المؤلفون: Bhaskar V, Goldfine ID, Bedinger DH, Lau A, Kuan HF, Gross LM, Handa M, Maddux BA, Watson SR, Zhu S, Narasimha AJ, Levy R, Webster L, Wijesuriya SD, Liu N, Wu X, Chemla-Vogel D, Tran C, Lee SR, Wong S

المصدر: Diabetes; May2012, Vol. 61 Issue 5, p1263-1271, 9p

المؤلفون: Bedinger DH; XOMA Corporation, Berkeley, CA, USA. Electronic address: bedinger@xoma.com., Adams SH; Arkansas Children's Nutrition Center and University of Arkansas for Medical Sciences, Department of Pediatrics, Little Rock, AR, USA.

المصدر: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2015 Nov 05; Vol. 415, pp. 143-56. Date of Electronic Publication: 2015 Aug 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Signaling System*, Insulin/*metabolism, Humans ; Metabolic Diseases/drug therapy ; Metabolic Diseases/metabolism ; Organ Specificity ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/agonists ; Receptor, Insulin/metabolism

المؤلفون: Bedinger DH; XOMA Corporation, Berkeley, California.; Molecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, California., Kieffer DA; Graduate Group in Nutritional Biology -and- Department of Nutrition, University of California, Davis, California., Goldfine ID; XOMA Corporation, Berkeley, California., Roell MK; XOMA Corporation, Berkeley, California., Adams SH; Molecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, California.; Graduate Group in Nutritional Biology -and- Department of Nutrition, University of California, Davis, California.; Arkansas Children's Nutrition Center -and- University of Arkansas for Medical Sciences, Department of Pediatrics, Little Rock, Arkansas.

المصدر: Journal of cellular biochemistry [J Cell Biochem] 2015 Sep; Vol. 116 (9), pp. 2109-19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*administration & dosage , Blood Glucose/*drug effects , Insulin/*administration & dosage , Liver/*metabolism , Receptor, Insulin/*agonists, 3-Hydroxybutyric Acid/blood ; Adipose Tissue/metabolism ; Animals ; Antibodies, Monoclonal/pharmacology ; CHO Cells ; Cricetulus ; Humans ; Injections, Intravenous ; Insulin/pharmacology ; Male ; Mice ; Muscles/metabolism ; Organ Specificity ; Phosphorylation/drug effects ; Receptor, Insulin/metabolism

المؤلفون: Bedinger DH; XOMA Corporation, Berkeley, California (D.H.B., I.D.G., J.A.C., M.K.R.); Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center and Department of Nutrition, Davis, California (S.H.A.); and Molecular, Cellular and Integrative Physiology Graduate Group, University of California at Davis, Davis, California (D.H.B., S.H.A.)., Goldfine ID; XOMA Corporation, Berkeley, California (D.H.B., I.D.G., J.A.C., M.K.R.); Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center and Department of Nutrition, Davis, California (S.H.A.); and Molecular, Cellular and Integrative Physiology Graduate Group, University of California at Davis, Davis, California (D.H.B., S.H.A.)., Corbin JA; XOMA Corporation, Berkeley, California (D.H.B., I.D.G., J.A.C., M.K.R.); Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center and Department of Nutrition, Davis, California (S.H.A.); and Molecular, Cellular and Integrative Physiology Graduate Group, University of California at Davis, Davis, California (D.H.B., S.H.A.)., Roell MK; XOMA Corporation, Berkeley, California (D.H.B., I.D.G., J.A.C., M.K.R.); Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center and Department of Nutrition, Davis, California (S.H.A.); and Molecular, Cellular and Integrative Physiology Graduate Group, University of California at Davis, Davis, California (D.H.B., S.H.A.)., Adams SH; XOMA Corporation, Berkeley, California (D.H.B., I.D.G., J.A.C., M.K.R.); Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center and Department of Nutrition, Davis, California (S.H.A.); and Molecular, Cellular and Integrative Physiology Graduate Group, University of California at Davis, Davis, California (D.H.B., S.H.A.) shadams@uams.edu.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 Apr; Vol. 353 (1), pp. 35-43. Date of Electronic Publication: 2015 Jan 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , Receptor, Insulin/*metabolism, Allosteric Regulation ; Animals ; Antibodies, Monoclonal/metabolism ; CHO Cells ; Cricetulus ; Drug Partial Agonism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Insulin/metabolism ; Insulin/pharmacology ; Phosphorylation ; Protein Binding ; Protein Isoforms/agonists ; Protein Isoforms/immunology ; Protein Isoforms/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/agonists ; Receptor, Insulin/immunology ; Signal Transduction

