المؤلفون: Costa-Oliveira CND; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Paiva-Cavalcanti M; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil. Electronic address: milena.cavalcanti@fiocruz.br., Barros MDS; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Nakazawa M; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Melo MGN; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Pessoa-E-Silva R; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Torres DJL; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Oliveira KKDS; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Moreira LR; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Morais RCS; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Goes TC; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil., Oliveira GMA; Health Secretariat of Pernambuco, Recife, Pernambuco, Brazil., Júnior WO; Cardiac Emergency of Pernambuco (PROCAPE) - Pernambuco University (UPE), Recife, Pernambuco, Brazil., Silva MMME; University Hospital Oswaldo Cruz (HUOC) - Pernambuco University (UPE), Recife, Pernambuco, Brazil., Batista FP; University Hospital Oswaldo Cruz (HUOC) - Pernambuco University (UPE), Recife, Pernambuco, Brazil., Montenegro D; University Hospital Oswaldo Cruz (HUOC) - Pernambuco University (UPE), Recife, Pernambuco, Brazil., Lorena VMB; Aggeu Magalhães Institute, Recife, Pernambuco, Brazil.

المصدر: Experimental parasitology [Exp Parasitol] 2023 Apr; Vol. 247, pp. 108478. Date of Electronic Publication: 2023 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE

مواضيع طبية MeSH: Chagas Disease*/diagnosis , Chagas Disease*/epidemiology , Chagas Disease*/drug therapy , Trypanosoma cruzi*/genetics, Humans ; Brazil/epidemiology ; Pathology, Molecular ; DNA, Protozoan/genetics ; Real-Time Polymerase Chain Reaction/methods ; Disease Outbreaks

المؤلفون: Cruz FJFD; Universidade Federal de Pernambuco, Hospital das Clínicas, Departamento de Geriatria, Recife, PE, Brasil., Figueiredo EAP; Universidade Federal de Pernambuco, Hospital das Clínicas, Departamento de Geriatria, Recife, PE, Brasil., Batista FP; Hospital Santa Joana Recife, Departamento de Doenças Infecciosas, Recife, PE, Brasil., Gallindo MAC; Hospital Santa Joana Recife, Unidade de Terapia Intensiva, Recife, PE, Brasil., Fernandes ACDS; Hospital Santa Joana Recife, Unidade de Terapia Intensiva, Recife, PE, Brasil.

المصدر: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2022 Mar 14; Vol. 55, pp. e0377. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Macrophage Activation Syndrome*/complications , Macrophage Activation Syndrome*/diagnosis , Macrophage Activation Syndrome*/drug therapy, Early Diagnosis ; Fever ; Humans ; Male ; Middle Aged ; SARS-CoV-2

المؤلفون: de Oliveira Ramos Silva A; Oswaldo Cruz Universitary Hospital, Recife, Pernambuco State, Brazil., Barata ESR; Oswaldo Cruz Universitary Hospital, Recife, Pernambuco State, Brazil., Ferraz TLL; Oswaldo Cruz Universitary Hospital, Recife, Pernambuco State, Brazil., Batista FP; Oswaldo Cruz Universitary Hospital, Recife, Pernambuco State, Brazil., Medeiros ACR; Oswaldo Cruz Universitary Hospital, Recife, Pernambuco State, Brazil., Ferraz CE; Hospital of Clinics, Federal University of Pernambuco (UFPE), Recife, Pernambuco State, Brazil.; Department of Tropical Medicine, UFPE, Recife, Pernambuco State, Brazil., Inácio CP; Department of Tropical Medicine, UFPE, Recife, Pernambuco State, Brazil., de Lima-Neto RG; Hospital of Clinics, Federal University of Pernambuco (UFPE), Recife, Pernambuco State, Brazil. reginaldo.limant@ufpe.br.; Department of Tropical Medicine, UFPE, Recife, Pernambuco State, Brazil. reginaldo.limant@ufpe.br.

المصدر: Mycopathologia [Mycopathologia] 2021 Jun; Vol. 186 (3), pp. 465-467. Date of Electronic Publication: 2021 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 7505689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0832 (Electronic) Linking ISSN: 0301486X NLM ISO Abbreviation: Mycopathologia Subsets: MEDLINE

مواضيع طبية MeSH: Fusariosis*/drug therapy , Fusarium*, Antifungal Agents/therapeutic use ; Farmers ; Humans ; Skin

المؤلفون: DE Melo ES; Universidade Federal de Pernambuco, Unidade de Neurologia e Neurocirurgia, Departamento de Neuropsiquiatria, Recife PE, Brazil.; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., Barbosa BJAP; Universidade Federal de Pernambuco, Unidade de Neurologia e Neurocirurgia, Departamento de Neuropsiquiatria, Recife PE, Brazil., Lima CFLS; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., Silva MMME; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., Lima ARMC; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., Batista FP; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., Montenegro D; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil., ValenÇa LPAA; Universidade Federal de Pernambuco, Unidade de Neurologia e Neurocirurgia, Departamento de Neuropsiquiatria, Recife PE, Brazil.; Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife PE, Brazil.

