نتائج البحث - "Benjamin Caleb"

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دورية أكاديمية

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/bcd02552d59140f1871d75acbfffec14

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Figures S13-S19 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9c652f36eba7990109355ffbc45bde
https://doi.org/10.1158/2159-8290.22532926

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Supplementary Methods from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d273e24b0b70562bfd8ace053d7ea075
https://doi.org/10.1158/2159-8290.22532917.v1

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Tables S3-S4 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448ee55b6f74e7115d7952f4c0f92306
https://doi.org/10.1158/2159-8290.22532911.v1

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

المؤلفون: Sean Eckley, Markus Warmuth, Ping Zhu, Deepti Banka, Zhenhua J. Wu, Nicholas A. Larsen, Sudeep Prajapati, Ricardo Ribas, Ming-Hong Hao, Pavan Kumar, Pete Smith, Michael J. Wick, Kiran Aithal, Crystal Mackenzie, John D. Norris, Sasirekha Sivakumar, V. Subramanian, Tuong-Vi Nguyen, Lihua Yu, Sean Irwin, Andrew Hart, Craig Furman, Alyssa Moriarty, Amy Kim, Benjamin Caleb, O'shea Morgan Welzel, Craig Karr, Sunil Pancholi, Frédéric H. Vaillancourt, Silvia Buonamici, Manav Korpal, Namita Kumar, Weidong G. Lai, Diana Melchers, Peter Fekkes, René Houtman, Lesley-Ann Martin, Xiaoling Puyang, Victoria Rimkunas, Michael Thomas, Amy Siu, Reynolds Dominic, Sujatha Rajagopalan, Suzanne E. Wardell, John Wang, Jaya Julie Joshi, Zheng Guo Zhu, David M. Bolduc, Nathalie Rioux, Subhasree Das, Sergei Agoulnik, Shihua Yao, Galina Kuznetsov

المصدر: Cancer Discovery. 8:1176-1193

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0120259fcf7ad9215e86543a6ac089d0
https://doi.org/10.1158/2159-8290.cd-17-1229

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Abstract P1-10-08: Development of a first-in-class oral selective ERα covalent antagonist (SERCA) for the treatment of ERαWT and ERαMUT breast cancer

المؤلفون: Sean Irwin, Guo-Zhu Zheng, Sherri Smith, Craig Furman, Deepti Banka, Nathalie Rioux, Victoria Rimkunas, J Norris, Prashant Kumar, Nicholas A. Larsen, Y Yu, Anand Selvaraj, Sergei Agoulnik, Craig Karr, Andrew Hart, T Bowser, Lorna Helen Mitchell, Crystal MacKenzie, Huilan Yao, Pete Smith, Tarek Sahmoud, Peter Fekkes, Jiayi Wu, T-V Nguyen, Zhaojie Zhang, Frédéric H. Vaillancourt, Betty Chan, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Manav Korpal, Markus Warmuth, Ping Zhu, S Wardell, Amy K. Kim, Galina Kuznetsov, Sean Eckley, Allison Davis, Sudeep Prajapati, Jun Wang, Ming-Hong Hao, V. Subramanian, Naresh Kumar, Xiaoling Puyang, Lihua Yu, Jaya Julie Joshi, Reynolds Dominic, G W Lai

المصدر: Cancer Research. 78:P1-10

مصطلحات موضوعية: Cancer Research, Fulvestrant, Chemistry, Antagonist, Estrogen receptor, medicine.disease, Breast cancer, Oncology, Mechanism of action, Cancer research, medicine, medicine.symptom, Receptor, Estrogen receptor alpha, Tamoxifen, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07d855e8c12d90a391ebb18e38827bdf
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-08

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

المصدر: Cancer Research. 77:DDT01-04

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::71b5b0fa7e9d8e6795b2dcf66171548d
https://doi.org/10.1158/1538-7445.am2017-ddt01-04

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

المصدر: Nature medicine. 24(4)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4078739ee0c363415f375eded064d591
https://pubmed.ncbi.nlm.nih.gov/29500297

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

المصدر: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

مصطلحات موضوعية: 0301 basic medicine, Adenosine, Protein Conformation, General Physics and Astronomy, RNA-binding protein, Plasma protein binding, Crystallography, X-Ray, Mass Spectrometry, Exon, 0302 clinical medicine, Genetics, Multidisciplinary, RNA-Binding Proteins, Exons, Recombinant Proteins, Cell biology, 030220 oncology & carcinogenesis, RNA splicing, RNA Interference, Macrolides, RNA Splicing Factors, Fatty Alcohols, Protein Binding, Spliceosome, Cell Survival, Science, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Humans, Spiro Compounds, Cell Proliferation, Pyrans, Sequence Analysis, RNA, Alternative splicing, Cryoelectron Microscopy, Intron, General Chemistry, HCT116 Cells, Phosphoproteins, Introns, Alternative Splicing, 030104 developmental biology, Mutation, Mutagenesis, Site-Directed, Spliceosomes, Trans-Activators, Epoxy Compounds, Myeloid Cell Leukemia Sequence 1 Protein, Herboxidiene, Carrier Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163a1e80e4630732321afc5c9498ba49
https://pubmed.ncbi.nlm.nih.gov/28541300

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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex

المصدر: Cancer Research. 77:126-126

مصطلحات موضوعية: Cancer Research, Oncology, Biochemistry, Action (philosophy), RNA splicing, medicine, Binding pocket, Point (geometry), Computational biology, Biology, Adenosine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8075fa200716d9194a81bcb8042cc0
https://doi.org/10.1158/1538-7445.am2017-126

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