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1Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure
المؤلفون: Ben, Acton, Helen F, Small, Kate M, Smith, Alison, McGonagle, Alexandra I J, Stowell, Dominic I, James, Niall M, Hamilton, Nicola, Hamilton, James R, Hitchin, Colin P, Hutton, Ian D, Waddell, Donald J, Ogilvie, Allan M, Jordan
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Cyclopropanes, Glycoside Hydrolases, Administration, Oral, GI, gastrointestinal, Article, Mice, Animal welfare, Microsomes, Liver, Animals, Humans, PARG, poly-ADP ribose glycohydrolase, Ataxia, PK, Pharmacokinetics, ComputingMethodologies_COMPUTERGRAPHICS, Half-Life, Toxicophore
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المؤلفون: Julie A. Tucker, Ben Acton, Ian D. Waddell, Alexandra Stowell, Nicola Hamilton, Niall M. Hamilton, Kate M. Smith, Stuart Donald Jones, James R. Hitchin, Bohdan Waszkowycz, Alison E. McGonagle, Dominic I. James, Allan M. Jordan, Daniel P. Mould, Clifford David Jones, Colin Hutton, Helen F. Small, Emma E. Fairweather, Donald J. Ogilvie, Louise A. Griffiths
المصدر: Waszkowycz, B, Smith, K, Mcgonagle, A, Jordan, A, Acton, B, Fairweather, E, Griffiths, L, Hamilton, N M, Hamilton, N, Hitchin, J R, Hutton, C, James, D I, Jones, C D, Jones, S, Mould, D, Small, H F, Stowell, A, Tucker, J, Waddell, I & Ogilvie, D J 2018, ' Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides ', Journal of Medicinal Chemistry, vol. 61, no. 23, pp. 10767–10792 . https://doi.org/10.1021/acs.jmedchem.8b01407
مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, DNA Repair, Glycoside Hydrolases, DNA repair, Administration, Oral, Biological Availability, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Catalytic Domain, Drug Discovery, Structure–activity relationship, Animals, Humans, Glycoside Hydrolase Inhibitors, Poly(ADP-ribose) glycohydrolase, Quinazolinones, chemistry.chemical_classification, Virtual screening, PARG, Manchester Cancer Research Centre, Chemistry, ResearchInstitutes_Networks_Beacons/mcrc, Small molecule, 030104 developmental biology, Enzyme, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, HeLa Cells
وصف الملف: application/msword
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3
المؤلفون: Ian D. Waddell, Helen F. Small, Samantha Hitchin, Allan M. Jordan, Mandy Watson, Habiba Begum, Rebecca Newton, Ben Acton, Donald J. Ogilvie, Paul A.T. Kelly
المصدر: Molecular Cancer Therapeutics. 17:A123-A123
مصطلحات موضوعية: Cancer Research, Mutation, endocrine system diseases, business.industry, Cancer, Resistance mutation, medicine.disease, medicine.disease_cause, Oncology, Protein kinase domain, In vivo, Cancer research, Medicine, Adenocarcinoma, Kinase activity, business, Lung cancer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed7e31fb4d1262c1e87e15138d2bb330
https://doi.org/10.1158/1535-7163.targ-17-a123 -
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المؤلفون: Samantha Hitchin, Mandy Watson, Ian D. Waddell, Helen F. Small, Allan M. Jordan, Donald J. Ogilvie, Habiba Begum, Gina Paris, Rebecca Newton, Ben Acton, Paul A.T. Kelly
المصدر: Cancer Research. 77:2092-2092
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Cabozantinib, business.industry, Cancer, medicine.disease, Vandetanib, chemistry.chemical_compound, chemistry, In vivo, Internal medicine, medicine, Cancer research, Adenocarcinoma, Potency, Lung cancer, business, Tyrosine kinase, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::af4d41d88f48a88a7d1eec6bfa94c2e7
https://doi.org/10.1158/1538-7445.am2017-2092 -
5
المؤلفون: Stuart Donald Jones, James R. Hitchin, Julie A. Tucker, Donald J. Ogilvie, Alison E. McGonagle, Helen F. Small, Cliff Jones, Katherine Clegg Smith, Ben Acton, Bohdan Waszkowycz, Colin Hutton, Allan M. Jordan, Ian D. Waddell, Alex Stowell, Dominic I. James, Nicola Hamilton
المصدر: Cancer Research. 76:3715-3715
