المؤلفون: Thea Norman, Tsotne Javahishvili, Stuart Bussell, David C. Litzinger, Stephanie Chu, Bruce E. Kimmel, Ricky Lieu, Sami Kaphle, Bee-Cheng Sim, Peter G. Schultz, Thomas L. Daniel, Mike Ong, Anna-Maria A. Hays Putnam, Zhenwei Maio, Ying Buechler, Richard D. DiMarchi, Ho Cho, Andrew R. Hoffman, Guillermo Viramontes, Paola Castiglioni, Douglas W. Axelrod, Becky Gc, Vadim Kraynov, Nick Knudsen

المصدر: Proceedings of the National Academy of Sciences. 108:9060-9065

مصطلحات موضوعية: Male, Polymers, Phenylalanine, Mutant, Polyethylene glycol, Biology, Protein Engineering, medicine.disease_cause, Polyethylene Glycols, Rats, Sprague-Dawley, chemistry.chemical_compound, Residue (chemistry), Endocrinology, PEG ratio, Genetic variation, medicine, Animals, Humans, Expanded genetic code, chemistry.chemical_classification, Mutation, Multidisciplinary, Dose-Response Relationship, Drug, Human Growth Hormone, Genetic Variation, Biological Sciences, Rats, Amino acid, chemistry, Biochemistry, Peptides, Ribosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b5edb326f7ee27edbdf4cea0830975
https://doi.org/10.1073/pnas.1100387108

المؤلفون: Cho H; Ambrx Incorporated, 10975 North Torrey Pines Road, La Jolla, CA 92037, USA. ho.cho@ambrx.com, Daniel T, Buechler YJ, Litzinger DC, Maio Z, Putnam AM, Kraynov VS, Sim BC, Bussell S, Javahishvili T, Kaphle S, Viramontes G, Ong M, Chu S, Becky GC, Lieu R, Knudsen N, Castiglioni P, Norman TC, Axelrod DW, Hoffman AR, Schultz PG, DiMarchi RD, Kimmel BE

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 May 31; Vol. 108 (22), pp. 9060-5. Date of Electronic Publication: 2011 May 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Human Growth Hormone/*genetics , Human Growth Hormone/*pharmacology, Animals ; Dose-Response Relationship, Drug ; Endocrinology/methods ; Genetic Variation ; Humans ; Male ; Mutation ; Peptides/chemistry ; Phenylalanine/analogs & derivatives ; Phenylalanine/chemistry ; Polyethylene Glycols/chemistry ; Polymers/chemistry ; Protein Engineering/methods ; Rats ; Rats, Sprague-Dawley ; Ribosomes/chemistry