المصدر: Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2021 Jan; Vol. 79 (1), pp. 89.

نوع المنشور: Editorial

بيانات الدورية: Publisher: Thieme Country of Publication: Germany NLM ID: 0125444 Publication Model: Print Cited Medium: Internet ISSN: 1678-4227 (Electronic) Linking ISSN: 0004282X NLM ISO Abbreviation: Arq Neuropsiquiatr Subsets: MEDLINE

مواضيع طبية MeSH: Chagas Disease*/complications , Facial Paralysis*/etiology, Acute Disease ; Facial Nerve ; Humans

المؤلفون: Lobo YA; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Bonazza C; Gynecology, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Batista FP; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Castro RA; Gynecology, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Bonturi CR; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Salu BR; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., de Cassia Sinigaglia R; Electron Microscopy Center at the Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Toma L; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Vicente CM; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Pidde G; Immunochemistry, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Tambourgi DV; Immunochemistry, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Alvarez-Flores MP; Center of Excellence in New Target Discovery (CENTD), Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Chudzinski-Tavassi AM; Center of Excellence in New Target Discovery (CENTD), Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Oliva MLV; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil. Electronic address: mlvoliva@unifesp.br.

المصدر: Cancer letters [Cancer Lett] 2020 Oct 28; Vol. 491, pp. 108-120. Date of Electronic Publication: 2020 Aug 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

مواضيع طبية MeSH: Cytokines/*antagonists & inhibitors , Fabaceae/*chemistry , Glycosaminoglycans/*metabolism , Triple Negative Breast Neoplasms/*drug therapy , Trypsin Inhibitors/*pharmacology, Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Collagen Type I/metabolism ; Cytokines/biosynthesis ; Female ; Humans ; Matrix Metalloproteinases/metabolism ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Trypsin Inhibitors/therapeutic use

المؤلفون: Batista FP; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., de Aguiar RB; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., Sumikawa JT; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., Lobo YA; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Bonturi CR; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Ferreira RDS; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Andrade SS; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., Guedes Paiva PM; Department of Biochemistry, Federal University of Pernambuco (UFPE), Brazil., Dos Santos Correia MT; Department of Biochemistry, Federal University of Pernambuco (UFPE), Brazil., Vicente CM; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Toma L; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Sampaio MU; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Paschoalin T; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., Girão MJBC; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., de Moraes JZ; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., de Paula CAA; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Oliva MLV; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil. Electronic address: olivaml.bioq@epm.br.

المصدر: Biochimie [Biochimie] 2019 Nov; Vol. 166, pp. 173-183. Date of Electronic Publication: 2019 Apr 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inducing Agents/*pharmacology , Chondroitin/*metabolism , Heparitin Sulfate/*metabolism , Neovascularization, Physiologic/*drug effects , Plant Lectins/*pharmacology, Animals ; Capparaceae/metabolism ; Cell Movement/drug effects ; Chemotactic Factors/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Wound Healing/drug effects

المؤلفون: Pasqualotto AC; Universidade Federal de Ciências da Saude de Porto Alegre, Porto Alegre, RS, Brazil; Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address: Pasqualotto@santacasa.org.br., Almeida CS; Universidade de Caxias de Sul, Caxias do Sul, RS, Brazil., Kliemann DA; Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil., Barcellos GB; Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; Choosing Wisely, Brazil., Queiroz-Telles F; Universidade Federal do Paraná, PR, Curitiba, Brazil., Abdala E; Universidade de São Paulo, São Paulo, SP, Brazil., Resende M; Universidade Estadual de Campinas, Campinas, SP, Brazil., Batista FP; Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, PE, Brazil., Vidal JE; Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brazil., Rocha J; Pontifícia Universidade Católica do Paraná, PR, Curitiba, Brazil., Raboni SM; Universidade Federal do Paraná, PR, Curitiba, Brazil., Cimerman S; Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brazil., Gales AC; Universidade Federal de São Paulo, São Paulo, SP, Brazil.

المصدر: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2019 Sep - Oct; Vol. 23 (5), pp. 331-335. Date of Electronic Publication: 2019 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Editora Country of Publication: Brazil NLM ID: 9812937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4391 (Electronic) Linking ISSN: 14138670 NLM ISO Abbreviation: Braz J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Societies, Medical*, Communicable Diseases/*diagnosis , Unnecessary Procedures/*statistics & numerical data, Brazil ; Global Health ; Health Services Research ; Humans

