/drug therapy ; Parasitic Sensitivity Tests/methods

المؤلفون: Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Meuser MB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Demarque KC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Fulco TO; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Patrick DA; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunova SM; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunov SA; University of North Carolina, Chapel Hill, North Carolina, USA., Tidwell RR; University of North Carolina, Chapel Hill, North Carolina, USA., Oliveira GM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Britto C; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Moreira OC; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Mar 25; Vol. 60 (4), pp. 2425-34. Date of Electronic Publication: 2016 Mar 25 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Chagas Disease/*drug therapy , Parasitemia/*drug therapy , Terphenyl Compounds/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Amides/chemical synthesis ; Amidines/pharmacology ; Animals ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Disease Models, Animal ; Drug Administration Schedule ; Drug Dosage Calculations ; Drug Synergism ; Drug Therapy, Combination ; Female ; Mice ; Nitroimidazoles/pharmacology ; Parasite Load ; Parasitemia/mortality ; Parasitemia/parasitology ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Survival Analysis ; Terphenyl Compounds/chemical synthesis ; Trypanocidal Agents/chemical synthesis ; Trypanosoma cruzi/growth & development

المؤلفون: Timm BL; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Tidwell RR; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Patrick DA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Jones SK; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Bakunov SA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Bakunova SM; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Soeiro Mde N; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Jul; Vol. 58 (7), pp. 3720-6. Date of Electronic Publication: 2014 Apr 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Amidines/therapeutic use ; Amidines/toxicity ; Animals ; Cell Survival ; Chagas Disease/drug therapy ; Chagas Disease/parasitology ; Galactosidases/metabolism ; Male ; Mice ; Nitroimidazoles/pharmacology ; No-Observed-Adverse-Effect Level ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Primary Cell Culture ; Trypanocidal Agents/therapeutic use ; Trypanocidal Agents/toxicity

المؤلفون: Patrick DA; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Bakunov SA; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Bakunova SM; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA., Wenzler T; Swiss Tropical and Public Health Institute, Medical Parasitology & Infection Biology, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Brun R; Swiss Tropical and Public Health Institute, Medical Parasitology & Infection Biology, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Tidwell RR; University of North Carolina, Pathology & Laboratory Medicine, 805 Brinkhous-Bullitt Bldg, CB 7525, Chapel Hill, NC 27599-7525, USA. Electronic address: Tidwell@med.unc.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Jan 01; Vol. 22 (1), pp. 559-76. Date of Electronic Publication: 2013 Nov 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*therapeutic use , Isoxazoles/*chemical synthesis , Plasmodium falciparum/*drug effects , Prodrugs/*therapeutic use , Trypanosomiasis, African/*drug therapy, Animals ; Antiprotozoal Agents/pharmacology ; Isoxazoles/chemistry ; Isoxazoles/pharmacology ; Mice ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Patrick DA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA., Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2013 Sep; Vol. 67, pp. 310-24. Date of Electronic Publication: 2013 Jun 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents/*pharmacology , Leishmania donovani/*drug effects , Pentamidine/*analogs & derivatives , Pentamidine/*pharmacology , Phenyl Ethers/*chemical synthesis , Phenyl Ethers/*pharmacology , Plasmodium falciparum/*drug effects , Trypanosoma brucei rhodesiense/*drug effects , Trypanosomiasis/*drug therapy, Animals ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Dose-Response Relationship, Drug ; Mice ; Molecular Structure ; Myoblasts/drug effects ; Parasitic Sensitivity Tests ; Pentamidine/chemical synthesis ; Pentamidine/chemistry ; Phenyl Ethers/chemistry ; Rats ; Structure-Activity Relationship ; Trypanosomiasis/veterinary