المؤلفون: Issafras H; Preclinical Research, XOMA Corporation, Berkeley, CA, USA issafras@xoma.com., Bedinger DH; Preclinical Research, XOMA Corporation, Berkeley, CA, USA., Corbin JA; Preclinical Research, XOMA Corporation, Berkeley, CA, USA., Goldfine ID; Preclinical Research, XOMA Corporation, Berkeley, CA, USA Department of Medicine, University of California, San Francisco, USA., Bhaskar V; Preclinical Research, XOMA Corporation, Berkeley, CA, USA., White ML; Preclinical Research, XOMA Corporation, Berkeley, CA, USA., Rubin P; Preclinical Research, XOMA Corporation, Berkeley, CA, USA., Scannon PJ; Preclinical Research, XOMA Corporation, Berkeley, CA, USA.

المصدر: Journal of diabetes science and technology [J Diabetes Sci Technol] 2014 Jul; Vol. 8 (4), pp. 865-73. Date of Electronic Publication: 2014 Apr 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 101306166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-2968 (Electronic) Linking ISSN: 19322968 NLM ISO Abbreviation: J Diabetes Sci Technol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*therapeutic use , Hyperglycemia/*drug therapy , Hypoglycemia/*drug therapy , Hypoglycemic Agents/*therapeutic use , Receptor, Insulin/*immunology, Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Insulin/blood ; Insulin/metabolism ; Oncogene Protein v-akt/metabolism ; Phosphorylation

المؤلفون: Corbin JA; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Bhaskar V; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Goldfine ID; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America., Bedinger DH; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lau A; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Michelson K; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Gross LM; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Maddux BA; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America., Kuan HF; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Tran C; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lao L; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Handa M; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Watson SR; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Narasimha AJ; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Zhu S; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Levy R; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Webster L; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wijesuriya SD; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Liu N; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wu X; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Chemla-Vogel D; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lee SR; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wong S; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wilcock D; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., White ML; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America.

المصدر: PloS one [PLoS One] 2014 Feb 12; Vol. 9 (2), pp. e88684. Date of Electronic Publication: 2014 Feb 12 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*chemistry , Antigens, CD/*metabolism , Glucose/*metabolism , Receptor, Insulin/*metabolism, Allosteric Site ; Animals ; C-Peptide/chemistry ; CHO Cells ; Cell Separation ; Cricetinae ; Cricetulus ; Diabetes Mellitus, Type 2/metabolism ; Flow Cytometry ; Humans ; Hyperglycemia/metabolism ; Hyperinsulinism/metabolism ; Insulin/chemistry ; Insulin Resistance ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Peptide Library ; Phosphorylation ; Protein Structure, Tertiary ; Signal Transduction

المؤلفون: Corbin JA; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Bhaskar V; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Goldfine ID; Department of Medicine; University of California; San Francisco, CA USA., Issafras H; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Bedinger DH; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Lau A; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Michelson K; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Gross LM; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Maddux BA; Department of Medicine; University of California; San Francisco, CA USA., Kuan HF; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Tran C; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Lao L; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Handa M; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Watson SR; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Narasimha AJ; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Zhu S; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Levy R; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Webster L; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Wijesuriya SD; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Liu N; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Wu X; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Chemla-Vogel D; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Lee SR; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Wong S; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Wilcock D; Preclinical Research; XOMA Corporation; Berkeley, CA USA., Rubin P; Preclinical Research; XOMA Corporation; Berkeley, CA USA., White ML; Preclinical Research; XOMA Corporation; Berkeley, CA USA.