المؤلفون: Bonturi CR; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. camilabntr@gmail.com., Silva MCC; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. mariana.cabral@kroton.com.br., Motaln H; Department of Biotechnology, Jozef Stefan Institute, 1000 Ljubljana, Slovenia. helena.motaln@ijs.si., Salu BR; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. bruno_salu@hotmail.com., Ferreira RDS; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. rodrigobioq@gmail.com., Batista FP; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. fabriciopbat@gmail.com., Correia MTDS; Department of Biochemistry, Federal University of Pernambuco, 50670-910 Recife, PE, Brazil. mtscorreia@gmail.com., Paiva PMG; Department of Biochemistry, Federal University of Pernambuco, 50670-910 Recife, PE, Brazil. ppaiva63@yahoo.com.br., Turnšek TL; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, 1000 Ljubljana, Slovenia. tamara.lah@nib.si., Oliva MLV; Department of Biochemistry, Federal University of São Paulo, 04044-020 São Paulo, SP, Brazil. olivaml.bioq@epm.br.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2019 Jun 04; Vol. 24 (11). Date of Electronic Publication: 2019 Jun 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Capparaceae/*chemistry , Mesenchymal Stem Cells/*drug effects , Plant Bark/*chemistry , Plant Extracts/*pharmacology , Plant Lectins/*pharmacology , Protease Inhibitors/*pharmacology, Cell Adhesion/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coculture Techniques ; Cytokines/biosynthesis ; Glioblastoma/metabolism ; Humans ; Mesenchymal Stem Cells/metabolism ; Metalloproteases/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Plant Extracts/chemistry ; Plant Lectins/chemistry ; Protease Inhibitors/chemistry

المؤلفون: Guarnieri MC; Department of Zoology, Federal University of Pernambuco, Av. Prof Moraes Rego 1235, CEP 50670-901, Cidade Universitária, Recife, PE, Brazil; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: miriam.guarnieri@ufpe.br., de Albuquerque Modesto JC; Vitória Academic Center, Federal University of Pernambuco, Rua Alto do Reservatório, s/n, CEP 55608-680, Bela Vista, Vitória de Santo Antão, PE, Brazil. Electronic address: jeanne.modesto@ufpe.br., Pérez CD; Vitória Academic Center, Federal University of Pernambuco, Rua Alto do Reservatório, s/n, CEP 55608-680, Bela Vista, Vitória de Santo Antão, PE, Brazil. Electronic address: cdperez@ufpe.br., Ottaiano TF; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: tatiana.ottaiano@gmail.com., Ferreira RDS; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: rodrigobioq@gmail.com., Batista FP; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: fabriciopbat@gmail.com., de Brito MV; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: marlonvilela@yahoo.com.br., Campos IHMP; Department of Zoology, Federal University of Pernambuco, Av. Prof Moraes Rego 1235, CEP 50670-901, Cidade Universitária, Recife, PE, Brazil. Electronic address: ikaromendescampos@gmail.com., Oliva MLV; Biochemistry Department, Federal University of São Paulo, Rua Três de maio 100, CEP 04044-020, Vila Clementino, São Paulo, SP, Brazil. Electronic address: olivaml.bioq@epm.br.

المصدر: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2018 Mar 01; Vol. 143, pp. 96-107. Date of Electronic Publication: 2018 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

مواضيع طبية MeSH: Anthozoa/*chemistry , Mucus/*chemistry , Proteins/*pharmacology, Animals ; Anti-Infective Agents ; Biological Products ; Brazil ; Crotalid Venoms/antagonists & inhibitors ; Erythrocytes ; Hemagglutination ; Humans ; Medicine, Traditional ; Metalloproteases/antagonists & inhibitors

المؤلفون: Andrade SS; Department of Gynecology of The Federal University of São Paulo, Brazil.; Charitable Association of Blood Collection - COLSAN, São Paulo, SP, Brazil.; Cell and Molecular Biology Laboratory, Center for Nuclear Energy in Agriculture CENA, University of São Paulo USP, Piracicaba, SP, Brazil., Sumikawa JT; Department of Gynecology of The Federal University of São Paulo, Brazil., Castro ED; Department of Biochemistry of The Federal University of São Paulo, Brazil., Batista FP; Department of Biochemistry of The Federal University of São Paulo, Brazil., Paredes-Gamero E; Department of Biochemistry of The Federal University of São Paulo, Brazil., Oliveira LC; Department of Biophysics of The Federal University of São Paulo, Brazil., Guerra IM; Department of Gynecology of The Federal University of São Paulo, Brazil., Peres GB; Department of Biochemistry of The Federal University of São Paulo, Brazil., Cavalheiro RP; Department of Biochemistry of The Federal University of São Paulo, Brazil., Juliano L; Department of Biophysics of The Federal University of São Paulo, Brazil., Nazário AP; Department of Gynecology of The Federal University of São Paulo, Brazil., Facina G; Department of Gynecology of The Federal University of São Paulo, Brazil., Tsai SM; Cell and Molecular Biology Laboratory, Center for Nuclear Energy in Agriculture CENA, University of São Paulo USP, Piracicaba, SP, Brazil., Oliva ML; Department of Biochemistry of The Federal University of São Paulo, Brazil., Girão MJ; Department of Gynecology of The Federal University of São Paulo, Brazil.; Charitable Association of Blood Collection - COLSAN, São Paulo, SP, Brazil.

المصدر: Oncotarget [Oncotarget] 2017 Mar 07; Vol. 8 (10), pp. 16851-16874.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Blood Platelets/*pathology , Fibrin/*physiology , Platelet-Rich Plasma/*cytology, Breast Neoplasms/blood supply ; Breast Neoplasms/pathology ; Disease Progression ; Epithelial Cells/pathology ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Neovascularization, Pathologic/pathology ; Stromal Cells/pathology ; Tumor Microenvironment