مصطلحات موضوعية: Cancer Research, PARG, business.industry, Drug discovery, DNA repair, Poly ADP ribose polymerase, Pharmacology, PARP1, Oncology, Biochemistry, DNA Repair Protein, Medicine, Pharmacophore, business, Poly(ADP-ribose) glycohydrolase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a369d40a7b7c358c70282e25c732f04e
https://doi.org/10.1158/1538-7445.am2016-3715 -
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المؤلفون: Nicola Hamilton, Stuart Donald Jones, Ben Acton, Bohdan Waszkowycz, Helen F. Small, Katherine Clegg Smith, Allan M. Jordan, Daniel P. Mould, Julie A. Tucker, Donald J. Ogilvie, Ian D. Waddell, Dominic I. James, Alex Stowell, Alison E. McGonagle, Cliff Jones
المصدر: Cancer Research. 76:3714-3714
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, PARG, biology, DNA repair, Poly ADP ribose polymerase, chemistry.chemical_compound, Enzyme, Oncology, chemistry, Biochemistry, Ribose, Cancer cell, biology.protein, Poly(ADP-ribose) glycohydrolase, Polymerase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::189433740f0d1df0d075fea4683860ac
https://doi.org/10.1158/1538-7445.am2016-3714 -
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المؤلفون: Stuart Donald Jones, Bohdan Waszkowycz, Daniel P. Mould, Nicola Hamilton, Helen F. Small, Sam Fritzl, Alison E. McGonagle, Emma E. Fairweather, Dominic I. James, Alexandra Stowell, Ben Acton, Allan M. Jordan, Niall M. Hamilton, Donald J. Ogilvie, Ian D. Waddell, Kate M. Smith, Sarah Holt, James Hitchen, Colin Hutton
المصدر: Molecular Cancer Therapeutics. 14:C39-C39
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, PARG, DNA damage, DNA repair, Biology, Cell biology, chemistry.chemical_compound, Enzyme, Oncology, Biochemistry, chemistry, RNA interference, biology.protein, Poly(ADP-ribose) glycohydrolase, DNA, Polymerase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9816dbf4f7964a45b732efd4e40b9a1
https://doi.org/10.1158/1535-7163.targ-15-c39 -
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المؤلفون: Sarah Holt, Ben Acton, Katherine Clegg Smith, Alison E. McGonagle, Bohdan Waszkowycz, Dominic I. James, Ian D. Waddell, James Hitchen, Niall M. Hamilton, Helen F. Small, Donald J. Ogilvie, Allan M. Jordan, Colin Huttom, Emma E. Fairweather, Alex Stowell, Nicola Hamilton
المصدر: Cancer Research. 75:3656-3656
مصطلحات موضوعية: Oncology, chemistry.chemical_classification, Cancer Research, medicine.medical_specialty, PARG, biology, Chemistry, Poly ADP ribose polymerase, Cancer, medicine.disease, biology.organism_classification, HeLa, Enzyme, Cell culture, Internal medicine, medicine, biology.protein, Cancer research, Cytotoxicity, Polymerase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::052a37cd6af34cffec8364d9f5556f70
https://doi.org/10.1158/1538-7445.am2015-3656 -
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المؤلفون: Samantha J R Fritzl, Kristin M. Goldberg, Stuart Donald Jones, Kate Bowler, Rebecca Newton, Helen F. Small, Ben Acton, Niall M. Hamilton, Gemma Hopkins, Nikki March, Ian D. Waddell, Alexandra Stowell, Roger J. Butlin, Bohdan Waszkowycz, Daniel P. Mould, Sarah Holt, Allan M. Jordan, Donald J. Ogilvie, Mandy Watson
المصدر: Cancer Research. 75:778-778
مصطلحات موضوعية: Cancer Research, endocrine system diseases, biology, Cabozantinib, Oncogene, business.industry, Vandetanib, medicine.disease, Receptor tyrosine kinase, Thyroid carcinoma, chemistry.chemical_compound, Oncology, chemistry, Protein kinase domain, Cell culture, Immunology, biology.protein, Cancer research, Medicine, Adenocarcinoma, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bab693c868b606cda874c3b98165e04e
https://doi.org/10.1158/1538-7445.am2015-778 -
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المؤلفون: Kate M. Smith, Helen F. Small, Alison E. McGonagle, Stuart Donald Jones, Nicola Hamilton, Emma E. Fairweather, Allan M. Jordan, Sarah Holt, Bohdan Waszkowycz, Ian D. Waddell, C. Hutton, Ben Acton, Donald J. Ogilvie, James R. Hitchin, Dominic I. James, Alexandra Stowell
المصدر: European Journal of Cancer. 50:94
مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, PARG, Oncology, chemistry, Biochemistry, DNA damage, Ribose, Poly(ADP-ribose) glycohydrolase