المصدر: MAbs [MAbs] 2014 Jan-Feb; Vol. 6 (1), pp. 262-72.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*immunology , Congenital Hyperinsulinism/*immunology , Receptor, Insulin/*antagonists & inhibitors , Single-Chain Antibodies/*immunology, Animals ; Antibodies, Monoclonal/pharmacology ; Biological Transport, Active/drug effects ; Biological Transport, Active/immunology ; CHO Cells ; Congenital Hyperinsulinism/drug therapy ; Congenital Hyperinsulinism/pathology ; Cricetinae ; Cricetulus ; Glucose/immunology ; Insulin Resistance/immunology ; Mice ; Rats ; Receptor, Insulin/immunology ; Single-Chain Antibodies/pharmacology

المؤلفون: Lackey DE; Obesity & Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA. dlackey@ucsd.edu, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH

المصدر: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2013 Jun 01; Vol. 304 (11), pp. E1175-87. Date of Electronic Publication: 2013 Mar 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)/*metabolism , Adipose Tissue, White/*metabolism , Amino Acids, Branched-Chain/*metabolism , Obesity/*metabolism, Adipocytes/metabolism ; Adult ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Insulin/blood ; Mice ; Mice, Obese ; Middle Aged ; Rats ; Rats, Zucker

المؤلفون: Schwimmer LJ; XOMA Corp., 2910 Seventh St., Berkeley, CA 94710, United States. schwimmer@xoma.com, Huang B, Giang H, Cotter RL, Chemla-Vogel DS, Dy FV, Tam EM, Zhang F, Toy P, Bohmann DJ, Watson SR, Beaber JW, Reddy N, Kuan HF, Bedinger DH, Rondon IJ

المصدر: Journal of immunological methods [J Immunol Methods] 2013 May 31; Vol. 391 (1-2), pp. 60-71. Date of Electronic Publication: 2013 Feb 27.

نوع المنشور: Comparative Study; Journal Article; Validation Study

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1305440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7905 (Electronic) Linking ISSN: 00221759 NLM ISO Abbreviation: J Immunol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Cell Surface Display Techniques* , Peptide Library*, Immunoglobulin Fab Fragments/*immunology , Receptor, Insulin/*immunology , Receptor, TIE-2/*immunology , Single-Chain Antibodies/*immunology, Amino Acid Sequence ; Animals ; Antibody Affinity ; Antibody Specificity ; CHO Cells ; Cricetinae ; Cricetulus ; Humans ; Immunoglobulin Fab Fragments/biosynthesis ; Immunoglobulin Fab Fragments/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Open Reading Frames ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/genetics ; Receptor, TIE-2/genetics ; Single-Chain Antibodies/biosynthesis ; Single-Chain Antibodies/genetics ; Transfection

المؤلفون: Roell MK; Preclinical Research Department, XOMA (US) LLC, Berkeley, CA 94710, USA. roell@xoma.com, Issafras H, Bauer RJ, Michelson KS, Mendoza N, Vanegas SI, Gross LM, Larsen PD, Bedinger DH, Bohmann DJ, Nonet GH, Liu N, Lee SR, Handa M, Kantak SS, Horwitz AH, Hunter JJ, Owyang AM, Mirza AM, Corbin JA, White ML

المصدر: The Journal of biological chemistry [J Biol Chem] 2010 Jul 02; Vol. 285 (27), pp. 20607-14. Date of Electronic Publication: 2010 Apr 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , Interleukin-1beta/*physiology, Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Bioengineering ; Fibroblasts/cytology ; Fibroblasts/physiology ; HeLa Cells/drug effects ; HeLa Cells/physiology ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Interleukin-1/physiology ; Interleukin-1beta/drug effects ; Kidney/drug effects ; Kidney/physiology ; Kinetics ; Ligands ; Luciferases/genetics ; Lung/cytology ; Lung/physiology ; NF-kappa B/physiology ; Phosphoproteins/drug effects ; Phosphoproteins/metabolism ; Receptors, Interleukin-1/drug effects ; Receptors, Interleukin-1/physiology ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Signal Transduction/drug effects ; Signal Transduction/physiology